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7452705 |
N4 virion single-stranded DNA dependent RNA polymerase
A histidine-tagged, deletion mutant of bacteriophage N4-coded, virion RNA polymerase (mini-vRNAP) which is active has been developed. The his-tagged mini-vRNAP has been cloned under the control of...
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7452701 |
Methods for the preparation of β-amino acids
Purified β-amino acids are of considerable interest in the preparation of pharmacologically active compounds and industrial precursors. Although enantiomerically pure β-amino acids can be...
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7449315 |
Bifunctional energy-reversible acyl-compositions
Energy-reversible acyl conjugates, intermediates, and related compositions are disclosed. In preferred aspects, examples of such compositions include:
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7445918 |
Pullulanase variants and methods for preparing such variants with predetermined properties
The present invention relates to pullulanase variants, wherein the variants have improved properties, for example, altered pH optimum, improved thermostability, altered substrate specificity,...
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7445915 |
Mutant isopropylmalate isomerase
The present invention provides a polypeptide comprising an amino acid sequence in which at least one amino acid is deleted, substituted or added in an amino acid sequence of isopropylmalate...
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7445919 |
Zsig33-like peptides and polynucleotides
The present invention relates to polynucleotide related to the zsig33 peptide, including agonists, antagonists, and antibodies. Methods of modulating gastric contractility, nutrient uptake, growth...
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7442533 |
Nematode phosphoethanolamine N-methyltransferase-like sequences
Nucleic acid molecules from nematodes encoding phosphoethanolamine n-methyltransferase polypeptides are described. PEAMT-like polypeptide sequences are also provided, as are vectors, host cells,...
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7442768 |
Fluorescent protein and gene encoding the same
The present invention provides a novel fluorescent protein the wavelength of the maximum of the fluorescence of which exists in a wavelength side longer than 510 nm, and which exhibits yellow...
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7442532 |
Essential fungal CaYLR100w polypeptides, and methods of use
The present invention provides essential fungal polynucleotides and their encoded polypeptides, homologues thereof and their uses. Additionally, the invention provides methods for the...
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7439050 |
Corynebacterium glutamicum genes encoding diaminopimelate epimerase
Isolated nucleic acid molecules, designated MP nucleic acid molecules, which encode novel MP proteins from Corynebacterium glutamicum are described. The invention also provides antisense nucleic...
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7438920 |
Crystals of hepatitis C virus helicase or fragments thereof comprising a helicase binding pocket
The invention relates to the X-ray crystal structure of the hepatitis C virus helicase domain. More specifically, the invention relates to crystallized complexes of HCV helicase and an...
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7439419 |
Solanum tuberosum β-solanine/β-chaconine rhamnosyl transferase sequences and uses thereof
Nucleic acid sequences from potato that encode the enzyme β-solanine/β-chaconine rhamnosyltransferase (SGT3) are disclosed. Recombinant DNA molecules containing the sequences, and use thereof, in...
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7439049 |
Nucleic acid molecules coding for a dextran-saccharase catalysing the synthesis of dextran with α 1,2 osidic sidechains
The invention relates to an isolated polypeptide with an glycosyl transferase enzymatic activity for producing dextrans with α(1→2) sidechains, comprising at least one region for bonding to...
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7435583 |
Membrane fractions of 1,2-sn-diacylglycerol-enriched cells
The invention concerns membrane fractions of cells containing a recombinant MGDG synthase and enriched with 1,2-sn-diacylglycerol, their preparation method, their use for screening molecules...
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7435420 |
Dipeptidyl peptidase IV inhibitors for the treatment of anxiety
The present invention discloses a method for therapeutically treating an animal, including a human, for psychosomatic, depressive and neuropsychiatric diseases, such as anxiety, depression,...
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7435560 |
Method for producing purine nucleoside by fermentation
A microorganism which has a gene encoding an enzyme in which feedback inhibition is desensitized by substitution of one or two amino acids in PRPP amidotransferase encoded by purF of Escherichia...
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7432350 |
Recombinant biotin carboxylase domains for identification of Acetyle CoA carboxylase inhibitors
A peptide comprising an Acetyl CoA carboxylase (ACCase) having a deleted biotin binding domain, having a deleted carboxy transferase domain, and having a functional biotin carboxylase (BC) domain...
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7432093 |
Soluble, functional apoptotic protease-activating factor 1 fragments
The structure of a soluble, functional fragment of human Apaf-1 protein having ADP bound thereto is disclosed. The invention includes such soluble, functional fragments of human Apaf-1 and other...
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7427659 |
Process for purifying proteins in a hydrophobic interaction chromatography flow-through fraction
The present invention is a process for separating a target protein (such as a recombinant protein produced in a cell culture) from a mixture containing the target protein and contaminants (such as...
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7425423 |
Thermostable nucleic acid polymerase from Thermococcus gorgonarius
A purified thermostable enzyme is derived from the thermophilic archaebacterium Thermococcus gorgonarius. The enzyme can be native or recombinant, retains approximately 90% of its activity after...
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7422880 |
Method for producing an l-amino acid using a bacterium of the enterobacteriaceae family having a pathway of glycogen biosynthesis disrupted
There is provided a method for producing an L-amino acid using a bacterium of the Enterobacteriaceae family, particularly a bacterium belonging to the genus Escherichia or Pantoea , having the...
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7422882 |
Modified thermostable DNA polymerase
An object of the present invention is to provide a thermostable DNA polymerase with enhanced amplification efficiency and/or improved fidelity in polymerase chain reaction (PCR), and provide a...
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7422847 |
Human E3α ubiquitin ligase family
The present invention relates to a novel polypeptide encoding a protein which is the full length human ortholog of E3α ubiquitin ligase. The invention also relates to vector, host cells,...
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7419809 |
Method for glucose production with a modified cellulase mixture
The present invention pertains to a method of converting cellulose to glucose by treating a pretreated lignocellulosic substrate with an enzyme mixture comprising cellulase enzyme and a modified...
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7419815 |
Inhibitors of plant peptide deformylase for use as broad-spectrum herbicides and methods for identifying the same
The invention relates to a method of identifying herbicides and to the use of inhibitors of plant peptide deformylase as broad spectrum herbicides.
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7416868 |
Polyene polyketides, processes for their production and their use as a pharmaceutical
This invention relates to a new class of polyene polyketides, their pharmaceutically acceptable salts and derivatives, and to methods for obtaining the compounds. One method of obtaining these...
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7417135 |
Plasmidic gene, ways of acquiring this gene, the amylolytic enzyme it encodes and its application
The object of the invention is a novel plasmidic gene encoding an amylolytic enzyme which after introduction into a microbial strain, favorably bacterial, especially Lactococcus lactis , enables...
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7414120 |
Compounds and methods for modulating activation of NF-κB
Compositions and methods for modulating the activation of nuclear factor κB (NF-κB) are provided. The compositions comprise one or more agents that modulate ubiquitination of phosphorylated...
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7413856 |
In vitro transcription assay for T box antitermination system
A method and assay system is provided for screening for antimicrobial agents that inhibit or otherwise disrupt the transcription of bacterial aminoacyl-tRNA synthetases, particularly those in...
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7410774 |
Compounds modulating sister chromatid separation and method for identifying same
Method for identifying compounds that interfere with or modulate sister chromatid separation in animal or plant cells by modulating a protease with separin-like cysteine endopeptidase activity....
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7407785 |
Human DNase I hyperactive variants
The present invention relates to amino acid sequence variants of human DNase I that have increased DNA-hydrolytic activity. The invention provides nucleic acid sequences encoding such hyperactive...
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7407782 |
Nucleic acid detection compositions
The present invention relates to means for the detection and characterization of nucleic acid sequences, as well as variations in nucleic acid sequences. The present invention also relates to...
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7408033 |
PRO5995 polypeptides
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid...
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7407789 |
Recombinant staphylokinase derivatives and the preparation and applications thereof
The present invention relates to the biotechnology field, more particularly, to novel recombinant staphylokinase (RGD/KGD-Sak) derivatives and the preparation the thereof. The derivatives, have a...
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7407783 |
Fructosylamine oxidase
The present invention provides a fructosylamine oxidase which is obtainable by culturing Fusarium proliferatum , and purifying two types of fructosylamine oxidase (FAO) with different substrate...
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7407780 |
Process for producing glycerol in recombinant bacterial host cells
The invention provides methods for producing products comprising improved host cells genetically engineered to have uncoupled productive and catabolic pathways. In particular, the present invention...
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7402416 |
Antibacterial dentifrice exhibiting antiplaque and breath freshening properties
A dual component antiplaque oral composition having antimalodor properties in which a first component contains an antibacterial agent and the second component contains a proteolytic enzyme, the...
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7399622 |
Process for the extraction of β-amylase
The invention relates to a process for extracting beta-amylase from cereal by means of cellulase. The invention further relates to the use of cellulase in the extraction of β-amylase.
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7399620 |
Polypeptides and bacterial strains for increased protein production
The invention provides polypeptides, nucleic acid sequences, bacterial strains, methods and kits for producing exogenous protein. More specifically, the invention provides RNase E polypeptides that...
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7399619 |
Site specific incorporation of heavy atom-containing unnatural amino acids into proteins for structure determination
Translation systems and other compositions including orthogonal aminoacyl tRNA-synthetases that preferentially charge an orthogonal tRNA with an iodinated or brominated amino acid are provided....
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7396660 |
Cloning genes from Streptomyces cyaneogriseus subsp. Noncyanogenus for biosynthesis of antibiotics and methods of use
The present invention relates to the complete biosynthetic pathway for the formation of the LL-F28249 compounds and, most importantly, the major component LL-F28249α. The purified and isolated...
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7396656 |
Method of cross-linking peptides
A method of cross-linking a peptide to form a homopolymer of the peptide, to immobilize the peptide on a solid phase and to enhance antigenicity of the peptide is disclosed. The method comprises...
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7393668 |
Method of collecting highly pure polyhydroxyalkanoate from microbial cells
The present invention has an object to provide a method for separating and purifying a PHA without causing a serious decrease of the molecular weight to obtain a highly pure PHA in a high yield,...
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7393673 |
Thermal tolerant exoglucanase from Acidothermus cellulolyticus
The invention provides a thermal tolerant cellulase that is a member of the glycoside hydrolase family. The invention further discloses this cellulase as Gux1. Gux1 has been isolated and...
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7393675 |
Corynebacterium glutamicum genes encoding proteins involved in carbon metabolism and energy production
Isolated nucleic acid molecules, designated SMP nucleic acid molecules, which encode novel SMP proteins from Corynebacterium glutamicum are described. The invention also provides antisense...
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7393670 |
Tyrosyl-tRNA synthetase variants
Tyrosyl-tRNA synthetases having a modified amino acid sequence whereby unnatural amino acids can be more efficiently incorporated than original natural amino acids. More specifically, tyrosyl-tRNA...
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7393929 |
Inhibitors of cellulolytic, xylanolytic and β-glucanolytic enzymes
The present invention concerns an inhibitor of xylanolytic and/or β-glucanolytic enzymes, method for obtaining the inhibitor, said inhibitor and processes for obtaining micro-organism, plant or...
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7393679 |
Whole cell catalyst
A whole cell catalyst is described comprising a hydantoinase, a racemase and a carbamoylase. Thus this catalyst is able to degrade hydantoins directly into the amino acids. Additionally, a process...
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7391015 |
System and method for data collection in recursive mass analysis
Systems, methods, and computer programming for collecting data using a mass spectrometer comprising a particle detector or other mass analyzer. A data collection such as a tree or array structure...
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7384739 |
Compositions for enhancing DNA synthesis, DNA polymerase-related factors and utilization thereof
The invention provides methods, kits, and compositions for enhancing synthesis of DNA involving a carboxylate ion-supplying substance that is effective in promoting DNA synthesis in enzymatic DNA...
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