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8084239 |
Preparation of a therapeutic composition
Product R, a novel therapeutic composition for treating viral infections and stimulating the immune system comprises a unique peptide having 31 amino acids and another unique peptide having 21...
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7888083 |
Process for the preparation of dihydroxy esters and derivatives thereof
A process is provided for the preparation of a compound of formula (1) wherein R and R′ represent optionally substituted hydrocarbyl groups and X represents a hydrocarbyl linking group. The p...
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7524661 |
Preparation of a therapeutic composition
Product R, a novel therapeutic composition for treating viral infections and stimulating the immune system, comprises a unique peptide having 31 amino acids and another unique peptide having 21...
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7452692 |
Method for extracting a macrolide from biomatter
Provided is a method for obtaining a macrolide, especially tacrolimus, ascomycin, pimecrolimus, sirolimus, or everolimus, from biomatter.
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7166452 |
Aminoketone asymmetric reductase and nucleic acid thereof
A protein, which is an aminoketone asymmetric reductase, having an effect of producing d-pseudoephedrine by acting on 1-2-methylaminopropiophenone, and having the following physiochemical...
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7144715 |
Production of α-keto butyrate
A process of obtaining α-keto butyrate by bioconversion is disclosed. The molecule is accumulated in the medium and is apt to subsequent processing to food ingredients, such as top-note flavors. A ...
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7115412 |
Process for the preparation of optically active 7-substituted-3-(2-aminopropyl)indole derivatives and intermediates therefor
Disclosed are a process for preparation of an optically active 7-substituted 3-(2-aminopropyl)indole compound and an intermediate therefor. In the above preparation process, 7-substituted indole is...
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6972191 |
Method for production of geranylgeraniol and analogous compounds thereof by microorganisms
The present invention provides a method for producing geranylgeraniol and analogous compounds thereof, which comprises culturing yeast cells (ascomycetes and deuteromycetes), bacterial cells,...
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6936731 |
Pravastatin sodium substantially free of pravastatin lactone and epi-pravastatin, and compositions containing same
The present invention provides pravastatin sodium substantially free of pravastatin lactone and epiprava, the C-6 epimer of pravastatin. The present invention further provides a novel process for...
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6867023 |
Production method of polyhydroxyalkanoate from substituted fatty acid ester as raw material
Polyhydroxyalkanoates comprising a monomer unit having the following chemical formula (2): (where the reference characters R represents an arbitrarily selected substituent and x represents an...
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6835559 |
Process for the production of optically active β-amino alcohols
A process for producing an optical active β-amino alcohol, the method comprising the step of allowing at least one microorganism selected from the group consisting of microorganisms belonging to ...
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6699695 |
Rhodococcus microorganisms and process for producing amide compounds
A nitrile compound having a complicated structure (e.g., 2-hydroxy-4-methylthiobutyronitrile) is converted into an amide compound with high production efficiency, by using a novel microorganism of...
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6586393 |
Antibiotics GE 23077, pharmaceutically acceptable salts and compositions, and use thereof
The invention relates to an antibiotic substance of microbial origin, arbitrarily denominated GE23077 complex and the individual factors which constitute it, a mixture of said factors in any...
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6444448 |
Production of β-glucan-mannan preparations by autolysis of cells under certain pH, temperature and time conditions
There is provided a method of production of an immunostimulatory β-glucan-mannan preparation, comprising the step of autolysis of cells of a microorganism at a pH of 5 to 6 and a temperature of 35 ...
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6365383 |
Method of producing erythritol by repeated fed-batch fermentation
The invention relates to a method of producing erythritol by fed-batch and repeated fermentation of sugars by microorganisms which produce erythritol, characterised by the fact that the...
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6306629 |
Microorganism streptomyces exfoliatus yj-118 and a method for producing pravastatin sodium by using the strain
The present invention is related to a new microorganism Streptomyces exfoliatus YJ-118 and a method for producing pravastatin sodium by using this microorganism which shows a strong tolerance to...
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6300327 |
Compositions and methods for potentiation of neurotrophin activity
Compositions and methods for use in modulating neurotrophin activity, wherein the active agent is at least one compound which potentiates neurotrophin activity. A preferred class of active agents...
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6277602 |
Method of producing 1-menthyl- α-D-glucopyranoside
A method of producing 1-menthyl-α-D-glucopyranoside is provided, wherein microorganisms capable of producing 1-menthol glycoside from 1-menthol are added to sugars and 1-menthol. Bacteria selected ...
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6183972 |
Method for the determination of analyte concentration in a lateral flow sandwich immunoassay exhibiting high-dose hook effect
Disclosed is a method for determining the concentration of an analyte in a fluid test medium by use of an immunochromatographic test strip through which the test fluid can flow by capillarity. The...
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5962286 |
Process for the production of gluconic acid with a strain of Aureobasidium pullulans (de bary) Arnaud
Strains of Aureobasidium pullulans (de bary) Arnaud can be used for the commercial production of gluconic acid by fermentation in aqueous liquid containing sugar, which in continuous culture from...
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5925550 |
Method for selectively increasing the ratio of single major components of antibiotic A/16686 complex
The present invention relates to a method for selectively enhancing the production of factors A2 and/or A3 of antibiotic A/16686 either to isolate these single components or to enrich the complex...
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5843437 |
A82846 antibiotics
New glycopeptide antibiotic A82846, comprising A82846A, A82846B and A82846C, is produced by Nocardia orientalis strains NRRL 18098, NRRL 18099 and NRRL 18100. The A82846 antibiotics have activity...
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5843679 |
Method for selectively enhancing the production of factors A or B0 of antibiotic A 40926 complex
The present invention is directed to a method for selectively enhancing the production of factors A, and/or B0 of antibiotic A 40926 either to isolate these single components in better yields or to...
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5830693 |
Gene encoding a regulatory factor involved in activating expression of the nitrilase gene promoter
The invention relates to a regulatory factor substantially containing an amino acid sequence represented by SEQ ID NO:1 and having the action of activating a nitrilase gene promoter, a regulatory...
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5707833 |
Process of making cyclodextrin glucanotransferase with brevibacterium
This invention relates to a γ-cyclodextrin glucanotransferase having novel properties, to a process for the production of the γ-cyclodextrin glucanotransferase which comprises culturing a strain b...
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5627057 |
Inhibitor compounds of farnesyl-protein transferase and chemotherapeutic compositions containing the same, produced by strain ATCC 55532
The present invention is directed to compounds which inhibit farnesyl-protein transferase (FPTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to...
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5573946 |
Biologically pure culture of Streptomyces hygroscopicus ATCC 53718 capable of producing antibiotic compounds
The present invention relates to certain antibiotic compounds, designated N787-182 compounds herein and derivatives thereof, which are antiparasitic agents, active against insect pests, acari,...
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5494812 |
Suidatrestin and production thereof
A novel trehalase inhibitor having the following physicochemical properties: (1) Activity: a specific inhibitory activity to trehalase; (2) Form: white powder, water-soluble; (3) Somogy-Nelson...
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5378463 |
Antitumor antibiotic
A certain fermentation product of Actinomadura strain Q473-8 yield, when suitably treated, a novel compound having both antibiotic and antitumor activities.
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5372816 |
Trehalostatin and process for the preparation thereof
This invention relates to the substance Trehalostatin which is a white powder soluble in water but hardly or only slightly soluble in hexane, benzene, ethers and petroleum ether, shows no...
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5332574 |
Compounds produced by a strain of Streptomyces exfoliatus
Disclosed are active compounds BU-4726G-A and BU-4726G-B which contain a quinone chromophore and hydroquinone chromophore, respectively. The compounds are produced by fermentation of Streptomyces...
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5290772 |
Immunosuppressant agent
Described is a process for producing an immunosuppressant, "demethimmunomycin" (L-683,7411) a C-31 demethylated analog of L-683,590 under fermentation conditions utilizing the microorganism,...
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5286649 |
Antiviral antibiotic BU-3889V
Production of an antiviral antibiotic complex, BU-3889V and its bioactive components A1, A2, A3, D1, D2 and D3, by fermentation of a BU-3889V producing strain of the new microorganism Amycolatopsis...
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5281417 |
Antitumor process employing novel fermentate of an Actinomadura strain
A certain fermentation product of Actinomadura strain Q473-8 yields, when suitably treated, a novel compound having both antibiotic and antitumor activities.
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5275817 |
Physiologically active kanglemycin C
Novel physiologically active substance, kanglemycin C, having a molecular weight of 326 and is isolated from the fermentation broth of Nocardia mediterranei var. kanulensis 1747-64 which belongs to...
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5244790 |
Microorganisms for preparing traditional Korean soybean paste and the method for the production of soybean paste by using the same
The present invention relates to microorgaisms which produce the aroma and flavor of traditional Korean soybean paste. The present invention also relates to a method for producing the soybean paste...
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5217877 |
Process for the preparation of α-glucosidase inhibitor, pradimicin Q
The present invention relates to a novel α-glucosidase inhibitor, pradimicin Q, having the following formula ##STR1## and its pharmaceutically acceptable base salts.
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5192742 |
Compounds and compositions for the treatment of bacterial infections in animals
New glycopeptide antibiotics MM 49728, MM 55266, MM 55267/1, MM 55267/2 and MM 55268 are produced by fermentation of Amycolatopsis sp. NCIB 40089.
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5188961 |
DNA encoding a Streptomyces endochitinase 56 signal peptide
Engineered DNA encoding a pre-protein which comprises a Streptomyces chitinase signal sequence and a desired mature protein. Preferably, the signal sequence is from the S. plicatus endochitinase...
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5171740 |
Coumamidine compounds
A mixture of new coumamidine compounds are produced by a microorganism, belonging to the genus Saccharopolyspora. The compounds have antibiotic activity against a broad spectrum of bacteria.
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5168052 |
Method for producing 20-deoxotylosin
The present invention, utilizing recombinant DNA technology, provides a novel method for obtaining 20-deoxotylosin from a tylosin producing microorganism. 20-deoxotylosin is useful as an antibiotic...
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5153127 |
AB-011 Antibiotics and process for producing them
The AB-011 Antibiotics and the main components thereof: AB-011a and AB-011b, obtained by the controlled aerobial cultivation of Streptomyces s.p. NCIB 12629 in an aqueous nutrient cultivation...
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5149638 |
Tylosin biosynthetic genes tylA, tylB and tylI
Provided are gene sequences encoding tylosin biosynthetic gene products. In particular, recombinant DNA vectors comprising DNA sequences encoding the tylA, tylB, tylI and tylG activities of...
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5124150 |
Process for preparing antiviral antibiotic BU-3889V
Production of an antiviral antibiotic complex, BU-3889V and its bioactive components A1, A2, A3, D1, D2 and D3, by fermentation of a BU-3889V producing strain of the new microorganism Amycolatopsis...
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5122595 |
SAF polypeptide gene coding therefor, and SAF promoter
The cloning and characterization of a newly isolated gene, referred to as saf (secondary metabolism activation factor) is disclosed. This gene encodes a new amino acid polypeptide, referred to as...
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5116746 |
Cellulase-free endo-xylanase enzyme of use in pulp delignification
A method of treating lignocellulosic material with a cellulase-free endo-xylanase for delignification, brightening and viscosity improvement. The endo-xylanase is obtained by the overexpression of...
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5110908 |
Haemophilus influenzae peptides and proteins
Peptides and proteins related to an epitope comprising an outer membrane protein of Haemophilus influenzae are described. The peptides and proteins can be prepared by methods including novel and...
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5098837 |
Macrolide biosynthetic genes for use in streptomyces and other organisms
Spiramycin antibiotic biosynthetic genes of Streptomyces ambofaciens are provided by the present invention, in addition to a variety of recombinant DNA vectors. The genes also function in other...
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5091524 |
Glycosidase inhibitor salbostatin, process for its preparation, and its use
Salbostatin, a compound of the formula I ##STR1## acts as a glycosidase inhibitor and is suitable for use in pharmacy and in plant protection.
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5087567 |
Antitumor antibiotic BMY-42428
An antitumor antibiotic designated BMY-42428 is produced by fermentation of Actinomadura madurae ATCC-53806. The BMY-42428 antibiotic exhibits both antimicrobial and antitumor activities.
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