Patents in Class 435/188.5

Matches 1 - 50 out of 97

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Match	Document	Document Title
1	8088609	CAB molecules The present invention relates to CAB molecules, ADEPT constructs directed against CEA, and their use in therapy.
2	7906626	Immunological control of β-amyloid levels in vivo Disclosed are bispecific antibodies comprising a first antibody binding specificity which confers the ability of the bispecific antibody to cross the blood-brain barrier, and a second antibody...
3	7666658	Antibody catalysis of enantio- and diastereo-selective aldol reactions Nine efficient aldolase antibodies were generated using hapten 2. This hapten combines, in a single molecule, structural components employed for reactive immunization with structural components...
4	7524663	Covalently reactive transition state analogs and methods of use thereof Improved methods for the production, selection and inhibition of catalytic antibodies are disclosed.
5	7507540	Catalytic anti-factor VIII allo-antibodies A method is disclosed of determining the presence of catalytic anti-Factor VIII allo-antibodies capable of degrading Factor VIII in a mammal, and of characterising the cleavage sites in said Factor...
6	7456000	Deactivation of linking moieties in antibody-enzyme conjugates In some embodiments, the present invention pertains to a method for conjugating a first compound to a second compound wherein the conjugation involves an electrophilic moiety. The method comprises...
7	7413884	Immunological control of β-amyloid levels in vivo Disclosed are antibodies which catalyze hydrolysis of β-amyloid. Antibodies generated are characterized by the amide linkage which they hydrolyze. Methods of generating the antibodies by using ...
8	7410755	ADP detection using an enzyme-coupled reaction Methods and compositions are provided for determining ADP in the presence of ATP. These comprise including among the assay reagents at least one of the correcting components creatine phosphokinase...
9	7341720	Targeting of glycoprotein therapeutics Methods of making ligand-decorated polymer conjugates of therapeutic glycoproteins are described. Improved targeting of glycoproteins to specific tissues is achieved by masking the natural...
10	7335717	Methods, compositions, and biomimetic catalysts for the synthesis of silica, polysilsequioxanes, polysiloxanes, non-silicon metalloid-oxygen networks, polymetallo-oxanes, and their organic or hydrido conjugates and derivatives The in vitro polymerization of silica, silicone, non-silicon metalloid-oxane and metallo-oxane polymer networks, by combining a catalyst and a substrate to polymerize the substrate to form silica,...
11	7205136	Catalytic antibodies A method for increasing the rate of chemical reactions involving the conversion of at least one reactant to at least one product involves contacting the reactant with an appropriate monoclonal...
12	7148028	Methods and means relating to atherosclerosis The present invention relates to the identification of lipid oxidising antibodies as a key pathogenic factor in atherosclerotic disorders. The presence of such antibodies is a important marker for...
13	6974699	Pharmaceuticals and assays using enzyme subunits A method of releasing an agent for example, a chemotherapeutic, under predetermined conditions by protecting the agent within a lipid structure such as a liposome, causing lipase activity to be...
14	6946272	Transition state analogs Antigens capable of eliciting antibodies which can catalyze chemical reactions, in particular, the cleavage or formation of a peptide linkage, comprising a hapten or a hapten and a suitable carrier...
15	6913917	Anti-cocaine catalytic antibody Disclosed are catalytic antibodies and polypeptides capable of degrading cocaine. Said catalytic antibodies and polypeptides are characterized by the amino acid sequence of their complementary...
16	6913896	Assay with reduced background In as assay, an analyte is specifically associated with a reporter adenylate kinase, ADP is added and then formation of ATP is monitored. Prior to addition of ADP, adenylate kinase other than...
17	6867002	Sample treating kit and sample treating method using the same for analysis with a biosensor A sample solution treating instrument is provided for facilitating rapid and simplified adjustment of the condition of a sample solution proper for analysis with a biosensor before supplying the...
18	6855528	Methods for identifying inducers and inhibitors of proteolytic antibodies, compositions and their uses Covalently reactive antigen analogs are disclosed herein. The antigens of the invention may be used to stimulate production of catalytic antibodies specific for predetermined antigens assocated...
19	6846654	Catalytic antibodies as chemical sensors A system for detecting physical or chemical changes in an environment is disclosed. The system comprises means for conducting a chemical reaction; an active biological molecule whose physiological...
20	6720171	Combinatorial preparation and testing of heterogeneous catalysts A process for preparing arrays of two or more heterogeneous catalysts, heterogeneous catalyst precursors, or combinations thereof in a body having preferably parallel through-channels. In this...
21	6702705	Prodrugs activated by targeted catalytic proteins Catalytic antibodies are disclosed. The catalytic antibodies are specific for prodrug compounds. The catalytic antibodies enhance cleavage of an active drug moiety from a prodrug residue, thereby...
22	6696415	Treatment of ocular neovascularization and related diseases Tubedown-1 (tbdn-1), a protein associated with acetyltransferase activity has been characterized and its cDNA isolated. Tbdn-1 regulates endothelial differentiation through protein acetylation,...
23	6670438	Methods, compositions, and biomimetic catalysts for in vitro synthesis of silica, polysilsequioxane, polysiloxane, and polymetallo-oxanes Methods, compositions, and biomimetic catalysts, such as silicateins and block copolypeptides, used to catalyze and spatially direct the polycondensation of silicon alkoxides, metal alkoxides, and...
24	6670144	Compositions and methods for monitoring the phosphorylation of natural binding partners This invention relates to methods and compositions for monitoring the interaction of binding partners as a function of the addition or subtraction of a phosphate group to or from one of the binding...
25	6590080	Catalytic antibodies and a method of producing same The present invention relates generally to a growth factor precursor and its use to select production of antigen specific catalytic antibodies. Such catalytic antibodies are produced following B...
26	6589766	Aldol consensations by catalytic antibodies Catalytic antibodies, including 38C2 and 33F12, are capable of efficiently catalyzing a wide variety of ketone-ketone, ketone-aldehyde, aldehyde-ketone, and aldehyde-aldehyde intermolecular aldol...
27	6521432	Methods for enhancing the rate of modification of metastable bonds Antigens capable of eliciting antibodies which can enhance the rate of chemical reactions at peptide bonds are disclosed. In particular, the rate of cleavage or formation of metastable peptide...
28	6489418	Preparation and application of artificial anti-idiotypic imprints This patent application describes the use of molecular imprinting as a means for preparation of anti-idiotypic imprint matrices. With this technique, imprints of artificial or natural molecules...
29	6479265	Catalytic antibodies which hydrolyze primary amides and methods for eliciting and use of such antibodies Described and claimed are compounds of the formula wherein:Y is a polypeptide,R1 is bonded to the N-terminus of Y and is hydrogen or a branched or linear, substituted or unsubstituted, C1-21 alkyl,...
30	6451980	Signal enhancement of bispecific antibody-polymer probe for immunoassay use An immunoassay method including reacting a sample from a patient with a bispecific antibody, wherein the bispecific antibody includes one antibody specific for a compound to be detected and a...
31	6440710	Antibody-catalyzed deuteration, tritiation, dedeuteration or detritiation of carbonyl compounds Methods are provided for deuteration, tritiation, dedeuteration or detritiation of a carbonyl compound. A catalytic antibody that catalyzes an aldol addition reaction is contacted with a carbonyl...
32	6387674	Catalytic monoclonal antibodies with protease activity for selective lysis of protein component of plaques aggregates pathological conditions Catalytic monoclonal antibodies (abzymes) with selective protease activity in the pathologies characterized by the presence of plaques and fibrillar aggregates with protein component; methods for...
33	6368839	Aldolase catalytic antibody Antibodies that catalyze the aldol reaction are generated by immunization with a reactive compound that covalently traps a Lysine (Lys) residue in the binding pocket of the antibody by formation of...
34	6326176	Aldol condensations by catalytic antibodies Catalytic antibodies, including 38C2 and 33F12, are capable of efficiently catalyzing a wide variety of ketone-ketone, ketone-aldehyde, aldehyde-ketone, and aldehyde-aldehyde intermolecular aldol...
35	6294374	Use of catalytic antibodies for synthesizing epothilone Three monoclonal aldolase antibodies, generated against a β-diketone hapten by reactive immunization, catalyzed rapid and highly enantioselective retro-aldol reactions providing ent-9a-k by ...
36	6271009	Control of fruit ripening and senescence in plants Hapten and antigen designed for eliciting catalytic antibodies effective in inhibiting the ethylene production pathway in plants by deactivating a precursor thereof either by decomposition or...
37	6177270	Reaction-based selection for expression of and concentration of catalytic moieties Disclosed and claimed are methods for selecting a recombinant virus, phage or cell expressing a catalytic antibody or catalytic portion thereof, or for selecting catalytic activity by a moiety. The...
38	6156541	Compositions and methods for catalyzing hydrolysis of HIV gp120 A catalytic antibody and components thereof which cleave HIV gp120 are disclosed. Methods of isolating, cloning and purifying such antibodies or antibody components from patients are also...
39	6140091	Anti-idiotype vaccines to elicit catalytic antibodies Disclosed are methods for the production of second generation catalytic antibodies. The disclosed methods offer a variety of advantages relative to prior art techniques. For example, the methods of...
40	6130049	Assay methods and kits for diagnosing autoimmune disease
41	6057121	Method of catalyzing stereochemical reactions A method for increasing the rate of a chemical reaction involving conversion of at least one reactant to at least one product which comprises contacting the reactant with at least one appropriate...
42	6048717	Inhibitors of catalytic antibodies Specific, selective inhibitors of catalytic antibodies both synthetic and naturally occurring, their use and compositions thereof are disclosed. In particular, an inhibitor preventing the...
43	6042824	Methods using cross linked protein crystal formulations as catalysts in organic solvents The present invention relates to the application of biocatalysis technology for performing selective chemical reactions. In one embodiment, this invention relates to crosslinked protein crystal...
44	6017541	Immunogens for the production of cocaine-hydrolyzing catalytic antibodies Methods are described for the rapid synthesis in satisfactory yield of methyl ecgonine phenylphosphonates as analogues of transition states for the hydrolysis of the benzoyl ester of an ecgonine...
45	5985626	Catalytic antibody/substrate intermediates Antibodies that catalyze the aldol reaction are generated by immunization with a reactive compound that covalently traps a Lysine (Lys) residue in the binding pocket of the antibody by formation of...
46	5962291	Metal dependent catalytic antibodies and method for producing the same The present invention relates to catalytic antibodies and a method for producing the same wherein a host is immunized using an "antigen chelate" or more specifically a stable compound capable of...
47	5959083	Tetravalent bispecific receptors, the preparation and use thereof The invention relates to bispecific tetravalent receptors of the formula I ##STR1## or formula II ##STR2## against a tumor-associated antigen and against an agent active against tumors.
48	5932212	Crosslinked protein crystal formulations and their use as catalysts in organic solvents The present invention relates to the application of biocatalysis technology for performing selective chemical reactions. In one embodiment, this invention relates to crosslinked protein crystal...
49	5885816	Catalytic antibodies enantioselectively hydrolysing amino acid ester derivatives A process for conducting optical resolution of a racemic mixture of an amino acid derivatives and a process for preparing an optically active amino acid using a catalytic antibody...
50	5855885	Isolation and production of catalytic antibodies using phage technology Disclosed and claimed are methods for producing catalytic antibodies, including human catalytic antibodies, from bacteriophage. The methods require the cloning, selection, screening, and isolation...

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