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7595180 |
RNA-dependent RNA polymerase functioning preferably on a RNA matrix and promoter-dependent transcription process with said RNA-dependent RNA polymerase
RNA may be transcribed using a nucleotide reagent as the promoter. The reagent may enable RNA to be transcribed without sequence specification and without protein cofactors, by means of an RNA...
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7595182 |
Endoglucanase STCE and cellulase preparation containing the same
A novel endoglucanase derived from Staphylotrichum coccosporum , a polynucleotide encoding the endoglucanase, and a cellulase preparation containing the endoglucanase are disclosed. The...
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7592165 |
Process for the enzymatic preparation of an amide from a nitrile
Disclosed herein are cyanide-tolerant nitrile hydratases especially from Pseudomonas putida or Pseudomonas marginalis strains which exhibit increased cyanide tolerance. Also disclosed are...
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7585645 |
Thioredoxin and thioredoxin reductase containing oil body based products
The present invention provides novel emulsion formulations which comprise oil bodies. The invention also provides a method for preparing the emulsions and the use of the emulsions in a variety of...
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7585943 |
Compositions and methods for fusion protein separation
The present invention relates to compositions and methods for fusion protein separation utilizing a peptide linker comprising a novel thrombin cleavage site.
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7582291 |
Bacteriophage lysins for Enterococcus faecalis, Enterococcus faecium and other bacteria
The present disclosure relates to bacteriophage lysins useful for the reduction of certain bacterial populations, including methods and compositions for the treatment of various bacterial...
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7582463 |
Non-reducing saccharide-forming enzyme, trehalose-releasing enzyme, and process for producing saccharides using the enzymes
A non-reducing saccharide-forming enzyme and a trehalose-releasing enzyme, which have an optimum temperature in a medium temperature range, i.e., a temperature of over 40 or 45° C. but below 60°...
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7582420 |
Multiplex nucleic acid reactions
The invention is directed to a variety of multiplexing methods used to amplify and/or genotype a variety of samples simultaneously.
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7582465 |
Beta secretase genes
Disclosed are novel genes encoding beta secretase polypeptides. Also disclosed are methods of making and using the polypeptides.
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7579175 |
Process for producing N-acetylneuraminic acid
The present invention provides a process for economically producing N-acetylneuraminic acid without using expensive materials such as pyruvic acid and phosphoenolpyruvic acid. The process...
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7579180 |
Beta secretase polypeptides
Disclosed are novel genes encoding beta secretase polypeptides. Also disclosed are methods of making and using the polypeptides.
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7575883 |
Cytochrome c acetylation
Modulation of cytochrome c acetylation, e.g., with a SIR polypeptide, enables interventions that modulate lifespan regulation and cell proliferation, e.g., by modulating apoptosis and/or...
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7575900 |
Non-reducing saccharide-forming enzyme, trehalose-releasing enzyme, and process for producing saccharides using the enzymes
A non-reducing saccharide-forming enzyme and a trehalose-releasing enzyme, which have an optimum temperature in a medium temperature range, i.e., a temperature of over 40 or 45° C. but below 60°...
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7572614 |
Crystal structure of soluble glutaminyl cyclase
A crystalline structure of glutaminyl cyclase (QC). is described. Also described are the methods of preparing the crystalline structure of QC and the methods for identifying candidate inhibitors of...
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7572615 |
Gene encoding formate dehydrogenases D and E and method for preparing succinic acid using the same
Nucleotide sequences encoding formate dehydrogenases D & E and a method for preparing succinic acid using the same, more particularly, formate dehydrogenases D & E converting formate to carbon...
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7572903 |
Method of regulation of bacterial persister status
In one embodiment, the present invention is a method of controlling persister status in a bacterial cell population comprising the step of modulating the expression of native chromosomal sequences...
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7572613 |
Drug delivery system for accelerated subcutaneous absorption
A method for accelerating subcutaneous absorption of a fluid or drug into the systemic circulation of a specific targeted tissue. A first drug operative to produce local capillary vasodilatation...
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7569391 |
Method for making β-secretase co-crystals complexed with a ligand
The present application relates to methods for growing crystals of both the uncomplexed and complexed forms of β-secretase (BACE) polypeptide. The present application also relates to crystalline...
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7566555 |
Method of expressing proteins comprising non-naturally-occurring amino acids
A method of expressing a protein having an unnatural amino acid integrated thereinto comprising expressing (A) a mutant tyrosyl tRNA synthase that is derived from Escherichia coli -origin tyrosyl...
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7566553 |
Microorganism of Escherichia Sp, or Corynebacterium Sp, comprising foreign NADP dependent glyceraldehyde-3-phosphate dehydrogenase gene and method for producing L-lysine using the same
Provided are an Escherichia species microorganism and Corynebacterium species microorganism that are transformed with a foreign NADP dependent glyceraldehydes-3-phosphate dehydrogenase gene and...
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7566559 |
Human cyclin-dependent kinase (hPNQALRE)
A human gene encoding a novel cyclin-dependent kinase termed hPNQALRE and its expression products can be used to provide reagents and methods for detecting neoplasia. Compositions and methods for...
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7566741 |
Methods of inhibiting osteoclast activity
Methods of inhibiting osteoclastogenesis and the activity of osteoclasts are disclosed. Methods of treating patients who have diseases characterized bone loss are disclosed. According to the...
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7563864 |
Prolyl endopeptidase mediated destruction of T cell epitopes in whole gluten
Celiac Sprue and/or dermatitis herpetiformis are treated by interfering with HLA binding of immunogenic gluten peptides. The antigenicity of gluten oligopeptides and the ill effects caused by an...
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7563610 |
Crystalline composition of farsenyl pyrophosphate synthase (IspA)
Provided are crystals relating to Farsenyl Pvrophosphate Synthase (IspA) from E. coli and its various uses.
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7560260 |
Compositions with polymerase activity
The invention provides novel compositions with polymerase activity and methods of using the compositions.
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7560258 |
Glass-immobilized, protein-acrylamide copolymer and method of making thereof
Disclosed are a polyacrylamide-based method of fabricating surface-bound peptide and protein arrays, the arrays themselves, and a method of using the arrays to detect proteins and to measure their...
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7560424 |
Targeted therapeutic proteins
Targeted therapeutics that localize to a specific subcellular compartment such as the lysosome are provided. The targeted therapeutics include a therapeutic agent and a targeting moiety that binds...
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7556958 |
Enzyme derived from thermophilic organisms that functions as a chromosomal replicase, and preparation and uses thereof
A DNA Polymerase has been identified in a thermophile that functions as a chromosomal replicase. The specific enzyme is a holoenzyme III that has been identified in Thermus thermophilus , and...
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7558717 |
Crystal structure of human JAK3 kinase domain complex and binding pockets thereof
The present invention relates to human Janus Kinase 3 (JAK3) and JAK3-like binding pockets. The present invention provides a computer comprising a data storage medium encoded with the structure...
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7556956 |
Enzymes for the preparation of amides
A novel biotechnological process for the preparation of nitriles, starting from amides, is described. Micro-organisms of the genus Amycolatopsis, Actinomadura or Rhodococcus are employed for...
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7556947 |
Method for producing β-hydroxy amino acid and enzyme used therefor
A method for producing β-hydroxy amino acid and its optically-active isomer is provided. The β-hydroxy amino acid is produced by reacting a predetermined D-α-amino acid and 5,10-methylene...
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7556950 |
Crystallization of the catalytic domain of human phosphodiesterase 4-D3 (PDE4-D3)
Provided are crystals relating to human phosphodiesterase 4-D3 (PDE4-D3), methods for forming crystals comprising PDE4-D3 and crystals comprising PDE4-D3 co-crystallized with a ligand molecule, and...
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7556654 |
Methods for cleaning materials
Methods are disclosed for cleaning a material by applying a cleaning composition having one or more biosurfactants and one or more enzymes to the material. During use, the material is agitated with...
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7553950 |
Chondroitinase ABC I polynucleotides
The invention relates to chondroitinase ABC I and uses thereof. In particular, the invention relates to recombinant and modified chondroitinase ABC I, their production and their uses. The...
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7553650 |
Polynucleotide encoding a mutant transglutaminase
The present invention relates to a method for designing and preparing mutant transglutaminases on the basis of the three-dimensional structure of MTG derived from Streptoverticillium mobaraense ...
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7547532 |
Three-dimensional structure of prostaglandin D synthase and utilization thereof
A method of designing an anti-allergic agent, sleep controlling agent, anti-obestic agent and remedy for brain injury acting via the inhibition of biosynthesis of prostaglandin D 2 . Crystal of a...
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7547533 |
Use of intramolecularly, covalently cross-linked proteins as binding partners in immunoassays
The invention concerns the use of intramolecularly, covalently cross-linked proteins and covalently cross-linked reverse transcriptase from HIV as immunological binding partners in immunoassays. It...
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7544466 |
Ghrelin o-acyltransferase (GOAT) biochemical assay
Ghrelin is acylated by ghrelin O-acyltransferase. Ghrelin O-acyltransferase assays comprise contacting a mixture of ghrelin and recombinant ghrelin O-acyltransferase with an agent; and detecting a...
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7544497 |
Compositions for manipulating the lifespan and stress response of cells and organisms
Provided herein are methods and compositions for modulating the activity of sirtuin deacetylase protein family members; p53 activity; apoptosis; lifespan and sensitivity to stress of cells and...
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7541193 |
Caged sensors, regulators and compounds and uses thereof
A number of caged (e.g., photoactivatable) compositions are provided, for example, caged enzyme sensors, caged binding sensors, caged nucleic acid probes, caged interfering RNAs, caged antisense...
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7541170 |
Nucleic acid modifying enzymes
This invention provides for an improved generation of novel nucleic acid modifying enzymes. The improvement is the fusion of a sequence-non-specific nucleic-acid-binding domain to the enzyme in a...
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7538198 |
Methods for protein refolding
The present invention discloses improved methods of disaggregating protein aggregates, and refolding denatured proteins, using high pressure. In particular, the present invention provides for the...
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7538194 |
Genes encoding several poly (ADP-ribose) glycohydrolase (PARG) enzymes, the proteins and fragments thereof, and antibodies immunoreactive therewith
The isolation and characterization of cDNAs encoding poly(ADP-ribose) glycohydrolase (PARG) enzymes and the amino acid sequences of PARGs from several species are described. PARG is involved in the...
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7537826 |
Cellulosic and lignocellulosic materials and compositions and composites made therefrom
Cellulosic or lignocellulosic materials, and compositions and composites made therefrom, are disclosed.
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7538191 |
Centromeric protein shugoshin
The present invention is to provide meiosis-specific novel kinetochore protein Sgo1 (shugoshin) derived from fission yeast Schizosaccharomyces pombe , and a homologue or paralogue thereof having a...
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7534935 |
Phospholipid:diacylglycerol acyltransferases
This invention relates to an isolated nucleic acid fragment encoding an acyltransferase, more specifically a phospholipid:diacylglycerol acyltransferase. The invention also relates to the...
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7534592 |
Crystallization of carboxyltransferase domain of Acetyl-CoEnzyme A Carboxylase 2 with a ligand
Provided are crystals relating to the carboxyltransferase domain of human Acetyl-Coenzyme A Carboxylase 2 and its various uses.
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7531336 |
Methods for producing recombinant histidine-tagged inosine nonophosphate dehydrogenase polypeptides
The invention relates to a modified IMPDH polypeptide wherein the IMPDH polypeptide has a histidine tag and where the subdomain of the IMPDH polypeptide is modified so that the rate stability of...
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7531338 |
Purified and isolated heparan sulfate 3-O-sulfotransferase isoform 5 nucleic acids and polypeptides and therapeutic and screening methods using same
3-OST-5 proteins, and nucleic acid molecules encoding the same. Recombinant host cells, recombinant nucleic acids and recombinant proteins are also disclosed, along with methods of producing each....
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7531348 |
Recombinant yeast for lignocellulose raw materials
The present invention relates to a method for obtaining a recombinant yeast of Saccharomyces cerevisiae , which ferments lignocellulose raw materials to ethanol, including introducing DNA into a...
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