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6994960 |
Nucleic acid diagnostics based on mass spectrometry or mass separation and base specific cleavage
A method of detecting a mutation or a difference of one or more nucleotides between a nucleic acid molecule to be tested and a reference nucleic acid molecule, said method comprising subjecting the...
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6991900 |
Methods for identifying an essential gene in a prokaryotic microorganism
Methods are provided for the rapid identification of essential or conditionally essential DNA segments in any species of haploid cell (one copy chromosome per cell) that is capable of being...
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6992236 |
Plant UDP-glucose epimerases
This invention relates to an isolated nucleic acid fragment encoding a UDP-galactose 4-epimerase. The invention also relates to the construction of a chimeric gene encoding all or a portion of the...
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6989258 |
DNA encoding a plant deoxyhpusine synthase, a plant eukaryotic initiation factor 5A, transgenic plants and a method for controlling senescence programmed and cell death in plants
Regulation of expression of programmed cell death, including senescence, in plants is achieved by integration of a gene or gene fragment encoding senescence-induced deoxyhypusine synthase,...
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6989260 |
Human poly(ADP-ribose) polymerase 2 materials and methods
The invention provides a novel human poly(ADP-ribose) polymerase (hPARP2) polypeptides, polynucleotides encoding the polypeptides, expression constructs comprising the polynucleotides, and host...
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6989256 |
Subfamily of RNA helicases which are modulators of the fidelity of translation termination and uses thereof
An isolated multiprotein complex of S. cerevisiae components is provided that is effective to modulate peptidyl transferase activity during translation. This complex includes a Modulator of...
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6989255 |
Methionyl tRNA synthetase polypeptides from Staphylococcus aureus
The invention provides methionyl tRNA synthetase (tRS) enzymes from Staphylococcus aureus and methods of producing such tRS by recombinant techniques. Also provided are methods for utilizing tRS...
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6986985 |
Process for producing multiple nucleic acid copies in vivo using a protein-nucleic acid construct
This invention provides in vitro processes for producing copies of specific nucleic acids using protein-nucleic acid constructs which are part of conjugates which are introduced into cells....
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6987015 |
Nucleotide sequences encoding the pfkA gene
An isolated polynucleotide containing a polynucleotide sequence selected from the following group:
a) a polynucleotide which is at least 70% identical to a polynucleotide which codes for a...
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6984510 |
Vitamin B6-phosphate phosphatase
A purified vitamin B 6 -phosphate phosphatase (VB6PP), having the following physico-chemical properties: a) Molecular weight: 29,000±5,000 (consisting of a monomer having a molecular weight of...
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6984515 |
Macrolide analogs
A polyketide or glycosylated polyketide which has the formula:
wherein R* is methyl or ethyl;
each of R 1 -R 6 is methyl;
X 1 is OH or H; and/or
X 2 is=O, OH or H;
X 3 is OH or H;
...
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6982159 |
Trichoderma β-glucosidase
The present invention provides a novel β-glucosidase nucleic acid sequence, designated bgl3, and the corresponding BGL3 amino acid sequence. The invention also provides expression vectors and host...
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6982147 |
Apparatus for assaying biopolymer binding by means of multiple measurements under varied conditions
An apparatus for assaying specific binding of a probe to a target, includes: a sample support; a light source; an optical train; a light detector; an electricity source; an electrical property...
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6982158 |
Extraction and purification of phosphodiesterase 1
A process for purifying a phosphodiesterase 1 (PDE-1) from a cell including heating an extract of a cell formed from a solution including at least one divalent cation, to increase the specific...
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6982363 |
UDP-glucose modifiers
This invention relates to an isolated nucleic acid fragment encoding a UDP glucose pyrophosphorylase. The invention also relates to the construction of a chimeric gene encoding all or a portion of...
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6982083 |
Starch granules containing a recombinant polypeptide of interest, method for obtaining them, and their uses
The present invention relates to starch granules containing a fusion polypeptide between a starch synthase and a recombinant polypeptide of interest, the nucleotide sequences used for obtaining...
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6979725 |
Rad2/FEN-1 orthologues and uses thereof
The invention provides isolated Rad2/FEN-1 nucleic acids and their encoded proteins. The present invention provides methods and compositions relating to altering Rad2/FEN-1 concentration and/or...
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6979563 |
Attenuation of tumor growth, metastasis and angiogenesis
A highly purified and specific glycosaminoglycan degrading enzyme, chondroitinase AC, and to a lesser extent, chondroitinase B, can be used in the treatment of metastatic cancers and in other...
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6977142 |
High-throughput turbidometric assay for screening inhibitors of protein disulfide isomerase activity
Methods for performing an end-point assay of protein disulfide isomerase activity. The method may be based on the enzyme-catalyzed reduction of insulin in the presence of dithiothreitol; measuring...
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6977169 |
Methods and compositions for treating neoplasms
The present invention comprises the periodic administration of a solution of neuraminidase to a patient with a neoplasm until the neoplasm has receded. The administration of the solution of...
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6977295 |
Locked nucleic acid hybrids and methods of use
The invention relates to methods for inhibiting, cloning, modifying or labelling an endogenous DNA sequence using compositions comprising recombinases in combination with exogenous polynucleotides...
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6969785 |
Sterol metabolism enzymes
This invention relates to an isolated nucleic acid fragment encoding a sterol metabolism enzyme. The invention also relates to the construction of a chimeric gene encoding all or a portion of the...
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6969587 |
Detection of nucleic acid heteroduplex molecules by anion-exchange chromatography
The present invention describes a method for separating or partially separating heteroduplex and homoduplex DNA molecules in a mixture. In the method, the mixture is applied to an anion-exchange...
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6967093 |
Glycosyl sulfotransferase-3
A novel human glycosylsulfotransferase expressed in high endothelial cells (GST-3) and polypeptides related thereto, as well as nucleic acid compositions encoding the same, are provided. The...
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6967262 |
Plant raffinose saccharide biosynthetic enzymes
This invention relates to an isolated nucleic acid fragment encoding a galactinol synthase. The invention also relates to the construction of a chimeric gene encoding all or a portion of the...
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6967080 |
Proteins with changed epitopes and methods for the production thereof
The present invention relates to methods for modifying proteins by mapping one or more epitopes of the protein and altering the amino acid sequence of one or more epitopes of the protein in order...
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6964847 |
Derivative nucleic acids and uses thereof
The invention features a method for multiplexed analysis of a plurality of target nucleic acid sequences in a sample. The method provides a derivative nucleic acid for each target sequence analyzed...
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6964858 |
Processes for producing sugar nucleotides and complex carbohydrates
This invention relates to a process for producing a sugar nucleotide, in which a) a culture broth of a microorganism capable of producing NTP from a nucleotide precursor, or a treated product of...
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6962793 |
Methods for detecting Alzheimers disease
Methods for diagnosing and monitoring Alzheimer's Disease in a subject comprising measuring hK6 in a sample from the subject. hK6 may be measured using a reagent that detects or binds to hK6,...
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6960704 |
Phosphatidylcholine biosynthetic enzymes
This invention relates to an isolated nucleic acid fragment encoding a phosphatidylcholine biosynthetic enzyme. The invention also relates to the construction of a chimeric gene encoding all or a...
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6960453 |
Hybrid polyketide synthases combining heterologous loading and extender modules
A hybrid type I polyketide synthase gene typically containing a starter module and a plurality of heterologous extender modules is used to synthesize novel polyketides. It is preferably under the...
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6960461 |
Gene coding for cyclodextrin glucanotransferase chiefly producing γ-cyclodextrin and use thereof
The invention provides a gene (isolated nucleic acid molecule) encoding the cyclodextrin glucanotransferase which produces a considerable amount of γ-cyclodextrin (γ-CD) from the substrates...
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6958215 |
Methods and compositions for inhibition of RNA splicing
A method of inhibiting the self-splicing of a Group I intron is disclosed. The method uses an oligonucleotide having a sequence essentially identical to a guide sequence found in the 5′ flanking...
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6958228 |
Nucleotide sequence which code for the metH gene
An isolated polynucleotide comprising a polynucleotide sequence selected from the group consisting of
a) polynucleotide which is at least 70% identical to a polynucleotide that codes for a...
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6955907 |
Alkaline, protease VapK suitable for laundry detergent, VapK gene, recombinant expression vector, and transformed microorganisms
A novel alkaline protease VapK suitable for a laundry detergent is disclosed. The gene vapk coding for the protease VapK, the recombinant plasmids containing said gene, and the transformed V....
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6955906 |
Biotin biosynthetic genes having biotin synthase activity
The present invention relates to the production process of biotin by fermentation using a genetically engineered microorganism, and DNA sequences and vectors to be used in such process.
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6953834 |
Transcription factors related to TFIIA
The invention provides human polynucleotide sequences that encode transcription factor polypeptides that are termed ALF and SALF, and an alternative C-terminal sequence. The invention includes ALF,...
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6953680 |
Mitofusins, Fzo Homologs and functional derivatives thereof
Mitofusin genes and encoded polypeptides are provided, including the Drosophila Fzo protein and its homologs from insects, other invertebrates, yeast, and vertebrates including mouse and humans....
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RE38825 |
Glyphosate tolerant plants
Genes encoding a glyphosate oxidoreductase enzyme are disclosed. The genes are useful in producing transformed bacteria and plants which degrade glyphosate herbicide as well as crop plants which...
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6953677 |
Recombinant L-N-carbamoylase from Arthrobacter aurescens and method of producing L-amino acids therewith
A novel rec-L-N-carbamoylase from Arthrobacter aurescens and its method of use for producing L-amino acids. The recombinantly produced L-carbamoylase is unexpectedly stable, so that an industrial...
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6951751 |
DNA and amino acid sequences of a tyrosine-inducible tyrosine ammonia lyase enzyme from the yeast Trichosporon cutaneum
A novel tyrosine-inducible tyrosine ammonia lyase enzyme was isolated from the yeast Trichosporon cutaneum . This enzyme has a higher activity for tyrosine than for phenylalanine and is useful for...
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6949634 |
Method for synthesizing cDNA
A method for synthesizing cDNA characterized by performing a reverse transcription reaction in the presence of an enzyme having a reverse transcriptional activity and another enzyme different from...
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6949336 |
Murf gene and enzyme of Pseudomonas aeruginosa
This invention provides isolated polynucleotides that encode the MurF (UDP-N-acetylmuramyl-L-alanine-D-glutamate-m-DaD:D-alanine-D
-alanine ligase) protein of Pseudomonas aeruginosa . Purified and...
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6949371 |
Isolated human drug-metabolizing proteins, nucleic acid molecules encoding human drug-metabolizing proteins, and uses thereof
The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the drug-metabolizing enzyme peptides of the present invention. The present...
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6949370 |
High fidelity thermostable ligase and uses thereof
The present invention is directed to a thermostable ligase having substantially higher fidelity than either T4 ligase or Thermus thermophilus ligase. The DNA molecule encoding this enzyme as well...
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6949372 |
Engineering intracellular sialylation pathways
Methods for manipulating carbohydrate processing pathways in cells of interest are provided. Methods are directed at manipulating multiple pathways involved with the sialylation reaction by using...
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6946271 |
Nucleotide sequences which code for the menE gene
The invention relates to an isolated polynucleotide comprising a polynucleotide sequence chosen from the group consisting of
a) polynucleotide which is identical to the extent of at least 70% to a...
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6946273 |
Compositions and methods utilizing DNA polymerases
The invention features a novel isolated Family B DNA polymerase, a Thermococcus polymerase JDF-3, and mutant recombinant forms thereof. Mutant polymerases of the invention are deficient in 3′...
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6943000 |
JNK3 modulators and methods of use
The c-Jun NH 2 -terminal kinase (JNK) group of MAP kinases are activated by exposure of cells to environmental stress. The role of JNK in the brain was examined by targeted disruption of the gene...
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6942996 |
Isolated polynucleotide from Corynebacterium encoding a homocysteine methyltransferase
An isolated polynucleotide comprising a polynucleotide sequence selected from the group consisting of
a) polynucleotide which is at least 70% identical to a polynucleotide that codes for a...
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