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7618799 |
Bacterial leader sequences for increased expression
Compositions and methods for improving expression and/or secretion of protein or polypeptide of interest in a host cell are provided. Compositions comprising a coding sequence for a bacterial...
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7618795 |
Starch process
The present invention relates to a process for enzymatic hydrolysis of granular starch into a soluble starch hydrolysate at a temperature below the initial gelatinization temperature of said...
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7615681 |
Methods for modifying plant responses to stress and correspondingly derived plants
Plant stresses such as pest drought, and excessive temperatures can lead to significant losses of crops each year. There is a continuing need to develop novel plant varieties that are less...
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7615365 |
α(1,6)-linked glucose oligosaccharide hydrolyzing enzyme polynucleotides and polypeptides and methods of use thereof
This invention relates to a method for utilizing less purified starch in fermentation processes. One example is a recombinant E. coli containing a exogenous extracellular isoamylase activity that...
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7615363 |
Aggrecanase structure
This invention relates to aggrecanase polypeptides and aggrecanase polypeptide/ligand complexes, crystals of aggrecanase and aggrecanase polypeptide/ligand complexes, and related methods and...
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7615362 |
Isolated xylanase gene with mutations and site-specific mutagenesis method thereof
A mutated xylanase gene with a broad pH range of reaction includes a forty-first amino acid or a twenty-first amino acid generated from transforming asparagine to aspartic acid so as to form the...
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7611874 |
PUFA polyketide synthase systems and uses thereof
The invention generally relates to polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems, to homologues thereof, to isolated nucleic acid molecules and recombinant nucleic acid...
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7611873 |
Method for producing L-methionine by fermentation
L-Methionine is produced by culturing a microorganism which is deficient in repressor of L-methionine biosynthesis system and/or enhanced intracellular homoserine transsuccinylase activity is...
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7608753 |
PUFA polyketide synthase systems and uses thereof
The invention generally relates to polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems, to homologues thereof, to isolated nucleic acid molecules and recombinant nucleic acid...
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7608703 |
PUFA polyketide synthase systems and uses thereof
The invention generally relates to polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems isolated from or derived from non-bacterial organisms, to homologues thereof, to isolated...
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7608702 |
PUFA polyketide synthase systems and uses thereof
The invention generally relates to polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems isolated from or derived from non-bacterial organisms, to homologues thereof, to isolated...
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7608443 |
Lysophosphatidic acid acetyltransferases
An isolated nucleic acid fragment encoding an LPAAT isozyme is disclosed. Construction of a chimeric gene encoding all or a portion of the LPAAT isozyme, in sense or antisense orientation, wherein...
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7608441 |
Sequence-determined DNA fragments encoding sterol desaturase proteins
The present invention provides DNA molecules that constitute fragments of the genome of a plant, and polypeptides encoded thereby. The DNA molecules are useful for specifying a gene product in...
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7608434 |
Mutated Tn5 transposase proteins and the use thereof
Transposase proteins that are modified relative to and have higher transposase activities than the wild-type Tn5 transposase are disclosed. A transposase protein of the present invention differs...
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7608432 |
Method for producing purine nucleoside by fermentation
A microorganism which has a gene encoding an enzyme in which feedback inhibition is desensitized by substitution of one or two amino acids in PRPP amidotransferase encoded by purF of Escherichia...
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7605245 |
PUFA polyketide synthase systems and uses thereof
The invention generally relates to polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems isolated from or derived from non-bacterial organisms, to homologues thereof, to isolated...
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7604976 |
Sequence-determined DNA fragments encoding glutamine amidotransferase proteins
The present invention provides DNA molecules that constitute fragments of the genome of a plant, and polypeptides encoded thereby. The DNA molecules are useful for specifying a gene product in...
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7604972 |
Nicotianamine synthase
A nicotianamine synthase is isolated and purified. Then the gene of this enzyme is cloned and the base sequence and amino acid sequence thereof are determined. This gene is employed in constructing...
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7604971 |
Sequence-determined DNA fragments encoding UBIE/COQ5 methyltransferase family proteins
The present invention provides DNA molecules that constitute fragments of the genome of a plant, and polypeptides encoded thereby. The DNA molecules are useful for specifying a gene product in...
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7604968 |
Microorganisms for the recombinant production of resveratrol and other flavonoids
The invention provides methods and materials related to producing flavonoids as well as other organic compounds. For example, the invention provides isolated nucleic acids, polypeptides, host...
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7604958 |
Synthetic mammalian α-N-acetylglucosaminidase and genetic sequences encoding same
The present invention relates generally to mammalian α-N-acetyglucosaminidase and to genetic sequences encoding same and to their use in the investigation, diagnosis and treatment of subjects...
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7601526 |
Purified FabI polypeptides from Fransicella tularensis
The present invention relates to novel drug targets for pathogenic bacteria. Accordingly, the invention provides purified protein derived from Fransicella tularensis comprising the amino acid...
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7601519 |
Method for producing purine nucleoside by fermentation
A microorganism which has a gene encoding an enzyme in which feedback inhibition is desensitized by substitution of one or two amino acids in PRPP amidotransferase encoded by purF of Escherichia...
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7601517 |
Split protein self complementing fragments, systems, and methods of use thereof
Briefly described, embodiments of this disclosure include split protein systems, fusion proteins, methods of producing the split protein systems, methods of screening macromolecular delivery...
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7598288 |
Inhibitors of glycogen synthase kinase-3 (GSK-3) for treating glaucoma
The use of inhibitors of GSK-3 useful for treating glaucoma is disclosed.
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7598068 |
Chondroitin polymerase and DNA encoding the same
A chondroitin polymerase having such properties that it transfers GlcUA and GalNAc alternately to a non-reduced terminal of a sugar chain from a GlcUA donor and a GalNAc donor, respectively, and...
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7598065 |
S-adenosylmethionine-6-N-lysine-methyltransferase from Neurospora crassa, a gene encoding the same, a vector and host cell containing the same, and method for producing trimethyllysine using the host cell
Provided is S-adenosylmethionine-6-N-lysine-methyl-transferase obtained from Neurospora crassa , a polynucleotide encoding the same, a vector and host cell containing the polynucleotide, and a...
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7598062 |
Process for the production of L-amino acids using strains of the family enterobacteriaceae that contain an attenuated fruR gene
A process for the production of L-amino acids, in particular L-threonine, in which the following steps are carried out:
(a) fermentation of the microorganisms of the family...
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7595182 |
Endoglucanase STCE and cellulase preparation containing the same
A novel endoglucanase derived from Staphylotrichum coccosporum , a polynucleotide encoding the endoglucanase, and a cellulase preparation containing the endoglucanase are disclosed. The...
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7595180 |
RNA-dependent RNA polymerase functioning preferably on a RNA matrix and promoter-dependent transcription process with said RNA-dependent RNA polymerase
RNA may be transcribed using a nucleotide reagent as the promoter. The reagent may enable RNA to be transcribed without sequence specification and without protein cofactors, by means of an RNA...
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7595179 |
Recombinant reverse transcriptases
The present invention relates to a gene that encodes a hyperactive reverse transcriptase having DNA polymerase activity and substantially reduced RNase H activity, vectors containing the gene and...
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7592165 |
Process for the enzymatic preparation of an amide from a nitrile
Disclosed herein are cyanide-tolerant nitrile hydratases especially from Pseudomonas putida or Pseudomonas marginalis strains which exhibit increased cyanide tolerance. Also disclosed are...
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7585943 |
Compositions and methods for fusion protein separation
The present invention relates to compositions and methods for fusion protein separation utilizing a peptide linker comprising a novel thrombin cleavage site.
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7585645 |
Thioredoxin and thioredoxin reductase containing oil body based products
The present invention provides novel emulsion formulations which comprise oil bodies. The invention also provides a method for preparing the emulsions and the use of the emulsions in a variety of...
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7582465 |
Beta secretase genes
Disclosed are novel genes encoding beta secretase polypeptides. Also disclosed are methods of making and using the polypeptides.
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7582463 |
Non-reducing saccharide-forming enzyme, trehalose-releasing enzyme, and process for producing saccharides using the enzymes
A non-reducing saccharide-forming enzyme and a trehalose-releasing enzyme, which have an optimum temperature in a medium temperature range, i.e., a temperature of over 40 or 45° C. but below 60°...
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7582420 |
Multiplex nucleic acid reactions
The invention is directed to a variety of multiplexing methods used to amplify and/or genotype a variety of samples simultaneously.
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7582291 |
Bacteriophage lysins for Enterococcus faecalis, Enterococcus faecium and other bacteria
The present disclosure relates to bacteriophage lysins useful for the reduction of certain bacterial populations, including methods and compositions for the treatment of various bacterial...
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7579180 |
Beta secretase polypeptides
Disclosed are novel genes encoding beta secretase polypeptides. Also disclosed are methods of making and using the polypeptides.
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7579175 |
Process for producing N-acetylneuraminic acid
The present invention provides a process for economically producing N-acetylneuraminic acid without using expensive materials such as pyruvic acid and phosphoenolpyruvic acid. The process...
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7575900 |
Non-reducing saccharide-forming enzyme, trehalose-releasing enzyme, and process for producing saccharides using the enzymes
A non-reducing saccharide-forming enzyme and a trehalose-releasing enzyme, which have an optimum temperature in a medium temperature range, i.e., a temperature of over 40 or 45° C. but below 60°...
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7575883 |
Cytochrome c acetylation
Modulation of cytochrome c acetylation, e.g., with a SIR polypeptide, enables interventions that modulate lifespan regulation and cell proliferation, e.g., by modulating apoptosis and/or...
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7572903 |
Method of regulation of bacterial persister status
In one embodiment, the present invention is a method of controlling persister status in a bacterial cell population comprising the step of modulating the expression of native chromosomal sequences...
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7572615 |
Gene encoding formate dehydrogenases D and E and method for preparing succinic acid using the same
Nucleotide sequences encoding formate dehydrogenases D & E and a method for preparing succinic acid using the same, more particularly, formate dehydrogenases D & E converting formate to carbon...
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7572614 |
Crystal structure of soluble glutaminyl cyclase
A crystalline structure of glutaminyl cyclase (QC). is described. Also described are the methods of preparing the crystalline structure of QC and the methods for identifying candidate inhibitors of...
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7572613 |
Drug delivery system for accelerated subcutaneous absorption
A method for accelerating subcutaneous absorption of a fluid or drug into the systemic circulation of a specific targeted tissue. A first drug operative to produce local capillary vasodilatation...
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7569391 |
Method for making β-secretase co-crystals complexed with a ligand
The present application relates to methods for growing crystals of both the uncomplexed and complexed forms of β-secretase (BACE) polypeptide. The present application also relates to crystalline...
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7566741 |
Methods of inhibiting osteoclast activity
Methods of inhibiting osteoclastogenesis and the activity of osteoclasts are disclosed. Methods of treating patients who have diseases characterized bone loss are disclosed. According to the...
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7566559 |
Human cyclin-dependent kinase (hPNQALRE)
A human gene encoding a novel cyclin-dependent kinase termed hPNQALRE and its expression products can be used to provide reagents and methods for detecting neoplasia. Compositions and methods for...
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7566555 |
Method of expressing proteins comprising non-naturally-occurring amino acids
A method of expressing a protein having an unnatural amino acid integrated thereinto comprising expressing (A) a mutant tyrosyl tRNA synthase that is derived from Escherichia coli -origin tyrosyl...
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