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6825001 |
DNA molecules and protein displaying improved triazine compound degrading ability
This invention relates to the identification of homologs of atrazine chlorohydrolase and the use of these homologs to degrade s-triazine-containing compounds. In particular, this invention includes...
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6824988 |
Method and compositions for use in diagnosing and characterizing chronic immune disease
Methods are provided for diagnosing and/or characterizing chronic immune disease activity in a subject. In the subject methods, a sample is obtained from a subject suspected of having or known to...
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6811990 |
Methods and compositions for coupled luminescent assays
The present invention provides a set of methods and compositions for homogeneous coupled luminescent assays of cytotoxicity and/or proliferation of cells, as well as for enzymatic activity. In both...
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6811994 |
Method for quantitating triglycerides in lipoproteins
The present invention relates to a method for conveniently quantitating TGs contained in various lipoproteins. A method for quantitating trigyceride (TG) in a particular lipoprotein which comprises...
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6800433 |
Process for purification of proanthocyanidin oligomer
The present invention relates to a process for purifying dimeric to pentameric proanthocyanidin oligomers which comprises extracting the proanthocyanidin oligomers from raw materials containing the...
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6794158 |
Fluorescence polarization assay
This invention is directed to a fluorescence polarization assay useful in the detection and evaluation of soluble epoxide hydrolase (sEH) inhibitors. This invention also relates to novel...
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6794125 |
Method for assessing fowl sperm quality
A method of assessing sperm viability by measuring the ability of the sperm to reduce a tetrazolium dye and allowing color development over a range of weakly acidic pHs.
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6790605 |
Methods for obtaining a desired bioactivity or biomolecule using DNA libraries from an environmental source
Disclosed is a process for obtaining an enzyme having a specified enzyme activity derived from a heterogeneous DNA population by screening, for the specified enzyme activity, a library of clones...
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6790627 |
Methods and compositions for the modulation of acid-sphingomyelinase-related apoptosis
The present invention relates, first, to methods for the modulation of acid sphingomyelinase (ASM)-related processes, including apoptosis. Such apoptosis can include, but is not limited to,...
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6787327 |
Methods for determining tyrosine-DNA phosphodiesterase activity
The present invention provides human tyrosine-DNA phosphodiesterases (TDPs). In particular, the present invention provides novel recombinant nucleic acids and proteins, including mutant TDPs,...
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6789022 |
Method for assaying clustered DNA damages
Disclosed is a method for detecting and quantifying clustered damages in DNA. In this method, a first aliquot of the DNA to be tested for clustered damages with one or more lesion-specific cleaving...
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6783949 |
Processes for determining whether a test substance contains lipases or lipase inhibitors
Processes for determining whether a test substance contains lipases or lipase inhibitors are provided. Processes for determining the activity of lipases or lipase inhibitors are also provided....
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6783731 |
Dry analytical element for acetaminophen assay
A spectrophotometric assay for the detection of acetaminophen in aqueous fluids is carried out with a dry analytical element. The element comprises a support having thereon one or more reagent...
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6770453 |
Methods of detecting chitinous material in a non-chitinous biological material
Methods for the detection of chitinous contaminants of non-chitinous biological materials are described. The methods are accurate, highly reproducible, rapid and relatively inexpensive. The methods...
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6770451 |
Screening for enzyme inhibitors
Systems, including methods and reagents, for identifying enzyme inhibitors. The systems employ a conjugate of a known inhibitor of a target enzyme and an enzyme donor, an enzyme acceptor that binds...
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6767728 |
Composition for enzymatic deinking of waste paper
A method and composition for deinking noncontact-printed wastepaper, particularly xerographic and laser-printed paper, and mixtures of contact and noncontact-printed wastepaper, using an enzyme...
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6764829 |
Nucleoside hydrolase and nucleoside phosphorylase detection kits, dipsticks and substrates
The invention relates to a method of detecting and/or assaying nucleoside hydrolases or nucleoside phosphorylases using a chromogenic substrate. Preferred chromogenic substrates have formula (I)...
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6756209 |
7-Alkoxycoumarins as CYP2C9 substrates and activity assay
Coumarin derivatives as substrates for cytochrome P450 enzyme.
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6750030 |
Method of detecting cardiac ischemia using fatty acid binding protein
A method of detecting cardiac ischemia by detecting elevated levels of serum free fatty acids in serum unbound to serum albumin (FFA U ) compared to an average FFA U level in individuals without...
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6750033 |
Positive response biosensors and other sensors
A sensor for detecting an analyte in an environment includes a first reaction system including a first enzyme and a substrate for the first enzyme. The analyte inhibits the reaction of the...
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6740496 |
Determination of biologically active forms of proteolytic enzymes
A process is provided for the assessment of an active proteolytic enzyme in a blood or another biological fluid sample possibly comprising a complex of said proteolytic enzyme and α 2...
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6737247 |
Imaging of enzymatic activity
The invention features methods of detecting enzymatic activity (e.g., in a magnetic resonance image). In general, the methods include: (1) providing a monomeric substrate (e.g., a substrate that is...
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6737246 |
Method for detecting protein inhibitors and ligands of medical value
The invention relates to a method for detecting inhibitors or ligands of binding domains, which comprises using a protein which contains at least one catalytic domain and at least one binding...
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6730493 |
Method for determining the state of substances containing keratin and suitable devices and means therefor
The method for recognizing damage and determining the extent of the damage to a keratin-containing material, such as hair or wool, includes subjecting a sample of it in aqueous solution to an...
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6720174 |
Phytases
This invention relates to improved phytases, preferably phytases of an increased thermostability, and a process of producing them. In particular, stabilizing amino acid mutations are introduced...
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6720014 |
Phytase-containing foodstuffs and methods of making and using them
A purified recombinant phytase enzyme derived from Escherichia coli B. The enzyme has a molecular light of about 47.1 kilodaltons and has phytase activity. The enzyme can be produced from native...
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6716827 |
Complexes for immobilizing isothiocyanate natural precursors in cyclodextrins, preparation and use
The invention concerns inclusion complexes of precursors from a natural source of organic isothiocyanates, in particular having bacteriostatic, bactericidal and/or fungicidal properties, in...
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6713273 |
High expression and production of high specific activity recombinant S-adenosyl homocysteinase (SAHH) and improved assays for S-adenosylmethionine (SAM)
The invention provides novel methods relating to SAM detection and production as well as a novel SAHH enzymatic activity for use in such methods. Additional methods, compositions, and kits relating...
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6713294 |
DNA glycosylases and their use
Novel cytosine-, thymine- and uracil-DNA glycosylases, subcellular localization peptides, nucleic acid molecules containing the same, methods of identifying such enzymes and their use in various...
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6706539 |
Enzyme substrate delivery and product registration in one step enzyme immunoassays
One-step enzyme immunoassays in which enzyme-antibody conjugate or label and enzyme substrate are separated until separation of bound and free enzyme conjugate or label is complete. This separation...
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6699704 |
Heat tolerant phytases
The present invention relates to heat tolerant phytases and DNA sequences which code therefor. The phytases are useful in hydrolyzing phytate to inositol and inorganic phosphates. The phytases are...
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6699685 |
Method, test media and chromogenic compounds for identifying and differentiating general coliforms and escherichia coli bacteria
A chromogenic β-galactosidase substrate producing an insoluble precipitate of a first color when reacted upon by β-galactosidase and a chromogenic β-glucuronidase substrate producing an...
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6699681 |
Endothelin converting enzymes and the amyloid β peptide
The invention describes catabolism of Aβ by endothelin converting enzymes (ECEs). Methods of identifying compounds that upregulate ECEs are provided by the invention. Further provided by the...
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6699682 |
Assay for inhibitors of fatty-acid amide hydrolase
The soporific activity of cis-9,10-octadecenoamide and other soporific fatty acid primary amides is neutralized by hydrolysis in the presence of fatty-acid amide hydrolase (FAAH). Hydrolysis of...
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6696267 |
Methods and compositions for screening Icrac modulators
The present invention relates to compositions and methods directed at screening or characterizing compounds that modulate the activity of calcium channels in cells preferably, calcium-release...
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6686172 |
Method of measuring total homocysteine
The present invention provides a method and a kit for detecting or quantitatively determining homocysteine rapidly and simply and with high sensitivity by oxidizing the residual homocysteine...
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6682904 |
Specific inhibitors of hyaluronidase 2, and methods of identifying and using same
Methods for identifying a hyaluronidase 2 (HYAL2) specific inhibitor, which selectively inhibits HYAL2 activity, but does not substantially affect the activity of non-inflammatory hyaluronidases,...
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6680377 |
Nucleic acid-based detection
The invention relates to compositions, systems, and methods for simultaneously detecting the presence and quantity of one or more different compounds in a sample using aptamer beacons. Aptamer...
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6673565 |
Enzymatic polymeric sensors
A sensor for detecting an analyte enzyme includes at least one substrate compound and at least one indicator compound selected to produce a measurable change of state as a result of the interaction...
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6667161 |
Chromogenic substrates of sialidase of bacterial, viral, protozoa, and vertebrate origin and methods of making and using the same
The current invention relates to the design, synthesis, and biochemical evaluation of chromogenic substrate compounds for sialidases of bacterial, viral, protozoa, and vertebrate (including human)...
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6660494 |
Detection of microbial metabolites
Chromogenic 3-Indoxyl choline phosphate compounds of formula (I): wherein R is selected from the group consisting of hydrogen and C 1-4 alkyl, such as methyl, ethyl, propyl and butyl while R 1...
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6656699 |
Methods and compositions for glycosidase assays
The present invention is directed to compositions and methods for measuring enzymatic activity, particularly glycosidase activity. Methods of the present invention include assays for quantitatively...
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6653093 |
Accelerated stability test
Enzyme granulates contain besides the enzyme water-soluble and water-insoluble fillers, binders and if required other additives for granulates. In order to stabilize the enzyme, an alkaline or...
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6649395 |
Tyrosine-containing cyclophilin and related methods
The present invention relates to the use of these cyclophilins, hereinafter referred to as ‘tyrosine-containing’ cyclophilins, in a method for identifying compounds capable of binding to and/or...
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6645736 |
Calcium independent cytosolic phospholipase A2/B enzymes
The invention provides a novel calcium-independent cytosolic phospholipase A 2 /B enzyme, polynucleotides encoding such enzyme and methods for screening unknown compounds for anti-inflammatory...
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6645750 |
Polynucleotides encoding polypeptides having β-primeverosidase activity
A β-primeverosidase gene characterized by encoding a protein containing the amino acid sequence represented by SEQ ID NO:1 in the Sequence Listing or an amino acid sequence derived from this...
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6642016 |
Biosensor and its use to indicate the status of a product
A biosensor comprises a unit, comprising a substrate and an enzyme, which when brought into contact with the substrate is adapted to affect the substrate so that its conductivity changes as a...
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6635462 |
Mutated form of arginine deiminase
The present invention discloses arginine deiminase that is genetically modified for more efficient manufacturing and processing. The present invention discloses recombinant DNA molecules and...
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6632614 |
Method for detecting anti-Streptococcus pyogenes DNase B antibody in a test sample
The gene for Streptococcus pyogenes DNase B has been cloned and vectors incorporating the cloned DNA have been used to transform Escherichia coli , allowing efficient and rapid production of the...
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6632930 |
Method of increasing recovery of heterologous active enzymes produced in plants
A method of increasing recovery of active enzyme produced in a plant is provided where the enzyme requires a transitional metal cofactor for activation. The metal cofactor is supplied to the enzyme...
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