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9029401 Sorafenib derivatives as sEH inhibitors  
The present invention provides compounds for the inhibition of soluble epoxide hydrolase and associated disease conditions.
9028844 Vaccine against Trypanosoma cruzi infection  
The present invention relates to a vaccine against Trypanosoma cruzi infection, useful in the prevention and/or treatment of the Chagas disease. More specifically, the present invention relates to...
9012166 Method for assaying histone methylation enzyme activity  
Provided are a method for measuring histone methyltransferase activity, a method for screening for compounds that inhibit histone methyltransferase activity, a reagent kit for measuring histone...
8999632 Method for measuring ATR inhibition mediated increases in DNA damage  
The present relates to methods for detecting DNA damage in subjects treated with an ATR inhibitor. More specifically, this invention relates to a method for measuring changes in levels of γH2AX...
8999660 Methods Relating to Mammalian Rictor Polypeptide  
The invention describes isolated mTOR-associated proteins (“mTOR-APs”) as well as isolated variants and fragments thereof and the isolated nucleic acids encoding them. The invention also describes...
8999896 Discovery and applications of the proteolytic function of N-terminal acetylation of cellular proteins  
Screening assays that allow for the identification of agents that modulate the activity of N-terminal acetylation of a polypeptide and the Doa10 branch of the N-end rule pathway are provided. Also...
8993231 Methods for stem cell production and therapy  
The present invention relates to methods for rapidly expanding a stem cell population with or without culture supplements in simulated microgravity conditions. The present invention relates to...
8962268 Method for determining survival prognosis of patients suffering from non-small cell lung cancer (NSCLC)  
The present invention relates to a method for determining the survival prognosis of patients suffering from non-small cell lung cancer. More specifically, the present invention provides methods...
8962267 Method for predicting the response of non-small cell lung cancer patients to targeted pharmacotherapy  
The present invention relates to a method for determining or predicting the response of a patient diagnosed with non small cell lung cancer to targeted pharmacotherapy. The present invention also...
8932818 Screening assays for compounds that modulate programmed ribosomal frameshifting  
The present invention relates to compounds that modulate ribosomal frameshifting and nucleic acid constructs for use in methods for identifying or validation of compounds that modulate ribosomal...
8932586 Modified forms of Pseudomonas exotoxin A  
Pseudomonas exotoxin A or “PE” is a 66 kD, highly potent, cytotoxic protein secreted by the bacterium Pseudomonas aeruginosa. Various forms of PE have been coupled to other proteins, such as...
8927225 Human catechol-O-methyltransferase (COMT) assay  
Disclosed is an assay (method) to quantify the amounts of catecholamine-O-methyltransferase (COMT) protein in samples, such as extracts from cell cultures, body fluids, tissues, and environmental...
8927300 Method and compositions for the detection of protein glycosylation  
The invention provides methods and compositions for the rapid and sensitive detection of post-translationally modified proteins, and particularly of those with posttranslational glycosylations....
8927220 Method for diagnosing immunoglobulin A nephropathy and TGBM nephropathy  
A protein used as a biomarker for diagnosing IgA nephropathy and TGBM (thin-glomerular-basement-membrane) using urine through a target proteomics method. A diagnosis biomarker protein and a kit...
8921062 Diagnostic and prognostic assays based on circulating tyrosine kinase activity  
Provided herein are methods for the diagnosis, prognosis, or management of diseases, such as cancer, by measuring the tyrosine kinase activity in acellular body fluids. Further provided are...
8916357 Dynamic monitoring of activation of receptor tyrosine kinase (RTK) in living cells using real-time microelectronic cell sensing technology  
Methods for identifying a compound capable of interacting with a Receptor Tyrosine Kinase (RTK) including providing a device capable of measuring cell-substrate impedance, adding test cells...
8906636 High level expression of recombinant toxin proteins  
The present invention relates to the field of recombinant toxin protein production in bacterial hosts. In particular, the present invention relates to production processes for obtaining high...
8883435 Inhibitors of Bruton's tyrosine kinase  
Described herein are irreversible kinase inhibitor compounds, methods for synthesizing such irreversible inhibitors, and methods for using such irreversible inhibitors in the treatment of...
8883445 Protein glycosylation modification in methylotrophic yeast  
The present invention provides genetically engineered strains of methylotrophic yeast including Pichia and especially Pichia pastoris capable of producing proteins with reduced or modified...
8859220 Luciferase-based assays  
A method and kit are provided for enhancing the tolerance of an assay reagent to compounds in an assay sample, the assay reagent including a luciferase enzyme. The method includes contacting the...
8828356 Farnesyltransferase inhibitors for treatment of laminopathies, cellular aging and atherosclerosis  
Although it can be farnesylated, the mutant lamin A protein expressed in Hutchinson Gilford Progeria Syndrome (HGPS) cannot be defarnesylated because the characteristic mutation causes deletion of...
8822171 Methods for screening for inhibitors of tau phosphorylation by casein kinase I  
Methods for screening for substances capable of modulating the phosphorylation of tau protein are disclosed, and in particular paired helical filament (PHF) tau, and the use of such modulators in...
8815530 AKT ligands and polynucleotides encoding AKT ligands  
The invention relates to kinase ligands and polyligands. In particular, the invention relates to ligands, homopolyligands, and heteropolyligands that modulate AKT activity. The ligands,...
8815529 Sulfotransferase assay  
Assays and methods for detecting and/or quantifying activity of a test sulfotransferase comprising by releasing a free phosphate from the PAP produced by the sulfotransferase reaction and...
8809009 Methods of diagnosing a disease and methods of monitoring treatment of a disease by quantifying a non-reducing end glycan residual compound and comparing to a second biomarker  
Provided herein are methods of diagnosing or monitoring the treatment of abnormal glycan accumulation or a disorder associated with abnormal glycan accumulation.
8802411 ADP detection based luminescent phosphotransferase or ATP hydrolase assay  
The invention provides compositions and methods to determine or detect the activity of enzymes, including phosphotransferases such as kinases (e.g., protein, lipid, and sugar kinases) and ATP...
8795978 Modulating latency and reactivation of Mycobacterium tuberculosis  
Methods for screening for agents that modulate the activation state, i.e., active growth or persistence, of Mycobacterium tuberculosis (Mtb), methods of treating an Mtb infection in a subject...
8790886 Methods to assay kinase activity  
Methods to assay kinase activity are provided herein. The methods employ elemental analysis, including inductively charged plasma mass spectrometry (ICP-MS). The methods allow for the convenient...
8778627 Enzyme substrate comprising a functional dye and associated technology and methods  
Enzyme substrates and associated technology of the present invention are provided. An enzyme substrate of the invention may comprise a biologically functional fluorescent dye and an...
8771974 Methods of determining the presence and/or amount of a biomarker to determine the presence, identity, and/or severity of a lysosomal storage or neurological disorder  
Provided herein are methods of diagnosing or monitoring the treatment of abnormal glycan accumulation or a disorder associated with abnormal glycan accumulation.
8759012 Method of determining dose and administration of statin  
The object of the present invention is to provide a method of determining the dose and/or administration of statins to a patient suffering from a cardiovascular disease. The object is achieved by...
8758989 Enzymatic detection techniques  
A diagnostic test kit for detecting the presence or quantity of an enzyme or enzyme inhibitor is provided. The diagnostic kit utilizes substrate conjugates to facilitate the detection of the...
8728749 Detection of LCAT activity  
The present disclosure relates to methods for detecting and measuring the activity of lecithin:cholesterol acyltransferase (LCAT) in solution (e.g. serum, plasma, cell culture media, aqueous...
8715927 Inhibition of DNA polymerases to augment chemotherapeutic and antimicrobial agents  
Disclosed herein is the identification of human DNA polymerase κ (pol κ) as the polymerase that mediates repair of DNA containing interstrand cros slinks (ICLs). The mechanism of action of a...
8712749 Crystal structure of human JAK3 kinase domain complex and binding pockets thereof  
The present invention relates to human Janus Kinase 3 (JAK3) and JAK3-like binding pockets. The present invention provides a computer comprising a data storage medium encoded with the structure...
8697380 Method for detecting compounds modulating dimers of VFT domain membrane proteins  
The invention relates to a method for selecting compounds having a modulating effect on the activation state of a dimer of VFT-domain proteins expressed in cell membranes present in a measuring...
8697379 Lysosomotropic inhibitors of acid ceramidase  
The presently disclosed subject matter provides compounds of the formula, formula (Ia): and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5, X, Y, and n are as defined...
8691518 Systems and methods for predicting response to minoxidil for the treatment of androgenetic alopecia  
Methods, processes, systems, and apparatuses are disclosed for predicting minoxidil response in the treatment of androgenetic alopecia based on colorimetric assay.
8691520 Reagentless ceria-based colorimetric sensor  
A colorimetric reagent in the form of nanoparticles, composite nanoparticles, and nanoparticle coatings, including methods of use, methods of preparation, deposition, and assembly of related...
8685679 Acyltransferase regulation to increase the percent of polyunsaturated fatty acids in total lipids and oils of oleaginous organisms  
Methods to increase the percent of polyunsaturated fatty acids (PUFAs) within the total lipids and oils of PUFA-producing oleaginous organisms are provided herein, by regulating the activity of...
8685664 Use of inhibtors of glutaminyl cyclases for treatment and prevention of disease  
Novel physiological substrates of mammalian glutaminyl cyclase (QC, EC 2.3.2.5), new effectors of QC, methods for screening for such effectors, and the use of such effectors and pharmaceutical...
8680157 Androgen receptor-dependent gene expression control  
The invention relates to the use of at least one amine oxidase inhibitor for modulating the activity of the lysine-specific demethylase (LSD1) in a mammal and to pharmaceutical compositions for...
8673587 Methods for identifying allosteric and other novel acyl-coenzyme A:cholesterol acyltransferase inhibitors  
The present invention is a method for identifying compounds that are allosteric and/or other novel ACAT inhibitors that is based on the novel finding that pregnenolone is a substrate for ACAT;...
8673586 Compounds that interact with kinases  
A method of inhibiting or effecting the activity of protein kinase activity which comprises contacting a protein kinase with a compound of formula (I) being a derivative of a furanose or pyranose...
8658622 Methods and compositions for preventing and treating a disease related to glycan dysregulation  
Contemplated compositions and methods are directed to prevent and/or treat various autoimmune diseases that are typically associated with glycan dysregulation, and especially autoimmune...
8632992 Methods for assaying enzyme activities  
The present invention provides compounds and methods for assaying activities of enzymes such as histone deacetylases and histone acetyltransferases. In some embodiments, the methods may be...
8623627 Labelling of fusion proteins with synthetic probes  
The invention relates to new proteins called alkylcytosine transferases (ACTs) derived from O6-alkylguanine-DNA alkyltransferase, and to substrates for ACTs specifically transferring a label to...
8617836 Method for predicting the response of locally advanced rectal cancer to chemoradiotherapy  
The present invention relates to a method for determining or predicting the response of a patient diagnosed with locally advanced rectal cancer to chemoradiotherapy. The present invention also...
8592387 Methods for treating or preventing heart damage with integrin-linked kinase (ILK) compositions  
The present invention generally provides methods for administering a composition having an ILK-based protein or peptide having a sequence that is at least 90% homologous to wild-type human...
8580251 PIM-3 kinase as a target for type 2 diabetes mellitus  
The invention relates to isolated nucleic acid molecules and to host cells comprising such nucleic acid molecules. Moreover, the invention relates to a polypeptide having PIM-3 activity and having...