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5846762 |
Structurally stable gel bead containing entrapped enzyme and method for manufacture thereof
A structurally stable gel bead containing an entrapped enzyme and a method for its manufacture. The enzyme is covalently cross-linked to gelatin in the presence of glutaraldehyde prior to the...
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5837483 |
Enzymatic method for producing N-formyl-α-L-aspartyl-L-phenylalanine methyl ester
An enzymatic method for producing N-formyl-α-L-aspartyl-L-phenylalanine methyl ester by a condensation reaction between N-formyl-L-aspartic acid and L-phenylalanine methyl ester or...
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5837234 |
Bioartificial organ containing cells encapsulated in a permselective polyether suflfone membrane
A bioartificial organ for implanting to provide a therapeutic effect is prepared containing a core of living cells encapsulated in a foam-like membrane having three regions: a dense, fine-pored,...
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5834005 |
Bioartificial devices and cellular matrices therefor
A device for the effective release of cellular moieties, including hormones, wherein a matrix containing a hormone producing cellular moiety is encapsulated with a non-immunogenic polymeric...
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5834232 |
Cross-linked gelatin gels and methods of making them
Enzymatically cross-linked protein gels and methods for preparing them are disclosed. The methods comprise adding a transglutaminase, such as factor XIII, to a composition of a...
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5821193 |
Adsorbent having a terminal hydrazine group and a method for removing ketoamine-containing protein
An adsorbent for removing ketoamine-containing protein, which comprises carrying a compound having a terminal functional group of the formula: ##STR1## wherein each of R 1 and R 2 is an organic...
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5817454 |
Portable apparatus and method for detection of methylxanthine chemical species
A portable apparatus for detecting the presence of at least one methylxanthine chemical species such as caffeine or theophylline in a beverage comprises a first portion comprising an effective...
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5817493 |
Lipases immobilized in sol-gel processed hydrophobic materials
A process for the preparation of immobilized lipases through reaction on a silica matrix containing non-hydrolyzable organic substituents attached through Si--C bonds.
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5807724 |
Degradation of petroleum hydrocarbons with organisms encapsulated in wax
Organisms that degrade hydrocarbon-based substances are encapsulated in wax to form organism-containing wax microshells that are used for removing oil-based substances such as oil spills on land...
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5807757 |
Preparation of ionically cross-linked polyphosphazene microspheresy by coacervation
A method is provided for preparing polyphosphazene microspheres wherein the polyphosphazene microspheres are produced by coacervation. A solution containing a polyphosphazene is admixed with a...
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5795790 |
Method for controlling proliferation and differentiation of cells encapsulated within bioartificial organs
Methods and compositions are provided for controlling cell distribution within a bioartificial organ by exposing the cells to a treatment that inhibits cell proliferation, promotes cell...
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5795570 |
Method of containing core material in microcapsules
A core material such as animal tissue or cells is contained within a semipermeable vessel which may be a microcapsule, hollow fiber or plastic membrane having a semipermeable wall by a method that...
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5788988 |
Method for making cytoprotective, biocompatible, retrievable microcapsule containment systems
The present invention is directed to a macrocapsule for encapsulating microcapsules containing biologically active material, such as living cells or free living cells, to make the system more...
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5786216 |
Inner-supported, biocompatible cell capsules
A biocompatible capsule for containing cells for implantation is prepared containing an inner support that provides tensile strength to the capsule. The capsule may be a tubular semipermeable...
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5776748 |
Method of formation of microstamped patterns on plates for adhesion of cells and other biological materials, devices and uses therefor
The disclosed invention is a device for adhering cells in a specific and predetermined position. The device comprises a plate defining a surface and a plurality of cytophilic islands that adhere...
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5776747 |
Method for controlling the distribution of cells within a bioartificial organ using polycthylene oxide-poly (dimethylsiloxane) copolymer
This invention relates to methods and compositions of controlling cell distribution within a bioartificial organ by exposing the cells to a treatment that inhibits cell proliferation, promotes cell...
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5773238 |
Droplet chemical reaction chamber
A reaction chamber is constructed of a reactant-containing aqueous solution, which may be in droplet form, coated with a fluoropolymer powder such as Polytetrafluoroethylene (PTFE), preferably...
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5773270 |
Three-layered membrane for use in an electrochemical sensor system
A system for electrochemical measurement of glucose concentration in an undiluted test sample, e.g. blood is provided containing a sensor including a three-layered contiguous membrane. The membrane...
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5766907 |
Method for immobilization of whole microbial cells in calcium alginate capsules
A method is provided for immobilization of whole microbial cells containing enzymes in Ca-alginate capsules. Whole microbial cells are mixed with a CaCl 2 solution, a small amount of xanthan gum...
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5759578 |
Cytoprotective, biocompatible, retrievable macrocapsule containment systems for biologically active materials
The present invention is directed to a macrocapsule for encapsulating microcapsules containing biologically active material, such as living cells or free living cells, to make the system more...
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5756350 |
Method for producing oriented connective tissue
The present invention pertains to an oriented tissue-equivalent formed by contracting a collagen solution with connective tissue cells. In the method of the present invention, the contraction of...
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5741685 |
Parenchymal cells packaged in immunoprotective tissue for implantation
Cells for implantation into a patient are packaged within a barrier of immunoprotective tissue prior to implantation to obviate or minimize rejection of the cells. The preferred immunoprotective...
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5739021 |
Heat-sterilizable porous carrier for biocatalysts
A porous carrier for biocatalysts (a) comprising a water-insoluble inorganic filler and a polyolefine binder selected from polyethylene and polypropylene, (b) having open pores allowing cells to...
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5739020 |
Encapsulation of animal and microbial cells in an inorganic gel prepared from an organosilicon
Living animal tissue cells and microbial cells such as yeast cells are encapsulated in an inorganic gel prepared from an organosilicon. Encapsulation of tissue cells is performed by mixing an...
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5733763 |
Enzyme granulate formed of an enzyme-containing core and an enzyme-containing shell
An enzyme-containing granulate is prepared containing a core and a shell wherein the core and/or shell contain an enzyme and the shell contains artificial or cellulose fibers in an amount of...
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5719039 |
Enzyme-surfactant ion-pair complex catalyzed reactions in organic solvents
Organic enzyme solutions comprise an ion pair complex of an enzyme and a surfactant, and an organic solvent in which the enzyme-surfactant ion pair is dissolved. The solution has catalytic activity...
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5712161 |
Method for culturing animal cells in collagen drops on a support
Animal cells are cultured while embedded in a collagen gel. The gel containing cells is formed by dispersing animal cells in a collagen solution, placing a drop (or drops) of the cell-containing...
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5705382 |
Method for preserving nitrile hydratase or nitrilase activity of microbial cells with inorganic salts
Cells having enzyme activity, and the enzyme activity thereof, are preserved for a prolonged period of time, as a suspension of microbial cells or as a suspension of immobilized cells in particles,...
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5700848 |
Gel compositions prepared from crosslinkable polysaccharides, polycations and/or lipids and uses therefor
The present invention relates to a new form of biocompatible materials (e.g., lipids, polycations, polysaccharides) which are capable of undergoing free radical polymerization, e.g., by using...
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5698413 |
Method of evaluating chemotherapeutic agents in vivo
The present invention relates to a method of screening chemotherapeutic agents in vivo. The method comprises implanting into a laboratory animal a biocompatible, semi-permeable encapsulation device...
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5693514 |
Non-fibrogenic high mannuronate alginate coated transplants, processes for their manufacture, and methods for their use
A transplant with a core of a viable, physiologically active, cell(s) and a non-fibrogenic coating of alkaline earth metal alginate having a high mannuronate to guluronate molar ratio and free from...
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5693513 |
Encapsulation of living tissue cells in an organosilicon
Living tissue cells such as animal or plant tissue cell are encapsulated in an inorganic gel by mixing an organosilicon precursor with an aqueous acidic solution to form a gel forming solution and...
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5691154 |
Enzyme linked immunoassay with stabilized polymer saccharide enzyme conjugates
An improvement in enzyme linked immunoassays is disclosed wherein the enzyme is in the form of a water soluble polymer saccharide conjugate which is stable in hostile environments. The conjugate...
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5683916 |
Membrane affinity apparatus and purification methods related thereto
A method and apparatus for carrying out affinity purification of a ligate. The method comprising, (a) providing a ligate containing liquid to a first side of at least one porous hollow fiber...
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5656450 |
Activation of latent transforming growth factor β by matrix vesicles
A latent growth factor such as transforming growth factor beta (TGFβ) is converted to active form by matrix vesicles or an extract from matrix vesicles. The matrix vesicles may be stimulated with...
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5656468 |
Cells or tissue coated with non-fibrogenic alginate less than 200 μm thick
An electrostatic process is used for coating a biological material with a uniform, continuous polymer layer by discharging a suspension of the biological material in a gelable coating polymer...
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5656469 |
Method of encapsulating biological substances in microspheres
A method for encapsulating biological substances in biocompatible microcapsules is disclosed, the method comprising: (a) maintaining a coating-forming liquid film sheet transverse to a vertical...
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5648252 |
Supported polyionic hydrogels containing biologically active material
A supported polyionic hydrogel containing biologically active material is epared by impregnating into a porous support material a solution of anionic polysaccharide, a solution of cationic...
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5643773 |
Preparation of elongated seamless capsules containing a coaxial rod and biological material
Elongated seamless capsules containing biological material are prepared by a method in which a coagulant, which includes a cell suspension or other biological material, and a polymeric casting...
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5643764 |
Reactions using heat-releasable reagents in wax beads
A reagent such as a heat resistant enzyme is entrapped in a material such as wax or a liposome that releases the reagent when heated so the reagent is available for reaction. In a preferred...
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5643594 |
Spin encapsulation apparatus and method of use
A coating apparatus includes a rotary cup for forming beads and projecting them radially outwardly, and one or more collection basins surrounding the bead forming cup. The cup is adjustably...
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5629187 |
Process and apparatus for forming solid particles by cross-linking drops of a cross-linkable material with a cascading stream of cross-linking agent
A process and apparatus are provided for making solid Particles from an ionically cross-linkable material by cross-linking drops of the material with a cross-linking agent in the form of a falling...
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5627062 |
Preparation of a dehydrated polysaccharide gel containing microorganisms and a hydrophilic substance for producing fermented drinks
A polysaccharide gel enclosing microorganisms is soaked in a solution of a high concentration such as at least 500 g/l of hydrophilic substance and the gel is at least partially dehydrated to...
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5627063 |
Dehydrated polysaccharide gel containing microorganisms and a hydrophilic substance
A polysaccharide gel enclosing microorganisms is soaked in a solution of a high concentration such as at least 500 g/l of hydrophilic substance and the gel is at least partially dehydrated to...
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5620883 |
Living cells microencapsulated in a polymeric membrane having two layers
A biocompatible microcapsule containing living cells encapsulated in a membrane is disclosed. The membrane is a complex formed by the cohesion of two polymer layers. An inner layer comprises a...
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5618736 |
Method for using synthesized kaolinite as carrier for bioreactor, a composite body composed substantially of synthesized kaolinite as carrier and enzyme carried on synthesized kaolinite, and bioreactor system using such a composite body
A process using hydrothermally synthesized porous kaolinite as a carrier for use in a bioreactor. A carrier-biocatalyst composite body for use in a bioreactor, includes the synthesized kaolinite as...
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5601835 |
Polymeric device for controlled drug delivery to the CNS
Disclosed is a polymeric drug delivery system for delivery of any substance to the central nervous system. The delivery system is preferably implanted in the central nervous system for delivery of...
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5595909 |
Filter device
A filter device containing cell masses and single cells is described. The device contains porous hollow fibers and hepatocytes entrapped within a contracted gel matrix.
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5589370 |
Process for encapsulating sensitive materials
The present invention relates to an improved curing or hardening process for the continuous production of capsules containing a sensitive material. The process allows capsules to be formed...
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5585183 |
Preparation of liquid-core microcapsules for cell cultures
A method for preparing liquid-core microcapsules for cell cultures, using a hardening solution containing CaCl 2 and polyethyleneimine to harden gel-core beads before coating them with polylysine...
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