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7402381 |
Method of immobilizing molecules onto a solid phase substrate and method of fabricating a biosensor using the method
Aspects of the invention can provide a method capable of easily realizing immobilization with the optimum density derived from a concentration control and without phase separation in coadsorption...
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7351838 |
N-sulfonyldicarboximide containing tethering compounds
Compounds having two reactive functional groups are described that can be used as a tethering compound to immobilize an amine-containing material to a substrate. The first reactive functional group...
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7351798 |
Stabilized protein crystals, formulations comprising them and methods of making them
This invention relates to methods for the stabilization, storage and delivery of biologically active macromolecules, such as proteins, peptides and nucleic acids. In particular, this invention...
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7332314 |
Biosensor for analyzing quantitatively analyte with a predetermined size and larger than, and manufacturing method thereof
The present invention discloses a biosensor for quantitatively analyzing a bio-material and a manufacturing method thereof. The biosensor has an exposed conductive region of a few-nanometer scale...
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7323167 |
Method of treatment with modified arginine deiminase
The present invention is directed to arginine deiminase modified with polyethylene glycol, to methods of treating cancer, and to methods of treating and/or inhibiting metastasis.
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7312056 |
Enhancement of enzyme activity through purification and immobilization
An improved method of making an immobilized enzyme comprising (a) treating an immobilization support with an aqueous solution comprising a cross-linking agent and polymeric aldehyde species and...
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7262063 |
Directed assembly of functional heterostructures
The present invention relates to a systematic process for the creation of functionally organized, spatially patterned assemblies polymer-microparticle composites including the AC electric...
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7241628 |
Method for immobilizing conjugates in diagnostic tests
The invention concerns a method for the detection of an analyte in a sample using analyte-specific conjugates which have at least one heterologous group for an analyte-independent binding to a...
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7214388 |
Degradable heterobifunctional poly(ethylene glycol) acrylates
A heterobifunctional poly(ethylene glycol) is provided having a hydrolytically degradable linkage, a first terminus comprising an acrylate group, and a second terminus comprising a target such as a...
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7208299 |
Composition and method for regulating the adhesion of cells and biomolecules to hydrophobic surfaces
The present invention is directed to a composition and method for regulating the adhesion of cells and biomolecules to hydrophobic surfaces and hydrophobic coated surfaces. The composition is a...
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7204980 |
Methods for inhibiting viral replication in vivo
The present invention is directed to methods of modulating viral replication in vivo comprising administering to an individual a therapeutically or prophylactically effective amount of a...
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7195923 |
Ratiometric determination of glycated protein
The present invention provides methods for determining a ratio of an amount of a glycated form of a protein to a total amount of the protein in a sample containing the glycated protein, the...
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7166304 |
Degradable heterobifunctional poly(ethylene glycol) acrylates
A heterobifunctional poly(ethylene glycol) is provided having a hydrolytically degradable linkage, a first terminus comprising an acrylate group, and a second terminus comprising a target such as a...
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7122381 |
Selective affinity material, preparation thereof by molecular imprinting, and use of the same
A selective adsorption material made by the process comprising: a) non-cavalently or reversibly-covalently binding a print molecule to at least two styrene, acrylate or silica monomers, each of...
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7122356 |
Method for attachment of biomolecules to medical device surfaces
A method for making a medical device having at least one biomolecule immobilized on a substrate surface is provided. One method of the present invention includes immobilizing a biomolecule...
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7112453 |
Retentate chromatography and protein chip arrays with applications in biology and medicine
This invention provides methods of retentate chromatography for resolving analytes in a sample. The methods involve adsorbing the analytes to a substrate under a plurality of different selectivity...
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7105339 |
Retentate chromatography and protein chip arrays with applications in biology and medicine
This invention provides methods of retentate chromatography for resolving analytes in a sample. The methods involve adsorbing the analytes to a substrate under a plurality of different selectivity...
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7087728 |
Carbohydrate crosslinked glycoprotein crystals
The present invention relates to the field of carbohydrate crosslinked glycoprotein crystals. Advantageously, such crosslinked glycoprotein crystals display stability to harsh environmental...
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7087658 |
Water-soluble coating agents bearing initiator groups
A method of forming a polymer layer on a support surface by the use of a coating agent and polymerizable compounds. The coating agent provides photoreactive groups adapted to attach the agent to...
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7083812 |
Chemical library preparation method from natural product
The present invention relates to a preparation method of a general library and a focused library from crude extracts of natural products including herbal drugs, said libraries, and the method for...
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7070941 |
Methods and compositions for tagging via azido substrates
The invention provides methods and compositions for azide tagging of biomolecules. In one embodiment of the invention, proteins are tagged by metabolic incorporation of prenylated azido-analog...
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7067294 |
Catalytic surfaces for active protection from toxins
A bioactive catalytic material is disclosed for providing protection from chemical exposure. The material is composed of enzymes immobilized within polyelectrolyte multilayers and a polymerizable...
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7052887 |
Method for immobilization of (an) affinity reagent(s) on a hydrophobic solid phase
The invention relates to a method of immobilizing an affinity reagent or affinity reagents on a hydrophobic solid phase which can be used in biological assays for analyte detection. The invention...
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7026166 |
Fluorogenic dyes
The present invention relates to the use of fluorogenic or chromogenic dyes as reporter molecules for detecting cell entry by a specific molecule.
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7022673 |
Method for increasing the serum half-life of a biologically active molecule
A method is provided for preparing a biologically active molecule having an increased serum half-life. The method involves conjugating a polymer such as polyethylene glycol to the biologically...
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7008634 |
Cell growth substrates with tethered cell growth effector molecules
Described are compositions with tethered growth effector molecules, and methods of using these compositions for growing cells and tissues. Growth effector molecules, including growth factors and...
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6998246 |
Method for immobilizing conjugates in diagnostic tests
The invention concerns a method for the detection of an analyte in a sample using analyte-specific conjugates which have at least one heterologous group for an analyte-independent binding to a...
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6995259 |
Method for the chemical synthesis of oligonucleotides
The present invention features novel compositions, linkers, derivatized solid supports, and methods for the efficient solid phase synthesis of oligonucleotides, including RNA, DNA, RNA-DNA...
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6989143 |
Depletion method of blood plasma ascorbate
Artificial modulation of ascorbate level was investigated in mice capable of de novo synthesis of ascorbate. When mice were given exogenous ascorbate or its physiological precursor,...
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6951745 |
Polyhydroxyalkanoate-containing structure and manufacturing method thereof
A method for manufacturing polyhydroxyalkanoate-containing structure, at least a part of a base material surface of the structure being coated with polyhydroxyalkanoate, the method comprises the...
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6939681 |
Method of detecting an antibody in a liquid sample
The invention relates to a method of evaluating the immunological status of a subject comprising the steps of 1) determining the content of an antibody in a liquid sample from the subject using an...
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6929955 |
Interactive system for presenting and eliminating substances
The present invention relates to an interactive system comprising at least one active surface of plastic from monomers containing at least one structural element derived from a carbon dioxide (A),...
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6913915 |
PEG-modified uricase
The present invention is directed to uricase modified with polyethylene glycol and to methods of treating different illnesses characterized by increased circulating uric acid levels, including but...
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6893881 |
Method for detection of specific target cells in specialized or mixed cell population and solutions containing mixed cell populations
The invention relates to a method for detecting specific target-cells in a simple and time saving way, using paramagnetic particles, antibodies recognizing the Fc portions of target-cell...
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6869784 |
Passivation of nerve agents by surface modified enzymes stabilized by non-covalent immobilization on robust, stable particles
Enzymes are modified by incorporating anchor sites for linking the enzymes to a target surface without destroying the catalytic activity of the enzymes. A stable carrier to accommodate and bind the...
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6852513 |
Method for extracting an insulin using enzymes which are bonded to a non-porous polymer support
The invention relates to a method for catalysing complex reactions or large molecules, more specifically, to enzyme-catalysed reactions during which undesirable consecutive or subsidiary reactions...
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6825032 |
High capacity assay platforms
A high capacity assay platform capable of binding target molecules includes a substrate and a polymer matrix attached to the substrate. The polymer matrix comprises a plurality of polymer molecules...
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6815078 |
Substrate for protein microarray containing functionalized polymer
A gelatin-based substrate for fabricating protein arrays, the substrate comprising: gelatin having at least one surface; a polymer scaffold affixed to the gelatin surface; wherein the polymer in...
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6812000 |
Product removal process for use in a biofermentation system
This invention relates to a bioprocess engineering solution for a product removal process for use in a biofermentation. The invention discloses a process for withdrawing an aliquot of broth from a...
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6808908 |
Functionalized porous substrate for binding chemical and biological moieties
The invention relates to porous polymeric materials, methods of making them, and applications in medical devices. A specific embodiment of the invention encompasses a material comprising a porous...
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6790942 |
Biologically active conjugates having a detectable reporter moiety and method of identification of the derivative
Biologically active drug polymer derivatives, namely peptides or protein derivatives, are useful medicaments and are represented by the generic formula: RO—(CH 2 —CH 2 O) n...
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6790827 |
Bioconjugates and delivery of bioactive agents
The present invention relates to bioconjugates and the delivery of bioactive agents which are preferably targeted for site-specific release in cells, tissues or organs. More particularly, this...
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6790609 |
Thin membrane for detecting thiol-containing compounds
A method for measuring a thiol group-containing compound, which comprises the steps of (1) contacting a sample containing a thiol group-containing compound with a thin membrane comprising a...
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6777237 |
Bioconjugates and delivery of bioactive agents
The present invention relates to bioconjugates and the delivery of bioactive agents which are preferably targeted for site-specific release in cells, tissues or organs. More particularly, this...
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6770220 |
Production and use of luminescent microparticles and nanoparticles
Luminescent microparticles and nanoparticles are provided for use either as internal standards for referencing fluorescent signals, or as markers for detecting biomolecules. Luminescence dyes are...
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6749865 |
Modification of biopolymers for improved drug delivery
A biologically active conjugate is disclosed comprising a biopolymer and a therapeutic agent joined by a disulfide bond. The conjugate, when formulated in a pharmaceutical composition with a...
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6737259 |
Modified arginine deiminase
The present invention is directed to arginine deiminase modified with polyethylene glycol, to methods of treating cancer, and to methods of treating and/or inhibiting metastasis.
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6733894 |
High-density functional slide and preparation method thereof
The invention features a method for preparing a high-density functional slide by coating a sol-gel containing amine-group bearing silanes and a solution containing polyaldehyde groups onto an...
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6730144 |
Air purifying filter using modified enzymes
An air purifying filter includes a modified enzyme immobilized on a surface of a carrier. The modified enzyme has been modified with a bonding agent that improves bonding. The surface of the...
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6703207 |
Method of screening substances with a glycidyl methacrylate covered styrene-glycidyl methacrylate polymer
A compound possessing physiological activity is coupled to a styrene-glycidyl methacrylate polymer through a spacer. Compounds that may be used include receptors such as proteins, and...
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