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8182986 |
Assays for nucleic acid modifying enzymes
Methods and compositions are provided for assaying for enzymes capable of releasing an enzyme donor fragment (ED) conjugated to a nucleic acid strand bonded to a surface. Conveniently, the beads...
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8180580 |
Method for identifying a compound that modulates SIR2 protein activity
The present invention relates to a method for identifying compounds that modulate the activity of sirtuin deacetylase protein family members. Compounds of the invention are identified by designing...
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8173402 |
Modified yeasts and uses thereof, in particular for producing steroid derivatives
The present invention relates to novel yeast strains, methods and genetic constructs for their preparation, and their use for the synthesis or modification of steroidal compounds. More...
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8173437 |
Rapid serum sugar biomarker assay of rheumatoid arthritis
The present invention includes compositions, methods, kits and diagnostics for biosugar profiling of biological samples from a patient suspected of having a disease associated with changes in the...
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8173385 |
Method for stabilization of peptides in a biological sample
The present invention provides a simple method for the stabilization of a peptide in a biological sample and a reagent for the stabilization, a simple method for the preservation of a biological...
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8168405 |
Covalent tethering of functional groups to proteins and substrates therefor
A mutant hydrolase optionally fused to a protein of interest is provided. The mutant hydrolase is capable of forming a bond with a substrate for the corresponding nonmutant (wild-type) hydrolase...
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8163880 |
Production of biologically active proteins
A fusion protein that is expressed in a recombinant protein body-like assembly (RPBLA) in host eukaryotic cells and organisms is disclosed. More particularly, a biologically active polypeptide...
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8163514 |
Methods of cleaving DNA with rationally-designed meganucleases
Rationally-designed LAGLIDADG meganucleases and methods of making such meganucleases are provided. In addition, methods are provided for using the meganucleases to generate recombinant cells and...
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8153400 |
Nucleic acids encoding a mutT domain-containing polypeptide
The invention pertains to nucleic acids encoding a mutT domain-containing polypeptide, including fragments and biologically functional variants thereof. The invention also pertains to therapeutics...
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8153391 |
Hydrolases, nucleic acids encoding them and methods for making and using them
Provided are hydrolases, including lipases, saturases, palmitases and/or stearatases, and polynucleotides encoding them, and methods of making and using these polynucleotides and polypeptides....
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8153436 |
Assays for disease-associated crystals in biological samples
Methods of assaying for disease-associated crystal species in biological samples are described. Such methods involve contacting a patient sample with an excess of a detectable crystal-tagging...
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8148096 |
Microtitration plates comprising wells coated with a lipid substrate and a method of preparing
A method for the detection and/or measurement in vitro of a lipase or phospholipase activity, including the addition of a sample likely to contain said lipase or phospholipase into the wells of...
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8148097 |
Screening method for identification of compounds with calcium-independent phospholipase A2β (iPLA2β) modulating activity
An in vitro screening method for identifying a compound with iPLA2β modulating activity.
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8148098 |
Methods of cleaving DNA with rationally-designed meganucleases
Rationally-designed LAGLIDADG meganucleases and methods of making such meganucleases are provided. In addition, methods are provided for using the meganucleases to generate recombinant cells and...
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8143015 |
Methods of cleaving DNA with rationally-designed meganucleases
Rationally-designed LAGLIDADG meganucleases and methods of making such meganucleases are provided. In addition, methods are provided for using the meganucleases to generate recombinant cells and...
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8143014 |
CD38 and obesity
This document provides methods and materials relating to obesity. For example, methods and materials related to treating obesity and identifying agents having the ability to treat obesity are...
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8143040 |
Process for whole cell saccharification of lignocelluloses to sugars using a dual bioreactor system
The present invention describes a process for saccharification of lignocelluloses to sugars using whole microbial cells, which are enriched from cultures inoculated with paper mill waste water,...
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8143016 |
Methods of cleaving DNA with rationally-designed meganucleases
Rationally-designed LAGLIDADG meganucleases and methods of making such meganucleases are provided. In addition, methods are provided for using the meganucleases to generate recombinant cells and...
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8137938 |
Method for producing an L-amino acid
An L-amino acid is produced by culturing a bacterium belonging to the family Enterobacteriaceae, which is able to produce the L-amino acid, and is modified so that the activity of ribonuclease G is...
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8137942 |
Method of preparing a modified surface
Reactive surfaces, substrates and methods of producing and using such substrates and surfaces are provided. The substrates and surfaces provide low density reactive groups preferably on an...
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8133697 |
Methods of cleaving DNA with rationally-designed meganucleases
Rationally-designed LAGLIDADG meganucleases and methods of making such meganucleases are provided. In addition, methods are provided for using the meganucleases to generate recombinant cells and...
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8129134 |
Methods of cleaving DNA with rationally-designed meganucleases
Rationally-designed LAGLIDADG meganucleases and methods of making such meganucleases are provided. In addition, methods are provided for using the meganucleases to generate recombinant cells and...
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8129133 |
Devices and methods for the rapid, reliable detection and determination of acrylamide concentration in food substances and prevention of acrylamide formation in the same
A device and associated analytical method to use for the sensitive detection and accurate, rapid determination of acrylamide in food substances is presented. Also described is the use of a kit...
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8129346 |
Compounds for enzyme inhibition
Peptide-based compounds including heteroatom-containing, three-membered rings efficiently and selectively inhibit specific activities of N-terminal nucleophile (Ntn) hydrolases. The activities of...
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8124371 |
Compositions and methods for destabilizing lysosomes to increase oncogenic or aberrant protein degradation
The present invention relates to compositions for destabilizing lysosomes to increase the degradation of oncogenic or aberrant proteins for the prevention or treatment of disease. Methods for...
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8124369 |
Method of cleaving DNA with rationally-designed meganucleases
Rationally-designed LAGLIDADG meganucleases and methods of making such meganucleases are provided. In addition, methods are provided for using the meganucleases to generate recombinant cells and...
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8119361 |
Methods of cleaving DNA with rationally-designed meganucleases
Rationally-designed LAGLIDADG meganucleases and methods of making such meganucleases are provided. In addition, methods are provided for using the meganucleases to generate recombinant cells and...
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8119364 |
Methods for generating analogs of coenzyme A
Methods to generate analogs of coenzyme A in vivo are disclosed. The methods to generate analogs of coenzyme A in a cell comprise reacting pantetheine or a derivative thereof with a reporter to...
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8119383 |
Glycosidase enzymes
A thermostable glycosidase enzymes derived from various Thermococcus, Staphylothermus and Pyrococcus organisms is disclosed. The enzymes are produced from native or recombinant host cells and can...
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8101376 |
Swatch for testing the washing performance of an enzyme
The present invention relates to a swatch comprising a pH-indicator substance and a substrate for an enzyme for testing the washing performance of the enzyme, e.g. an enzyme for use in detergent...
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8101373 |
β-galactosidase donor fragments
Truncated fragments of the small fragment of β-galactosidase are provided that have low affinity for the large fragment of β-galactosidase and provide for robust signals when two fusion proteins a...
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8088741 |
Compounds for enzyme inhibition
Peptide-based compounds including heteroatom-containing, three-membered rings efficiently and selectively inhibit specific activities of N-terminal nucleophile (Ntn) hydrolases. The activities of...
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8080386 |
Polypeptides having endoglucanase activity and polynucleotides encoding same
The present invention relates to isolated polypeptides having endoglucanase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs,...
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8071734 |
Nucleic acid-based detection
The invention relates to compositions, systems, and methods for simultaneously detecting the presence and quantity of one or more different compounds in a sample using aptamer beacons. Aptamer...
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8071351 |
Family 44 xyloglucanases
The present invention relates to xyloglucanases belonging to family 44 of glycosyl hydrolases and having a relative xyloglucanase activity of at least 30% between pH 5 and pH 8 are derived from the...
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8071327 |
Screening assays for agents that alter inhibitor of apoptosis (IAP) protein regulation of caspase activity
The present invention relates to an action between an inhibitor of apoptosis (IAP) protein and members of the caspase family of cell death proteases, for example, an interaction of the X chromosome...
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8071347 |
Ketoreductases and uses thereof
The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides...
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RE42931 |
Covalent tethering of functional groups to proteins
A mutant hydrolase optionally fused to a protein of interest is provided. The mutant hydrolase is capable of forming a bond with a substrate for the corresponding nonmutant (wild-type) hydrolase...
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8043828 |
Modified endoglucanase II and methods of use
Described herein is a modified EGII cellulase having the amino acid sequence shown in SEQ ID NO:1, compositions comprising the modified EGII and methods of use.
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8039228 |
Signal amplification using a synthetic zymogen
Described herein are zymogens, methods of use for zymogens, and devices that incorporate zymogens. The zymogens include a substrate and an enzyme. The substrate can inhibit the enzyme and is a...
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8034579 |
Proteins with enhanced functionality and methods of making novel proteins using circular permutation
The present disclosure is relates to novel proteins and peptides having novel and/or enhanced functions and/or behaviors with respect to a native protein or peptide, and methods of making the novel...
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8017350 |
Glimepiride- and insulin-induced glycosylphosphatidylinositol-specific phospholipase C regulation
The present invention relates to a method for identification of a chemical compound which modulates the activity of mammalian GPI-PLC wherein a] a mammalian cell is incubated with glimepiride;b]...
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7989663 |
Compounds and methods of use thereof for assaying lysophospholipase D activity
Fluorogenic lysophosphatidic acid derivatives which can be used as substrates in a continuous, fluorogenic assay that can be performed in microtiter plates. The assays permit measuring LysoPLD...
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7989215 |
Methods and systems for adding a reagent to an analyte in a gel
The present invention relates to methods and systems for adding a reagent to an analyte in a gel. The invention further provides methods and systems for transferring liquid analyte reagent mixtures...
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7985563 |
HIFαprolyl hydroxylation assay
The present invention provides methods of identifying compounds that decrease proline hydroxylation of the alpha subunit of hypoxia inducible factor (HIFα).
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7977080 |
Phospholipases, nucleic acids encoding them and methods for making and using them
The invention provides novel polypeptides having phospholipase activity, including, e.g., phospholipase A, B, C and D activity, patatin activity, phosphatidic acid phosphatases (PAP)) and/or lipid...
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7972831 |
Lipases from thermophilic anaerobes
The inventors have identified polypeptides having lipase activity in anaerobic thermophilic bacteria. Accordingly, the invention provides a process for hydrolyzing an ester bond in a substrate,...
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7972806 |
Phospholipase
The present invention is related to a method for producing a phospholipase by processing an expressed fungal peptide and to certain specified phospholipases. Furthermore the invention provides a...
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7968318 |
Process for conversion of granular starch to ethanol
A method is disclosed for producing glucose from a granular starch substrate including, contacting a slurry comprising granular starch obtained from plant material with an alpha-amylase at a...
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7951552 |
Method of preparing non-human tissues for xenotransplantation using α-galactosidase
This invention relates to novel α-galactosidases for the enzymatic removal of the immunodominant monosaccharides on blood products and tissues. Specifically this invention provides a novel family ...
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