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8137985 |
Polyelectrolytic internal calibration system of a flow-through assay
A flow-through assay for detecting the quantity of an analyte residing in a test sample is provided. The flow-through assay contains a porous membrane that is in fluid communication with probe...
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8124368 |
Fluorogenic protein kinase substrates
The present invention relates to kinase sensors comprising a metal chelator and a fluorophore, where the chelator comprises a quinoline group and where the fluorophore is conjugated to the...
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7939340 |
Hydroxyl radical detection
The invention relates to compositions, kits and methods used in hydroxyl radical detection. In some embodiments, the invention relates to compositions comprising a dye preferably methylene blue...
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7935493 |
Protein fragment complementation assays for high-throughput and high-content screening
The present invention provides protein fragment complementation assays for drug discovery, in particular to identify compounds that activate or inhibit cellular pathways. Based on the selection of...
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7927829 |
Method for in vitro phosphorylation of trap of Staphylococcus aureus and a method for screening the inhibitor of the trap phosphorylation
The present invention relates to a method for in vitro phosphorylation of TRAP derived from Staphylococcus aureus. In the present invention, the TRAP is first identified as a kinase that...
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7824880 |
High sensitivity assay for detection of nucleoside diphosphate production
The present invention provides assays for detecting ADP, GDP and inorganic phosphate. These assays can be used directly to detect the presence of ADP, GDP and inorganic phosphate or can be used as...
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7816099 |
Enzyme assay and use thereof
An assay and kit for determining the activity of an enzyme such as kinase, ATPase and GTPase is disclosed. The assay and kit are useful in drug screening to select modulators of such an enzyme.
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7759085 |
14189, a novel human kinase and uses thereof
A novel human kinase protein and nucleic acid molecule is disclosed. In addition to the isolated kinase protein, the invention further provides isolated kinase fusion proteins, antigenic peptides,...
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7666617 |
Devices and methods for profiling enzyme substrates
The present invention relates to apparatus and methods for separating and detecting enzyme substrates using separation gels. For example, the apparatus and methods can be used to separate and...
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7651841 |
Polyelectrolytic internal calibration system of a flow-through assay
A flow-through assay for detecting the quantity of an analyte residing in a test sample is provided. The flow-through assay contains a porous membrane that is in fluid communication with probe...
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7635572 |
Methods for conducting assays for enzyme activity on protein microarrays
The present invention relates to methods of conducting assays for enzymatic activity on microarrays useful for the large-scale study of protein function, screening assays, and high-throughput...
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7585644 |
Mycopolasma detecting methods and materials
The invention relates to a method of detecting the presence of mycoplasma in a test sample comprising: (i) providing a test sample; and(ii) detecting and/or measuring the activity of acetate kinase...
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7485434 |
Method for screening compounds for those that modulate transducers of regulated CREB activity
In accordance with the present invention, it has been discovered that glucose and incretin hormones promote pancreatic islet cell survival via the calcium and cAMP dependent induction,...
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7482134 |
Signals and molecular species involved in senescence
The present invention relates to (a) a method for detecting a senescent cell, which comprises measuring a relative alteration to young cell in a signal or molecular species involved in signal...
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7470542 |
Proteins in type 2 diabetes
The present invention relates to the use of naturally occurring compounds and derivatives thereof as markers for predisposition of diabetes related diseases. The invention also relates to a...
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7449299 |
Quantum dot nanoparticle-based universal neurotoxin biosensor
The present invention is directed to a quantum dot nanoparticle-based universal neurotoxin biosensor having three components (a) a dendrimer-encapsulated quantum dot nanoparticle; (b)...
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7416856 |
High sensitivity assay for detection of nucleoside diphosphate production
The present invention provides assays for detecting ADP, GDP and inorganic phosphate. These assays can be used directly to detect the presence of ADP, GDP and inorganic phosphate or can be used as...
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7378254 |
Compositions and assays utilizing ADP or phosphate for detecting protein modulators
Described herein are methods which identify candidate agents as binding to a protein or as a modulator of the binding characteristics or biological activity of a protein. Generally, the methods...
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7376117 |
Interleaving circuit for a multiband OFDM transceiver
Interleaving circuit for a multiband OFDM (orthogonal frequency division multiplexing) transceiver of a ultra wide band wireless personal access network transmitting OFDM modulated symbols, wherein...
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7338775 |
Enzyme assay and use thereof
An assay and kit for determining the activity of an enzyme such as kinase, ATPase and GTPase is disclosed. The assay and kit are useful in drug screening to select modulators of such an enzyme.
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7317038 |
Nerve regeneration promoters containing semaphorin inhibitor as the active ingredient
To provide a semaphorin inhibitor; a peripheral or central nerve regeneration promoter which contains said semaphorin inhibitor as an active ingredient; and a preventive or remedy for a neuropathic...
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7238483 |
Method for detecting catalytic activity
This invention has as its object a method for detecting catalytic activity of a sample, characterized in that it comprises: the incubation of a substrate (S) with the sample that may have the...
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7223610 |
Direct phosphorylation state monitoring on biomolecules
Method for measuring the presence or absence of chemical groups, in particular phosphate groups, attached to biological molecules in a sample in which these molecules are tagged with fluorescent...
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7198955 |
Method and apparatus for measurement of blood substitutes
A method is disclosed whereby the concentration of a blood substitute, such as cross-linked hemoglobin, in a serum or plasma specimen is rapidly and accurately identified and quantified. The method...
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7195894 |
MKK7 activation inhibitor
PAK4 and JIK, both of which bind to MKK7 and directly phosphorylate MKK7, were found in the present invention. The present invention provides an inhibitor of c-Jun phosphorylation caused by JNK3...
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6995004 |
UDP-N-ACETYLGLUCOSAMINE: GALACTOSE-β 1,3-N-ACETYLGALACTOSAMINE-α-R / N-ACETYLGLUCOSAMINE-β 1,3,-N-ACETYLGALACTOSAMINE-α-R (GLCNAC TO GALNAC) β1,6-N-ACETYLGLUCOSAMINYLTRANSFERASE, C2/4GNT
A novel gene defining a novel human UDP-GlcNAc: Gal/Gl cNAcβ 1-3GalNAc αβ1, 6GlcNAc-transferase, termed C2/4GnT, with unique enzymatic properties is disclosed. The enzymatic activity of C2/4GnT is...
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6905836 |
Methods for identifying compounds that inhibit ubiquitin-mediated proteolysis of iκb
Compounds that inhibit ubiquitin-mediated proteolysis of phosphorylated IκB by interfering, directly or indirectly, with the ability of β-TrCP/E3RS to engage in protein-protein association i...
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6872553 |
Nucleotide sequences which code for the pck gene
The invention relates to isolated nucleotide sequences from Coryneform bacteria which code for the pck gene encoding the enzyme phosphoenol pyruvate carboxykinase (PEP carboxykinase). The invention...
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6756230 |
Quantitative analysis
Amounts of components in a specimen can be analyzed with excellent quantitativity. The analysis includes: measuring an amount of a component to be analyzed in a specimen; measuring an amount of a...
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6599712 |
Method and apparatus for measuring sample by luminescence
A method for measuring stains of a test sample by measuring adenosine phosphates. Luminescence of the adenosine phosphates is induced by a luminescent reagent (33) containing an ATP regenerating...
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6596760 |
Antidiabetic 4-hydroxy-2-furoic acids
Substituted 4-hydroxy-2-furoic acids are obtained by the fermentation of an asterriquinone, which is a natural product having a 2,5-dioxy-3,6-bis(indolyl)quinone structure. The compounds modulate...
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6566086 |
Diagnostic kit for detecting creatine levels
Methods for the detection of creatine compound levels in body fluid samples are discussed. Portable kits capable of determining creatine levels using non-invasive and visually detectable methods...
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6500628 |
Nucleic acid molecules encoding human kinase and phosphatase homologues and uses therefor
The invention provides isolated nucleic acids molecules, designated Kinase and Phosphatase nucleic acid molecules, which encode novel protein kinase and protein Phosphatase polypeptides. The...
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6413733 |
Stabilized reagent and method for determining creatine kinase
A stabilized reagent for the photometric enzymatic determination of creatine kinase (CK) in biological sample material by forming ATP from creatine phosphate and ADP and detecting the ATP formed,...
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6350601 |
Enzyme composition for use as a clinical diagnostic reagent
Disclosed is a stabilized enzyme composition for use in clinical examination, comprising: (a) an enzyme component comprising at least two enzymes selected from the group consisting of alkaline...
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6306617 |
Liquid reagent to detect creatine kinase
A liquid reagent for detecting creatine kinase activity. The liquid reagent includes G6PDH, hexokinase, creatine phosphate, glucose, ADP, NAD(P) and thioglycerol, which are split into two separate...
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6294350 |
Methods for treating fibroproliferative diseases
In accordance with the present invention, fibroproliferative disease or condition characterized by such symptoms as increased levels of c-Jun homodimers, increased heterodimerization of c-Jun with...
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6130054 |
Test strip for creatine kinase activity measurement
Test strips by which creatine kinase activity can be quantitatively measured at a high sensitivity within a broad measuring range and which have excellent storage stability. Particularly, test...
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6051389 |
Enzyme sensor
The present invention relates to an enzyme sensor for measuring the concentration or activity of an analyte in a test fluid. The sensor has at least one enzyme layer comprising an immobilized...
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6043045 |
Screening methods for the identification of novel antibiotics
The present invention relates to screening methods for the identification of compounds and compositions useful as novel antibiotics and antibacterial agents. In particular, the present invention...
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5998158 |
Glucose free, stable dry analytical element for quantitative analysis of creatine kinase MB isozyme
A dry analytical element for quantitatively analyzing creatine kinase MB isozyme is composed of a support and a creatine kinase MB isozyme-detecting agent layer. The detecting layer contains an...
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5985592 |
Uses for pentoxifylline or functional derivatives/metabolites thereof
In accordance with the present invention, it has been discovered that monocyte conditioned medium (MCM) obtained from patients with liver disease stimulates the proliferation of fibroblasts....
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5972635 |
Sulfonic acid group buffered dry analytical element for quantitative analysis of creatine kinase or its MB isozyme
A dry analytical element for quantitatively analyzing creatine kinase is composed of a support and a creatine kinase-detecting agent layer. The creatine kinase-detecting agent layer contains...
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5916757 |
Specific binding assay using enzyme inhibitor and anti-inhibitor antibodies
Specific binding ligands can be detected with an assay which utilizes an immobilized receptor for the ligand, an immobilized reporter enzyme, an inhibitor antibody and a a water-soluble conjugate...
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5916761 |
Method for assaying vital sample
A method for determining adenosine 5' diphosphate (ADP) contained in a liquid sample by means of an enzymatic reaction, comprising reacting the sample at 15 to 45° C. at least in the presence of ...
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5914241 |
Assays and kits for detecting analytes in the presence of cross-reacting substances
An immunoassay is provided which is selective for an analyte over immunologically related substances which may be present in a sample to be tested. The presence of the analyte is detected using a...
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5874229 |
Method for avoiding influence of hemoglobin
A method for avoiding influence of hemoglobin, in which the influence is caused by the changes with time in the absorption wavelength of hemoglobin when light absorption of a color reaction of a...
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5874230 |
Assays using TRAF2-associated protein kinase polypeptides
A TRAF2 (Tumor Necrosis Factor receptor Associated Factor-2) kinase and DNA encoding it are described. The invention provides assays employing the TRAF2 kinase which are useful to identify...
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5871951 |
Compositions and methods for treatment of infection caused by Haemophilus influenzae and Streptococcus pneumoniae
The invention relates to a method of identifying a compound capable of disrupting the addition of choline onto a bacterial cell surface component comprising incubating a sample of bacteria in a...
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5851786 |
Product and process to regulate actin polymerization
The present invention relates to methods useful for identifying compounds capable of specifically regulating actin polymerization, stress fiber formation or focal adhesion assembly by regulating...
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