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5348873 Immobilization of an anti-thrombogenic substance with a photo-reactive azide and a photo-crosslinking material  
An anti-thrombogenic substance is immobilized on a base of a medical device to impart anti-thrombogenic properties to the medical device. The method comprises the steps of applying a photo-reactive...
5342772 Process for enzyme immobilization on a fluorocarbon surface  
The fluorocarbon surface of a solid or liquid support is activated with a highly fluorinated isocyanate-modified ligand or with a reactive poly(fluoroalkyl) sugar reagent containing a polyhydroxy...
5342765 Method of producing extracellular products from aerobic microorganisms  
Disclosed is a method of producing an extracellular product from an aerobic microorganism. The microorganism is grown in an aqueous medium on one side of an oxygen-permeable surface while the...
5330905 Method for isolating an enzyme from a fermentation broth  
To obtain enzymes from an enzyme-containing suspension, such as fermentation broth, the suspension is placed, together with particulate material capable of binding enzyme, such as ion exchange...
5328840 Method for preparing targeted carrier erythrocytes  
The present invention provides new compounds and methods for promoting platelet aggregation, and controlling bleeding. The present invention is based on the surprising discovery that erythrocytes...
5324649 Enzyme-containing granules coated with hydrolyzed polyvinyl alcohol or copolymer thereof  
A granular enzyme composition is produced, having reduced tendencies to form dust and leave residue, and exhibiting improved stability and delayed release characteristics. The granular composition...
5324647 Fibrin coated polymer surfaces  
Surfaces of polymeric materials are coated with a layer of thermally denatured fibrinogen. The fibrinogen may be treated with thrombin to produce fibrin, and additional fibrinogen and factor XIII...
5314814 Preparation of novel immobilized biocatalysts  
Immobilized water-insoluble biocatalysts in particulate form comprise living cells, particularly yeast, dispersed in a cross-linked gelling agent. An enzyme, particularly amyloglucosidase, may be...
5314810 Fructose transferring enzyme absorbed on a granular carrier for production of fructooligosaccharides  
A fructose transferring enzyme is immobilized by adsorption on a granular carrier having a primary to quaternary amine. The carrier is preferably an epoxy polymer, a vinyl polymer or a chitosan...
5312744 Method of immobilizing and preserving an immunologically reactive substance  
A method is provided for immobilizing and preserving an immunologically reactive antigen substance such as antigenic cells or non-cell bound antigens for use in solid-phase immunoassay. The antigen...
5312762 Method of measuring an analyte by measuring electrical resistance of a polymer film reacting with the analyte  
The change in electrical resistance of an electroactive polymer such as polypyrrole, polyaniline or polythiophene when it reacts with an analyte is used to measure the analyte. The open circuit...
5310688 Method and apparatus for eluting proteins in affinity membrane process  
This invention relates to methods and apparatus for carrying out affinity separations of proteins under conditions optimized for recovering biologically active protein. The method utilizes a...
5310786 Reversibly precipitable, water-soluble polymer conjugates  
The invention relates to polymer conjugates which are reversibly precipitable from aqueous solution and are composed of a carrier polymer which is soluble in aqueous medium and of a catalytically...
5308641 Biocompatibility of solid surfaces  
An improved spacer material for improving the biocompatibility of a biomaterial and a method for making it in which a polyalkylimine is covalently attached to an aminated substrate and combined...
5306632 Porous acrylonitrile polymer substrate for bonding ligands and separating biologically active substances  
A porous shaped substrate such as a porous bead is formed from polyacrylonitrile or a copolymer thereof containing nitrile groups. The substrate has a hydrophilic surface containing amide groups...
5298264 Oxygen removal with immobilized dried Saccharomyces cerevisiae  
The oxidative deterioration of water-containing products for human consumption, e.g. beverages and oil and/or fat based products is minimized by introduction of immobilized yeast. Yeast is...
5294551 Cell culture substrate coated with polypeptides having fibronectin activity  
A composition which can bind heparin and promote cellular adhesion and neurite outgrowth is provided which consists essentially of a polypeptide of the formula:...
5292649 Method for reaction of lipase upon fatty acid  
The reaction of a lipase upon a fatty acid is effected by an improved method which comprises bringing the lipase bonded at multiple points to an anion-exchange residue or a carrier and a carrier...
5290693 Immobilization of microorganisms or enzymes in polyvinyl alcohol beads  
Microorganisms or enzymes are immobilized by using polyvinyl alcohol to form beads containing a microorganism or an enzyme. An aqueous solution of about 10 to about 20 wt % polyvinyl alcohol...
5284754 Process for the continuous conversion of cephalosporin derivatives into glutaryl-7-aminocephalosporanic acid derivatives  
A process for the continuous conversion of cephalosporin derivatives into glutaryl-7-aminocephalosporanic acid derivativesA process for the continuous conversion of cephalosporin derivatives into...
5284911 Surface-modified polyacrylonitrile substrates  
A composition is disclosed herein which comprises a core of a polyacrylonitrile homopolymer or copolymer and a surface of N-haloamides. Also disclosed is a process for the production of said...
5283182 Preparation of immobilized hydantoinase stabilized with divalent metal ions  
An immobilised hydantoinase containing a divalent metal ion selected from Mn++, Co++, Fe++, Ni++ and Mg++ is produced that is useful for the preparation of a D(-)(optionally substituted...
5283186 Preparation of a compressed membrane containing immobilized biologically acting material  
A porous carrier containing an immobilized biologically active material is prepared in which a relatively large amount of an enzyme or an antibody has been immobilized in a manner that produces a...
5279948 Immobilization of enzymes with a cross-linking agent and a polymer containing l-amino ethylene moieties  
Physically strong particles containing an immobilized enzyme are prepared for use in a fixed bed-column. The particles are prepared by adding a homopolymer of 1-amino ethylene or a copolymer of...
5278054 Process for the enzymatic hydrolysis of a carboxylic acid derivative  
A process for the enzymatic hydrolysis of a carboxylic acid derivative by dissolving the carboxylic acid derivative in an organic solvent which is miscible with water only to a slight extent,...
5270193 Immobilization of biomolecules on perfluorocarbon surfaces  
Biomolecules such as a ligand or binder for the ligand are securely but reversibly attached to a perfluorocarbon carrier with a water soluble polymer, a perfluorocarbon anchoring group and...
5268287 Phosphazene polymer for immobilizing biologically active substances  
A phosphazene polymer for immobilizing biologically active substances such as enzymes is prepared that does not lower activity originally possessed by the biologically active substance and does not...
5268271 Method for the synthesis of semi-synthetic antibiotics in thermodynamically controlled water-cosolvent organic miscible apolar systems by using penicillin G acylase  
Synthesis of semi-synthetic monobactamic or β-Lactamic antibiotics by using derivatives stabilized by various methods of penicillin G acylase from various microbial sources according to a ...
5268306 Preparation of a solid phase matrix containing a bound specific binding pair  
A specific binding pair is bound to an insoluble carrier for use in determining an analyte such as in an immunoassay. The carrier is coated with a first polymer containing a protein polymer having...
5268286 Method for immobilizing biocatalyst in granular form with a photo-crosslinkable resin  
A biocatalyst is immobilized with a graft product of a polymer and saponified polyvinyl acetate containing a stilbazolium group as a photo-crosslinking group. The polymer is preferably gelatin,...
5266476 Fibrous matrix for in vitro cell cultivation  
There is provided a matrix and cultivation system for anchorage dependent cells. The matrix is characterized by a substantially increased available effective surface area for cell attachment which...
5266471 Solid carriers modified with 2,4,6-trichloro-s triazine to immobilize biomolecules  
A modified solid carrier is used to covalently immobilize biomolecules such as proteins. The carrier is based on well-known matrix materials modified to have covalently bound functional groups of...
5264359 Methods for large-scale cultivation of animal cells and for making supporting substrata for the cultivation  
A method for the large-scale cultivation of animal cells wherein animal cells are embedded in a collagen gel which is covered by a protective coating. The protective coating supports and protects...
5262317 Polyacrylonitrile modified with hydrogen halide for immobilization of biological substances  
Polyacrylonitrile is chemically modified with HX (Cl, Br, I, CF3 SO3 H) to produce a polymer with readily replaceable X groups. The modified polyacrylonitrile is useful as an immobilization...
5254471 Carrier for cell culture  
A carrier for cell culture comprising ultra fine fibers with a fineness of not more than 1.0 denier. The carrier makes it possible for the cells to retain their differentiation and proliferation...
5254283 Isophthalic polymer coated particles  
The invention relates to use of a water dispersible isophthalic acid polymer as a dust free coating on particulates. The particles provide a timed release of the contents of the particle which...
5254468 Bilayer pellet containing immobilized xylose isomerase and urease for the simultaneous isomerization and fermentation of xylose to ethanol  
A bilayered immobilized enzyme pellet and a process to manufacture this pellet are provided for use in a process involving the simultaneous isomerization of xylose to xylulose and fermentation of...
5246829 Products for separation applicable to cells in the immunopurification field  
The invention relates to a product to permit separation of cells in the domain of immunopurification and consisting of a finely divided carrier of a density lower than that of the medium from which...
5246863 Karl Fischer titration techniques  
An improved technique and apparatus for automatic titration for determining the water content of a sample by a Karl Fischer (K.F.) reaction. Rather than requiring titration from one endpoint to...
5244799 Preparation of a polymeric hydrogel containing micropores and macropores for use as a cell culture substrate  
A hydrophilic substituent of a bicontinuous cubic phase in equilibrium is polymerized and the unpolyermized components subsequently removed and replaced with water, creating a hydrogel which is...
5244807 Production of Pseudomonas XA cells containing indolyl-3-alkane alpha-hydroxylase  
A culture of Pseudomonas XA cells containing indolyl-3-alkane alpha-hydroxylase(INDH) is produced by aerobic batch fermentation in a culture medium. The culture medium is in a vessel having a means...
5242964 Process for the preparation of aqueous dispersions of magnetizable polymer particles with a desired size narrow distribution, and aqueous dispersions thereof, and uses thereof  
A process for the preparation of aqueous dispersions of magnetizable polymer particles with a narrow distribution from aqueous dispersions with a wide distribution. The amount of water in the...
5242793 Selective permeable membrane and electrode using the same  
An electrode comprising an electrically conductive base, and a selectively permeable membrane which is produced by forming a membrane from a mixed solution comprising (a) albumin, (b) at least one...
5243037 Poly(fluoroalkyl) sugar reagents for surface modification of supports  
Poly(fluoroalkyl) sugar reagents are prepared containing a sugar such as a monosaccharide or a disaccharide to which are bonded multiple fluoroalkyl anchor groups capable of attaching to a...
5240747 Process for modifying surfaces of materials  
A process for modifying the surface of a material such as plastics, metals, glasses and ceramics which comprises the steps of (1) coating a compound having at least one azido group on the surface...
5232843 Preparation of immobilized lipase by adsorption of lipase and a non-lipase protein on a support  
Lipase is supported on a carrier material, which may hydrophobic or formed of an ion-exchange resin, by adsorbing to the carrier the lipase and a substantial coating of a non-lipase protein such as...
5229280 Process for the continuous biotechnological preparation of optical isomer S(+) of 2-(6-methoxy-2-naphthyl) propionic acid  
Continuous biotechnological preparation of optical isomer S(+) of 2-(6-methoxy-2-naphthyl) propionic acid consisting in the reaction of a racemic (R,S) ester of 2-(6-methoxy-2-naphthyl) propionic...
5229284 Enzyme immobilzation on a macropermable agglomerate of microporous α- a  
Enzymes are immboilized on an inorganic carrier which is a round, macropermeable agglomerate having a mulberry-type structure formed from spherical microporous α-aluminum oxide hydroxide ...
5223124 Method for immobilizing a polypeptide in a polymer and a membrane produced thereby  
The present invention relates generally to the immobilization or incorporation of polypeptides, especially enzymes or other bioactive polypeptides into polymeric matrixes, especially polyurethane,...
5219926 Method of covalently bonding biopolymer to a solid hydrophilic organic polymer  
A process for covalently bonding biopolymer, such as protein, to an organic polymer surface coated with hydrophilic nonionic polymer having groups reactive with the biopolymer and having a cloud...