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5736353 |
Assay reagents
The present invention relates to a peroxidase-containing reagent comprising a buffered aqueous solution of a peroxidase conjugate and a substrate for the peroxidase, in the absence of peroxide. The...
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5736343 |
Detection of organic compounds through regulation of antibody-catalyzed reactions
The present invention provides a method for determining the presence of a target organic molecule in a sample which comprises either (A): first, adding a substrate molecule to the sample, the...
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5733764 |
Method for purification of an aqueous enzyme solution
Particular enzymes are precipitated from a mixture of proteins by the simultaneous addition of a soluble aluminate and acid. The pH of the mixture is at least one pH unit from the isoelectric point...
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5728560 |
Method of treating CD4+ T cell lymphopenia in immuno-compromised patients
The present invention is directed to methods of treating CD4+ T cell lymphopenia in HIV-infected patients. The methods include administering an effective mount of adenosine deaminase or related...
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5728804 |
Use of cyclodextrins for protein renaturation
A method for renaturing a denatured protein is provided comprising contacting a solution or suspension of said denatured protein in a detergent-free liquid medium with an amount of a cyclodextrin...
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5719115 |
Coated enzyme preparation for detergents and cleaning formulations
Enzyme granules containing an enzyme, an inorganic or organic carrier material and a uniform outer pigment-containing coating layer on the granules, wherein the outer coating layer contains 30 to...
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5710009 |
Receptor:release ligand (reland) complexes and release assays using said reland and methods and kits based thereon
Assays using receptor:reland complexes capable of releasing the reland in the presence of an analyte are described, wherein the reland does not detectably compete with analyte for binding to the...
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5710040 |
Stable enzymatic aqueous liquid composition for the production of leather
An aqueous liquid composition containing one or more enzymatic active substances and at least 10 wt % to a maximum of (100-x) wt % molasses, wherein x is the fraction of enzymatic active substances...
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5707844 |
Immunoassay reagents and methods for detecting brequinar and analogs
The present invention is directed to immunoassay reagents including specific antibodies to quinoline carboxylic acids, such as brequinar; novel quinoline carboxylic acid haptens useful as standards...
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5705153 |
Glycolipid enzyme-polymer conjugates
Conjugates containing glucocerebrosidase and non-antigenic polymers such as polyethylene glycol are disclosed. The conjugates circulate for extended times and have prolonged activity in vivo when...
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5705382 |
Method for preserving nitrile hydratase or nitrilase activity of microbial cells with inorganic salts
Cells having enzyme activity, and the enzyme activity thereof, are preserved for a prolonged period of time, as a suspension of microbial cells or as a suspension of immobilized cells in particles,...
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5691154 |
Enzyme linked immunoassay with stabilized polymer saccharide enzyme conjugates
An improvement in enzyme linked immunoassays is disclosed wherein the enzyme is in the form of a water soluble polymer saccharide conjugate which is stable in hostile environments. The conjugate...
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5686253 |
Method of stabilizing enzyme conjugates
A method is disclosed for stabilizing a conjugate of an enzyme and a member of a specific binding pair (enzyme conjugate). The method comprises the step of combining the enzyme conjugate with an...
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5681750 |
Process for preparing a C1-esterase inhibitor concentrate (C1-INH), and concentrate obtained, for therapeutic use
Disclosed is a process for preparing a C1-esterase inhibitor concentrate, of human plasma origin, comprising 2 separations by chromatography on ion exchanger gels of tentacular type.
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5681927 |
Metal-radionuclide-labeled proteins and glycoproteins for diagnosis and therapy
Chelated radionuclide compositions are provided for conjugation to polypeptides and carbohydrates. The resulting conjugates may be used in diagnosis and therapy.
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5679548 |
Methods for producing polypeptide metal binding sites and compositions thereof
The present invention describes methods for producing metal binding sites on polypeptides, and particularly for producing metal binding sites within the CDR regions of immunoglobulin heavy or light...
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5674726 |
Enzyme stabilization with poly-L-lysine
An enzyme reaction stabilizer consisting of poly-L-lysine or its salt as an effective constituent, a method for using the enzyme reaction stabilizer, and an enzyme preservative consisting of...
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5674833 |
Detergent compositions containing protease and novel inhibitors for use therein
A detergent composition and additive comprising a protease and a reversible protease inhibitor of the peptide or protein type, wherein the ratio of the dissociation constant to the protease...
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5672489 |
Catalytic antibodies hydrolyzing acylated carbohydrates in a regioselective and stereoselective manner
A method of regio-and stereoselective hydrolysis to deprotect an acylated hydroxy group in acylated carbohydrates, which contributes to synthesis of complex oligosaccharides, is provided. The...
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5660978 |
Stabilization of analytes
A method for stabilizing analytes with antibodies and antibody fragments comprises dissolving the analyte in a liquid to form a solution, adding analyte-specific antibodies, fragments of such...
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5661020 |
Low diol polyalkylene oxide biologically active proteinaceous substances
Disclosed are pharmaceutical compositions containing low diol polyethylene glycol, covalently attached to superoxide and dismutase process of making the compositions. Also disclosed is a method of...
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5658753 |
Catalytic antibody components
Catalytic antibody components, methods for producing catalytic antibody components, methods for using catalytic antibody components, in particular, single chain and smaller components are...
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5658752 |
Method of catalyzing chemical reactions
A method for increasing the rate of chemical reactions involving the conversion of at least one reactant to at least one product involves contacting the reactant with an appropriate monoclonal...
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5650333 |
Immunoassay method and kit using superaggregated complex
Methods of assaying samples for the presence or quantity of an analyte involving immobilization of a gold sol, and optionally an enzyme capable of generating a reaction product, on a solid phase....
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5648075 |
Iodine based germicidal composition
The present invention relates generally to an enzymatically generated iodine microbiocide and more specifically to the use of such a microbiocide for the inactivation of pathogenic organisms that...
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5641865 |
Interaction system comprising a surfactant-stabilized disperse aqueous phase containing an antibody or antibody fragment
An interaction system, including an antibody or, antibody fragment having functional capability, which comprises a surfactant-stabilized microheterogeneous dispersion of aqueous phase in a...
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5639633 |
Method for synthesizing peptides with saccharide linked enzyme polymer conjugates
A method is disclosed for synthesizing peptides using water soluble enzyme polymer conjugates. The method comprises catalyzing the peptide synthesis with enzyme which has been covalently bonded to...
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5639481 |
Method for the therapeutic treatment of a mammalian eye using an admixed composition containing free molecular iodine
The present invention relates generally to an enzymatically generated iodine microbicide and more specifically to the use of such a microbiocide for the inactivation of pathogenic organisms that...
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5637473 |
Liquid-phase immunodiagnostic assay
Reagents for a liquid-phase immunodiagnostic assay (LIDA) method comprise a first enzyme; a second enzyme; a first agent which is capable of binding with an analyte to form a complex, the agent...
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5637468 |
Salt stabilization of antibody-enzyme conjugates heat-dried into paper
New and useful methods of producing stabilized enzyme antibody conjugates are disclosed which are particularly useful in forming multi-layer immunoassay test devices. In particular, the invention...
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5637467 |
Heterogeneous assay using a pendulous drop
As method of determining an analyte is described, where a medium suspected of containing an analyte is drawn into a capillary tube by capillary action, such that if the analyte is present, it...
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5621002 |
Prodrugs for enzyme mediated activation
Enzymatically clearable prodrugs with reduced Michaelis-Menten constant (Km) are described.
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5618681 |
Polyaromatic hydrocarbon (PAH) immunoassay method, its components and a kit for use in performing the same
An immunoassay method that integrates a sample processing component that enables the testing of a variety of environmental matrixes and the components for performing the method, wherein the...
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5612306 |
Stable enzyme-containing aqueous laundry prespotting composition
A stable, enzyme-containing aqueous laundry prespotting composition. The composition includes at least one detergent enzyme in an amount effective to reduce fabric stains; an enzyme stabilizing...
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5612460 |
Active carbonates of polyalkylene oxides for modification of polypeptides
Poly(ethylene glycol)-N-succinimide carbonate and its preparation are disclosed. Polyethylene glycol (PEG) is converted into its N-succinimide carbonate derivative. This form of the polymer reacts...
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5610283 |
Opiate derivatives and protein and polypeptide opiate derivative conjugates and labels
The present invention is directed to novel opiate derivatives which are synthesized for the covalent attachment to antigens (proteins or polypeptides) for the preparation of antibodies or receptors...
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5605661 |
Methods of using liquid enzyme compositions containing mixed polyols
Compositions containing a stable, liquid, ophthalmically acceptable enzyme and methods involving the combined use of these compositions with a polymeric antimicrobial agent are disclosed for the...
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5603931 |
Method for delivering a bioactive molecule to a cellular target
Hybrid reagents comprising a first portion having an affinity for a cellular target and a second portion having an affinity for a bioactive molecule are described, said hybrid reagents being...
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5601994 |
Immunoassay with novel labeled drug hapten analogues
The invention is directed to labeled drug hapten analogues comprising: (A) a label, of the type used in immunoassays, having an amine or sulfhydryl group; (B) a drug hapten nucleus selected...
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5602015 |
Autoantibodies which enhance the rate of a chemical reaction
Autoantibodies which enhance the rate of a chemical reaction of a substrate, processes for their preparation, their use and compositions thereof are disclosed. In particular, an autoantibody...
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5599538 |
Autoantibodies which enhance the rate of a chemical reaction
Autoantibodies which enhance the rate of a chemical reaction of a substrate, processes for their preparation, their use and compositions thereof are disclosed. In particular, an autoantibody...
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5595732 |
Polyethylene-protein conjugates
The present invention is a physiologically active, substantially non-immunogenic water soluble polyethylene glycol protein conjugate having the same utility as the protein which forms the...
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5591828 |
Bispecific and oligospecific mono-and oligovalent receptors, the preparation and use thereof
The invention relates to bispecific and oligospecific, mono- and oligovalent receptors which are prepared by gene manipulation by fusion of DNA coding for F(ab) fragments of antibodies of two or...
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5589370 |
Process for encapsulating sensitive materials
The present invention relates to an improved curing or hardening process for the continuous production of capsules containing a sensitive material. The process allows capsules to be formed...
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5589169 |
Method and therapeutic compositions for the prevention of fibrin deposition or adhesions
A method and pharmaceutical composition for the prevention of fibrin deposition or adhesion formation by topical application of a composition to a site of potential fibrin deposition or adhesion...
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5580486 |
Liquid detergents containing an α-amino boronic acid
Aqueous liquid detergent compositions are described which comprise a proteolytic enzyme wherein the proteolytic activity is reversibly inhibited by an α-amino boronic acid.
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5578457 |
Immunoassays with novel labeled carbamazepine hapten analogues
An immunoassay method and analytical elements for detecting carbamazepine drugs, for example, in body fluids, is described. The immunoassay method comprises: (A) contacting a liquid sample,...
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5578500 |
Reagents and methods for the quantification of imipramine or desipramine in biological fluids
Immunoassay methods and reagents for the specific quantification of imipramine or desipramine in a test sample are disclosed. The measurement of imipramine or desipramine is accomplished in a...
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5576174 |
Catalytic antibody with primary amine cofactor
Antibodies raised against the quaternary piperidinium haptens are shown to catalyze the aldol stereoselective addition of acetone to aldehydes using the primary benzylamine as a cofactor.
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5571681 |
Chemical event selection by suicide substrate conjugates
Molecules having covalent catalytic activity are identified by panning synthetic and semisynthetic combinatorial libraries on solid phase suicide substrates. In an alternative mode, mechanism-based...
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