|
Match
|
Document |
Document Title |
|
|
7622289 |
Ornithine aminotransferase (OAT): a target for anticancer drugs
Ornithine δ-aminotransferase (OAT) facilitates microtubule assembly in addition to its aminotransferase activity in mitochondria. An N-terminal proteolysis of the first 17 amino acids of OAT block...
|
|
|
7620502 |
Methods for identifying sets of oligonucleotides for use in an in vitro recombination procedure
In silico nucleic acid recombination methods, related integrated systems utilizing genetic operators are used to identify sets of oligonucleotides for in vitro recombination.
|
|
|
7608437 |
Method of constructing amino acid producing bacterial strains, and method of preparing amino acids by fermentation with the constructed amino acid producing bacterial strains
A method of producing coryneform bacteria having an improved amino acid or nucleic acid-productivity comprises the steps of introducing a mutation in a promoter sequence of amino acid- or nucleic...
|
|
|
7601489 |
Manganese ion regulation of reverse transcriptase activity and methods of modulating same
Methods of identifying agents that modulate reverse transcriptase activity in a cell by affecting manganese ion transport across a membrane of the cell are provided, as are agents identified using...
|
|
|
7599066 |
Localized plasmon resonance sensor
A localized plasmon resonance sensor for detecting a change in optical constant uses a structure including metal. In a response spectrum with respect to light incident on the structure, there are...
|
|
|
7598288 |
Inhibitors of glycogen synthase kinase-3 (GSK-3) for treating glaucoma
The use of inhibitors of GSK-3 useful for treating glaucoma is disclosed.
|
|
|
7588901 |
Modulation of angiogenesis through targeting of arginyl transferase (ATE1)
The invention provides methods and compositions for modulating angiogenesis in a subject. The methods of modulating angiogenesis in a subject include administering to the subject a modulator of...
|
|
|
7588899 |
Fluorescent probes for use in protein kinase inhibitor binding assay
The invention provides methods relating to a screening assay format that can be applied to broad members of the protein kinase gene family. The assay uses a series of labeled, active site probes...
|
|
|
7585643 |
Method for detecting kinase activity with thiol reactive fluorescent reagents
Disclosed are assays useful for detecting kinase activity. The assays utilize thiol-reactive fluorescent reagents and include reacting a reaction mixture that contains an ATP analog such as ATPβS...
|
|
|
7584087 |
Structure of protein kinase C theta
A three-dimensional structure of human protein kinase C theta (PKCθ) can be used in methods of designing an agent that interacts with PKCθ. The agent can be an inhibitor of PKCθ activity.
|
|
|
7575885 |
Tyrosylprotein sulfotransferases and methods of use thereof
Tyrosylprotein sulfotransferases and nucleic acids encoding the tyrosylprotein sulfotransferases are described. Dual isotopes of the enzyme and of the nucleic acids encoding said enzymes have been...
|
|
|
7566550 |
Screening method for developing drugs against pathogenic microbes having two-component system
The present invention relates to a package of screening methods for developing drugs against pathogenic microbes having two-component system of DevR-DevS and/or DevR-Rv2027c and its homologues,...
|
|
|
7563589 |
Reconstituted histone methyltransferase complex and methods of identifying modulators thereof
The present invention provides a reconstituted complex including EED, EZH2 and SUZ12 wherein the reconstituted complex has histone methyltransferase (HMTase) activity for lysine 27 of histone H3...
|
|
|
7563574 |
Methods, systems and compositions for monitoring enzyme activity and applications thereof
Methods of monitoring enzyme mediated reactions, and particularly nucleic acid synthesis reactions such as pyrosequencing methods that employ enzymatic reporter systems. The methods and systems...
|
|
|
7561973 |
Methods for determining properties that affect an expression property value of polynucleotides in an expression system
A method of determining a property that affects expression of polynucleotides in an expression system. A plurality of polynucleotides, each encoding a polypeptide sequence, is constructed. An amino...
|
|
|
7561972 |
Synthetic nucleic acids for expression of encoded proteins
A method of designing a polynucleotide sequence encoding a polypeptide sequence of a predetermined polypeptide is provided. A frequency lookup table corresponding to an expression system is...
|
|
|
7558717 |
Crystal structure of human JAK3 kinase domain complex and binding pockets thereof
The present invention relates to human Janus Kinase 3 (JAK3) and JAK3-like binding pockets. The present invention provides a computer comprising a data storage medium encoded with the structure...
|
|
|
7556935 |
Induction of apoptosis by cellular stress
The invention provides methods of screening to identify compounds that modulate the ability of a protein to translocate to the mitochondria when a cell is subjected to cellular stress. Such...
|
|
|
7550271 |
Detecting phospho-transfer activity
Disclosed are methods and reagents for detecting the presence of and/or activity of one or more phospho-transfer activities such as kinase, phosphatase, nucleotide cyclase, or phosphodiesterase...
|
|
|
7544479 |
Method for identifying MLK inhibitors for treatment of neurological conditions
The present invention describes methods for identifying compounds that inhibit JNK and MLK kinase activity as drugs for treating a mammal susceptible to or having a neurological condition. This...
|
|
|
7537887 |
Net, a transcription factor of the TCF family, as regulator of angiogenic factor expression
The present invention relates to the regulation of the activity of NET (ERP/SAP-2) protein and to compounds which modify or regulate NET protein activity. The invention further relates to methods...
|
|
|
7531318 |
Screening of agents for activity against ischemic myocardial insults
Integrin-linked kinase (ILK) and Akt/protein kinase B (PKB) are important mediators of signaling in cardiomyocytes and can both prevent damage and promote healing associated with ischemic injury to...
|
|
|
7527953 |
Genes from Propionibacterium freudenreichii encoding enzymes involved in vitamin B12 biosynthesis
Four new genes, and the enzymes that they encode, are disclosed, which are present in Propionibacterium freudenreichii, and which are involved in at least five steps in the biosynthetic pathway...
|
|
|
7510850 |
Isolation of the mitotic spindle matrix and its methods of use
The invention encompasses a purified preparation of the mitotic spindle matrix essential for mitotic spindle assembly, which allows for identifying an agent that modulates a cell division and/or...
|
|
|
7507555 |
Probe for detecting and quantifying lipid second messenger and method of detecting and quantifying lipid second messenger using the same
The present invention provides probes for detection and quantification of a lipid second messenger, which comprises: a polypeptide specifically bound to the lipid second messenger; two chromophores...
|
|
|
7504242 |
Process for the fermentative production of amino acids using coryneform bacteria in which OpcA gene expression is amplified
The present invention relates to polynucleotides that encode proteins having OpcA enzymatic activity. These polynucleotides can be used for increasing lysine biosynthesis in Coryneform glutamicum.
|
|
|
7504234 |
Assays for S-adenosylmethionine (AdoMet)-dependent methyltransferase activity
The present invention relates to coupled enzyme assays. In particular, the present invention provides a coupled fluorescent assay for detection of S-adenosylmethionine (AdoMet)-dependent...
|
|
|
7504205 |
Uncharacterized ORF3 in SARS-coronavirus is a cyclic-AMP-dependent kinase and a target for SARS therapy
The present invention relates to novel methods for identifying antiviral agents which selectively interfere with viral proteins that cause the unique infectivity activity of the SARS-coronavirus in...
|
|
|
7501257 |
Molecular diagnostic method of a cancer tissue or a cancer cell
The present invention relates to a more accurate method of diagnosing cancer in a tissue or a cell by measuring the expression and activity of cell cycle related proteins and analyzing a cell cycle...
|
|
|
7501249 |
Human cytoplasmic polyadenylation element binding protein and uses thereof
The present invention provides genomic and cDNA encoding human cytoplasmic polyadenylation element binding protein, expression vectors comprising human cytoplasmic polyadenylation element binding...
|
|
|
7498128 |
Methods of determining contributions to metabolic pathways
The present invention provides methods for assessing contribution of one or more pathways to the biosynthesis of a metabolite, e.g., a lipid using the levels of the product made and the metabolite...
|
|
|
7491545 |
Excitation ratiometric fluoroscent biosensor for zinc ion at picomolar levels
A highly selective and sensitive of a carbonic anhydrase-based method for measurement of zinc ion by an excitation ratiometric format based on resonance energy transfer: i.e., where the zinc ion...
|
|
|
7491506 |
Inhibition of B-cell maturation and antibody production
The present invention provides methods and compositions for the inhibition of B-cell maturation and antibody production without interfering with innate or T-cell mediated immunity.
|
|
|
7488592 |
Human protein acyl transferases and methods of uses therefor
The present invention provides the identification of human Ras palmitoyl acyl transfersase complexes, and nucleic acids coding therefore. In addition, methods of screening for modulators of human...
|
|
|
7482146 |
Phenylethanolamine-N-methyltransferase sequence variants
Isolated PNMT nucleic acid molecules that include a nucleotide sequence variant and nucleotides flanking the sequence variant are described, as well as PNMT allozymes. Methods for determining if a...
|
|
|
7482133 |
Catalytic domains of β(1,4)-galactosyltransferase I having altered donor and acceptor specificities, domains that promote in vitro protein folding, and methods for their use
Disclosed are methods and compositions that can be used to synthesize oligosaccharides; mutants of galactosyltransferases having altered donor and acceptor specificity; methods for increasing the...
|
|
|
7482132 |
Method for determining the activity of ornithine decarboxylase and for identifying effectors of ornithine decarboxylase activity
The present invention relates to a method for determining the activity of ornithine decarboxylase and for identifying effectors of ornithine decarboxylase activity, to the effectors of ornithine...
|
|
|
7479392 |
Quantitative analysis of a biological sample of unknown quantity
Disclosed is a method for testing a modified specimen such as a dried blood spot, plasma or serum specimen, for an analyte of interest, such as cholesterol. In accordance with the disclosed subject...
|
|
|
7479387 |
Compositions and methods for the synthesis and subsequent modification of uridine-5′-diphosphosulfoquinovose (UDP-SQ)
The present invention is directed to compositions and methods related to the synthesis and modification of uridine-5′-diphospho-sulfoquinovose (UDP-SQ). In particular, the methods of the present...
|
|
|
7470542 |
Proteins in type 2 diabetes
The present invention relates to the use of naturally occurring compounds and derivatives thereof as markers for predisposition of diabetes related diseases. The invention also relates to a...
|
|
|
7465565 |
Methods of increasing triacylglycerol content in oleaginous yeasts via expression of acyltransferases
Two acyltransferases are provided, suitable for use in the manufacture of microbial oils enriched in omega fatty acids in oleaginous yeast (e.g., Yarrowia lipolytica ). Specifically, the genes...
|
|
|
7452689 |
Method for rapid determination of thiopurine methyltransferase activity
This document provides methods and materials related to rapid, quantitative determination of TPMT activity in biological samples. Also featured are compositions and kits useful for determination of...
|
|
|
7452688 |
Transformed cell with enhanced sensitivity to antifungal compound and use thereof
The present invention provides a transformed cell in which a polynucleotide having a nucleotide sequence encoding an amino acid sequence of an osmosensing histidine kinase having no transmembrane...
|
|
|
7452687 |
Method of detecting mild impaired glucose tolerance or insulin secretory defect
It is intended to provide a noninvasive method of conveniently detecting mild impaired glucose tolerance and/or insulin hyposecretion at the early stage with the use of an enzyme. Namely, mild...
|
|
|
7452686 |
JNK inhibitors for the treatment of neurological disorders
The present invention describes methods for identifying compounds that inhibit JNK and MLK kinase activity as drugs for treating a mammal susceptible to or having a neurological condition. This...
|
|
|
7452664 |
Methods for identifying agents which alter histone protein acetylation
Methods of identifying agents which alter the NAD-dependent acetylation status and mono-ADP-ribosylation of nuclear proteins are disclosed. The methods further include identifying agents which...
|
|
|
7444273 |
Crystallization of aurora/LPL1P-related kinase
Provided are crystals relating to Aurora/LPL1P-related kinase and its various uses.
|
|
|
7435556 |
Method for increasing the ratio of p-hydroxybenzoic acid ester glucoside to total p-hydroxybenzoic acid glucose conjugates in p-hydroxybenzoic acid-producing microorganisms and green plant cells
This invention pertains to a method for increasing the ratio of the pHBA ester glucoside to total pHBA glucose conjugates in pHBA-producing microorganisms and green plant cells using nucleic acid...
|
|
|
7432070 |
Homogenous assay for enzymatic activity
An assay is disclosed for measuring activity of enzymes, such as kinases, phosphatases, and proteases. Measurements of enzymatic activity are accomplished in a homogenous assay format utilizing a...
|
|
|
7429460 |
Methods of screening for inhibitors of phospholipid synthesis related to glycolipid-storage diseases
The present invention discloses methods of screening for identification of compounds that inhibit novel targets in the enzymatic pathway of phospholipid synthesis that are related to glycolipid...
|