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8183007 |
ADP detection based methods using adenylate cyclase and bioluminescence
The disclosure provides compositions and methods to determine or detect ADP or the activity of enzymes, including phosphotransferases such as kinases (e.g., protein, lipid, and sugar kinases) and...
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8183006 |
Screening method for identifying new aminoacyl-tRNA synthetase inhibitors
The method comprising: a) obtaining a gene sequence codifying a naturally occurring aminoacyl-tRNA synthetase; b) engineering the gene codifying for said aminoacyl-tRNA synthetase, resulting into...
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8183005 |
Pharmaceutical agents for treating HCV infections
The present inventors examined the inhibitory activity against HCV replicon of myriocin, fumonisin B1, and ceramide trafficking inhibitor HPA-12, which are compounds derived from microorganisms...
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8178323 |
Emulsifier prepared using a glycosyl transferase
The invention relates to an emulsifier, a method for preparing said emulsifier, and to its use in various applications, primarily food and cosmetic applications. The invention also relates to the...
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8178314 |
Pyrimidines reacting with O6-alkylguanine-DNA alkyltransferase fusion protein and method for detecting protein
The invention relates to pyrimidines suitable as substrates for O6-alkylguanine-DNA alkyltransferases (AGT) of formula (I) wherein R1 is hydrogen, lower alkyl, halogen, cyano, trifluoromethyl or...
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8168383 |
Gene defects and mutant ALK kinase in human solid tumors
Novel gene deletions and translocations involving chromosome 2 resulting in fusion proteins combining part of Anaplastic Lymphoma Kinase (ALK) kinase with part of a secondary protein have now been...
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8158376 |
Bisubstrate fluorescent probe binding to protein kinases
This invention relates to fluorescent probes for identification of compounds binding to protein kinases, for measurement of the affinity of inhibitors of protein kinases, and determination of the...
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8153390 |
FRET-based binding assay
The present invention provides for an assay that identifies kinase inhibitors by employing fluorescence resonance energy transfer in a competition binding approach.
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8153399 |
Methods and compositions for inactivating glutamine synthetase gene expression
Disclosed herein are methods and compositions for inactivating a glutamine synthetase (GS) gene, using fusion proteins comprising a zinc finger protein and a cleavage domain or cleavage...
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8153389 |
Methods for the identification of PI3K interacting molecules and for the purification of PI3K
The present invention relates to methods for the identification of a PI3K interacting compound using phenylthiazole ligand 1.
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8148157 |
Reference, calibrator, or control composition of PIGF-1 and sFlt-1
Disclosed herein are compositions and methods comprising two or more proteins in which at least one of the proteins has been altered to reduce their mutual recognition and binding. Such...
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8137942 |
Method of preparing a modified surface
Reactive surfaces, substrates and methods of producing and using such substrates and surfaces are provided. The substrates and surfaces provide low density reactive groups preferably on an...
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8138321 |
Acetolactate synthase (ALS) selectable marker from Trichoderma reesei
A nucleic acid encoding an acetolactate synthase (ALS) protein that provides resistance to ALS inhibitors, e.g., sulphonylurea and imidazolinone compounds, is provided. The nucleic acid may be used...
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8124368 |
Fluorogenic protein kinase substrates
The present invention relates to kinase sensors comprising a metal chelator and a fluorophore, where the chelator comprises a quinoline group and where the fluorophore is conjugated to the...
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8124381 |
Process and materials for production of glucosamine and N-acetylglucosamine
A biosynthetic method for producing glucosamine and N-acetylglucosamine is disclosed. Such a method includes the fermentation of a genetically modified microorganism to produce glucosamine and/or...
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8119116 |
Therapeutics for cancer using 3-bromopyruvate and other selective inhibitors of ATP production
The present invention relates to methods of treating a cancerous tumor using selective inhibitors of ATP production. The present invention also relates to pharmaceutical preparations comprising...
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8114653 |
Thermostable Y-family polymerases and chimeras
The present disclosure is related to thermostable Y-family polymerases, in particular several novel Y-family polymerases and chimeras made therefrom, as well as methods of identifying other...
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8105799 |
Methods of screening compounds inhibiting signal transduction through inflammatory cytokines
Revealed are that the actions of inflammatory cytokine and the production of inflammatory cytokines such as IL-1 and TNF induced by an inflammatory stimulus as well as the production of other...
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8105766 |
Method of measuring pyrophosphate
Provided is a novel and useful method of measuring pyrophosphate in a sample. There may be provided a novel and useful method of measuring pyrophosphate in a sample using pyruvate orthophosphate...
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8101375 |
Compositions and methods for detecting phosphomonoester
The invention provides a method of modifying a phosphomonoester moiety of a target compound. The method can include the steps of (a) providing a target compound having an electrophilic moiety and a...
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8097431 |
Methods and compositions for detecting steroids
The present invention provides for methods and systems for detecting steroids. Examples of such steroids include estrogen, progesterone, androgen, testosterone, and derivatives and analogs thereof....
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8097432 |
Method for diagnosing hemangiosarcoma in canine using detection of thymidine kinase activity
The disclosure relates to a method for detecting hemangiosarcoma in canines. The method includes the steps of: (1) obtaining a quantity of blood from the subject canine; (2) separating the quantity...
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8093014 |
Kit for detecting and measuring element tagged kinases and phosphatases by inductively coupled plasma mass spectrometry
Kits for the assay of enzymes involved in post-translational modifications are provided. The kits facilitate the execution of methods of assay that allow for convenient and accurate analysis using...
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8080425 |
Quantitative analysis of a biological sample of unknown quantity
Disclosed is a method for testing a modified specimen such as a dried blood spot, plasma or serum specimen, for an analyte of interest, such as cholesterol. In accordance with the disclosed subject...
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8076098 |
Mnk kinase homologous proteins involved in the regulation of energy homeostasis and organelle metabolism
The present invention discloses Mnk homologous proteins regulating the energy homeostasis, the metabolism of triglycerides, and/or is contributing to membrane stability and/or function of...
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8067536 |
Kinase and phosphatase assays
Compositions, methods, and kits for detecting and monitoring kinase, phosphatase and protein post-translational modification activity are described. The compositions typically include a peptide, a...
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8039794 |
Mass spectrometry assay for thiopurine-S-methyl transferase activity and products generated thereby
Methods are described for measuring the amount of a methylation TPMT enzyme product in a sample. More specifically, mass spectrometric methods are described for detecting and quantifying 6-MMP or...
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8008053 |
Allosteric control of proteins by manipulating mechanical tension
A method of altering the conformation of a polypeptide having a known three-dimensional structure is described. The method comprises attaching a first end of a polymer to a first portion of the...
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8003342 |
Method for identifying farnesyl transferase inhibitors
Disclosed are methods and compositions for the identification of inhibitors of farnesyl protein transferases, enzymes involved in the farnesylation of various cellular proteins, including cancer...
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8003095 |
Method of using lipid acyltransferase
A method for the in situ production of an emulsifier in a foodstuff, wherein a lipid acyltransferase is added to the foodstuff. Preferably the emulsifier is produced without an increase or without...
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8003315 |
TAOJIKs as modifiers of the beta-catenin pathway and methods of use
Human TAOJIK genes are identified as modulators of the beta-catenin pathway, and thus are therapeutic targets for disorders associated with defective beta-catenin function. Methods for identifying...
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7998718 |
Identification and functional characterization of a novel ribosomal S6 protein kinase
A novel S6 kinase, p70βS6k is described, along with methods of making and using p70βS6k protein and related nucleic acids. The invention also discloses methods of identifying agents which m...
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7981598 |
Preventive/remedy for respiratory diseases
It is intended to provide a compound inhibiting the activity of a protein having an amino acid sequence which is the same or substantially the same as one of the amino acid sequences represented by...
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7981633 |
Method for measuring tyrosine kinase phosphorylation
The present invention relates to methods for measuring the autophosphorylation of one or more tyrosine kinases and use of such methods in profiling kinase inhibitors and activators. As a...
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7977043 |
Assays useful in determining CD38 inhibition
An assay for use in high-throughput screening of chemical libraries to determine whether compounds in such libraries will inhibit CD38 catalytic activity, and CD38 production of ADPR and cADPR.
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7972805 |
Phytase-containing animal food and method
A method is described for improving the nutritional value of a foodstuff comprising a source of myo-inositol hexakisphosphate by feeding the foodstuff in combination with a phytase expressed in...
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7968318 |
Process for conversion of granular starch to ethanol
A method is disclosed for producing glucose from a granular starch substrate including, contacting a slurry comprising granular starch obtained from plant material with an alpha-amylase at a...
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7968309 |
Method for improving the thermostability of sucrose phosphorylase (SP)
A sucrose phosphorylase (SP) having improved thermostability obtained by modifying a natural SP and a method for producing the SP having improved thermostability is provided. This SP having...
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7964629 |
Inhibitors of isoprenylcysteine carboxyl methyltransferase
The present invention relates, in general, to isoprenylcysteine carboxyl methyltransferase (Icmt) and, in particular, to inhibitors of Icmt and to methods of disease treatment using same.
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7964372 |
Size self-limiting compositions and test devices for measuring analytes in biological fluids
A test strip or electrochemical sensor for measuring the amount of an analyte in a biological fluid, e.g. the glucose content of whole blood, includes a size self-limiting reagent formulation...
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7964373 |
Transformed cell with enhanced sensitivity to antifungal compound and use thereof
The present invention provides a transformed cell in which a polynucleotide having a nucleotide sequence encoding an amino acid sequence of an osmosensing histidine kinase having no transmembrane...
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7966133 |
Method of identifying a potential substrates of an O-methyltransferase
The invention provides crystalline O-methyltransferases and isolated non-native O-methyltransferases as well as sets of their structural coordinates. Also provided are methods of predicting the...
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7960134 |
Kinase inhibition models and their uses
The present invention provides a c-Met inhibition model. The invention further provides a method to derive inhibition models for other kinases. The kinase inhibition models of the present invention...
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7960133 |
Methods of diagnosing leiomyoma by measuring catechol-O-methyltransferase
The present invention relates to an association between specific polymorphisms of the COMT polypeptide and the development, or risk of developing, preterm labor and uterine diseases and conditions....
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7955814 |
Method
A method for the in situ production of an emulsifier in a foodstuff, wherein a lipid acyltransferase is added to the foodstuff. Preferably the emulsifier is produced without an increase or without...
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7955813 |
Method of using lipid acyltransferase
A method for the in situ production of an emulsifier in a foodstuff, wherein a lipid acyltransferase is added to the foodstuff. Preferably the emulsifier is produced without an increase or without...
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7951530 |
Cyclic maltosylmaltose, cyclic maltosymaltose-forming enzyme, their preparation and uses
An object of the present invention is to provide an option of non-reducing saccharide by providing a novel non-reducing saccharide composed of glucose as constituents and to provide a novel enzyme...
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7947468 |
Methods
A method for identifying a compound expected to be useful in modulating a LRRK2 protein kinase activity, the method comprising the steps of (1) determining whether a test compound modulates the...
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7943665 |
Anticancer agents based on regulation of protein prenylation
Oncoproteins such as Ras and RhoB are known to induce cell division in an unrestrained manner when such proteins are localized at the inner surface of a cancer cell membrane. The localization is...
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7943358 |
Polymerase enhancing factor (PEF) extracts, PEF protein complexes, isolated PEF protein, and methods for purifying and identifying
The invention provides novel extracts, proteins, and complexes that improve the polymerization activity of nucleic acid polymerases. Included within the aspects of the invention are methods for...
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