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8178327 |
Microorganisms for the production of 1,4-butanediol
The invention provides non-naturally occurring microbial organisms comprising a 1,4-butanediol (BDO) pathway comprising at least one exogenous nucleic acid encoding a BDO pathway enzyme expressed...
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8133707 |
Methods of preparing activated polymers having alpha nitrogen groups
Methods for preparing substantially non-antigenic polymers having lone electron pair-containing moieties in high purity are disclosed. The polymers are useful as intermediates for synthesis of...
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8129156 |
Microorganisms for the production of 1,4-butanediol
The invention provides non-naturally occurring microbial organisms comprising a 1,4-butanediol (BDO) pathway comprising at least one exogenous nucleic acid encoding a BDO pathway enzyme expressed...
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8067214 |
Compositions and methods for the biosynthesis of 1,4-butanediol and its precursors
The invention provides a non-naturally occurring microbial organism having 4-hydroxybutanoic acid (4-HB) and 1,4-butanediol (1,4-BDO) biosynthetic pathways. The pathways include exogenous nucleic...
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8048624 |
Compositions and methods for 3-hydroxypropionate bio-production from biomass
Methods of obtaining mutant nucleic acid sequences that demonstrate elevated oxaloacetate α-decarboxylase activity are provided. Compositions, such as genetically modified microorganisms that ...
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7968319 |
Method for producing 1,3-propanediol and 2,3-butanediol from raw starch material
The invention discloses a method for producing 1,3-propanediol and 2,3-butanediol from raw starch materials, including the following steps: 1) Candida krusei or Hansenula Arabitolgens Fang are...
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7947483 |
Methods and organisms for the growth-coupled production of 1,4-butanediol
The invention provides a non-naturally occurring microorganism comprising one or more gene disruptions, the one or more gene disruptions occurring in genes encoding an enzyme obligatory to coupling...
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7923226 |
Synthesis of 1,2,4-butanetriol enantiomers from carbohydrates
A bioengineered synthesis scheme for the production of L-1,2,4-butanetriol, D-1,2,4-butanetriol and racemic mixtures thereof from a carbon source is provided. Methods of producing...
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7867740 |
Thermotoga maritima mannitol dehydrogenase
Nucleic acids encoding Thermotoga maritima mannitol dehydrogenase and the Thermotoga maritima mannitol dehydrogenase polypeptide are disclosed. Further provided are an electrochemical bioreactor...
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7858350 |
Microorganisms for the production of 1,4-butanediol
The invention provides non-naturally occurring microbial organisms comprising a 1,4-butanediol (BDO) pathway comprising at least one exogenous nucleic acid encoding a BDO pathway enzyme expressed...
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7846702 |
Method for preparing xylitol with high yield using recycling microorganism
Provided is a process for continuously producing xylitol in high yield and productivity using a vacuum microfiltration bioreactor containing a fermentation medium for a strain of the genus Candida,...
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7820414 |
Xylitol dehydrogenase-inactivated and arabinose reductase-inhibited mutant of Candida tropicalis, method of producing high-yield of xylitol using the same, and xylitol produced thereby
Disclosed herein are Xylitol dehydrogenase-inactivated and arabinose reductase-inhibited mutant of Candida tropicalis, a method of producing a high yield of xylitol using the same, and xylitol...
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7807419 |
Process for concentrated biomass saccharification
Processes for saccharification of pretreated biomass to obtain high concentrations of fermentable sugars are provided. Specifically, a process was developed that uses a fed batch approach with...
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7807426 |
Processes for producing optically active 1-substituted 2-methylpyrrolidine
The present invention relates to a process for producing an optically active 1,4-pentanediol by asymmetrically reducing 5-hydroxy-2-pentanone, which is easily available at low cost. The present...
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7771964 |
Method of overproduction of polyhydroxybutyrate
The present invention relates to a recombinant Escherichia coli having phbCAB originated from Alcaligenes eutrophus and an overproduction method of polyhydroxyalkanoate using the same, more...
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7745184 |
Process for the biological production of 1,3-propanediol with high yield
The present invention provides a microorganism useful for biologically producing 1,3-propanediol from a fermentable carbon source at higher yield than was previously known. The complexity of the...
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7727746 |
Upflow reactor for enzymatic hydrolysis of cellulose
A process for the enzymatic hydrolysis of cellulose to produce a hydrolysis product from a pre-treated cellulosic feedstock is provided. The process comprises introducing an aqueous slurry of the...
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7700329 |
Methods for making simvastatin and intermediates
The invention provides synthetic chemical and chemoenzymatic methods of producing simvastatin and various intermediates. In one aspect, enzymes such as hydrolases, e.g., esterases, are used in the...
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7645853 |
Processes for producing random polytrimethylene ether ester
Processes for preparing random polytrimethylene ether ester are provided. The processes include contacting 1,3-propanediol with a suitable polymerization catalyst, wherein the 1,3-propanediol...
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7572376 |
Process for producing 1,3-propanediol
Disclosed herein are processes for the recovery of 1,3-propanediol from an aqueous feed stream. The present invention involves contacting an aqueous feed stream that comprises water,...
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7528169 |
Substance having antitumor/anti-inflammatory activity
A compound represented by the following formula (I) or a salt thereof which has excellent antitumor activity and angiogenesis inhibitory action in a low oxygen condition, and a medicament such as...
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7482144 |
Method for the production of xylitol
The invention relates to a method for the production of xylitol, the method comprising (a1) providing (i) a microorganism having xylanolytic activity, and (ii) a microorganism capable of converting...
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7427500 |
Method for preparing xylitol with high yield using recycling microorganism
Provided is a process for continuously producing xylitol in high yield and productivity using a vacuum microfiltration bioreactor containing a fermentation medium for a strain of the genus Candida,...
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7405063 |
Biooxidation capabilities of Candida sp
A bioprocess for producing carboxylic acids, alcohols and aldehydes is provided by culturing Candida sp. in a fermentation medium containing various defined substrates.
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7371558 |
Process for the biological production of 1,3-propanediol with high yield
The present invention provides a microorganism useful for biologically producing 1,3-propanediol from a fermentable carbon source at higher yield than was previously known. The complexity of the...
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7358072 |
Fermentative production of mannitol
The invention provides processes for continuous fed-batch fermentative production and continuous recycle fermentative production of mannitol.
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7341855 |
Plant mangrove-associated fungus Curvularia lunata and a simple and efficient method of obtaining high yield of pure mannitol from the same
The present invention relates to a plant mangrove-associated fungus Curvularia lunata, and a simple and efficient method of obtaining high yield of pure mannitol from a plant mangrove-associated...
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7323539 |
Polytrimethylene ether glycol and polytrimethylene ether ester with excellent quality
A process is provided comprising contacting 1,3-propanediol with a suitable polymerization catalyst to produce polytrimethylene ether glycol or random polytrimethylene ether ester, wherein the...
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7247458 |
Enzymatic decarboxylation of 2-keto-L-gulonic acid to produce xylose
The invention is drawn to the enzymatic decarboxylation of 2-keto-L-gulonic acid (2-KLG) to produce xylose. The invention is also drawn to a method to detect xylose in vitro or in vivo...
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7229803 |
Reaction of (di)amines in the presence of a lysine oxidase and of a reducing agent
The invention relates to methods for reacting (di)amines as substrates in the presence of a lysine oxidase arid a reducing agent, resulting in alcohols, diols or cyclic secondary amines. In a...
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7169588 |
Bioconversion of a fermentable carbon source to 1,3-propanediol by a single microorganism
A new polypropylene terephthalate composition is provided. The polypropylene terephthalate is comprised of 1,3-propanediol and terephthalate. The 1,3-propanediol is produced by the bioconversion of...
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7135309 |
Processes for the bioconversion of a fermentable carbon source to 1,3-propanediol by a single microorganism
A process is provided for the bioconversion of a carbon substrate to 1,3-propanediol by a single organism utilizing microorganisms, such as, Citrobacter, Enterobacter, Clostridium, Klebsiella,...
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7109005 |
Process for the simultaneous production of xylitol and ethanol
Effective processes are provided for the production of xylitol and ethanol and other products from solutions derived from lignocellulose-containing material in biomass. The solutions can be...
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7098368 |
Hydrogenation of biochemical derived 1,3 -propanediol
The invention discloses a hydrogenation process for removing impurities and controlling acid for use in downstream processing of biochemically-derived 1,3-propanediol. Preferably, the...
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7060477 |
Epoxide hydrolases of aspergillus origin
The invention concerns proteins of fungal origin having an epoxide hydrolase activity, such as those obtained in essentially pure form by extraction from fungi cells, or by culturing in host cells...
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6953684 |
Method for the recombinant production of 1,3-propanediol
The present invention provides a microorganism for the production of 1,3-propanediol from a variety of carbon sources in an organism capable of 1,3-propanediol production and comprising a) at least...
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6924131 |
Xylitol dehydrogenase of acetic acid bacteria and gene thereof
Xylitol is produced by allowing xylitol dehydrogenase or cells instoduced with a DNA coding for xylitol dehydrogenase, which is a protein of the following (A) or (B) to act on D-xylulose, and...
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6916639 |
Erythritol-producing moniliella strains
An isolated strain of the Moniliella species that converts glucose to erythritol with a conversion rate of at least about 45% is disclosed, as is a method of producing erythritol from such a strain.
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6911565 |
Process for the production of xylitol
The present invention relates to a process for the production of xylitol. The process utilises ribulose for the preparation of xylitol and involves several different conversion reactions, such as...
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6900361 |
Process for lactose conversion to polyols
A process for converting lactose into polyols that includes (a) hydrolyzing lactose to produce a hydrolyzate that includes at least one monosaccharide, (b) subsequently hydrogenating the...
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6893849 |
Fermentation process for production of xylitol from Pichia sp
The present invention deals with an improved fermentation process for the production of xylitol from Pichia sp. and the said process is submerged fermentation for the production of xylitol using...
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6855526 |
Method for making mannitol with Lactobacillus intermedius
Mannitol is produced in a highly efficient fermentative method using Lactobacillus intermedius NRRL B-30560, or in a biochemical method using mannitol dehydrogenase isolated from this strain....
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6846657 |
Process for the simultaneous production of xylitol and ethanol
The invention relates to a process for the simultaneous production of xylitol and ethanol from a hydrolyzed lignocellulose-containing material starting. The starting material is fermented with a...
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6828115 |
Epoxide hydrolases from streptomyces
A description is given of epoxide hydrolases from bacteria of the genus Streptomyces, a novel process for the enzymatic separation of epoxide enantiomeric mixtures, of a novel detection method for...
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6803218 |
Enzymes which dehydrate glycerol
The present invention relates to improved methods and reagents for the production of 1,3-propanediol. In particular, the present invention provides novel thermophilic organisms and thermostable...
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6750049 |
Synthesis of 1,2,3,4-tetrahydroxybenzenes and 1,2,3-trihydroxybenzenes using myo-inositol-1-phosphate synthase and myo-inositol 2-dehydrogenase
A bioengineered synthesis scheme for the production of 1,2,3,4-tetrahydroxybenzene from a carbon source is provided. Methods of producing 1,2,3,4-tetrahydroxybenzene from a carbon source based on...
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6733997 |
Isolated nucleic acids encoding a secretory signal for expression and secretion of heterologous recombinant proteins
A universal secretory signal originally derived from a piscine vitellogenin (Vtg) gene is inserted into various expression vectors for driving the secretion of the recombinant protein into the...
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6682916 |
Chlorohydroxyacetone derivative and process for producing optically active chloropropanediol derivative from the same
A process for efficiently preparing an optically active chloropropanediol derivative, especially (S)-1-benzyloxy-3-chloro-2-propanol, which has a high optical purity and is useful as an...
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6649382 |
Methods of making polyhydroxyalkanoate using biosynthesis genes from alcaligenes latus
There are described methods for making polyhydroxyalkanoate and its copolymers, by culturing a host cell transformed with a vector comprising a polyhydroxyalkanoate biosynthesis-related DNA...
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6638759 |
Process for preparation of optically active 1,2-diols by cultivating microorganisms
A process for preparation of an optically active 1,2-diol compound of the following formula: wherein R is alkyl group, hydroxy substituted alkyl group, or alkenyl group, which comprises reacting a...
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