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7320885 |
Method of perforating membrane and apparatus therefor
A method of perforating a membrane 10 is presented. The method comprises: bringing a membrane-denaturing substance into contact with or close proximity to at least a site of said membrane 10 ,...
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7132285 |
Apoptotic entities for use in treatment of neurodegenerative and other neurological disorders
Treatment and/or prophylaxis, in mammalian patients, of neurodegenerative and other neurological medical disorders is effected by administering to the patient effective amounts of apoptotic bodies...
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7129070 |
Targeted system for removing tumor cells from cell populations
A method is presented for killing a first population of cells within a mixture of viable cells by providing the mixture of viable cells, contacting the cells with a label, illuminating a portion of...
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6989086 |
Channel-less separation of bioparticles on a bioelectronic chip by dielectrophoresis
The present invention comprises devices and methods for performing channel-less separation of cell particles by dielectrophoresis, DC high voltage-pulsed electronic lysis of separated cells,...
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6977156 |
Flow cytometry reagent and system
An improved reagent system for preparation of cells for flow cytometry having a physiologically compatible salt solution composition including a lysing agent, an agent for minimizing white blood...
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6939696 |
Cell disruption method using sonication
The present invention relates to a method for disrupting cells by subjecting the cells to ultrasonic energy in the absence of beads. The present invention also relates to the enhancement of cell...
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6927049 |
Cell viability detection using electrical measurements
A method of determining information about cell viability and other characteristics relating to cell membrane permeability is disclosed. The method involves determining the effect of a cell on...
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6887693 |
Device and method for lysing cells, spores, or microorganisms
A device for lysing components (e.g., cells, spores, or microorganisms) of a fluid sample comprises a cartridge having a lysing chamber for receiving the sample and having at least one solid phase...
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6887362 |
Dielectrophoretic separation and immunoassay methods on active electronic matrix devices
This invention relates to devices and methods for performing active, multi-step molecular and biological sample preparation and diagnostic analyses employing immunochemical techniques. It relates...
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6812204 |
Delivery of an agent
The invention relates to a method for selectively releasing an agent loaded into a red blood cell, comprising electrosensitizing the red blood cell by application of an electric field and...
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6811981 |
Release of intracellular material
Intracellular material is released from bacterial, yeast, plant, animal, insect or human cells by the application of a low voltage such as 1 to 10 V to a suspension containing the cells. The...
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6787339 |
Microfluidic devices having embedded metal conductors and methods of fabricating said devices
The present invention provides low cost microfluidic devices having embedded metal conductors. The devices of the invention comprise a electronic component comprising a substrate having a first...
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6777214 |
Method for controlling organisms and material therefor, method for selective adsorption of proteins and material therefor, cement material and biomaterial
A method for controlling organisms which comprises growing, decreasing, activating or inactivating cells, bacteria, viruses or fungi at an N-surface or a P-surface of a ceramic which is formed by...
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6773903 |
Laser cell purification system
A process and apparatus for cell purification and ablation is disclosed. The present invention comprises a laser system which directs radiant energy at computer or manually selected individual...
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6743591 |
Method for counting leukocytes and leukocyte counter
A method for counting leukocytes which comprises liberating elastase from granulocytes contained in a specimen, adding an anti-granulocyte elastase antibody to the thus liberated elastase,...
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6706498 |
Method for isolating DNA
The invention describes a method for the isolation of components from samples, particularly large molecular weight DNA from biological samples. The method involves the application of controlled...
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6686195 |
Method and apparatus for ultrasonic lysis of biological cells
An apparatus including at least one sonotrode ( 2 ) designed to generate ultrasound of variable power in at least one biological sample ( 5 ) containing cells to be lysed, the sample ( 5 ) being...
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6623964 |
Method for treatment of an aqueous flux by electropulsation of a field parallel to the flow, pulsation chamber and uses thereof
The invention concerns a method for treating an aqueous flow colonized by cells with a pulsed electric field applied to a flow, characterized in that the applied field is substantially parallel to...
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6623945 |
System and method for microwave cell lysing of small samples
Efficient cell lysis in small samples, i.e., samples less than one milliliter, is achieved by exposing the sample to microwave radiation in the frequency range of 18 to 26 GHz. The sample...
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6605454 |
Microfluidic devices with monolithic microwave integrated circuits
A microwave device has a monolithic microwave integrated circuit (MMIC) disposed therein for applying microwave radiation to a microfluidic structure, such as a chamber, defined in the device. The...
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6558671 |
Cysteine-depleted peptides recognized by A3-restricted cytotoxic lymphocytes, and uses therefor
Cysteine-depleted CTL epitopes can elicit a stronger or more specific CTL response than the native, cysteine-containing CTL epitope of a disease associated antigen.
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6495351 |
Loading system and method for using the same
A loading system for providing a cell suitable for delivery of an agent to a vertebrate, the system comprise a loading module for loading a cell with an agent; and a sensitisation module in fluid...
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6482619 |
Cell/tissue analysis via controlled electroporation
An electrical current is created across an electrically conductive medium comprising a cell which may be part of a tissue of a living organism. A first electrical parameter which may be current,...
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6471860 |
Magnetic micro separation column and method of using it
A micro column system is provided for high gradient magnetic field separation of macromolecules and/or cells. The system provides fast kinetics and high efficiency as well as the purity and...
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6455287 |
Mechanical disruption of bacterial cells for plasmid recovery
The recovery yields of intact plasmids from bacterial cells mechanically disrupted by various methods were measured. Bacterial cell disruption through bead milling and microfluidization were found...
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6455286 |
Psoralens for pathogen inactivation
Psoralen compound compositions are synthesized which have primaryamino substitutions on the 3-, 4-, 5-, and 8-positions of the psoralen, which yet permit their binding to nucleic acid of pathogens....
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6395538 |
Method and system for providing real-time, in situ biomanufacturing process monitoring and control in response to IR spectroscopy
A method and system for providing real-time, biomanufacturing process monitoring and control in response to infra-red (IR) spectroscopic fingerprinting of a biomolecule. IR spectroscopy is used to...
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6387671 |
Electrical impedance tomography to control electroporation
Images created by electrical impedance tomography (EIT) are used to adjust one or more electrical parameters and obtain a desired degree of electroporation of cells in tissue. The parameters...
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6355485 |
Electrofusion chamber
A new and useful apparatus for producing cell electrofusion is provided. The apparatus comprises: a. a chamber with a substrate disposed therein, b. means for directing the cells to be fused...
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6344349 |
Process and system for electrical extraction of intracellular matter from biological matter
A process and system for electrical extraction of intracellular matter from biological matter, and intracellular matter products formed thereby, based on preparing a mixture of biological matter...
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6326177 |
Method and apparatus for intracellular electro-manipulation
A method for intracellular electro-manipulation is provided. The method includes applying at least one ultrashort electric field pulse to target cells. The ultrashort electric field pulse has...
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6303129 |
Production of borrelia burgdorferi vaccine, product produced thereby and method of use
A process for the preparation of a vaccine from substantially viable spirochetal bacteria of Borrelia, preferably Borrelia burgdorferi having immunogenic or therapeutic properties and capable of...
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6245342 |
Cosmetic preparation with a peptide addition
A cosmetic preparation contains peptide derivatives from α-MSH, as well as other active components. A cosmetic product has the property of activating the melanogenesis and being an...
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6235501 |
Method for isolation DNA
The invention describes a method for the isolation of components from samples, particularly large molecular weight DNA from biological samples. The method involves the application of controlled...
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6156549 |
Method of destroying cells via resonant destruction of intracellular structures
A method of destroying cells selected for destruction within a host body with little to no collateral damage to healthy surrounding tissue utilizes energy to effect resonant destruction of...
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6143535 |
Targeted system for removing tumor cells from cell populations
A method is presented to remove contaminating tumor cells from a cell population. The method includes labeling individual tumor cells in the population and then killing them with a high energy...
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6071480 |
Method for generating a standing sonic wave, methods of sonication with a standing sonic wave, and a standing sonic wave sonicator
The present invention provides a standing sonic wave sonicator, methods of generating a standing sonic wave and a method of sonication which employs a standing sonic wave to disrupt particulate...
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6060315 |
Method for facilitating the introduction of material into cells
The present invention is a method for creating a localized disruption within a boundary of a cell or structure by exposing a boundary of a cell or structure to a set of energetically charged...
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6022728 |
Method for producing a bacterial vaccine and novel vaccines produced thereby
A new method for the preparation of a whole cell bacterial vaccine for improved protection against bacterial pathogens, particularly against those pathogens which have multiple antigenic serotypes...
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6022720 |
Bax protein channel formation
The present invention relates, in general, to a protein that regulates programmed cell death and, in particular, to the pro-apoptotic protein, Bax, which forms channels in lipid membranes. The...
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5985593 |
Compositions and methods for enzymatic decontamination
The present invention is related to a method for the enzymatic decontamination of specimens as a means to control microbiological contamination. The compositions and methods of the invention are...
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5942425 |
Method to access nucleic acids from cells
The present invention relates to a sample processing method for rendering cellular components such as nucleic acids in a sample accessible. The method involves subjecting a sample of disrupted...
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5916775 |
Method for the purification of DNA
Disclosed is a method for collecting DNA by lysing microbial cells, adsorbing released DNA on a carrier and collecting the DNA adsorbed on the carrier, which method comprises the following steps of...
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5891694 |
Method for recovering nucleic acid and device for the same purpose
This invention provides a method for recovering nucleic acids and a device for the same purpose, which method and device are capable of continuously recovering nucleic acids by enabling the...
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5700639 |
Method for the detection of metabolically labelled DNA
The invention concerns a method for the non-radioactive detection of metabolically labelled DNA, in one aspect detecting labelled DNA indicative of cell lysis or apoptosis.
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5629185 |
Process for disintegrating cell dispersions or cell suspensions by means of ultrasonication for the purpose of isolating cell constituents
A process capable of being continuously carried out, for disintegrating cell material in the form of dispersions or suspensions in water for the purpose of obtaining cell constituent. Selected...
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5582829 |
Sonicated borrelia burgdorferi vaccine
A process for the preparation of a vaccine from substantially viable spirochetal bacteria of Borrelia, preferably Borrelia burgdorferi having immunogenic or therapeutic properties and capable of...
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5558996 |
Fungus extraction method, kit, and extraction solution
A method and kit for extracting fungus from a plant. An extraction solution is combined with tissue from a plant and the combination is agitated, preferably by shaking, to extract a detectable...
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5552145 |
Feed composition and a method for decreasing piglet mortality in piglets
Administering a feed composition, containing at least one member selected from the group consisting of sterilized bacterial cells; disrupted cell fragments obtained by mechanical disruption or...
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5422272 |
Improvements to apparatus and method for electroporation
A new quickly replaceable electrode assembly for electroporation that also provides the functions of a pipette, capable of sucking up samples; applying extremely high electric field strength to...
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