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7531318 |
Screening of agents for activity against ischemic myocardial insults
Integrin-linked kinase (ILK) and Akt/protein kinase B (PKB) are important mediators of signaling in cardiomyocytes and can both prevent damage and promote healing associated with ischemic injury to...
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7527943 |
Compositions of orthogonal glutamyl-tRNA and aminoacyl-tRNA synthetase pairs and uses thereof
Compositions and methods of producing components of protein biosynthetic machinery that include glutamyl orthogonal tRNAs, glutamyl orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of...
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7528242 |
Methods and compositions comprising Renilla GFP
The invention relates to methods and compositions utilizing Renilla green fluorescent proteins (rGFP), and Ptilosarcus green fluorescent proteins (pGFP). In particular, the invention relates to...
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7527947 |
Signal peptide for producing a polypeptide
The present invention relates to a method for producing a polypeptide comprising using a signal peptide, to nucleic acid constructs comprising a first nucleotide sequence encoding the signal...
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7524659 |
Isogenic strain line of bacterium for producing polyhydroxyalkanoate in which polyhydroxyalkanoate synthase gene is disrupted and method for producing polyhydroxyalkanoate using the same
A host-vector system which is equipped with a substrate supply system enzyme for polyhydroxyalkanoate synthase and which is suitable for evolutionary engineering modification of...
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7524934 |
Human brain carboxypeptidase B antibodies
A novel carboxypeptidase and the encoding gene thereof were successfully identified by screening a human hippocampus extract using brain-APP-cleaving activity as an index. Antibodies against the...
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7521546 |
Branched and multi-chain nucleic acid switches for sensing and screening
Embodiments of the invention relate to a branched or multichain nucleic acid switch adapted to switch from a first conformation to a second conformation upon ligand binding. The switch includes a...
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7521044 |
Human histone deacetylase, HDAC9c
The present invention relates to newly discovered human histone deacetylases (HDACs), also referred to as histone deacetylase-like polypeptides. The polynucleotide sequences and encoded...
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7517971 |
Muteins of human telomerase reverse transcriptase lacking telomerase catalytic activity
The invention provides compositions and methods related to human telomerase reverse transcriptase (hTRT), the catalytic protein subunit of human telomerase. The polynucleotides and polypeptides of...
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7517970 |
Nucleic acids encoding kinase and phosphatase enzymes, expression vectors and cells containing same
Methods for expressing active enzymes are described that involve co-expressing a first enzyme with a second enzyme that has an enzymatic activity that reverses a modification on the first enzyme...
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7517678 |
Method for protein production
Provided is a novel comprising culturing host cells into which a foreign gene has been introduced for producing a protein in a soluble form encoded by the foreign gene, recombinant cells are...
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7514408 |
β-secretase enzyme compositions and methods
Disclosed is an active, isolated β-secretase enzyme in purified and recombinant form. This enzyme is implicated in the production of amyloid plaque components which accumulate in the brains of...
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7514245 |
Method for producing chiral α-hydroxycarboxylic acids by enzymatic hydrolysis of chiral cyanohydrins
The invention relates to a method for producing chiral α-hydroxycarboxylic crystalline acids consisting in transforming cyanhydrins (R) or (S) into α-hydroxycarboxylic acids (R) or (S),...
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7514253 |
URA5 gene and methods for stable genetic integration in yeast
A novel gene encoding P. pastoris orotate-phosphoribosyl transferase (URA5) is disclosed. Methods for producing and selecting yeast strains capable of stable genetic integration of heterologous...
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7510831 |
Trichoderma reesei phytase enzymes, nucleic acids encoding such phytase enzymes, vectors and host cells incorporating same and methods of making and using same
A novel DNA is provided which encodes an enzyme having phytase activity isolated from Trichoderma . Also provided for is a method of isolating DNA encoding an enzyme having phytase activity from...
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7511018 |
Juvenile hemochromatosis gene (HFE2A) cleavage products and uses thereof
Isolated fragments of the HFE2A protein able to bind and modulate HFE2A and other proteins, such as hepcidin, involved in the iron metabolism pathway are disclosed, such fragments being of...
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7507570 |
Recombinant chondroitinase ABC I and uses thereof
The invention relates to chondroitinase ABC I and uses thereof. In particular, the invention relates to recombinant and modified chondroitinase ABC I, their production and their uses. The...
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7507567 |
RNA polymerase mutants with increased thermostability
The present application relates to mutated RNA polymerases from bacteriophages that have increased stability, for example under high temperature conditions. Preferred mutated RNA polymerases...
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7507558 |
Processes for producing inulin
The present invention provides a method of producing inulin by bringing inulin synthase into contact with sucrose, wherein: (1) the average polymerization degree of inulin is regulated by...
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7507573 |
Modification of protein glycosylation in methylotrophic yeast
The present invention relates to methods and genetically engineered methylotrophic yeast strains for producing glycoproteins with mammalian-like glycosylation. The present invention also relates to...
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7501266 |
Differentiating homozygous, heterozygous and wild-type alleles using a multiplexed hybridization-mediated assay
Described are methods of assay design and assay image correction, useful for multiplexed genetic screening for mutations and polymorphisms, including CF-related mutants and polymorphs, using an...
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7501237 |
Polymerases for analyzing or typing polymorphic nucleic acid fragments and uses thereof
The present invention provides methods for use in identifying, analyzing and typing polymorphic DNA fragments, particularly minisatellite, microsatellite or STR DNA fragments. In particular, the...
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7501246 |
Gene for coding thermostable L-arabinose isomerase and method for producing the same
Disclosed are a gene coding for L-arabinose isomerase derived from Thermotoga neapolitana 5068, a thermostable arabinose isomerase expressed from the gene, a recombinant expression vector...
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7494797 |
Recombinant terminal deoxynucleotidyl transferase with improved functionality
Truncated terminal deoxynucleotidyl transferase (TdT) derivative from calf thymus, characterized in that the derivative in comparison to the native TdT is N-terminally truncated by up to 161 amino...
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7494801 |
Method of selecting Escherichia coli strain which highly expresses exogenous genes, Escherichia coli mutant strains selected by this method and process for producing enzymes and compounds using the same
The invention relates to a selection method of an Escherichia coli mutant strain which expresses an exogenous gene at a high level, wherein stress resistance such as hydrogen peroxide...
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7491524 |
Human RNase III and compositions and uses thereof
The present invention provides polynucleotides encoding human RNase III and polypeptides encoded thereby. Methods of using said polynucleotides and polypeptides are also provided.
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7491854 |
Enzymatic method of making aldehydes from fatty acids
The present invention provides methods of enzymatically preparing aldehydes from fatty acids by utilizing a carboxylic acid reductase enzyme to reduce the fatty acids to their corresponding...
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7485424 |
Labeled nucleotide phosphate (NP) probes
The present invention is directed to a method of sequencing a target nucleic acid molecule having a plurality of bases. In its principle, the temporal order of base additions during the...
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7485294 |
Galenic pectinate formulation for colon-targeted delivery of antibiotic-inactivating enzymes and method of use thereof
Forms of colonic delivery suited to be used orally and designed for colonic delivery of active ingredients selected from the group comprising enzymes capable of inactivating macrolide antibiotics...
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7485446 |
Stable retrovirus and methods of use
The present invention is a mutant retroviral protease which confers an increase in retroviral stability. Retroviruses expressing the instant mutant retroviral protease exhibit at least a 2-fold...
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7479382 |
Nematode fatty acid desaturase-like sequences
Nucleic acid molecules from nematodes encoding fatty acid desaturase polypeptides are described. Fatty acid desaturase-like polypeptide sequences are also provided, as are vectors, host cells, and...
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7479387 |
Compositions and methods for the synthesis and subsequent modification of uridine-5′-diphosphosulfoquinovose (UDP-SQ)
The present invention is directed to compositions and methods related to the synthesis and modification of uridine-5′-diphospho-sulfoquinovose (UDP-SQ). In particular, the methods of the present...
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7479538 |
Irreversibly-inactivated pepsinogen fragment and pharmaceutical compositions comprising the same for detecting, preventing, and treating HIV
An isolated antiviral peptide is characterized by the amino acid sequence GDEPLENYLDTEYF and a significant in vitro binding affinity for HIV-1 gp 120 and gp 41, and human CD4 cells. The peptide...
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7476512 |
Methods of identifying dermal papilla cells
Methods and compositions for identifying and isolating dermal papilla cells are described. DP cells can be identified based on corin expression. Isolated DP cells can be used, e.g., to modulate...
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7470661 |
Delivery of superoxide dismutase to neuronal cells
A composition for delivery of superoxide dismutase to neuronal cells comprise a superoxide dismutase linked by a linker to a neuronal cell targeting component, which component comprises a first...
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7468262 |
Polynucleotides encoding useful polypeptides in corynebacterium glutamicum ssp. lactofermentum
The present invention provides novel polypeptides and polynucleotides useful as biotechnological tools, specifically identified in a coryneform bacterium Corynebacterium glutamicum ssp. ...
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7468265 |
Stabilizing agent for enzymes
The present invention provides a safe and novel stabilizing agent for enzymes; a composition containing an enzyme and the stabilizing agent; and a kit containing the stabilizing agent composition....
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7468472 |
Polynucleotides encoding proteins involved in plant metabolism
The invention provides isolated pyruvate dehydrogenase kinase nucleic acids and their encoded polypeptides. The present invention provides methods and compositions relating to altering pyruvate...
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7465793 |
Synthetic Δ17 desaturase derived from Phytophthora ramourum and its use in making polyunsaturated fatty acids
The present invention relates to Δ17 desaturases, which have the ability to convert ω-6 fatty acids into their ω-3 counterparts (i.e., conversion of arachidonic acid [20:4, ARA] to...
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7465734 |
Methods and compositions for overcoming resistance to biologic and chemotherapy
This invention provides a method for identifying potential therapeutic agents by contacting a target cell with a candidate therapeutic agent which is a selective substrate for an endogenous,...
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7465572 |
De-immunized streptokinase
A target protein is rendered less immunogenic to a given species by (a) determining at least part of the amino acid sequence of the target protein; (b) identifying in the amino acid sequence one or...
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7465568 |
Essential fungal polynucleotides, polypeptides, and methods of use
The presnt invention provides essential fungal polynucleotides and their encoded polypeptides, homologues thereof and their uses. Additionally, the invention provides methods for the identification...
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7465573 |
Molecular sequence of swine retrovirus and methods of use
Purified nucleic acid which can specifically hybridize with the sequence of swine retroviruses.
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7462473 |
Use of food colours to dye enzyme solutions
The present invention relates to the use of food colors for coloring enzyme solutions, to enzyme solutions provided with food colors as well as their use.
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7462472 |
Methods and compositions relating to anthrax pathogenesis
The structures of Edema Factor alone and Edema Factor bound to calmodulin without substrate has been crystallized and its structure determined by x-ray crystallography. Based upon these crystal...
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7462447 |
Methods for evaluating susceptibility to a bone homeostasis disorder
The invention provides mutant SH3-binding protein (SH3BP2) nucleic acids, polypeptides, and agents which selectively bind to the mutant SH3BP2 molecules and which do not bind to the wild type...
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7462475 |
Use of whole blood in PCR reactions
A method of obtaining DNA amplification of a nucleic acid target from a volume of whole blood comprising performing DNA amplification in a PCR assay mixture with a blood-resistant polymerase.
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7459295 |
Fibrinogen-based tissue adhesive containing an elastase inhibitor
The present invention provides a fibrinogen-based tissue adhesive which contains an elastase inhibitor.
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7456271 |
Glutamate 2,3-aminomutases and methods of use thereof
There are provided nucleic acids, including isolated DNA molecules, which encode glutamate 2,3-aminomutase enzymes, polypeptides produced from such nucleic acids and methods of making the nucleic...
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7455979 |
Polysaccharide structure and sequence determination
The invention provides a method for the structural analysis of a saccharide, comprising: a) providing on a surface a plurality of essentially sequence- and/or site-specific binding agents; b)...
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