|
Match
|
Document |
Document Title |
|
|
5686269 |
Method of diagnosing Alzheimer's disease by detecting the level of cathepsin D in cerebrospinal fluid
Disclosed is a method of diagnosing Alzheimer's disease in a patient by measuring the level of cathepsin D in the patient's cerebrospinal fluid.
|
|
|
5681727 |
Process for preparing fatty acid esters of alkyl glycosides
Fatty acid esters of alkyl glycosides are enzymatically prepared by forming a micro-emulsion from a fatty acid, an alkyl glycoside and a nonionic or anionic surface active agent. The viscosity of...
|
|
|
5681710 |
Reagent for determining (1➝3)-β-D-glucan
The present invention provides a reagent for determining (1➝3)-β-D-glucan comprising a lysate substantially free from any endotoxin-sensitive factor, which is obtained by contacting limulus...
|
|
|
5679538 |
Method for using lead-sensitive enzymes to determine levels of lead in blood and other types of samples
A method is described for determining the level of lead in blood and other types of samples. The level of lead is determined by using a lead-sensitive enzyme. As a first step, a native...
|
|
|
5672482 |
Method for purifying cyclic inulooligosaccharide
An exo-enzyme having an ability to cut β-(2➝1) fructoside bond or a microorganism which produces the enzyme is allowed to act on a saccharide solution containing cyclic inulooligosaccharide in...
|
|
|
5667979 |
Use of specific properties of allergens, allergens from animal or botanical sources and methods for their isolation
It was found that atopic allergens have enzymatic properties, in particular the properties to hydrolyze amide and/or ester linkages. These properties may be used for various purposes, e.g. for...
|
|
|
5667984 |
Sequencing of oligosaccharides
A process suitable for use in the sequencing of an oligosaccharide compound includes a first analysis of a primary oligosaccharide compound's monosaccharide composition, selection of sequencing...
|
|
|
5663055 |
Methods for diagnosing human influenza and 4-position modified chromogenic N-acetylneuraminic acid substrated for use therein
Chromogenic derivatives of N-acetylneuraminic acid modified in the 4-position to contain a hydrogen atom, a fluorine atom, a methoxy group, or an ethoxy group are used as substrates in colorimetric...
|
|
|
5663044 |
Methodology for colorimetrically determining the concentration of white blood cells in a biological fluid
A composition, method and test device for determining the presence of leukocytes, esterase or protease in a test sample are disclosed. The composition comprises an ester which is hydrolyzed in the...
|
|
|
5654152 |
Method of measuring enzyme activity by using a column having an immobilized substrate
Enzyme activity is measured promptly with a high accuracy by introducing an enzyme, the activity of which is to be measured, into a column comprising a hollow tube packed with a filler comprising a...
|
|
|
5646002 |
Method for increasing the sensitivity of assays for target ligand
A method for treating serum samples to remove sialic acid from ligands to expose binding sites to enhance immunological binding, for use in assays and to generate novel anti-ligands is described....
|
|
|
5643734 |
Methods for protein binding enzyme complementation assays
This invention relates to improved methods and novel compositions for enzyme complementation assays for qualitative and quantitative determination of a suspected analyte in a sample. The use of...
|
|
|
5641753 |
10-AZA-9-deoxo-11-deoxy-erythromycin A and derivatives combined with sulfisoxazole
Pharmaceutical compositions of an erythromycin derivative combined with sulfisoxazole according to the structural formulas: ##STR1## where R is hydrogen, C1-C10 alkylcarbonyl or C1-C10 alkyl...
|
|
|
5641643 |
Horseshoe crab amebocyte lysate factor G activation inhibitor
This invention relates to a horseshoe crab amebocyte lysate factor G activation inhibitor comprising as an active ingredient a polyglycoside containing at least one poly-(1➝3)-β-D-glucoside...
|
|
|
5639630 |
Method and reagent composition for performing leukocyte differential counts on fresh and aged whole blood samples, based on intrinsic peroxidase activity of leukocytes
The present invention provides an improved reagent composition and method to perform white blood cell differential counting and subpopulation analysis using both fresh and aged blood samples with...
|
|
|
5637474 |
Process for measuring amount of endotoxin or (1➝3)-β-D-glucan by kinetic turbidimetric method
A process for measuring the amount of endotoxin or (1➝3)-β-D-glucan (referred to hereinafter as β-glucan) contained in a sample, which comprises mixing the sample with amebocyte lysate of...
|
|
|
5633129 |
Electrophoretic detection and separation of mutant DNA using replaceable polymer matrices
The disclosure relates to a method for resolving double-stranded DNA species differing by at least one base pair. Each of the species is characterized by an iso-melting domain with a unique melting...
|
|
|
5631219 |
Method of stimulating hematopoiesis with hemoglobin
The present invention relates to a method for stimulating hematopoiesis in a mammal comprising administration of a therapeutically effective amount of a hemoglobin, including recombinant...
|
|
|
5631127 |
Enzymatic assay for homocysteine and a kit therefor
The invention relates to a method for assaying homocysteine in a sample such as blood, plasma or urine, which comprises the steps of contacting the sample with a homocysteine converting enzyme and...
|
|
|
5622830 |
Method of identifying interleukin 1β converting enzyme inhibitors
A compound of the formula R 1 --A 2 --A 1 --Asp-p-nitroanilide I wherein: A 1 is a residue of any of the naturally occurring α-amino acids or a homolog, analog or derivative of...
|
|
|
5620846 |
Diagnostic and prognostic indices for cancer and aids
Cancerous cells and HIV-infected cells secrete α-N-acetylgalactosaminidase into the blood stream, resulting in deglycosylation of serum Gc protein. This inactivates the MAF precursor activity of...
|
|
|
5618685 |
Activation of herpes simplex virus protease by kosmotropes
Native Herpes Simplex Virus type 1 (HSV type 1) protease has a rather low activity. It has been found however, that the presence of a kosmotropic anion can increase the activity of the protease...
|
|
|
5614375 |
Method and test kit for the rapid detection of biotoxic contaminants
The invention provides a method for the rapid detection of biotoxic contaants in a test material comprising combining a sample of the test material with activated spores essentially devoid of...
|
|
|
5612178 |
Method of quantitative enzyme determination
Methods and kits are provided for the quantitative determination of the presence of an enzyme analyte in a sample by determination of the rate of analyte catalyzed reaction on a chromatographic...
|
|
|
5610026 |
Agent for the determination of peroxidase activity, a process for its preparation and its use
An agent for the detection of peroxidase or of pseudoperoxidase activity, and its preparation and its use are described. The agent contains a tetraalkylbenzidine, a peroxide and buffer substances....
|
|
|
5607837 |
Method for the determination of the plasminogen activator activity in samples containing alpha-2-antiplasmin
The disclosed invention provides a method for determining the plasminogen activator (PA) activity in a biological fluid. The method involves the use of proteolytically-degraded plasminogen and...
|
|
|
5607838 |
Method for determination of α-amylase activity
A method for determining α-amylase activity which involves bringing a sample into contact with an α-glucosidase in the presence of an α-amylase substrate and optically determining a liberated...
|
|
|
5605795 |
Assays using chemiluminescent, enzymatically cleavable substituted 1,2-dioxetanes and kits therefor
Dioxetane compounds reactable with an enzyme to release optically detectable eneregy are disclosed. These compounds have the formula: ##STR1## wherein T is a cycloalkyl group or a fused...
|
|
|
5605809 |
Compositions for the detection of proteases in biological samples and methods of use thereof
The present invention provides for novel reagents whose fluorescence increases in the presence of particular proteases. The reagents comprise a characteristically folded peptide backbone each end...
|
|
|
5599694 |
Process for producing an oligosaccharide compound by using glycosidases from a mollusc
Oligosaccharide compounds GlcNAcβ1-3Galβ-OMe, GlcNAcβ1- 6Galα-OMe, GalNAcβ1-3Galβ-OMe, GalNAcα1-3Galα-OMe, and Fucα1-6Galβ-OMe.
|
|
|
5597702 |
Automated lead assay
Detection of lead present in a sample, comprising the steps of: (a) adding a lead recovery agent to an assay solution containing lead from the sample; (b) adding to the assay solution a disulfide...
|
|
|
5591589 |
Process for separating and measuring glycoprotein
The degree of a structure change of the sugar chain of a glycoprotein caused by a disease can be measured with high precision rapidly by separating and measuring two or more forms of glycoproteins...
|
|
|
5589347 |
Multilayer analysis elements for the determination of total cholesterol
A multilayer analysis element for determination of total cholesterol is prepared having a light-transmissive water-impermeable support, at least one hydrophilic polymer layer on said support and a...
|
|
|
5589328 |
Chemiluminescence assays based on indoxyl substrates, thioindoxyl substrates and other substrates
Chemiluminescence-based assays that detect or quantify enzymes that catalyze the hydrolysis of indoxyl esters are provided. The assays are based on the hydrolysis of indoxyl esters by enzymes of...
|
|
|
RE35417 |
Oligosaccharide sequencing
A method of oligosaccharide sequencing in which the components are determined essentially simultaneously is disclosed which comprises a series of steps as follows: A. Placing an identifying label...
|
|
|
5585273 |
Test device for assays for hydrolytic enzyme activity
A dry, self-contained test device for assaying for the presence of an enzymatically active hydrolase in a sample is disclosed. The test device combines a reporter enzyme immobilized on a solid...
|
|
|
5585248 |
Method for assaying activity of prophenoloxidase activating enzyme and application thereof
A method for assaying an activity of a prophenoloxidase activating enzyme (PPAE), comprising assaying at least X-Arg or Y produced upon contact of the PPAE with a peptide chain of the formula ...
|
|
|
5583001 |
Method for detection or quantitation of an analyte using an analyte dependent enzyme activation system
The present invention concerns a method to catalyze reporter deposition to improve detection or quantitation of an analyte in a sample by amplifying the detector signal which comprises reacting an...
|
|
|
5580730 |
Enzyme digestion method for the detection of amplified DNA
Qualitative and quantitative methods for detecting the presence of double-stranded, non-5'-phosphorylated DNA in samples that may also contain 5'-phosphorylated DNA and/or single-stranded DNA are...
|
|
|
5580747 |
Non-radioactive enzyme assay
The present invention is directed to the assay and purification of proteins, and particularly to the non-radioactive assay and purification of protein kinases, phosphatases and protease by...
|
|
|
5580749 |
Internal reference for chemically modified spheres
A probe system for monitoring chemical activity of a target chemical in an environment has first and second marker compounds each bonded to a common substrate to keep the respective markers in...
|
|
|
5580746 |
Isolation of pseudomonas salicylate hydroxylase and its use for the identification and quantitation of salicylate in body fluids
Salicylate hydroxylase isolated from Pseudomonas bacteria can be used to determine the level of salicylate in a body fluid by reacting a sample of the fluid with the enzyme and monitoring the...
|
|
|
5571673 |
Methods for in-solution quenching of fluorescently labeled oligonucleotide probes
The present invention provides methods of detecting a change in the length of an oligonucleotide labeled with a light-emitting label by measuring the light emission in the presence of a DNA binding...
|
|
|
5571684 |
Assay for proline iminopeptidase and other hydrolytic activities
The presence of an enzymatically active hydrolase in a fluid sample is detected by contacting the sample with a solid-phase conjugate which is susceptible to cleavage by the hydrolase, and...
|
|
|
5571683 |
β-glucans detection reagents and methods of detecting β-glucans
A β-glucan detection reagent includes a horseshoe crab hemocyte lysate containing an endotoxin neutralizing peptide and a chromogenic substrate. The reagent provides a very sensitive method for...
|
|
|
5567597 |
Hydrolytic enzyme inhibitors/inactivators and methods for using same
The present invention provides compounds that function as hydrolytic enzyme inhibitors (inactivators) and substrates. These compounds are useful in assays to detect and measure levels of hydrolytic...
|
|
|
5565318 |
Room temperature stable reagent semi-spheres
A reagent semi-sphere is disclosed comprising at least one biological reagent and a glass forming filler material in a concentration sufficient to facilitate formation of a glassy, porous...
|
|
|
5565328 |
Measurement of color reactions by monitoring a change of fluorescence
The present invention relates to a method to determine the concentration of an unknown substance in a colorimetric reaction using a fluorometric reader. The change in color can be monitored by...
|
|
|
5561051 |
Screen for inhibitors of chitinase
The present invention is directed to a method for screening samples for the identification of agents exhibiting potential fungicidal and insecticidal activity for a wide variety of agricultural,...
|
|
|
5559003 |
Assay method for biological components
The method is directed to assaying for biological components in a sample comprising step (A) generating an oxidase substrate in the presence of an amphoteric surfactant and in the absence of...
|