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6180378 |
Immobilization of bioactive protein in phyllosilicates
Immobilized bioactive protein compositions are prepared containing a bioactive protein such as an enzyme intercalated into galleries of a phyllosilicate, and a crosslinking compound crosslinking...
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6180007 |
Membrane formed by an acrylonitrile-based polymer
A permselective graft polymer is disclosed that is formed by converting into intermediate reactive sites a portion of the cyano groups of a backbone polymer containing --CH 2 --CH(--C.tbd.N)--...
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6171813 |
Enzyme catalysis in organic solutions containing water
A method is presented for catalyzing the conversion of substrate into product in an organic reaction solvent with an enzyme-surfactant ion pair. The enzyme-surfactant ion pair comprises the enzyme...
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6153416 |
Immobilization of microbial cells and enzymes in calcium alginate-polyethylene glycol-polyethylene imide beads
Microorganisms or enzymes immobilized in beads are prepared using a combination of calcium alginate, polyethylene glycol (PEG) and polyethylene imide (PEI). An aqueous solution containing 1-14% by...
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6150472 |
Multi-functional site containing polymers, and applications thereof
Polymers having multi-functional sites and a gel comprising a solvent swollen network of cross-linked polymer(s), of which at least one polymer comprises at least one multi-functional site. A...
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6146665 |
Entrapment or microencapsulation of drugs in a polyhydroxyalkanoate formed by enzyme synthesis
A hydrophilic or lipophilic drug is entrapped or microencapsulated in a polyhydroxyalkanoate homopolymer or copolymer. The homopolymer or copolymer is synthesized in an aqueous medium containing a...
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6140089 |
Chitosan core matrix containing cells encapsulated in a thermoplastic semipermeable membrane
Encapsulated viable cells for implanting are prepared having cells dispersed in a particulate, essentially non cross-linked chitosan core matrix that is enclosed within a semipermeable membrane....
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6133004 |
Bioreactor carrier gel prepared from a crosslinked N-vinylcarboxamide resin
A bioreactor carrier is provided composed of a water absorption gel of a crosslinked N-vinylcarboxamide resin which has a great moisture content and excellent physical strength, is not eroded by...
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6127448 |
Biocompatible polymeric coating material
The invention provides a biocompatible polymeric coating material, wherein the polymeric material is selected from the group consisting of linear, dendrimeric and branched polymers which contain...
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6126936 |
Microcapsules and composite microreactors for immunoisolation of cells
Microcapsules and composite microreactors are prepared that immunoisolate living cells such as islet cells or genetically engineered cells. A reduced volume microcapsule is formed by coating a gel...
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6110902 |
Method for the inhibition of neuronal activity leading to a focal epileptic seizure by local delivery of adenosine
The present invention relates to the treatment of conditions associated with neuronal activity. Specifically, the invention is drawn to methods and compositions for administering adenosine to...
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6107102 |
Therapeutic microdevices and methods of making and using same
A suspension of microfabricated microdevices for use in therapeutic applications is disclosed. The microdevices have a selected shape, and uniform dimensions preferably in the 100 nm to 10 Am...
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6103528 |
Reversible gelling culture media for in-vitro cell culture in three-dimensional matrices
A gelling cell culture medium useful for forming a three dimensional matrix for cell culture in vitro is prepared by copolymerizing an acrylamide derivative with a hydrophilic comonomer to form a...
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6090793 |
Non-mitogenic substance, its preparation and use
Proposed is a mitogen-free substance comprising cross-linked copolymers including 10 to 90 mole % of guluronic acid, the balance being made up of mannuronic acid. The substance has a molecular...
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6083523 |
Implantable biocompatable immunoisolatory vehicle for delivery of selected therapeutic products
An immunoisolatory vehicle for the implantation into an individual of cells which produce a needed product or provide a needed metabolic function. The vehicle is comprised of a core region...
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6080402 |
Immobilization of lipases by entrapment in silica matrices
Lipases are immobilized by entrapment in silicon-containing matrices obtained by hydrolysis of alkoxy-silicon compounds in the presence of a catalyst and additives such as proteins, polyhydroxy...
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6066331 |
Method for preparation of vesicles loaded with biological structures, biopolymers and/or oligomers
A composition useful for preparing vesicles loaded with biological cell-structures, biopolymers and/or -oligomers is prepared by solubilizing amphiphatic material such as a phospholipid in a...
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6034175 |
Salts of peptides with carboxy-terminated polyesters
This invention relates to novel salts composed of a cation derived from a peptide containing at least one basic group and an anion derived from a carboxy-terminated polyester, processes for the...
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6033887 |
Dehydrated polysaccharide gel containing microorganisms, a sugar and a polyol for producing fermented drinks
Improved fermentation activity of microorganisms in a polysaccharide gel such as an alginate gel is obtained after dehydration, staorage and rehydration by soaking the gel containing the...
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6020175 |
Multiple layered functional thin films
Multiple layered functional thin films fixed on a solid support are provided which comprise multiple layers of functional molecules (such as enzymes and other proteins, pigments and dyes) admixed...
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6015572 |
Implantable device containing GDNF secreting cells for treating nerve damage and methods of use
A novel neurotrophic factor referred to as glial cell line-derived neurotrophic factor (GDNF) has been identified and isolated from serum free growth medium of B49 glioblastoma cells. Rat and human...
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6008027 |
Enteric polymer coated capsule containing dried bacterial culture for supplying lactase
A lactase-containing preparation is prepared for use by mammals having a lactase deficiency. A dried bacterial culture containing lactase is mixed with a desiccant such as silicon oxide to...
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6001585 |
Micro hollow fiber bioreactor
A "micro" hollow fiber bioreactor and method of use are provided for use in screening different cell lines and process conditions. The bioreactor includes the use of an oxygen permeable (e.g.,...
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5998185 |
Silicone rubber foam support structures for immobilization of cells
Resilient openly porous support structures containing silicon are prepared for cell immobilization. A preferred structure is made of porous silicone rubber foam, and cells are adsorbed to the...
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5985629 |
Cleaning and disinfecting contact lenses with a protease and chloramine-T or chloramine-B
Contact lens are cleaned and disinfected by contacting with an enzyme that functions as a cleaning agent by degrading deposits on the lens, and with an enzyme inhibitor that inhibits remaining...
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5981211 |
Maintaining cells for an extended time by entrapment in a contracted matrix
Methods of maintaining animal cells for product production, for supporting hepatocyte function and viability to treat a patient suffering from hepatic failure and for preserving tissue-specific...
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5976847 |
Hydrophilic urethane binder immobilizing organisms having active sites for binding noxious materials
A composite biosorption material is formed of a hydrophilic urethane binder containing immobilized bioactive organisms of at least about one micron in size and having active sites for binding and...
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5976780 |
Encapsulated cell device
A macroencapsulation device for somatic cells using ultrapurified Na alginate and polysulfone hollow fibers of 30 kDa molecular weight cutoff. Ultrapurified Na alginate material is used which has a...
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5972332 |
Wound treatment with keratinocytes on a solid support enclosed in a porous material
Devices and methods for enhancing the healing of wounds, especially chronic wounds (e.g., diabetic wounds), are provided involving the use of keratinocytes. Keratinocytes are grown on a...
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5968729 |
Use of centrifugation to prepare a retractable seal over reagents in a reaction container
A method is provided using centrifugation to prepare a seal of solidified wax, grease or polymer mix over an aqueous reagent in a reaction container such that the reagent is separated from contact...
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5962280 |
Microorganisms immobilized on a solid support with a quaternary polyallylamine polymer
Enzyme-containing cells are immobilized on a water-insoluble support with a polymer represented by the following general formula (I): ##STR1## wherein Y is a direct bond or a divalent group...
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5962281 |
Process for preparing L-tertiary-leucine and L-phosphinothricine by transamination
L-tertiary-Leucine and L-phosphinothricine are obtainable by transamination of the corresponding keto acids as a precursor in the presence of amino acids as amino group donors. The reaction is...
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5962309 |
Extruded foamed polyolefin resin carrier for microorganisms in a fluidized bed
A microorganism holding carrier for a fluidized bed is provided that includes an extruded foamed article having continuous cells and independent cells. The article is composed of a polyolefin resin...
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5952188 |
Reusable immobilized microbial composition useful as ready-to-use seed inoculum in BOD analysis
A reusable immobilized microbial composition is formulated. The formulated microbial composition comprises a synergistic mixture of the bacterial strains of Enterobacter cloaca, Citrobacter...
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5948655 |
Method of applying hepatocytes to hollow fibers
Cells such as hepatocytes are applied to hollow fibers by forming a first gelled matrix layer on the outside surface of the fibers, adhering cells to the matrix layer and forming a second gelled...
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5935572 |
Composition containing protease separate from glycosidase for removing nits in treating lice infestation
A composition containing a protease and glycosidase is provided for removing nits in the treatment of lice infestation. The protease and glycosidase are separated from each other to prevent the...
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5928918 |
Preparation of a hydrophobic polymer matrix containing immobilized enzymes
Biological components such as enzymes are immobilized in a three-dimensional cross-linked hydrophobic polymer. An enzyme is mixed with an aqueous solvent and a non-crosslinked prepolymer having an...
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5916775 |
Method for the purification of DNA
Disclosed is a method for collecting DNA by lysing microbial cells, adsorbing released DNA on a carrier and collecting the DNA adsorbed on the carrier, which method comprises the following steps of...
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5902745 |
Cell encapsulation device
The present invention is directed to a cell encapsulation device that permits rapid and straightforward cell transfer into the device. The preferred device includes components that allow a user to...
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5895757 |
Encapsulation of living tissue cells in inorganic microspheres prepared from an organosilicon
Living tissue cells such as from an animal or a plant are encapsulated in inorganic microspheres. An organosilicon precursor such as tetraethoxysilane or an organometallic precursor such as...
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5891477 |
Non-steroidal anti-inflammatory agents inhibition of fibrotic response to an implanted device
Methods for inhibition of fibrotic rejection of implanted devices which contain cells by administering to the recipient of the devices an amount of a non-steroidal anti-inflammatory agent (NSAID)...
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5879920 |
Coated enzyme-containing granule
A granular enzyme composition is produced having reduced tendency to form dust and leave a residue, and improved stability and delayed release characteristics. The composition has a core,...
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5879709 |
Method of treating patients with diabetes
The present invention is directed to a method of treating a patient with diabetes by implanting an improved macrocapsule containing living islet cells in the patient. The improved macrocapsules...
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5879950 |
Materials and methods for digestion of DNA or RNA using restriction endonucleases
Disclosed are improvements for enzyme-catalyzed reactions involving DNA or RNA, including restriction digests, which are based on conducting such reactions in the presence of lipids.
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5876742 |
Biological tissue transplant coated with stabilized multilayer alginate coating suitable for transplantation and method of preparation thereof
A biological tissue transplant coated with a stabilized multilayer alginate coating and a method for preparation of the stabilized multilayer coating. Coating has three primary layers of the...
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5871985 |
Particulate non cross-linked chitosan core matrices for encapsulated cells
Vehicles containing cells for implanting in the tissue of an individual are prepared having cells dispersed in a particulate, essentially non cross-linked chitosan core matrix that is enclosed...
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5863531 |
In vitro preparation of tubular tissue structures by stromal cell culture on a three-dimensional framework
A stromal cell-based three-dimensional cell culture system is provided which can be used to culture a variety of different cells and tissues in vitro for prolonged periods of time. The stromal...
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5858392 |
Supported polyionic hydrogels
A supported polyionic hydrogel is prepared by impregnating a support matel with a solution of anionic polysaccharide and a solution of cationic polysaccharide where the anionic polysaccharide and...
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5858747 |
Control of cell growth in a bioartificial organ with extracellular matrix coated microcarriers
Methods and compositions are provided for controlling cell distribution within an implantable bioartificial organ by exposing the cells to a treatment that inhibits cell proliferation, promotes...
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5856083 |
Lawn assay for compounds that affect enzyme activity or bind to target molecules
A lawn assay is described for determining compounds that affect enzyme activity or that bind to target molecules. Compounds to be screened are cleaved, and diffused from solid supports into a...
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