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7048915 |
Composition for cell-free protein synthesis
The present invention provides a composition for cell-free protein synthesis, which is superior in storage stability in a freeze-dried state, more particularly a freeze-dryable or freeze-dried...
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7049100 |
Multi-plasmid method for preparing large libraries of polyketides and non-ribosomal peptides
A multiple-plasmid system for heterologous expression of polyketides facilitates combinatorial biosynthesis. The method can be extended to any modular polyketide synthase (PKS) or non-ribosomal...
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7049400 |
Modified fluorescent proteins for detecting protease activity
The present invention concerns fluorescent proteins modified such that said modified fluorescent protein incorporates a cleavage site for a protease, cleavage of said modified fluorescent protein...
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7049125 |
EGVIII endoglucanase and nucleic acids encoding the same
The present invention provides a novel endoglucanase nucleic acid sequence, designated egl8, and the corresponding EGVIII amino acid sequence. The invention also provides expression vectors and...
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7045323 |
Glutathione reductase for therapy and prophylaxis of aids
The present invention concerns the use of glutathione-reductase (GSSG reductase) for the preparation of a medicament for the treatment of HIV-infected patients, seropositive or already affected by...
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7045329 |
Lipoprotein associated phospholipase A2, inhibitors thereof and use of the same in diagnosis and therapy
The enzyme Lp-PLA 2 in purified form, an isolated nucleic acid molecule encoding Lp-PLA 2 , the use of an inhibitor of the enzyme Lp-PLA2 in therapy and a method of screening compounds to identify...
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7045280 |
Assay method
The present invention provides a method for the measurement of the activity of a plasminogen activator, such as urokinase plasminogen activator (uPA) or tissue plasminogen activator (tPA) in a...
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7045326 |
Mono- and diacylglycerol acyltransferases and methods of use thereof
Nucleic acid compositions encoding polypeptide products with diglyceride acyltransferase and/or monoacylglycerol acyltransferase activity, as well as the polypeptide products encoded thereby, i.e.,...
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7045322 |
Process for producing lysosphingolipids
A process for producing lysosphingolipids by using an enzyme capable of specifically hydrolyzing the acid amide bond between a sphingoid and a fatty acid in a sphingolipid, characterized in that...
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7045332 |
BGL4 β-glucosidase and nucleic acids encoding the same
The present invention provides a novel β-glucosidase nucleic acid sequence, designated bgl4, and the corresponding BGL4 amino acid sequence. The invention also provides expression vectors and host...
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7041487 |
Recombinant α-L-iduronidase, methods for producing and purifying the same and methods for treating diseases caused by deficiencies thereof
The present invention provides a recombinant α-L-iduronidase and biologically active fragments and mutants thereof, methods to produce and purify this enzyme as well as methods to treat certain...
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7041793 |
Detergent compositions comprising benefit agents
Detergent composition comprising fusion protein comprising a cellulose binding domain and a domain having a high binding affinity for another ligand. Preferably, the domain having a high binding...
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7037705 |
Isolated human protease proteins, nucleic acid molecules encoding human protease proteins, and uses thereof
The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the protease peptides of the present invention. The present invention specifically...
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7037688 |
Method for using unequal primer concentrations for generating nucleic acid amplification products
The method provided herein is a method for detecting a target sequence in a test sample. Generally, the method comprises forming a reaction mixture comprising a test sample, amplification reagents,...
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7038108 |
Polynucleotide encoding lysyl-tRNA synthetase from Zea mays
This invention relates to isolated nucleic acid fragments encoding aminoacyl-tRNA synthetases and particulary lsoleucyl-, lysyl-, phenylalanyl- and prolyl-tRNA synthetases from Zea mays , Oryza...
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7037695 |
Methods of assessing wolframin protein activity
The present invention relates to a method of assaying modulators of the interaction between Wolframin protein and its identified cellular binding partner.
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7037894 |
Stabilized proteins
Isolated polypeptides or polypeptide chains are modified by di-tyrosine cross-linking such that the retain at least one functional activity. In one embodiment, the isolated polypeptide or...
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7037697 |
Isozyme of autoclavable superoxide dismutase (SOD), a process for the identification and extraction of the SOD and use of the said SOD in cosmetic, food, and pharmaceutical compositions
The invention relates to a novel purified isozyme of an autoclavable superoxide dismutase extracted from the plant Potentilla atrosanguinea Lodd. Var. areyrophylla, said isozyme having the...
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7033810 |
Sitosterolemia susceptibility gene (SSG): compositions and methods of use
The present invention provides nucleic acids encoding a novel ABC family cholesterol transporter, SSG. The herein-disclosed sequences can be used for any of a number of purposes, including for the...
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7034140 |
Genes involved in isoprenoid compound production
Genes have been isolated from Rhodococcus erythropolis AN12 strain encoding the isoprenoid biosynthetic pathway. The genes and gene products are the first isolated from a Rhodococcus strain....
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7033805 |
HCV NS3 protein fragments having helicase activity and improved solubility
The Hepatitis C Virus (HCV) NS3 protein contains amino acid motifs of a serine proteinase, a nucleotide triphosphatase (NTPase), and an RNA helicase. A carboxy fragment of the HCV NS3 protein was...
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7034125 |
Identification of new human gaba transporter
Human GABA transporter2 like protein polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing...
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7034206 |
Peptide deformylase
This invention relates to an isolated nucleic acid fragment encoding a metalloprotease, more specifically peptide deformylase. The invention also relates to the construction of a recombinant DNA...
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7033824 |
Ketogulonigenium shuttle vectors
The present invention relates, in general, to vectors comprising Ketogulonigenium replicons. More specifically, the present invention relates to vectors comprising a Ketogulonigenium replicon...
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7029887 |
Methods related to Streptomyces avermitilis gene directing the ratio of B2:B1 avermectins
The present invention relates to polynucleotide molecules comprising sequences encoding avec gene products, which polynucleotide molecules can be used to alter the ratio or amount of class 2:1...
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7029911 |
AFC1 and RCE1: isoprenylated CAAX processing enzymes
Two genes which encode polypeptides that mediate post-prenylation processing steps in CAAX polypeptides such as Ras are provided. The two genes (AFC1 and RCE1) encode polypeptides that mediate the...
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7029885 |
Process for the preparation of ampicillin
Ampicillin is produced in a batch process by enzymatic acylation of 6-aminopenicillanic acid (6-APA) with the aid of phenylglycine derivative such as D-phenylglycine amide. High conversions of...
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7029845 |
DNAs and proteins or peptides specific to bacteria of the species Neisseria meningitidis, processes for obtaining them and their biological uses
The DNA of the invention are characterised in that they concern the whole or part of genes, with their reading frame, to be found in Neisseria meningitidis , but not in Neisseria gonorrhoeae , or...
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7029901 |
Isolated human protese proteins, nucleic acid molecules encoding human protease proteins and uses thereof
The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the protease peptides of the present invention. The present invention specifically...
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7029886 |
Enzymatic substrate, synthesis method and uses
The invention concerns novel enzymatic substrates of general formula (I) wherein: X represents a nitrogen atom or a carbon atom substituted with a phenyl group, said phenyl group being optionally...
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7029895 |
27411, a novel human PGP synthase
The invention provides isolated nucleic acids molecules and proteins, designated 27411, 23413, 22438, 23553, 25278, 26212, NARC SC1, NARC 10A, NARC 1, NARC 12, NARC 13, NARC 17, NARC 25, NARC 3,...
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7026140 |
Serum paraoxonase
Human serum paraoxonase enzyme and DNA (RNA) encoding such serum paraoxonase enzymes are disclosed. Also provided is the procedure for producing such polypeptides by recombinant techniques. Uses of...
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7026149 |
Polynucleotides encoding polypeptides involved in the stress response to environmental changes in Methylophilus methylotrophus
The present invention provides polypeptides and polynucleotides involved in the stress response to environmental changes in Methylophilus methylotrophus and methods of producing amino acids in...
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7026152 |
Methods and compositions for simultaneous saccharification and fermentation
The invention provides compositions and methods for the synergistic degradation of oligosaccharides by endoglucanases. The invention further provides recombinant host cells containing one or more...
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7026527 |
Plant methionine synthase gene and methods for increasing the methionine content of the seeds of plants
This invention relates to a nucleic acid fragment encoding a plant 5-methyltetra-hydropteroyltriglutamate-homocysteine methyltransferase or methionine synthase. The invention also includes chimeric...
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7022526 |
Reducing branching and enhancing fragmentation in culturing filamentous microorganisms
The invention relates to the field of microorganisms and to the culturing of microorganisms. Means and methods are described for enhancing the culturing properties of filamentous microorganisms,...
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7022501 |
Ligation of double-stranded DNAs
The present invention relates to a DNA ligation method. Specifically, a DNA complex comprising a three-stranded structure in each of the ends of double-stranded DNAs, one of which has...
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7018806 |
Method for identifying endocrine disruptors and kit for carrying out the same
A method for identifying an endocrine disrupter using a cell line having aromatase activity, particularly, a human granulosa-like tumor cell line; and a kit for carrying out the method is disclosed.
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7018793 |
Combinatorial screening of mixed populations of organisms
Provided is a method of screening gene libraries derived from a mixed population of organisms for a bioactivity or biomolecule of interest. The mixed population of organisms can be a cultured...
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7018808 |
Polyketides and their synthesis and use
The rapamycin gene cluster is an example of a gene cluster which includes a gene (rapL) leading to the formation of a precursor compound (pipecolic acid, in this case) which is required for...
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7019120 |
Cloud-point extraction of enzymes and polypeptides from a fermentation broth using a non-ionic surfactant
A method of extracting a polypeptide of interest from a fermentation broth comprising:
i) adjusting the pH close to pI of the polypeptide of interest; ii) adding a non-ionic surfactant with...
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7014850 |
Nasal spray for treating streptococcal infections
A nasal spray for treating a streptococcal infection is disclosed. The spray comprises an effective amount of a lysin enzyme genetically coded for by a C 1 bacteriophage capable of infecting a...
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7014851 |
Process for inhibiting platelet aggregation
An object of the present invention is to provide a platelet aggregation inhibitor without side effects and a supplement food effective for inhibiting platelet aggregation. The platelet aggregation...
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7014994 |
Coupled polymerase chain reaction-restriction-endonuclease digestion-ligase detection reaction process
The present invention provides a method for identifying one or more low abundance sequences differing by one or more single-base changes, insertions, or deletions, from a high abundance sequence in...
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7015023 |
Compositions and methods for detection of active proteases
A novel assay system is disclosed for detecting the presence or amount of selected active proteases in biological samples. The assay system utilizes a chimeric protease detector protein composed of...
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7011964 |
Use of an enzyme for the manufacture of an agent for controlling bacterial infection
Provided is the use of a xylanane or a cellulase for the manufacture of an agent for the treatment and/or prophylaxis of bacterial infection in an animal caused by Salmonella, Campylobacter or ...
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7011965 |
Compositions and methods for stimulating wound healing and fibroblast proliferation
It has been found that placental alkaline phosphatase interacts synergistically with growth factors and corresponding serum factors to stimulate the proliferation of adult fibroblast cells....
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7011961 |
Method for L-threonine production
A method of producing L-threonine using a microorganism is provided, one or more copies of each of the phosphoenolpyruvate carboxylase gene and the threonine operon are additionally intedgrated...
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7005284 |
Transaldolase gene
Attempts are made to provide a novel transaldolase gene; a polypeptide encoded by this gene; a recombinant DNA obtained by integrating this gene; a microorganism carrying this recombinant DNA; and...
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7001751 |
PyrF gene and the utilization thereof
A pyrF gene is useful as a selection marker gene for an expression system for the production of proteins in mushrooms of the genus Trametes, Coriolus or Polyporus . The pyrF gene includes a DNA...
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