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7618646 |
Matrix, cell implant and method for their production and use
The invention relates to porous matrices based on a biologically compatible polymer or polymer mixture, to a cell implantation that is established on said matrices and to additional cell...
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7611878 |
Biocatalytic material comprising multilayer enzyme coated fiber
The present invention relates generally to high stability, high activity biocatalytic materials and processes for using the same. The materials comprise enzyme aggregate coatings having high...
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7611835 |
Process for preparing multilayer enzyme coating on a fiber
A process for preparing high stability, high activity biocatalytic materials is disclosed and processes for using the same. The process involves coating of a material or fiber with enzymes and...
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7604817 |
Method for promoting growth of tissue
A device and method for tissue engineering is disclosed. More particularly this invention relates to a bioabsorbable device and a method of its use which promotes controlled new tissue in-growth...
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7604746 |
Pervaporation composite membranes
The present application discloses a composite membrane comprising (a) a support member that has a plurality of pores extending through the support member and (b) a cross-linked copolymer comprising...
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7579179 |
Cell growth surface on a polymeric substrate
A product exhibiting an improved cell growth surface and cell attachment. According to the present invention, a stream of plasma is comprised of activated gaseous species generated by a microwave...
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7575935 |
Retentate chromatography and protein chip arrays with applications in biology and medicine
This invention provides methods of retentate chromatography for resolving analytes in a sample. The methods involve adsorbing the analytes to a substrate under a plurality of different selectivity...
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7547449 |
Method for treating a bone defect with an organic/inorganic composite
The subject invention concerns a composite comprising an organic fluid-swellable, fibrous matrix, such as collagen, and a mineral phase, such as calcium carbonate or phosphate mineral phase, for...
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7544438 |
Electron mediator, electron mediator immobilized electrode, and biofuel cell using the electrode
An object of the present invention is to provide a highly functional mediator capable of smoothly proceeding electron transfer between an electrode and a biocatalyst based on the premise that the...
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7537780 |
Method for preparing and implanting a cartilage construct to treat cartilage lesions
Neo-cartilage constructs for growth and surface coating for the de novo formation of a superficial cartilage layer. A method for generation of the neo-cartilage and the neo-cartilage construct. A...
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7534609 |
Method of expanding undifferentiated hemopoietic stem cells
A method of expanding undifferentiated hemopoietic stem cells to increase the number of the hemopoietic stem cells is provided. The method comprising: (a) obtaining the undifferentiated hemopoietic...
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7531334 |
Polymeric microcarriers for cell culture functions
Polymeric microcarriers suitable for use in cell culture processes and the methods of making such polymeric microcarriers by emulsion/aggregation polymerization processes.
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7521214 |
Method of immobilizing malate dehydrogenase on a substrate
Immobilization of malate dehydrogenase on a substrate using a glycerol solution containing malate dehydrogenase is achieved through dropping a mixed solution obtained by adding at least one...
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7520970 |
Immobilization support, process for producing the same, electrode, process for producing the same, electrode reaction utilizing apparatus and process for producing the same
An immobilization carrier containing an electron acceptor compound is used in addition to glutaraldehyde and poly-L-lysine to immobilize an enzyme and an electron acceptor compound simultaneously...
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7517674 |
Process of hydrolyzing oil or fat using a packed layer of immobilized enzyme
A process is disclosed for hydrolyzing an oil or fat by mixing and feeding an oil-phase substrate and a water-phase substrate to a packed layer with an immobilized enzyme packed therein. The oil or...
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7514249 |
Biomimetic organic/inorganic composites
The subject invention concerns a composite comprising an organic fluid-swellable, fibrous matrix, such as collagen, and a mineral phase, such as calcium carbonate or phosphate mineral phase, for...
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7514248 |
Process for making organic/inorganic composites
The subject invention concerns a composite comprising an organic fluid-swellable matrix, such as collagen, and mineral phase, such as calcium carbonate or phosphate mineral phase, for use as a...
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7507564 |
Tiacumicin production
Methods, processes and materials for the production and recovery of Tiacumicins produced by culturing a microorganism belonging to the species Dactylosporangium aurantiacum subspecies ...
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7494824 |
Interactive system for presenting and eliminating substances
An interactive system is provided with at least one active surface of plastic from monomers containing at least one structural element derived from a carbon dioxide (A), and at least one substance...
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7476523 |
Method of patterning a surface using a deformable stamp
A deformable stamp for patterning a surface. The stamp can be placed in contact with an entire 3-dimensional object, such as a rod, in a single step. The stamp can also be used to pattern the...
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7468192 |
Method for repair of cartilage lesions
A method for treatment of injured, damaged, diseased or aged articular cartilage using neo-cartilage constructs implanted into a joint cartilage lesion in situ. The implantation of the construct...
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7462471 |
Porous biodegradable polymeric materials for cell transplantation
Polymeric materials are used to make a pliable, non-toxic, injectable porous template for vascular ingrowth. The pore size, usually between approximately 100 and 300 microns, allows vascular and...
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7456025 |
Sintered polymer membrane for analyte detection device
The present invention relates to a sintered porous polymeric material useful as membrane in an analyte detection device, such as a lateral flow device, flow through device, or a dipstick device....
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7452920 |
Electronically and ionically conductive porous material and method for manufacture of resin wafers therefrom
An electrically and ionically conductive porous material including a thermoplastic binder and one or more of anion exchange moieties or cation exchange moieties or mixtures thereof and/or one or...
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7452533 |
Antimicrobial polymer conjugate containing lysostaphin and polyethylene glycol
Water-soluble polymer conjugates of antimicrobial agents retaining at least a portion of the antimicrobial activity of the agent, pharmaceutical compositions containing the polymer conjugates, and...
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7439062 |
Beads for capturing target cells from bodily fluid
Spheroidal beads present an exterior surface of a hydrophilic hydrogel, which is an isocyanate-functional polymer that is polymerized by urethane bonds and cross-linked by urethane and urea bonds....
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7435594 |
Scaffold for culturing cells
A cell culture scaffold containing a gel having a network structure comprised of a synthetic polymer such that cultured cells spread in a shorter time and the number of adsorbed cultured cells per...
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7429377 |
Therapeutic composition containing a plurality of immobilized proteases
A pharmaceutical composition having thrombolytic, anti-inflammatory and cytoprotective properties is described. The composition contains active proteases attached to a gel or to a mixture of a gel...
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7427410 |
Coating hydrophobic surfaces with amphiphilic thioethers to reduce protein adsorption and cell adhesion
The present invention provides methods and apparatus for coating surfaces with specially designed thioethers and amphiphilic thioethers that reduce protein adsorption and/or cell adhesion. This...
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7423010 |
Nonporous microparticle-prodrug conjugates for treatment of infection
This invention provides novel methods and reagents for specifically delivering biologically active compounds to phagocytic mammalian cells. The invention also relates to specific uptake of such...
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7422879 |
Process for producing porous polymer films
Porous films are provided which include a blend of a film forming polymer and a non-film forming material, the film having a network of pores or channels throughout the film. The porous polymer...
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7422737 |
Porous freeze-dried hydrocolloid beads containing viable microorganisms for biological control
The present invention provides cellular solid carriers comprising viable microorganisms capable of controlling plant pathogens. The cellular solid carriers are formed from water-soluble...
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7419600 |
Method for purifying a branched water-soluble polymer
Multi-armed, monofunctional, and hydrolytically stable polymers are described having the structure
wherein Z is a moiety that can be activated for attachment to biologically active molecules...
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7417021 |
Biologically active conjugate of a biopolymer and therapeutic agent
A biologically active conjugate is disclosed comprising a biopolymer and a therapeutic agent joined by a disulfide bond. The conjugate, when formulated in a pharmaceutical composition with a...
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7413883 |
Enantioselective immobilized lipase
Immobilization of Candida rugosa lipase on a carrier selected from the group consisting of macroporous adsorbent resin of the acrylic type, synthetic epoxy activated resin and...
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7410791 |
Device containing cytophilic islands that adhere cells separated by cytophobic regions
The invention provides a device for adhering cells in a specific and predetermined position, and associated methods. The device includes a plate defining a surface and a plurality of cytophilic...
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7402381 |
Method of immobilizing molecules onto a solid phase substrate and method of fabricating a biosensor using the method
Aspects of the invention can provide a method capable of easily realizing immobilization with the optimum density derived from a concentration control and without phase separation in coadsorption...
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7381552 |
Macroporous material in the form of plastic pearls
The invention relates to a macroporous plastics bead material with an average particle diameter from 10 to 1000 μm, containing a copolymer of a) 5-60 wt. % vinylically polymerizable monomers with...
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7378088 |
Base material for regenerating an air sinus and regeneration method thereof
The instant invention provides a base material characterized by having a continuous three-dimensional honeycomb structure for regenerating an air sinus. The invention further provides methods for...
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7371400 |
Multilayer device for tissue engineering
The invention provides for translating two-dimensional microfabrication technology into the third dimension. Two-dimensional templates are fabricated using high-resolution molding processes. These...
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7361946 |
Semiconductor device-based sensors
Semiconductor device-based chemical sensors and methods associated with the same are provided. The sensors include regions that can interact with chemical species being detected. The chemical...
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7361369 |
Implant with structure allowing injection of polymer for attaching implant to tissue
Methods and apparatus for bone implants that allow for the directed application of an osteogenic compound. The implant is preferably constructed of a biodegradable polymer formed into a structure...
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7354750 |
Methods for separating molecules
The present invention provides compositions and methods for the separation of metals or molecules such as polypeptides, nucleic acids, or endotoxins using a metal-modified solid support. The metals...
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7335383 |
Generation of nitric oxide in vivo from nitrite, nitrate or nitrosothiols endogenous in blood
A material includes a surface and a reactive agent that is located at the surface of the material, covalently attached to a backbone of the material, and/or located within the material. The...
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7332297 |
Enzymatic polymerization
The invention relates to a novel method for enzymatic polymerization which includes (1) obtaining a reaction mixture including a monomer, a template, and an enzyme; and (2) incubating the reaction...
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7332160 |
Medical device and method for tissue removal and repair
The present invention relates to medical devices that are to be implanted or inserted into the body of a patient for the purpose of removing undesired body tissues. In one embodiment of the...
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7323323 |
Preparation and xenotransplantation of porcine islets
The invention relates to developments in the treatment of diabetes in mammals. Particularly it relates to a method of preparing a xenotransplantable porcine islet preparation capable upon...
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7323190 |
Cell delivery system comprising a fibrous matrix and cells
Cell storage and delivery systems and methods for storing and delivering viable cells to a mammal are disclosed. The cell storage and delivery systems include a biodegradable and/or bioabsorbable...
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7323167 |
Method of treatment with modified arginine deiminase
The present invention is directed to arginine deiminase modified with polyethylene glycol, to methods of treating cancer, and to methods of treating and/or inhibiting metastasis.
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7316919 |
Composite materials comprising supported porous gels
This invention relates to a composite material that comprises a support member that has a plurality of pores extending through the support member and, located in the pores of the support member,...
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