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7618646 |
Matrix, cell implant and method for their production and use
The invention relates to porous matrices based on a biologically compatible polymer or polymer mixture, to a cell implantation that is established on said matrices and to additional cell...
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7615593 |
Bifunctional-modified hydrogels
Disclosed are hydrogels wherein a polymer matrix is modified to contain a bifunctional poly(alkylene glycol) molecule covalently bonded to the polymer matrix. The hydrogels can be cross-linked...
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7611878 |
Biocatalytic material comprising multilayer enzyme coated fiber
The present invention relates generally to high stability, high activity biocatalytic materials and processes for using the same. The materials comprise enzyme aggregate coatings having high...
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7611877 |
Granulates containing feed-enzymes
The present invention describes a process for the preparation of an enzyme-containing granulate wherein an aqueous enzyme-containing liquid is, optionally supplemented with a solid carrier and/or...
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7611855 |
Immunoassay method and kit to be used therein
Using two types of antibodies, i.e., a first antibody having a higher affinity for a target substance than for a competitive substance and a second antibody having a higher affinity for the...
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7611835 |
Process for preparing multilayer enzyme coating on a fiber
A process for preparing high stability, high activity biocatalytic materials is disclosed and processes for using the same. The process involves coating of a material or fiber with enzymes and...
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7611701 |
Preparation of phytase-containing granulates for use in animal feed
A process for the preparation of an enzyme-containing granulate is disclosed where an aqueous enzyme-containing liquid is mixed with an edible carbohydrate-based solid carrier, such as starch,...
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7604817 |
Method for promoting growth of tissue
A device and method for tissue engineering is disclosed. More particularly this invention relates to a bioabsorbable device and a method of its use which promotes controlled new tissue in-growth...
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7604746 |
Pervaporation composite membranes
The present application discloses a composite membrane comprising (a) a support member that has a plurality of pores extending through the support member and (b) a cross-linked copolymer comprising...
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7585929 |
Preparation and uses for polyarylates
The present invention is directed to polyarylates comprising repeating units having the structure:
as well as their preparation and use as cell growth substrates.
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7569399 |
Multiplex flow assays preferably with magnetic particles as solid phase
Heterogeneous assays for different analytes in a single biological sample are performed simultaneously in a multiplexed assay that combines flow cytometry with the use of magnetic particles as the...
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7556802 |
Polymer-coated, granulated enzyme-containing feed additives and method for the production thereof
A process is described for producing a polymer-coated, granulated, enzyme-containing feedstuff additive, the polymer-coated feedstuff additives obtainable in this manner and pelleted feedstuff...
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7547449 |
Method for treating a bone defect with an organic/inorganic composite
The subject invention concerns a composite comprising an organic fluid-swellable, fibrous matrix, such as collagen, and a mineral phase, such as calcium carbonate or phosphate mineral phase, for...
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7541167 |
Porous glass composite material
A porous glass composite material comprising at least one alkoxodisilane (precursor) having the general formula (or 1 ) 3 Si-spacer-Si(OR 2 ) 3 ,wherein R 1 and R 2 are the same or different and...
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7537780 |
Method for preparing and implanting a cartilage construct to treat cartilage lesions
Neo-cartilage constructs for growth and surface coating for the de novo formation of a superficial cartilage layer. A method for generation of the neo-cartilage and the neo-cartilage construct. A...
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7534609 |
Method of expanding undifferentiated hemopoietic stem cells
A method of expanding undifferentiated hemopoietic stem cells to increase the number of the hemopoietic stem cells is provided. The method comprising: (a) obtaining the undifferentiated hemopoietic...
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7521504 |
Irreversible immobilization of enzymes into polyurethane coatings
A method of irreversibly immobilizing an enzyme in a polyurethane and an enzyme-containing polyurethane having a degree of immobilization of the enzyme of approximately 100%. The synthesis of...
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7521214 |
Method of immobilizing malate dehydrogenase on a substrate
Immobilization of malate dehydrogenase on a substrate using a glycerol solution containing malate dehydrogenase is achieved through dropping a mixed solution obtained by adding at least one...
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7520912 |
Air purifying filter media and process for producing the same
It is intended to provide an air purification filter which has a high dry tensile strength, a high wet tensile strength in association with a high water resistance and a high water repellency and...
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7517675 |
Oxidation of carbohydrates by means of peroxidases and nitroxy radicals
A method of oxidising carbohydrates and/or carbohydrate derivatives having primary alcohol groups comprising contacting a reaction medium containing said carbohydrates and/or carbohydrate...
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7517674 |
Process of hydrolyzing oil or fat using a packed layer of immobilized enzyme
A process is disclosed for hydrolyzing an oil or fat by mixing and feeding an oil-phase substrate and a water-phase substrate to a packed layer with an immobilized enzyme packed therein. The oil or...
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7514249 |
Biomimetic organic/inorganic composites
The subject invention concerns a composite comprising an organic fluid-swellable, fibrous matrix, such as collagen, and a mineral phase, such as calcium carbonate or phosphate mineral phase, for...
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7514248 |
Process for making organic/inorganic composites
The subject invention concerns a composite comprising an organic fluid-swellable matrix, such as collagen, and mineral phase, such as calcium carbonate or phosphate mineral phase, for use as a...
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7482152 |
Methods and devices for microencapsulation of cells
Devices for the microencapsulation of cells include a first chamber for containing a cell-solution suspension. A plate covers one end of the first chamber. The plate has a plurality of apertures. A...
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7481975 |
Hydrogen peroxide indicator and method
The present invention provides a hydrogen peroxide indicator that includes a substrate on which is disposed an indicator composition that includes at least one of a select group of colorants. As a...
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7476523 |
Method of patterning a surface using a deformable stamp
A deformable stamp for patterning a surface. The stamp can be placed in contact with an entire 3-dimensional object, such as a rod, in a single step. The stamp can also be used to pattern the...
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7468192 |
Method for repair of cartilage lesions
A method for treatment of injured, damaged, diseased or aged articular cartilage using neo-cartilage constructs implanted into a joint cartilage lesion in situ. The implantation of the construct...
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7449180 |
Macroscopic scaffold containing amphiphilic peptides encapsulating cells
The invention features peptide scaffolds that are useful in the repair and replacement of various tissues. The invention also provides methods for making these scaffolds and methods for using them.
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RE40555 |
Preparation of agarose coated, solid agarose beads containing secretory cells
Biological agents such as secretory cells are encapsulated in a hydrophilic gel made of agarose or collagen-agarose and gelatin sponge-agarose combinations. In a preferred embodiment, semi-solid...
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7439062 |
Beads for capturing target cells from bodily fluid
Spheroidal beads present an exterior surface of a hydrophilic hydrogel, which is an isocyanate-functional polymer that is polymerized by urethane bonds and cross-linked by urethane and urea bonds....
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7435569 |
Method of forming a molded protein matrix for use in a sensor
A method for formulating and immobilizing a protein and a protein matrix formed by the method. The protein matrix preparation method results in a physically and chemically stable protein matrix...
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7429472 |
Method of immobilizing a protein or molecule via a mutant dehalogenase that is bound to an immobilized dehalogenase substrate and linked directly or indirectly to the protein or molecule
A mutant hydrolase optionally fused to a protein of interest is provided. The mutant hydrolase is capable of forming a bond with a substrate for the corresponding nonmutant (wild-type) hydrolase...
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7429377 |
Therapeutic composition containing a plurality of immobilized proteases
A pharmaceutical composition having thrombolytic, anti-inflammatory and cytoprotective properties is described. The composition contains active proteases attached to a gel or to a mixture of a gel...
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7422900 |
System and method for forming a connective tissue construct
A system and method are provided for forming a connective tissue construct, such as a tendon construct, in vitro. A substrate is provided with at least two anchors secured thereto in spaced...
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7422737 |
Porous freeze-dried hydrocolloid beads containing viable microorganisms for biological control
The present invention provides cellular solid carriers comprising viable microorganisms capable of controlling plant pathogens. The cellular solid carriers are formed from water-soluble...
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7419600 |
Method for purifying a branched water-soluble polymer
Multi-armed, monofunctional, and hydrolytically stable polymers are described having the structure
wherein Z is a moiety that can be activated for attachment to biologically active molecules...
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7417021 |
Biologically active conjugate of a biopolymer and therapeutic agent
A biologically active conjugate is disclosed comprising a biopolymer and a therapeutic agent joined by a disulfide bond. The conjugate, when formulated in a pharmaceutical composition with a...
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7410791 |
Device containing cytophilic islands that adhere cells separated by cytophobic regions
The invention provides a device for adhering cells in a specific and predetermined position, and associated methods. The device includes a plate defining a surface and a plurality of cytophilic...
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7402381 |
Method of immobilizing molecules onto a solid phase substrate and method of fabricating a biosensor using the method
Aspects of the invention can provide a method capable of easily realizing immobilization with the optimum density derived from a concentration control and without phase separation in coadsorption...
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7398161 |
Sampling method and sampling device, and logD measuring method and logD measuring system
A sampling method sampling a lower-layer liquid from a liquid body comprised of two layers of liquids, an upper-layer liquid (octanol) and the lower-layer liquid (buffer solution), without mixing...
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7390784 |
Administering bifunctional molecules containing a drug moiety and presenter protein ligand for therapy
Bifunctional molecules and methods for their use in the production of binary complexes in a host are provided. The bifunctional molecule is a conjugate of a drug moiety and a presenter protein...
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7371830 |
Method for separating biological material from a fluid using magnetic particles
Magnetic particles are prepared containing a magnetic core coated with a glass layer having a substantially pore-free glass surface or having pores with a diameter of less than 10 nm. The particles...
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7371400 |
Multilayer device for tissue engineering
The invention provides for translating two-dimensional microfabrication technology into the third dimension. Two-dimensional templates are fabricated using high-resolution molding processes. These...
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7364899 |
Device for monitoring haptotaxis
The present invention discloses a device for monitoring haptotaxis including a housing defining a chamber. The chamber comprises: a first well region including at least one first well, the first...
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7364884 |
Method for producing a hydroxylation catalyst and the use thereof
A process for preparing a hydroxylation catalyst by
i) embedding a cystochrome P450 monooxygenase in a sol-gel matrix, ii) embedding an enzymatic NADPH-regenerating system in a sol-gel...
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7361369 |
Implant with structure allowing injection of polymer for attaching implant to tissue
Methods and apparatus for bone implants that allow for the directed application of an osteogenic compound. The implant is preferably constructed of a biodegradable polymer formed into a structure...
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7354733 |
Method for sorting and separating living cells
We disclose methods of sorting or separating mixtures of living cells (e.g., eukaryotic, prokaryotic, mammalian, pathogenic, bacterial, viral, etc.). We perform our methods by activating...
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7354702 |
Processing tissue to produce a biopolymer scaffold for tissue engineering
A method of forming and preserving a bioremodelable, biopolymer scaffold material by subjecting animal tissue, particularly fetal or neo-natal tissue, to chemical and mechanical processing. The...
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7341738 |
Lipid-encapsulated polyanionic nucleic acid
Methods for the preparation of a lipid-nucleic acid composition are provided. According to the methods, a mixture of lipids containing a protonatable or deprotonatable lipid, for example an amino...
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7335383 |
Generation of nitric oxide in vivo from nitrite, nitrate or nitrosothiols endogenous in blood
A material includes a surface and a reactive agent that is located at the surface of the material, covalently attached to a backbone of the material, and/or located within the material. The...
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