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6180596 |
Methods of inhibiting phospholipase A2 and phospholipase A2 stimulator activities
A method for inhibiting PLA 2 or suppressing the activity of a PLA 2 stimulator in a body fluid of an animal with lung disease involves adding Annexin I, Annexin VIII or a mixture thereof to the...
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6174695 |
Epoxide hydrolase inhibitor methods
The present invention provides methods of treating inflammatory diseases mediated by poly-unsaturated lipid metabolites by inhibiting epoxide hydrolase, methods for assaying or screening the...
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6174678 |
Methods and compositions for modulation of bacterial topoisomerase enzymes
The present invention relates to methods and compositions for the modulation of bacterial topoisomerase enzymes within bacterial cells. More specifically, the present invention relates to bacterial...
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6171810 |
Method for detecting and assaying exoglycosidase activity
A method for detecting and measuring exoglycosidase activity is presented. The method employs derivatives containing the fluorescent group 4-methylumbelliferyl ("4-Mu") at a pH lower than that...
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6168924 |
Limulus reaction-activating substance, method for inactivating the substance and measuring its amount, and method for measuring limulus reaction
The presence of endotoxin in the outer membrane of cell wall of a Gram-negative bacteria is used to determine bacterial contamination in a biological product. The amount of endotoxin present in a...
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6165743 |
Culture medium for revealing enterohemorrhagic E. coli bacteria and procedure therefor
The invention concerns a culture medium and a method for revealing enterohemorrhagic E. coli bacteria, particularly serotypes O157 and/or O11, comprising a chromogenic substrate compound of the...
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6162615 |
Stabilized coenzyme solutions and their use thereof for the determination of dehydrogenases or the substrate thereof in an alkaline medium
Stabilized aqueous coenzyme solutions which contain up to ca. 60 mM of a heavy metal salt and optionally a complexing agent in a defined ratio to the heavy metal salt as well as their use for the...
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6162614 |
Sugar ester derivatives, reagents for measurement of hydrolase activity and methods for measurement of hydrolase activity
A sugar ester derivative of the general formula (I) ##STR1## wherein G stands for a group of the formula (A) ##STR2## or a group of the formula (B) ##STR3## wherein λ means 0 or 1; at least one of...
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6159719 |
Pan-bacterial and pan-fungal identification reagents and methods of use thereof
Murein binding polypeptide and antibiotic diagnostic reagents, methods and kits for detecting eubacteria and fungus in biological samples.
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6156555 |
Method of preparing an enzyme participating in C-terminal amidation
A purified enzyme-I is obtained that participates in C-terminal amidation by acting on a peptide C-terminal glycine adduct to form a peptide C-terminal α-hydroxyglycine adduct. The enzyme has an...
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6156527 |
Characterizing polypeptides
A method for characterizing polypeptides, which comprises: (a) treating a sample comprising a population of one or more polypeptides with a cleavage agent which is known to recognize a specific...
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6156526 |
Crystal of a Ras-Sos complex and methods of use thereof
A detailed three-dimensional structure for the complex formed between Ras and the Son of sevenless (Sos) protein is provided. Crystals of this complex are also included in the invention. The...
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6153397 |
Flea epoxide hydrolase proteins and uses thereof
The present invention relates to arthropod epoxide hydrolase proteins; to arthropod epoxide hydrolase nucleic acid molecules, including those that encode such epoxide hydrolase proteins; to...
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6153419 |
Method for quantitative determination of 1,5-anhydroglucitol
The present invention relates to a method for quantitative determination of 1,5-anhydroglucitol in a sample, which comprises mixing the sample and an enzyme having activity that is inhibited by...
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6143883 |
Water-soluble low molecular weight beta-glucans for modulating immunological responses in mammalian system
A fractionated, water-soluble, readily absorbable, low molecular weight beta-glucan is usable as an immune-modulator in the mammalian system. A method is disclosed, which produces a fractionated...
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6130055 |
Method for measuring the concentration or the activity of protease inhibitor
A method for measuring the concentration or the activity of UTI quickly and easily at high sensitivity. A urine sample, a buffer solution, a trypsin solution and a substrate solution are mixed and...
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6127137 |
Acidic phospholipase, production and methods using thereof
An acidic phospholipase is obtained from a strain of the genus Hyphozyma. It is able to hydrolyze both fatty acyl groups in intact phospholipid. Advantageously, it has no lipase activity and is...
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6126973 |
Soybean protein hydrolysate, process for producing the same, and meat products and drinks using the same
The present invention provides a soy protein hydrolysate with a low content of β-conglycinin and a process for producing the same. The soy protein hydrolysate with a low content of β-conglycinin...
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6120986 |
Electrochemiluminescence assay
A rapid single step assay suitable for the detection or quantification of β-lactam antibiotics and β-lactamases. The assay can be performed directly on samples of food, such as milk and meat,...
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6117663 |
Crystal of a Ras-Sos complex
A detailed three-dimensional structure for the complex formed between Ras and the Son of sevenless (Sos) protein is provided. Crystals of this complex are also included in the invention. The...
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6110684 |
Mismatch detection techniques
Disclosed herein is a method for detecting a mismatch in a duplex nucleic acid, involving: a) contacting the duplex nucleic acid with a reactive agent under conditions which permit the agent to...
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6110677 |
Oligonucleotide modification, signal amplification, and nucleic acid detection by target-catalyzed product formation
A method is disclosed for modifying an oligonucleotide, which method has application to the detection of a polynucleotide analyte. An oligonucleotide is reversibly hybridized with a polynucleotide,...
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6110696 |
Electrochemical enzyme assay
A diagnostic kit, method, and apparatus for electrochemically determining the presence or concentration of an analyte in a sample. A mixture is formed which includes the sample, an enzyme acceptor...
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6096499 |
Mammalian DNA primase screen and activity modulating agents
The invention provides DNA primase assays suitable for identifying DNA primase modulating agents, methods of modulating DNA primase activity and compositions which modulate DNA primase.
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6090573 |
Detecting eubacteria and fungus and determining their antibiotic sensitivity by using catalytically inactive murein binding enzymes
A method is presented for detecting eubacteria and fungus in biological samples, and, if present, determining their antibiotic sensitivity, where the presence and amount of eubacteria or fungus is...
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6083684 |
Viral products
Bacteriophages of food-contaminating or pathogenic bacteria or the lysins thereof are used to kill such bacteria. Examples include lysins from bacteriophages of Listeria monocytogenes and...
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6077671 |
Method for isolating chromosomal DNA in preparation for hybridization in suspension
A method is provided for detecting nucleic acid sequence aberrations using two immobilization steps. According to the method, a nucleic acid sequence aberration is detected by detecting nucleic...
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6071711 |
Degradation of biodegradable polyester amides with enzymes
A method is disclosed for the enzymatic degradation of polyester amides. The method involves mixing polyester amides with esterase or protease enzymes in aqueous solution.
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6068971 |
Process for determination of ions in fluids by masking of interfering ions
A process and a reagent for the determination of ions in fluids, wherein the influence of these ions on the activity of an enzyme is measured. The ions for example are sodium, potassium, calcium,...
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6066446 |
Assay member and method for its manufacture
Disclosed is a member comprising an interactive material which is covalently bonded to a support body by a linker material. The member can be used as a part of an assay, and the support body may...
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6063581 |
Immunoassay for homocysteine
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6063588 |
Method of diagnosing periodontal disease
This invention provides a method of diagnosing periodontal disease in a subject by detecting elevated concentrations of β-glucuronidase in saliva from the subject. The concentration of...
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6060262 |
Regulation of I Kappa B (IκB) degradation and methods and reagents related thereto
The present invention relates to drug screening assays which provide a systematic and practical approach for the identification of candidate agents able to inhibit ubiquitin-mediated degradation of...
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6054577 |
Oligosaccharides from enzymatic cleavage of fucoidan
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6054314 |
Method for collecting cells from internal organs
A substantially non-invasive and efficient method for collecting cells from the internal organs of a subject is provided. In one embodiment, energy from an external energy source is applied to the...
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6048696 |
Method of identifying nucleic acid molecules
A method of analyzing a DNA molecule is disclosed. In one embodiment the method comprises the steps of exposing a DNA molecule to an effective amount of a chemical modification reagent wherein the...
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6048707 |
Fluorophore assisted derivatization analysis of carbohydrates
Methods and kits for structurally analyzing carbohydrate molecules are taught. Carbohydrates for analysis are derivatized (preferably methylated) and then hydrolyzed into constituent...
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6045991 |
Compositions and methods for generating red chemiluminescence
Compounds which generate red chemiluminescence on reaction with a phosphatase enzyme are provided as well as intermediates useful for their preparation. The chemiluminescent compounds comprise a...
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6043023 |
Method of identification of novel substrates
The present invention provides a novel method for the rapid isolation and identification of large numbers of novel enzyme substrates. The novel method provided by the present invention identifies...
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6040430 |
Nucleic acid encoding site specific recombinase and nuclear receptor fusion protein
An invention is described that permits the regulation of recombination in cells, organisms or appropriate cell-free systems. The invention involves creating fusion proteins between recombinase...
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6037161 |
Enzyme with acetyl esterase activity
The present invention provides an enzyme with acetyl esterase activity comprising the amino acid sequence IxFGDxYYT(SEQ ID NO: 1), in which x designates any amino acid residue. The enzyme exhibits...
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6031094 |
Beta-lactam substrates and uses thereof
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6022682 |
Article and method for detection of enterotoxigenic staphylococci
An article for detecting thermostable nuclease positive, potentially enterotoxigenic, staphylococci, containing unhydrolyzed nucleotides, toluidine blue O, and a binder, wherein the article is...
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RE36536 |
Method of detecting a substance using enzymatically-induced decomposition of dioxetanes
In an assay method in which a member of a specific binding pair is detected by means of an optically detectable reaction, the improvement wherein the optically detectable reaction includes the...
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6015683 |
Dry analytical element for acetaminophen assay
A spectrophotometric assay for the detection of acetaminophen in aqueous fluids can be carried out with a dry analytical element. The element comprises a support having thereon one or more reagent...
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6015830 |
Antibacterial compounds for Ralstonia solanacearum
Antibacterial compounds for Ralstonia solanacearum having substantially (S)-3-(3-indolyl) butanoic acid of a specified structure or its salt as active component can selectively inhibit the growth...
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6004769 |
Compositions and procedures for the determination of hydrolytic enzymes
The invention relates to compositions and procedures for the determination of hydrolytic enzymes in liquid samples with the aid of indoxyl compounds and oxidizing agents. The procedure is...
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6004768 |
Biosensors, extracorporeal devices and methods for detecting substances using crosslinked protein crystals
Proteins such as enzymes and antibodies are immobilized by crosslinking crystals of the proteins such as microcrystals having a cross-section of 10 -1 mm or less with a multifunctional...
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5998132 |
Method and apparatus for detecting cancer, influenza, or HIV based on α-N-acetyl-galactosaminidase detection
HIV- and influenza virus-infected cells secrete α-N-acetylgalactosaminidase into the blood stream. Secretion of α-N-acetylgalactosaminidase is also associated with cancer. Elevated levels of...
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5994092 |
Use of β-D-galactopyranosyl-D-xyloses for the preparation of compositions and solutions intended to the evaluation of intestinal lactase, and production process
There is disclosed the use of O-β-D-galactopyranosyl-D-xyloses, particularly 2-O-β-D-galactopyranosyl-D-xylose and 3-O-β-D-galactopyranosyl-D-xylose, for the preparation of compositions and...
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