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6136578 |
Storage-stable liquid formulation comprising a laccase
The present invention relates to a storage-stable liquid formulation comprising a laccase comprising (i) a laccase, (ii) at least one polyalcohol, which formulation has a pH which is more alkaline...
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6132712 |
Superoxide dismutase stabilized with fragments of casein and pharmaceutical compositions incorporating same
A stabilized superoxide dismutase (SOD) peptide is described in which SOD is protected against premature proteolytic degradation by fragments of casein. The stabilized SOD is achieved by mixing the...
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6132713 |
Arginine deiminase derived from mycoplasma arthritidis and polymer conjugates containing the same
A purified arginine deiminase (ADI) obtained from Mycoplasma arthritidis having the amino acid sequence of SEQ ID NO:2 as well as an isolated nucleic acid molecule containing a nucleotide sequence...
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6132722 |
Recombinant antibody-enzyme fusion proteins
The invention is related to recombinantly produced fusion polypeptides comprising antibody V H and V L sequences operatively linked to a β-lactamase for use in the delivery of cytotoxic drugs to...
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6133229 |
Stabilization of proteins in solution
A protein stabilizer additive comprises two or more of a tris compound of the formula (1): (HOCH 2 ) 3 --C--R, wherein R is: C 1 -C 4 alkyl, substituted C 1 -C 4 alkyl, NH 2 ; NR 1 R 2 ...
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6130049 |
Assay methods and kits for diagnosing autoimmune disease
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6127155 |
Stabilized thermostable nucleic acid polymerase compositions containing non-ionic polymeric detergents
A purified thermostable nucleic acid polymerase is obtained that has unique characteristics. Preferably the nucleic acid polymerase is DNA polymerase isolated from a Thermus aquaticus species and...
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6114508 |
Cocaethylene immunogens and antibodies
The ethyl ester of derivatives of benzoyl ecgonine are provided having a linking group at the para position of the benzoyl group. The derivatives are used to bond to immunogenic polypeptides for...
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6114132 |
Prosphatase binding assay
Disclosed is a binding assay for proteases and phosphatases, which contain cysteine in their binding sites or as a necessary structural component for enzymatic binding. The sulfhydryl group of...
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6096309 |
Compositions containing thrombin and microfibrillar nanometer collagen, and methods for preparation and use thereof
The present invention relates to thrombin-containing hemostatic compositions, their preparation and use. In particular, it relates to hemostatic compositions comprising stabilized thrombin and...
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6083708 |
Polypeptide: dendrimer complexes
Compositions are disclosed, comprising dendrimers to which a first polypeptide is controllably coupled. Such polypeptide-dendrimer compositions are effective for controllably coupling a second...
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6057139 |
Preblend of microcrystalline cellulose and lactase for making tablets
A preblend for making lactase tablets is prepared containing about 1-99% (preferably about 20-60%) by weight lactase and about 1-99% (preferably about 40-80%) by weight microcrystalline cellulose....
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6057121 |
Method of catalyzing stereochemical reactions
A method for increasing the rate of a chemical reaction involving conversion of at least one reactant to at least one product which comprises contacting the reactant with at least one appropriate...
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6054271 |
Methods of using synthetic molecules and target sequences
The present invention features biarsenical molecules and target sequences that specifically react with the biarsenical molecules. Methods of using the biarsenical molecules, tetraarsenical...
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6048717 |
Inhibitors of catalytic antibodies
Specific, selective inhibitors of catalytic antibodies both synthetic and naturally occurring, their use and compositions thereof are disclosed. In particular, an inhibitor preventing the...
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6042824 |
Methods using cross linked protein crystal formulations as catalysts in organic solvents
The present invention relates to the application of biocatalysis technology for performing selective chemical reactions. In one embodiment, this invention relates to crosslinked protein crystal...
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6030821 |
Stabilized transglutaminase and enzyme preparation containing the same
This invention relates to stabilized transglutaminase which is obtained by drying a solution containing transglutaminase and a protein material and to a transglutaminase enzyme preparation that...
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6017541 |
Immunogens for the production of cocaine-hydrolyzing catalytic antibodies
Methods are described for the rapid synthesis in satisfactory yield of methyl ecgonine phenylphosphonates as analogues of transition states for the hydrolysis of the benzoyl ester of an ecgonine...
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6013488 |
Method for reverse transcription
A method for preparing a cDNA from a mRNA using a reverse transcriptase wherein reverse transcription is performed at a temperature at which the mRNA does not take a secondary structure, for...
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6004824 |
Propoxyphene derivatives for immunoassay reagents
The present invention provides hapten derivatives that are useful for the preparation of antigenic, antibody and label reagents having superior performance characteristics for use in immunoassays...
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5998158 |
Glucose free, stable dry analytical element for quantitative analysis of creatine kinase MB isozyme
A dry analytical element for quantitatively analyzing creatine kinase MB isozyme is composed of a support and a creatine kinase MB isozyme-detecting agent layer. The detecting layer contains an...
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5989842 |
Method of marking biomolecules using horseradish peroxidase
The invention is a method for the enzymatic labeling of biomolecules, such as immunoglobulin, peptide, hormone, or hapten, which involves oxidizing horseradishperoxidase (HRP) with a periodate,...
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5989880 |
Method of preparing lysozyme dimers
A method is provided for preparing a highly purified lysozyme dimer product which comprises dimerizing the lysozyme monomer with a suberimidate coupling reagent in a buffer solution adjusted to pH...
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5985626 |
Catalytic antibody/substrate intermediates
Antibodies that catalyze the aldol reaction are generated by immunization with a reactive compound that covalently traps a Lysine (Lys) residue in the binding pocket of the antibody by formation of...
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5985263 |
Substantially pure histidine-linked protein polymer conjugates
Substantially pure histidine-linked protein-polymer conjugates and processes for their preparation are disclosed. The processes include contacting a protein with an activated polymer under...
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5985631 |
Method for preventing the activation of inactive, recombinant Helicobacter pylori apourease
A method for preventing the activation of inactive, recombinant Helicobacter pylori apourease is presented. The method comprises contacting the apourease with a compound that modifies a sulfhydryl...
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5976842 |
Methods and compositions for use in high fidelity polymerase chain reaction
Methods and compositions are provided for performing high fidelity polymerase chain reactions. In the subject methods, primer extension products are produced with a low error frequency rate through...
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5976857 |
Cross-linked polypeptide fragments of β-galactosidase
Formation of an intramolecular cross-link in enzyme donor polypeptide fragments of β-galactosidase, thereby forming a cyclic enzyme donor which is hindered from complementation with an enzyme...
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5973124 |
Modified avidin and streptavidin molecules and use thereof
Biotin-binding modified avidin-type molecules are provided in which the essential tyrosine residue in the biotin-binding site is modified in such a way that its pKa is decreased in comparison to...
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5972669 |
Salt-stabilized enzyme preparations
The present invention discloses methods to improve the processing and storage stability of dry enzyme preparations. To this extend an inorganic salt, e.g. MgSO 4 , is dissolved in an enzyme...
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5972668 |
Production of multi-enzyme granules
A process is presented for producing stable multi-enzyme containing granules. The process involves the steps of mixing a reversible competitive inhibitor with a first enzyme, adding a second...
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5972635 |
Sulfonic acid group buffered dry analytical element for quantitative analysis of creatine kinase or its MB isozyme
A dry analytical element for quantitatively analyzing creatine kinase is composed of a support and a creatine kinase-detecting agent layer. The creatine kinase-detecting agent layer contains...
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5968887 |
Boronic acid or borinic acid derivatives as enzyme stabilizers
The invention relates to a liquid composition which comprises an enzyme and a enzyme stabilizing component. The enzyme stabilizing component is a boronic acid derivative.
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5962299 |
Method of stabilizing protein C or activated protein C and the stabilized composition obtained by said method
A method for stabilizing protein C or activated protein C and a preparation obtained by said method are provided, said method and preparation being applicable during procedures such as isolation...
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5962279 |
Process for producing D-amino acids with composite immobilized enzyme preparation
A process for the efficient production of a D-amino acid from the corresponding DL-5-substituted hydantoin by one-step reaction which comprises using a composite immobilized enzyme at a pH about...
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5962291 |
Metal dependent catalytic antibodies and method for producing the same
The present invention relates to catalytic antibodies and a method for producing the same wherein a host is immunized using an "antigen chelate" or more specifically a stable compound capable of...
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5959083 |
Tetravalent bispecific receptors, the preparation and use thereof
The invention relates to bispecific tetravalent receptors of the formula I ##STR1## or formula II ##STR2## against a tumor-associated antigen and against an agent active against tumors.
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5951981 |
Thrombolytic agents with antithrombotic activity
This invention provides thrombolytic agents and methods for making and using thrombolytic agents. Specifically, the invention provides thrombolytic agents comprising a thrombolytic proteinase and a...
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5952187 |
Topiramate immunoassay
The present invention provides a topiramate immunoassay and reagents for use in the immunoassay. In particular, topiramate is derivatized at the sulfamate moiety or the 9-carbon or 10-carbon methyl...
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5939318 |
Cholesterol disposal fusion enzymes
Fusion enzymes having multiple segments of different biological activity including one segment having P450scc activity and at least one segment having electron-transfer activity for transferring...
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5935834 |
Reverse transcriptase composition having improved storage stability
Disclosed is a reverse transcriptase composition having improved storage stability, comprising a reverse transcriptase, an effective stabilizing amount of at least one organic stabilizing reagent...
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5932462 |
Multiarmed, monofunctional, polymer for coupling to molecules and surfaces
Multi-armed, monofunctional, and hydrolytically stable polymers are described having the structure ##STR1## wherein Z is a moiety that can be activated for attachment to biologically active...
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5932212 |
Crosslinked protein crystal formulations and their use as catalysts in organic solvents
The present invention relates to the application of biocatalysis technology for performing selective chemical reactions. In one embodiment, this invention relates to crosslinked protein crystal...
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5914306 |
Stabilized enzymes
This invention relates to novel stabilized enzymes. More specifically the invention relates to novel stabilized enzymes, in which a naturally occurring amino acid residue (other than proline) has...
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5910435 |
Method of folding proteins with synthetic dithiol catalysts
An analysis of the protein folding characteristics of the eukaryotic protein folding enzyme protein disulfide isomerase (PDI) led to a study of the minimally sufficient motif for catalytic activity...
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5910422 |
Stable single liquid alpha-amylase reagent
A stable, single liquid alpha-amylase assay reagent comprises a polysaccharide or long chain oligosaccharide substrate for alpha-amylase having an optically detectable label bonded to the reducing...
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5905037 |
Liquid septic tank treatment composition
Aqueous septic tank maintenance compositions, process for their production, methods for their use as well as methods for the maintenance of sewage systems, particularly septic tanks and cesspools...
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5904921 |
Stabilized compositions of superoxide dismutase obtained from germinated plant seeds
Germinated plant seeds are disclosed as a source of superoxide dismutase (SOD). The SOD is stabilized to temperatures of at least 45° C. when combined in a stabilizing composition comprising a...
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5902723 |
Analysis of surface immobilized polymers utilizing microfluorescence detection
Means for simultaneous parallel sequence analysis of a large number of biological polymer macromolecules. Apparatus and methods may use fluorescent labels in repetitive chemistry to determine...
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5891506 |
Oxidative method for attachment of glycoproteins or glycopeptides to surfaces of medical devices
A method for making a medical device having at least one glycoprotein and/or glycopeptide immobilized on a substrate surface is provided. The method may include oxidizing 1,2 dihydroxy moieties...
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