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6632930 |
Method of increasing recovery of heterologous active enzymes produced in plants
A method of increasing recovery of active enzyme produced in a plant is provided where the enzyme requires a transitional metal cofactor for activation. The metal cofactor is supplied to the enzyme...
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6632600 |
Altered thermostability of enzymes
Provided is a method of screening gene libraries derived from a mixed population of organisms for a bioactivity or biomolecule of interest. The mixed population of organisms can be a cultured...
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6613528 |
Cellulose films for screening
The invention relates to a ellulose film comprising microfibrillated cellulose and to the use of it for screening of a biological compound and nucleic acids encoding a biological compound.
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6613551 |
Enzymatic esterification process
Aliphatic, saturated or unsaturated, straight or branched chain C2-C24 monocarboxylic acids and polyhydric alcohols, particularly glycerol are selectively reached to monoesters in the presence of...
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6610504 |
Methods of determining SAM-dependent methyltransferase activity using a mutant SAH hydrolase
The present invention relates to compositions and methods for assaying the activity of methyltransferases, such as S-adenosylmethionine (SAM)-dependent methyltransferases. The methods can be used...
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6593099 |
Regulation of human S-acyl fatty acid synthase thioesterase-like enzyme
Reagents which regulate human S-acyl fatty acid synthase thioesterase-like enzyme and reagents which bind to human S-acyl fatty acid synthase thioesterase-like enzyme gene products can play a role...
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6589759 |
Compositions and methods for producing platelets and/or proplatelets from megakaryocytes
The present invention describes novel compositions and methods to enhance the in vitro and in vivo production of platelets and/or proplatelets from megakaryocytes. The present invention describes...
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6589751 |
Immonological detection of the homocystamide adduct and a thiolactone immunoassay for endogeneous homocysteine
An antibody specific for homocystamide adducts is disclosed. In a preferred embodiment of the present invention, the antibody is used to evaluate the level of homocysteine in a biological sample.
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6586195 |
Method of detecting sugars
A method for detecting reducing sugars in samples using a test reagent containing an indicator capable of producing calorimetric changes when contacted with reducing sugars. Under alkaline...
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6585954 |
Method for searching steroid sulfatase inhibitors
The present invention provides a method of efficiently screening for steroid sulfatase activity-inhibiting compounds which are useful for the treatment of hormone-dependent diseases such as breast...
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6573060 |
Methods and compositions for targeting DNA metabolic processes using aminoglycoside derivatives
Protein targets for disease intervention through inhibition of nucleic acid metabolism are disclosed. Novel polypeptides for one such target, DNA-dependent ATPase A, and novel polynucleotides...
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6569619 |
High-throughput in vitro screening assays for modulators of nucleic acid helicases
The present invention provides solid phase assays for measuring helicase activity in the presence or absence of a potential helicase activity modulator. High throughput methods, compositions, kits...
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6566088 |
Prolyl-4-hydroxylases
The invention provides methods and compositions for assaying hypoxia-inducible factor (HIF) prolyl hydroxylation. Subject assays may be cell-based or in vitro, and comprise incubating a mixture...
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6551790 |
Process for glucuronidation screening
A fluorescence polarization process used to identify activity of conjugative enzymes involved in xenobiotic transformations, such as glucuronosyltransferases is provided.
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6548250 |
Methods for detection of a target nucleic acid sequence
The invention relates to a method of generating a signal indicative of the presence of a target nucleic acid sequence in a sample, where the method includes forming a cleavage structure by...
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6544746 |
Rapid and sensitive proximity-based assay for the detection and quantification of DNA binding proteins
Methods to determine the activity of any and all DNA binding factors, proteins or fragments thereof based upon the detection of a change in a luminescence or fluorescence signal are provided....
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6541216 |
Amperometric biosensor test strip
A reagent and method for determining the levels of 3-hydroxybutyric acid in a sample are provided. The reagent comprises a ferricyanide salt, a catalytic amount of a first enzyme operative to...
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6534278 |
Screening for antibiotics
Assays for the detection of β-lactamase induction can be used to identify compounds that kill bacteria (i.e., bacteriocidal activity) or inhibit bacterial growth (i.e., bacteriostatic activity)....
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6518035 |
Targeted methods of drug screening using co-culture methods
The present invention provides methods of screening for a molecule that inhibits the expression or activity of a protein encoded by a target gene which affects the fitness of a cell. The methods...
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6511816 |
DNA gyrase-inhibiting proteins
The present invention discloses a protein that possesses an ability to inhibit bacterial DNA gyrase activity (DNA Gyrase-inhibiting protein; DGI); a host cell transformed by a replicable expression...
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6506573 |
Additive formulation and method of use thereof
An additive formulation comprising heparinase and trehalose, a method for using the formulation and a device containing the formulation. The additive formulation is useful in substantially...
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6500648 |
Methods for recombinant peptide production
The present invention provides improved methods for the production of recombinant peptides from bacterial cells.
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6485926 |
Method for measuring protease activity
A method for measuring protease activity, which comprises the steps of: (1) bringing a biosample containing a protease into contact with a crosslinked and/or substantially water-insoluble thin...
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6485924 |
Method for identifying inhibitors of cytokinesis
Method for identifying compounds that inhibit cytokinesis, wherein the compounds are tested for their ability to modulate the formation and/or the stability of septin filaments. The compounds are...
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6472205 |
Cytosolic forms for β-lactamase and uses thereof
The present invention is directed to nucleic acid molecules that encode a cytosolic form of beta-lactamase, cells that include such nucleic acid molecules and methods for their use. These cells can...
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6465203 |
Glucan-containing compositions and paper
The present invention provides methods of making paper, utilizing glucans, produced by the glucosyltransferase B, C or D enzyme of the species Streptococcus mutans, instead of modified starches....
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6455268 |
Hydrolytic enzyme substrates and assay method
Compounds of the invention have the structure D—L—A*, where L is a linking moiety that maintains D and A in a configuration compatible with FRET, D is a fluorescent donor moiety capable of...
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6448025 |
Motor proteins and methods for their use
The present invention provides high throughput screening systems for identifying compounds useful in the treatment of cellular proliferation disorders. The method can be performed in plurality...
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6448027 |
Method for specific measurement of acid phosphatase derived from osteoclasts
A method for measuring activity of osteoclast-derived acid phosphatase located at Band 5 b of Band 5 in polyacrylamide gel electrophoresis of a sample which is characterized by using an...
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6444434 |
FVIIa/TF activity inhibiting compounds
The invention relates to compounds inhibiting the activation of FX to FXa by TF/FVIIa. The compounds are anticoagulants. The invention also relates to a method of identifying a drug candidate.
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6436658 |
Method for the determination of homocysteine
The invention relates to a method for determining homocysteine concentration in samples in which homocysteine is condensed using an enzyme cystathionine β sythase to form cystathionine. Pyruvate...
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6436687 |
cDNA sequence of mouse brain sialidase gene
The present invention concerns mouse brain sialidase gene activity. The invention further relates to nucleic acids encoding sialidase protein, vectors containing and capable of expressing such...
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6436649 |
Method for detecting and/or quantifying a hapten in a homogeneous phase and device for implementation thereof
The invention discloses a method for detecting and/or quantifying a hapten in a homogeneous phase, comprising the following steps: adding a known quantity of a hapten inhibitor complex to the...
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6428983 |
Histone deacetylase as target for antiprotozoal agents
Histone deacetylase inhibition provides a target for identifying potential antiprotozoal compounds. Histone deacetylase inhibitors are useful as therapeutic agents against protozoal infections.
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6426200 |
Methods for enzymatic deinking of waste paper
A method and composition for deinking noncontact-printed wastepaper, particularly xerographic and laser-printed paper, and mixtures of contact and noncontact-printed wastepaper, using an enzyme...
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6416965 |
Screening methods for presqualene disphosphate analogs
The present invention is directed to presqualene diphosphate (PSDP) analogs having an active region of natural PSDP and a metabolic transformation region resistant to rapid intracellular...
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6410696 |
Cyclosporin immunoassay
A method of measuring the amount of cyclosporin in a sample suspected of containing cyclosporin is disclosed. A method of inactivating interfering cross-reactive material in an assay for measuring...
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6406876 |
Immobilized enzymes biosensors for chemical toxins
Methods, compositions and materials useful in the detection of organophosphorous and organosulfur compounds are disclosed. In particular, biosensors wherein a porous or a non-porous support having...
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6403309 |
Methods for detection of nucleic acid polymorphisms using peptide-labeled oligonucleotides and antibody arrays
The present invention is directed to methods and compositions for use in screening nucleic acid populations for nucleic acid polymorphisms. The methods, referred to generally as ValiGene SM ...
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6403299 |
DEAH-box proteins
The present invention relates to the identification and molecular-biological and biochemical characterization of novel DEAH-box proteins which show structural similarity with other known helicases....
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6395468 |
Human phosphatidylinositol synthase
The present invention provides a human phosphatidylinositol synthase (PISH) and polynucleotides which identify and encode PISH. The invention also provides genetically engineered expression vectors...
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6395256 |
Adenosine detection in small samples
The invention relates to a method for detecting adenosine with the inactive S-adenosyl homocysteine hydrolase's enzyme which selectively and only binds adenosine with high affinity. The inventive...
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6395504 |
Use of phage associated lytic enzymes for the rapid detection of bacterial contaminants
A method for the use of a phage associated lysing enzyme for the detecting the presence and determining the quantity of bacteria present in or on a wide variety of substances is described. The...
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6391549 |
Monitoring gene expression
A method and system for detecting a parameter of a host cell, a cell culture or medium is provided. A host cell is transfected with an expressible DNA sequence which is under expression control of...
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6387361 |
Use for drug acarbose precose for weight control prevention of weight gain for weight loss for treatment and prevention of obesity
Control of weight gain has long been a problem for many people who if they lose weight by dieting often gain it back in a short period of time. Therefore, there has been much research to find a...
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6387648 |
Method for adjusting and disinfecting liquids
A Method for regulating the disinfection of a liquid includes a number of stages. At one stage of the said disinfection (stage 2), the activity of at least one enzyme is measured by bringing the...
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6387618 |
Micronucleus assay with genomic DNA hybridization probe and enzymatic color pigment detection
A method for detecting the presence of micronuclei in cells of an organism comprises the steps of (a) isolating cells of the organism, (b) exposing the cells to a hybridization probe, the...
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6387643 |
Human platelet heparanase polypeptides, polynucleotide molecules that encode them, and methods for the identification of compounds that alter heparanase activity
The present invention provides isolated human heparanase polypeptides, and the isolated polynucleotide molecules that encode them, as well as vectors and host cells comprising such polynucleotide...
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6379911 |
Enzyme detection/assay method and substrates
The invention relates to a method of detecting and/or assaying nucleoside hydrolases or nucleoside phosphorylases using a chromogenic substrate. Preferred chromogenic substrates have formula (I)...
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6379915 |
Diagnostic compositions and devices utilizing same
A dry chemistry dye indicator composition provides improved shelf life, stable color indication end point and capability for a system at near normal pH. The novel dry chemistry dye indication...
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