|
Match
|
Document |
Document Title |
|
|
7611860 |
Indicator for in-situ detecting of lysozyme
The present invention provides an indicator for the in-situ detection of the presence of a lysozyme or a microbe producing lysozyme at a location. The indicator comprises a layer ( 8 ) which is...
|
|
|
7608415 |
Analysis of intracellular modifications
Improved methods of determining the intracellular state of a protein as well as modifications of the protein are provided by introducing a surrogate fusion protein comprising a member of an enzyme...
|
|
|
7592152 |
Chondroitinase ABC I and methods of analyzing therewith
The invention relates to chondroitinase ABC I and uses thereof. In particular, the invention relates to recombinant and modified chondroitinase ABC I, their production and their uses. The...
|
|
|
7591978 |
Solid phase test device for sialidase assay
A solid-phase test device and a method for the detection of sialidase activity in a fluid sample. The test device includes a solid support provided with a pre-deposited dry form of a sialidase...
|
|
|
7588909 |
Method for detecting Streptococcus agalactiae using α-glucosidase activity
The present invention concerns a method for specifically detecting and identifying Streptococcus agalactiae, using a reaction medium comprising at least one α-glucosidase enzymatic substrate.
|
|
|
7579165 |
Methods for derivatizing protein or peptide with sulfonic acid groups
The present invention provides a method for effectively introducing sulfonic acid groups into the N-terminus of a protein or a peptide. The method comprises a modification step to react a...
|
|
|
7576070 |
Method for producing pectin hydrolysis products
The present invention relates to methods for the production of pectin hydrolysis products, the pectin hydrolysis products produced in this manner, as well as their use.
|
|
|
7575886 |
Analysis of sulfated polysaccharides
The invention relates to methods and products associated with analyzing and monitoring heterogeneous populations of sulfated polysaccharides. In particular therapeutic heparin products including...
|
|
|
7575883 |
Cytochrome c acetylation
Modulation of cytochrome c acetylation, e.g., with a SIR polypeptide, enables interventions that modulate lifespan regulation and cell proliferation, e.g., by modulating apoptosis and/or...
|
|
|
7563591 |
Method for assaying the activity of lysosomal enzymes
A method, and associated kit, for assaying the activity of lysosomal enzymes present in dried bodily fluids and cell tissue samples, such as α-L-iduronidase, β-D-galactosidase, β-D-glucosidase,...
|
|
|
7563590 |
Methods of quantifying methotrexate metabolites
The present invention provides a method for efficiently converting methotrexate polyglutamates to methotrexate in a cellular extract by contacting the cellular extract with gamma glutamyl hydrolase...
|
|
|
7556955 |
Nucleic acids encoding Candida kefyr cytosine deaminase
A new cytosine deaminase gene and protein from Candida kefyr are provided. This protein has increased ability to convert the 5-fluorocytosine prodrug to its toxic form when compared against the ...
|
|
|
7541422 |
Enzyme-catalyzed process for the preparation of macrocyclic polyester oligomers
A process for the enzyme-catalyzed preparation of cyclic ester oligomers from dicarboxylic acids and/or dicarboxylic acid derivatives and diols, hydroxycarboxylic acids and/or hydroxycarboxylic...
|
|
|
7538194 |
Genes encoding several poly (ADP-ribose) glycohydrolase (PARG) enzymes, the proteins and fragments thereof, and antibodies immunoreactive therewith
The isolation and characterization of cDNAs encoding poly(ADP-ribose) glycohydrolase (PARG) enzymes and the amino acid sequences of PARGs from several species are described. PARG is involved in the...
|
|
|
7537909 |
Enzymatic method of producing 4-O-β-D-galactopyranosyl-D-xylose, 4-O-β-D-galactopyranosyl-D-xylose obtained using said method, compositions contain same and the use thereof in evaluating intestinal lactase
An enzymatic process to obtain 4-O-β-D-galactopyranosyl-D-xylose useful in compositions or solutions in the in vivo evaluation of intestinal lactose activity in humans, that comprises the steps of...
|
|
|
7534581 |
Method for measurement of activity of homocysteinethiolactone hydrolyzing enzyme
The present invention provides a method for the measurement of the activity of homocysteinethiolactone hydrolyzing enzyme in a sample. The method involves mixing and reacting γ-thiobutyrolactone...
|
|
|
7531316 |
High throughput assay of Lp-PLA2 activity
This invention relates to a method for determining the activity of Lp-PLA2 in a plurality of samples from animals. The invention also relates to a kit for determining Lp-PLA2 activity in a...
|
|
|
7527958 |
Truncated 1,3-1,4-β-D-glucanase
A truncated 1,3-1,4-β-D-glucanase. Also disclosed are related nucleic acid, vector, host cell, and preparation method.
|
|
|
7527956 |
Modified human acid sphingomyelinase having increased activity, and methods for making the same
Deficiencies in the enzymatic activity of acid sphingomyelinase (ASM) result in Niemann-Pick disease. A variety of modifications which eliminate the activity of the free thiol on the C-terminal...
|
|
|
7527936 |
Modulators of angiogenesis
The present invention relates to regulation of angiogenesis. The invention further relates to methods for identifying and using agents, including small organic molecules, antibodies, peptides,...
|
|
|
7527934 |
Labeled substrate conjugates for identifying enzyme inhibitors
This invention provides labeled-substrate conjugates for assaying enzymes, particularly neuraminidases. Also provided are assays that are useful for identifying compounds that inhibit...
|
|
|
7521546 |
Branched and multi-chain nucleic acid switches for sensing and screening
Embodiments of the invention relate to a branched or multichain nucleic acid switch adapted to switch from a first conformation to a second conformation upon ligand binding. The switch includes a...
|
|
|
7514255 |
Methods and devices for detecting pancreatic lipase
A method and device for determining pancreatic lipase in an animal blood sample. In one aspect, the device includes a compartmentalized container for storing and reacting the reagents for use in...
|
|
|
7514247 |
Systems and processes for cellulosic ethanol production
A cellulosic ethanol production process. An implementation of a process for producing fuel ethanol and biodiesel from cellulose may include: providing a raw cellulose stream by mixing a waste...
|
|
|
7507570 |
Recombinant chondroitinase ABC I and uses thereof
The invention relates to chondroitinase ABC I and uses thereof. In particular, the invention relates to recombinant and modified chondroitinase ABC I, their production and their uses. The...
|
|
|
7507552 |
Crystallization of histone deacetylase 2
Provided are crystals relating to histone deacetylase 2 (HDAC-2) and its various uses.
|
|
|
7504234 |
Assays for S-adenosylmethionine (AdoMet)-dependent methyltransferase activity
The present invention relates to coupled enzyme assays. In particular, the present invention provides a coupled fluorescent assay for detection of S-adenosylmethionine (AdoMet)-dependent...
|
|
|
7504120 |
Xylanases, nucleic acids encoding them and methods for making and using them
The invention relates to xylanases and to polynucleotides encoding the xylanases. In addition, methods of designing new xylanases and methods of use thereof are also provided. The xylanases have...
|
|
|
7501273 |
Peptidylarginine deiminase 6
A nucleotide acid sequence is provided encoding a peptidylargine deiminase 6. The gene is found to be expressed in gonads only and may be used as target for male and female contraception. Its...
|
|
|
7501259 |
Method for making catalytic enzyme-modified textiles for active protection from toxins
Catalytic enzyme-modified textiles are disclosed for providing protection from chemical exposure. The textiles are composed of a cloth substrate, at least one polyelectrolyte layer, at least one...
|
|
|
7501258 |
Penicillin G biosensor, systems comprising the same, and measurement using the systems
A penicillin G biosensor, systems comprising the same, and measurement using the systems. The penicillin G biosensor has an extended gate field effect transistor (EGFET) structure and comprises a...
|
|
|
7498128 |
Methods of determining contributions to metabolic pathways
The present invention provides methods for assessing contribution of one or more pathways to the biosynthesis of a metabolite, e.g., a lipid using the levels of the product made and the metabolite...
|
|
|
7491545 |
Excitation ratiometric fluoroscent biosensor for zinc ion at picomolar levels
A highly selective and sensitive of a carbonic anhydrase-based method for measurement of zinc ion by an excitation ratiometric format based on resonance energy transfer: i.e., where the zinc ion...
|
|
|
7485435 |
Simultaneous detection of metabolic enzyme activity and metabolite levels
Provided are methods for detecting a metabolic disorder in an individual using mass spectrometry. One method involves (a) contacting a sample containing (i) one or more metabolically indicative...
|
|
|
7485433 |
Determination and quantification of red blood cell populations in samples
The invention relates to the detection and determination of erythrocytopathies and hemoglobinopathies. The invention provides a method for distinguishing between subsets of red blood cells in a...
|
|
|
7485181 |
Compositions for detecting hyaluronidase activity in situ and methods of utilizing same
A composition-of-matter is provided. The composition-of-matter comprising a chelator moiety-hyaluronan complex bound to a solid support. Also provided are methods of in-situ assessing hyaluronidase...
|
|
|
7479552 |
Type-1 ribosome-inactivating protein
The invention relates to a novel ribosome-binding protein derived from Bougainvillea spectabilis having a molecular weight of about 26,000 daltons by polyacrylamide gel electrophoresis under...
|
|
|
7459285 |
Compounds and methods of use thereof for assaying lysophospholipase D activity
Fluorogenic lysophosphatidic acid derivatives which can be used as substrates in a continuous, fluorogenic assay that can be performed in microtiter plates. The assays permit measuring LysoPLD...
|
|
|
7459284 |
Chemiluminescent acridinium compounds and analogues thereof as substrates of hydrolytic enzymes
A chemiluminescent substrate of a hydrolytic enzyme having the following general Formula I is disclosed, as follows:
Lumi-M-P Formula...
|
|
|
7459283 |
Nanoparticulate compositions having lysozyme as a surface stabilizer
The present invention is directed to nanoparticulate active agent compositions comprising lysozyme as a surface stabilizer. Also encompassed by the invention are pharmaceutical compositions...
|
|
|
7452690 |
Protease EFC cell surface fusion protein assay
Methods and reagents are provided for measuring protease activity. The reagent comprises a surface to which is linked an enzyme donor fragment through a protease recognition sequence, where the...
|
|
|
7445922 |
Zygomycetes-derived endoglucanase enzyme lacking cellulose-binding domain
This invention relates to a protein that is a Zygomycetes -derived endoglucanase lacking the cellulose-binding domain and exhibits endoglucanase activity, and a method for using the same. This...
|
|
|
7442372 |
Delivery of therapeutic compounds to the brain and other tissues
The present invention relates to the intrathecal (IT) administration of recombinant enzyme to treat lysosomal storage disorders. In an exemplary embodiment, intrathecal administration of human...
|
|
|
7439034 |
Alginases, systems containing alginases and methods of cloning, purifying and/or utilizing alginases
The present invention relates to cell wall degradative systems, in particular to systems containing enzymes that bind to and/or depolymerize cellulose. These systems have a number of applications.
|
|
|
7435794 |
Methods and compositions for selectively cleaving DNA containing duplex nucleic acids in a complex nucleic acid mixture, and nuclease compositions for use in practicing the same
Methods of selectively cleaving DNA containing duplex nucleic acids in a complex nucleic acid mixture, as well as nuclease containing compositions for use therein, are provided. In the subject...
|
|
|
7435572 |
Methods and compositions for DNA manipulation
Methods and compositions are provided for generating a single-stranded extension on a polynucleotide molecule, the single-stranded extension having a desired length and sequence composition....
|
|
|
7435557 |
Methods of identifying inhibitors of GTP cyclohydrolase I and II
The present invention relates to the identification of fungal GTP cyclohydrolase II as a target for fungicides, to a method for identifying antifungal agents based on fungal GTP cyclohydrolase II,...
|
|
|
7432098 |
Phytases and methods for making and using them
The invention provides isolated and recombinant phytase enzymes. In one aspect, the phytases are produced by modification of the wild type appA of E. coli. The enzyme can be produced from...
|
|
|
7427498 |
Composition, methods and reagents for the synthesis of a soluble form of human PHEX
This invention relates to a soluble form of PHEX, PHEX being a type II integral membrane glycoprotein. This enzyme is the gene product of a phosphate-regulating gene with homologies to...
|
|
|
7422887 |
Phospholipase A2 and gene thereof
To provide a novel phospholipase A 2 (PLA 2 ) associated with psoriasis, a nucleic acid encoding the same, a method for characterizing, identifying or screening an inhibitor for the PLA 2 or a...
|