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5389535 Method of encapsulating cells in a tubular extrudate  
Methods and systems are disclosed for encapsulating viable cells which produce biologically-active factors. The cells are encapsulated within a semipermeable, polymeric membrane by co-extruding an...
5387514 Acylation of alcohols with Pseudomonas lipase immobilized on a polystyrene resin  
The O-acylation of alcohols is carried out by reacting a vinyl ester or a carboxylic ester with Pseudomonas lipase immobilized on a hydrophobic carrier such as a polystyrene-based carrier. The...
5385836 Nonwoven fabric coated with a mixture of silk fibroin, gelatin and insolubilized chitosan for use as a carrier for animal cells  
A carrier for adhering animal cells during culturing or for immobilization of animal cells is produced by coating a porous substrate with a cell adhesive material in the form of a mixture with...
5384256 Pectin-modified lipase from Mucor javanicus with lowered saturated/unsaturated fatty acid ratio  
A native lipase from Mucor javanicus is modified by bonding it to a pectin. The pectin-modified lipase releases fatty acids of identical chain length from a lipidic substrate in a lower...
5384254 Immobilization of biomolecules on a fluorocarbon surface modified with a poly(fluoroalkyl) sugar reagent  
Poly(fluoroalkyl) sugar reagents are prepared containing a sugar such as a monosaccharide or a disaccharide to which are bonded a plurality of fluoroalkyl anchor groups capable of attaching to a...
5380658 Immobilization of biologically active substances with a polyphosphazene carrier  
A phosphazene polymer carrier is prepared that has functional groups capable of binding a biologically active substance such as an enzyme or antibody and groups which are non-reactive and...
5378462 Pancreatin micropellets prepared with polyethylene glycol 4000, paraffin and a lower alcohol by extrusion and rounding  
Pancreatin-containing micropellet cores which can be coated with a gastric juice-resistant film are prepared by extruding a mixture containing pancreatin, polyethylene glycol 4000 and a lower...
5369012 Method of making a membrane having hydrophilic and hydrophobic surfaces for adhering cells or antibodies by using atomic oxygen or hydroxyl radicals  
A portion of an organic polymer article such as a membrane is made hydrophilic by exposing a hydrophobic surface of the article to a depth of about 50 to about 5000 angstroms to atomic oxygen or...
5366532 Fertilizers containing microorganisms and their production processes  
Fertilizer containing microorganisms of the rhizosphere packaged by microencapsulation in a polysaccharide matrix. The inoculum obtained after microencapsulation can be mixed with a granular solid...
5352574 Surface functionalized and derivatized electroactive polymers with immobilized active moieties  
New variants of electroactive and optoactive polymers are formed from the surface chemical modification and derivization of free-standing and substrate-supported polymer films. The free-standing or...
5348873 Immobilization of an anti-thrombogenic substance with a photo-reactive azide and a photo-crosslinking material  
An anti-thrombogenic substance is immobilized on a base of a medical device to impart anti-thrombogenic properties to the medical device. The method comprises the steps of applying a photo-reactive...
5342772 Process for enzyme immobilization on a fluorocarbon surface  
The fluorocarbon surface of a solid or liquid support is activated with a highly fluorinated isocyanate-modified ligand or with a reactive poly(fluoroalkyl) sugar reagent containing a polyhydroxy...
5342765 Method of producing extracellular products from aerobic microorganisms  
Disclosed is a method of producing an extracellular product from an aerobic microorganism. The microorganism is grown in an aqueous medium on one side of an oxygen-permeable surface while the...
5330905 Method for isolating an enzyme from a fermentation broth  
To obtain enzymes from an enzyme-containing suspension, such as fermentation broth, the suspension is placed, together with particulate material capable of binding enzyme, such as ion exchange...
5328840 Method for preparing targeted carrier erythrocytes  
The present invention provides new compounds and methods for promoting platelet aggregation, and controlling bleeding. The present invention is based on the surprising discovery that erythrocytes...
5324649 Enzyme-containing granules coated with hydrolyzed polyvinyl alcohol or copolymer thereof  
A granular enzyme composition is produced, having reduced tendencies to form dust and leave residue, and exhibiting improved stability and delayed release characteristics. The granular composition...
5324647 Fibrin coated polymer surfaces  
Surfaces of polymeric materials are coated with a layer of thermally denatured fibrinogen. The fibrinogen may be treated with thrombin to produce fibrin, and additional fibrinogen and factor XIII...
5314814 Preparation of novel immobilized biocatalysts  
Immobilized water-insoluble biocatalysts in particulate form comprise living cells, particularly yeast, dispersed in a cross-linked gelling agent. An enzyme, particularly amyloglucosidase, may be...
5314810 Fructose transferring enzyme absorbed on a granular carrier for production of fructooligosaccharides  
A fructose transferring enzyme is immobilized by adsorption on a granular carrier having a primary to quaternary amine. The carrier is preferably an epoxy polymer, a vinyl polymer or a chitosan...
5312744 Method of immobilizing and preserving an immunologically reactive substance  
A method is provided for immobilizing and preserving an immunologically reactive antigen substance such as antigenic cells or non-cell bound antigens for use in solid-phase immunoassay. The antigen...
5312762 Method of measuring an analyte by measuring electrical resistance of a polymer film reacting with the analyte  
The change in electrical resistance of an electroactive polymer such as polypyrrole, polyaniline or polythiophene when it reacts with an analyte is used to measure the analyte. The open circuit...
5310688 Method and apparatus for eluting proteins in affinity membrane process  
This invention relates to methods and apparatus for carrying out affinity separations of proteins under conditions optimized for recovering biologically active protein. The method utilizes a...
5310786 Reversibly precipitable, water-soluble polymer conjugates  
The invention relates to polymer conjugates which are reversibly precipitable from aqueous solution and are composed of a carrier polymer which is soluble in aqueous medium and of a catalytically...
5308641 Biocompatibility of solid surfaces  
An improved spacer material for improving the biocompatibility of a biomaterial and a method for making it in which a polyalkylimine is covalently attached to an aminated substrate and combined...
5306632 Porous acrylonitrile polymer substrate for bonding ligands and separating biologically active substances  
A porous shaped substrate such as a porous bead is formed from polyacrylonitrile or a copolymer thereof containing nitrile groups. The substrate has a hydrophilic surface containing amide groups...
5298264 Oxygen removal with immobilized dried Saccharomyces cerevisiae  
The oxidative deterioration of water-containing products for human consumption, e.g. beverages and oil and/or fat based products is minimized by introduction of immobilized yeast. Yeast is...
5294551 Cell culture substrate coated with polypeptides having fibronectin activity  
A composition which can bind heparin and promote cellular adhesion and neurite outgrowth is provided which consists essentially of a polypeptide of the formula:...
5292649 Method for reaction of lipase upon fatty acid  
The reaction of a lipase upon a fatty acid is effected by an improved method which comprises bringing the lipase bonded at multiple points to an anion-exchange residue or a carrier and a carrier...
5290693 Immobilization of microorganisms or enzymes in polyvinyl alcohol beads  
Microorganisms or enzymes are immobilized by using polyvinyl alcohol to form beads containing a microorganism or an enzyme. An aqueous solution of about 10 to about 20 wt % polyvinyl alcohol...
5284754 Process for the continuous conversion of cephalosporin derivatives into glutaryl-7-aminocephalosporanic acid derivatives  
A process for the continuous conversion of cephalosporin derivatives into glutaryl-7-aminocephalosporanic acid derivativesA process for the continuous conversion of cephalosporin derivatives into...
5284911 Surface-modified polyacrylonitrile substrates  
A composition is disclosed herein which comprises a core of a polyacrylonitrile homopolymer or copolymer and a surface of N-haloamides. Also disclosed is a process for the production of said...
5283182 Preparation of immobilized hydantoinase stabilized with divalent metal ions  
An immobilised hydantoinase containing a divalent metal ion selected from Mn++, Co++, Fe++, Ni++ and Mg++ is produced that is useful for the preparation of a D(-)(optionally substituted...
5283186 Preparation of a compressed membrane containing immobilized biologically acting material  
A porous carrier containing an immobilized biologically active material is prepared in which a relatively large amount of an enzyme or an antibody has been immobilized in a manner that produces a...
5279948 Immobilization of enzymes with a cross-linking agent and a polymer containing l-amino ethylene moieties  
Physically strong particles containing an immobilized enzyme are prepared for use in a fixed bed-column. The particles are prepared by adding a homopolymer of 1-amino ethylene or a copolymer of...
5278054 Process for the enzymatic hydrolysis of a carboxylic acid derivative  
A process for the enzymatic hydrolysis of a carboxylic acid derivative by dissolving the carboxylic acid derivative in an organic solvent which is miscible with water only to a slight extent,...
5270193 Immobilization of biomolecules on perfluorocarbon surfaces  
Biomolecules such as a ligand or binder for the ligand are securely but reversibly attached to a perfluorocarbon carrier with a water soluble polymer, a perfluorocarbon anchoring group and...
5268287 Phosphazene polymer for immobilizing biologically active substances  
A phosphazene polymer for immobilizing biologically active substances such as enzymes is prepared that does not lower activity originally possessed by the biologically active substance and does not...
5268271 Method for the synthesis of semi-synthetic antibiotics in thermodynamically controlled water-cosolvent organic miscible apolar systems by using penicillin G acylase  
Synthesis of semi-synthetic monobactamic or β-Lactamic antibiotics by using derivatives stabilized by various methods of penicillin G acylase from various microbial sources according to a ...
5268306 Preparation of a solid phase matrix containing a bound specific binding pair  
A specific binding pair is bound to an insoluble carrier for use in determining an analyte such as in an immunoassay. The carrier is coated with a first polymer containing a protein polymer having...
5268286 Method for immobilizing biocatalyst in granular form with a photo-crosslinkable resin  
A biocatalyst is immobilized with a graft product of a polymer and saponified polyvinyl acetate containing a stilbazolium group as a photo-crosslinking group. The polymer is preferably gelatin,...
5266476 Fibrous matrix for in vitro cell cultivation  
There is provided a matrix and cultivation system for anchorage dependent cells. The matrix is characterized by a substantially increased available effective surface area for cell attachment which...
5266471 Solid carriers modified with 2,4,6-trichloro-s triazine to immobilize biomolecules  
A modified solid carrier is used to covalently immobilize biomolecules such as proteins. The carrier is based on well-known matrix materials modified to have covalently bound functional groups of...
5264359 Methods for large-scale cultivation of animal cells and for making supporting substrata for the cultivation  
A method for the large-scale cultivation of animal cells wherein animal cells are embedded in a collagen gel which is covered by a protective coating. The protective coating supports and protects...
5262317 Polyacrylonitrile modified with hydrogen halide for immobilization of biological substances  
Polyacrylonitrile is chemically modified with HX (Cl, Br, I, CF3 SO3 H) to produce a polymer with readily replaceable X groups. The modified polyacrylonitrile is useful as an immobilization...
5254471 Carrier for cell culture  
A carrier for cell culture comprising ultra fine fibers with a fineness of not more than 1.0 denier. The carrier makes it possible for the cells to retain their differentiation and proliferation...
5254283 Isophthalic polymer coated particles  
The invention relates to use of a water dispersible isophthalic acid polymer as a dust free coating on particulates. The particles provide a timed release of the contents of the particle which...
5254468 Bilayer pellet containing immobilized xylose isomerase and urease for the simultaneous isomerization and fermentation of xylose to ethanol  
A bilayered immobilized enzyme pellet and a process to manufacture this pellet are provided for use in a process involving the simultaneous isomerization of xylose to xylulose and fermentation of...
5246829 Products for separation applicable to cells in the immunopurification field  
The invention relates to a product to permit separation of cells in the domain of immunopurification and consisting of a finely divided carrier of a density lower than that of the medium from which...
5246863 Karl Fischer titration techniques  
An improved technique and apparatus for automatic titration for determining the water content of a sample by a Karl Fischer (K.F.) reaction. Rather than requiring titration from one endpoint to...
5244799 Preparation of a polymeric hydrogel containing micropores and macropores for use as a cell culture substrate  
A hydrophilic substituent of a bicontinuous cubic phase in equilibrium is polymerized and the unpolyermized components subsequently removed and replaced with water, creating a hydrogel which is...