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5888506 |
Methioninase formulations
Improved formulations of methioninase which contain methioninase in crystalline, lyophilized, or conjugated form are disclosed. The methioninase in these compositions has a specific activity of at...
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5885816 |
Catalytic antibodies enantioselectively hydrolysing amino acid ester derivatives
A process for conducting optical resolution of a racemic mixture of an amino acid derivatives and a process for preparing an optically active amino acid using a catalytic antibody...
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5883066 |
Liquid detergent compositions containing cellulase and amine
The present invention is a liquid detergent composition containing anionic surfactant and cellulase. Said composition further comprises hydrophobic amines as cellulase stabilizers.
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5880270 |
Aminooxy-containing linker compounds for formation of stably-linked conjugates and methods related thereto
Linker compounds for formation of stably-linked conjugates are disclosed. Such linker compounds are aminooxy-containing linker compounds useful in forming conjugates having stable oxime linkages....
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5879923 |
Stable plasmin solution
A plasmin solution, comprising: (A) plasmin, and (B) the following component (B-1), (B-2) or (B-3): (B-1) an oligopeptide comprising at least two amino acids bonded to each other, where the...
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5868868 |
Peg-modified proteases and methods of use in contact lens cleaning
The invention discloses PEG-modified proteases, compositions containing these modified enzymes, and methods for using them to clean contact lenses. The methods of the present invention are also...
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5864020 |
HTK ligand
A novel hepatoma transmembrane kinase receptor ligand (Htk ligand) which binds to, and activates, the Htk receptor is disclosed. As examples, mouse and human Htk ligands have been identified in a...
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5863748 |
p-Hydroxycinnamoyl-containing substrates for an analyte dependent enzyme activation system
The present invention concerns novel p-hydroxycinnamoyl-containing substrates which can be used in catalyzed reporter deposition to amplify the detector signal and improve assay detection limits.
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5861251 |
Lyophilized reagent for polymerase chain reaction
The present invention provides a process for preparing a ready-to-use reagent for PCR, which comprises the steps of adding the stabilizer, glucitol or glucose, to an aqueous polymerase chain...
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5855987 |
Bioactive conjugates of cellulose with amino compounds
Polymers containing a plurality of free hydroxy groups, such as cellulose, agarose or polyvinyl alcohol, are contacted in absence of reactants for hydroxy groups, with at least one N-heterocyclic...
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5855885 |
Isolation and production of catalytic antibodies using phage technology
Disclosed and claimed are methods for producing catalytic antibodies, including human catalytic antibodies, from bacteriophage. The methods require the cloning, selection, screening, and isolation...
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5851791 |
Ubiquitin conjugating enzyme (E2) fusion proteins
A novel class of fusion proteins based on the ubiquitin-conjugating enzyme, or E2, is described. The fusion proteins include, in addition to the E2 activity, a protein binding ligand having a...
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5830675 |
Methods for selectively detecting perinuclear anti-neutrophil cytoplasmic antibody of ulcerative colitis, primary sclerosing cholangitis, or type 1 autoimmune hepatitis
The invention is directed to methods and kits for detecting and measuring the presence or absence of perinuclear anti-neutrophil cytoplasmic antibody of ulcerative colitis, primary sclerosing...
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5827718 |
Lipase, microorganisms producing the lipase, method of producing the lipase and use of the lipase
Bacteria belonging to the genus Pseudomonas, alkaline lipase produced by the bacteria and having the following properties, a method of producing the lipase, and detergent compositions containing...
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5827709 |
Enzyme preparations stabilized with inorganic salts
The present invention discloses methods to improve the processing and storage stability of dry enzyme preparations. To this extent an inorganic salt, e.g. MgSO 4 , is dissolved in an enzyme...
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5821342 |
Carbamazepine derivatives/antigens
The present invention provides a novel carbamazepine hydrazide compound suitable for covalent attachment to a polymer particle reagent, having the general formula ##STR1## The present invention...
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5817467 |
Method for quantitatively determining creatinine kinase and a reagent therefor
The object of the invention is to provide a reagent for quantitatively determining creatine kinase with improved storability in liquid form as well as a method for quantitatively determining...
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5817529 |
Methods of making propoxphene derivatives
The present invention provides hapten derivatives that are useful for the preparation of antigenic, antibody and label reagents having superior performance characteristics for use in immunoassays...
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5814503 |
Fusion proteins comprising cell cycle regulatory proteins
The present invention provides novel fusion proteins comprising cyclins and CDKs. A preferred embodiment of the invention provides fusion proteins comprising human cyclin D1 and human CDK4. The...
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5814502 |
Stabilized liquid mixtures for labelling nucleic acids
Stable enzyme compositions are provided in a liquid form for the enzymatic radioactive and non-radioactive labelling of nucleic acids and oligonucleotides. The mixtures preferably contain 30-60%...
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5807688 |
Catalytic antibodies for carbamate activation by a non-spontaneous reaction mechanism
Catalytic antibodies capable of catalysing activation of a carbamate (--O--CO--NH--) containing prodrug suitable for Antibody Directed Abzyme Prodrug Therapy (ADAPT) by catalysing breakdown of the...
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5804047 |
Enzyme-immobilized electrode, composition for preparation of the same and electrically conductive enzyme
An enzyme sensor system capable of quantitatively determining a particular component contained in a biological sample in a rapid and easy manner is disclosed. More particularly, an electrically...
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5801140 |
Enzyme dispersions, their production and compositions containing them
A process for the production of stable fluid enzyme dispersions having a content of at least 0.5% by weight enzyme, in which the enzyme is present in the form of anhydrous particles of a diameter...
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5801047 |
Method for making stable extracellular tyrosinase and synthesis of polyphenolic polymers therefrom
A process for the in vitro production of chemically modified polyphenolic polymer (PPP). First, stable, highly active extracellular tyrosinase is produced from genetically transformed microorganism...
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5798241 |
ATP-diphosphohydrolases
The present invention relates to two ATP diphosphohydrolases ATPDase enzymes isolated from bovine aorta and pig pancreas, which enzymes have a molecular weight for their catalytic unit of about 78...
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5792636 |
Process for producing a stable carboxylesterase in dry form
A process is presented for producing a stable carboxylesterase in dry form wherein a saccharide selected from maltose, maltotriose, maltotetrose, maltopentaose, maltohexaose, maltoheptaose and...
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5786156 |
Immunoreactive peptides of APO(A)
The present invention relates to peptides immunoreactive with anti-apolipoprotein(a) antibodies and to their use in raising monoclonal and polyclonal antibodies, in immunoassays and of their...
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5782932 |
Enzymatic composition
Enzymatic compositions with improved storage stability of the enzymes contained therein are obtained by including an enzyme stabiliser, preferably by way of a particular process.
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5783627 |
Dense gas-compatible enzymes
An enzymatic reaction system including a modified enzyme, and a dense gas system; modified enzymes; and methods of reacting modified enzymes in a dense gas system or liquid carbon dioxide.
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5780283 |
Enzyme stabilization by oxygen-containing block copolymers
A method for stabilizing an enzyme against decomposition at elevated temperatures or by water is described which comprises combining the enzyme with stabilizing amounts of a non-ionic...
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5773271 |
Compounds from biopolymers and effector substances which are linked via optically active amino acid derivatives, processes for the preparation thereof and the use thereof
Compounds from biopolymers and effector substances which are linked via optically active amino acid derivatives, processes for the preparation thereof and the use thereof. The invention relates to...
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5773277 |
Crystalline chondroitinase isolated from Proteus vulgaris ATCC 6896
A crystallizable, purified chondroitinase ABC having a molecular weight of about 100,000 dalton by the measurement of the SDS-polyacrylamide gel electrophoresis (SDS-PAGE) and the measurement by...
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5766897 |
Cysteine-pegylated proteins
Methods and compositions are provided for the production of PEGylated proteins having polyethylene glycol covalently bound to a cysteine residue present in either the naturally-occurring protein or...
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5766861 |
Method for screening catalytic non-enzyme polypeptides and proteins
A method for screening or detection of a non-enzyme catalytic polypeptide or protein for the conversion of a substrate S to a product P is provided, in which a preparation containing the potential...
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5763157 |
Biological reagent spheres
A reagent sphere is disclosed comprising at least one biological reagent and a glass-forming filler material in a concentration sufficient to facilitate formation of a glassy, porous composition,...
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5763249 |
Antibody-mediated reduction of α-ketoamides
Monoclonal antibodies raised against a 4-nitrophenyl phosphonate hapten catalyze the stereospecific reduction of an α-ketoamide to the corresponding α-hydroxyamide in the presence of an...
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5763205 |
Producing pure chondroitinase ABC from Proteus vulgaris ATCC 6896
A crystallizable, purified chondroitinase ABC having a molecular weight of about 100,000 dalton by the measurement of the SDS-polyacrylamide gel electrophoresis (SDS-PAGE) and the measurement by...
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5759834 |
Synthetic sterically-constrained pepzyme catalysts modeled on lysozyme and ribonuclease
Pepzymes, chemically synthesized cyclic peptides, modeled on lysozyme and ribonuclease have been prepared which efficiently catalyze the same reaction as the native enzyme being modeled. The...
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5756301 |
Endogenous taxol-like substance in human serum, monoclonal antibodies directed thereto and methods of assaying therefor
The present invention provides two monoclonal antibodies capable of binding to taxol and taxol-like substances which are produced by hybridomas designated 69E4A8E, having ATCC Accession No. HB11281...
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5756092 |
Use, in a composition, as cyclooxygenase activator and/or stabilizer, of at least one pyrimidine derivative sustituted at the 6th position and a cyclooxygenase substrate
A composition and a method of treating alopecia or dermatological conditions with said composition are disclosed. The composition comprises at least one pyrimidine derivative substituted at the 6th...
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5753283 |
Method for stabilizing rice bran and rice bran products
A process for stabilizing rice bran containing protein and a naturally occurring lipase enzyme that causes rancidity. The rice bran is treated with an antilipase enzyme, preferably a nonspecific...
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5753443 |
Crystallized formulation for staining DNA, its preparation and kit
A process is disclosed for making a crystallized formulation for staining nuclear DNA to be used in flow cytometery. The crystallized DNA staining formulation and a kit containing the crystallized...
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5753487 |
Stabilised phenylalanine ammonia lyase
This invention relates to stabilization of phenylalanine ammonia lyase against proteolytic degradation by chemical modification with crosslinking agents, or by genetic modification, a phenylalanine...
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5750361 |
Formation and use of prion protein (PRP) complexes
Prion protein (PrP) peptides having at least one α-helical domain and forming a random coil conformation in aqueous solutions bind cellular PrP (PrP C ) to form a complex having characteristics of...
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5741686 |
Exopeptidase catalyzed site-specific bonding of supports, labels and bioactive agents to proteins
A method is provided for preparing a labeled protein, immobilized protein or protein-bioactive agent composition by attaching a label, support or bioactive agent to a protein by exopeptidase...
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5739091 |
Enzyme granulates
Enzyme granules which comprise in their composition, in addition to the enzyme, water-soluble and water-insoluble fillers, binders and if appropriate other granulating auxiliaries, a formate of an...
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5739023 |
Stabilized neutral metalloprotease composition, a method of making the composition, and a method of transporting the composition
A method for making a stabilized neutral metalloprotease enzyme composition is described in which a neutral metalloprotease and an aqueous solution are combined to obtain a solution or slurry...
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5736625 |
Method for stabilizing proteins with saccharide linked protein polymer conjugates
A method is disclosed for preparing water soluble protein polymer conjugates which stabilize the protein so as to retain functional properties in a hostile environment. The method comprises...
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5736353 |
Assay reagents
The present invention relates to a peroxidase-containing reagent comprising a buffered aqueous solution of a peroxidase conjugate and a substrate for the peroxidase, in the absence of peroxide. The...
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5736343 |
Detection of organic compounds through regulation of antibody-catalyzed reactions
The present invention provides a method for determining the presence of a target organic molecule in a sample which comprises either (A): first, adding a substrate molecule to the sample, the...
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