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7618392 |
Methods and compositions for detection of microbial contaminants in peritoneal dialysis solution
Methods and compositions for detection of microbial contaminants in peritoneal dialysis solutions are provided. The methods and compositions employ modified bioburden testing and the detection of...
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7615360 |
Use of Saccharomyces cerevisiae erg4 mutants for expressing mammalian glucose transporter
The invention relates to yeast strains in which a human GLUT4 transport or a human GLUT1 transporter can be functionally expressed and to particular GLUT4 transport proteins which can be...
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7611859 |
Method for improving heat stability of composition containing water-soluble coenzyme-bound glucose dehydrogenase (GDH)
The invention relates to a method for improving the heat stability of glucose dehydrogenase (GDH), comprising a step of combining, in a composition comprising soluble coenzyme-bound glucose...
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7604593 |
Methods for measuring analyte in a subject and/or compensating for incomplete reaction involving detection of the analyte
The present invention relates to a predictive-kinetic method for use with data processing of a sensor-generated signal, as well as, microprocessors and monitoring systems employing such a...
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7595170 |
Apparatus and method for measuring concentrations of molecules through a barrier
An apparatus and method for detecting the presence and measuring the concentrations of molecules through a barrier and/or at a distance utilizes the principle of chemical/electrostatic attraction...
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7592151 |
Redox polymers for use in electrochemical-based sensors
A redox polymer for use in an electrochemical-based sensor includes a hydrophobic polymer backbone (e.g., a hydrophobic poly(methyl methacrylate) polymer backbone) and at least one hydrophilic...
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7563588 |
Electrically non-conductive, nanoparticulate membrane
An electrically non-conductive, nanoparticulate membrane comprising nanoparticles of at least one inorganic oxide of an element selected from Group IA, IIA, IIIA, IVA, IB, IIB, IIIB, IVAB, VB, VIB,...
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7557081 |
Alpha-1-acid glycoprotein for the treatment of diabetes
Methods of using alpha-1-acid glycoprotein, or an active derivative, to modulate the blood glucose level in mammals, particularly humans, is described. A therapeutically effective amount of...
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7556934 |
Concentration measurement by sensing hydrogel pressure
A sensor and method for measuring the concentration of one or more chemical substances within a solution. The sensor including a body of saturated hydrogel held within a sensor body. A window to...
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7553614 |
High sensitivity fluorometric assays
Spectrophotometric assays are rendered more sensitive by adding to the assay mixture a light-emitting moiety. The decrease in intensity of light emitted due to the presence of a light-absorbing...
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7537910 |
Lactamase amplification substrate
An amplifiable β-lactamase substrate is provided comprising an enzyme donor fragment of β-galactosidase linked to form a ring to a β-lactam ring that is a substrate for lactamase and upon...
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7537909 |
Enzymatic method of producing 4-O-β-D-galactopyranosyl-D-xylose, 4-O-β-D-galactopyranosyl-D-xylose obtained using said method, compositions contain same and the use thereof in evaluating intestinal lactase
An enzymatic process to obtain 4-O-β-D-galactopyranosyl-D-xylose useful in compositions or solutions in the in vivo evaluation of intestinal lactose activity in humans, that comprises the steps of...
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7527980 |
Indirect detection of cardiac markers for assessing acute myocardial infarction
Assay systems and methods are provided for detecting a target antigen in a physiological fluid (e.g., blood, serum, or urine). The method includes linking via a first antibody a magnetic...
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7524642 |
Assays for identifying ubiquitin agents and for identifying agents that modify the activity of ubiquitin agents
Provided are methods and compositions for assaying for ubiquitin agents that are enzymatic components of ubiquitin-mediated proteolysis and, more particularly, methods and compositions for assaying...
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7521244 |
Standard reference solutions
Standard reference materials and related methods are described for quality testing and calibration of instruments used for the qualitative and quantitative determination of hemoglobin and glycated...
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7517664 |
Inactivated enzyme variants and associated process and reagent system
The present invention relates to oxidoreductase apoenzyme variants which are enzymatically inactive but have coenzyme-binding properties. Further, the present invention relates to DNA sequences...
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7514250 |
Coenzyme-binding glucose dehydrogenase
The present invention provides a microorganism-derived soluble coenzyme-binding glucose dehydrogenase which catalyzes a reaction for oxidizing glucose in the presence of an electron acceptor, has...
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7510849 |
OCT based method for diagnosis and therapy
This invention relates to a method of diagnosing or treating a biological subject, such as a person or animal, comprising the steps of subjecting at least a microsample of the subject's tissue to a...
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7504233 |
Methods for determining the metabolism of sugars and fats in an individual
Provided herein are methods for determining the metabolism of one or more sugars and/or fatty acids, and applications thereof. Such applications include determining the rate of glycogen synthesis...
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7462264 |
Subcutaneous glucose electrode
A small diameter flexible electrode designed for subcutaneous in vivo amperometric monitoring of glucose is described. The electrode is designed to allow “one-point” in vivo calibration, i.e.,...
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7452690 |
Protease EFC cell surface fusion protein assay
Methods and reagents are provided for measuring protease activity. The reagent comprises a surface to which is linked an enzyme donor fragment through a protease recognition sequence, where the...
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7439033 |
Method and test strip for determining a fluid analyte
A reagent strip for measuring the concentration of glucose in whole blood has a polymer on at least one side thereof to increase the opacity thereof, thereby reducing the effect of hematocrit on...
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7435569 |
Method of forming a molded protein matrix for use in a sensor
A method for formulating and immobilizing a protein and a protein matrix formed by the method. The protein matrix preparation method results in a physically and chemically stable protein matrix...
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7432353 |
Fluorescent indicator proteins
A protein biosensor having increased signal intensity to sugar concentration and the use thereof. A fluorescent indicator protein is described, in which fluorescent proteins of different emission...
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7432096 |
Glucose dehydrogenase and production thereof
The invention relates to novel PQQ-dependent soluble glucose dehydrogenases (sPQQGDH) from Acinetobacter and to a process for their preparation by overexpression in suitable microbial expression...
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7432069 |
Biocompatible chemically crosslinked hydrogels for glucose sensing
An hydrogel incorporating a biologically active component is provided that is useful as an interface material for transdermal sensing applications. Specifically, the hydrogel has a crosslinked gel...
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7429630 |
Redox polymers for use in electrochemical-based sensors
A redox polymer for use in an electrochemical-based sensor includes a hydrophobic polymer backbone (e.g., a hydrophobic poly(methyl methacrylate) polymer backbone) and at least one hydrophilic...
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7429462 |
Kits for assays of rapid screening of diabetes
The invention provides an in vivo screening assay and an in vitro screening assay for rapid screening of diabetes. A method of the invention includes determining a first glucose concentration in an...
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7427491 |
Nanoparticles for optical sensors
The present invention concerns a polymer layer for a sensor, wherein the polymer layer has nanoparticles embedded therein which impart to the polymer layer recognizing properties as well as...
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7416843 |
Post protein hydrolysis removal of a potent ribonuclease inhibitor and the enzymatic capture of DNA
The present invention concerns compositions and methods of extracting infectious pathogens from a volume of blood. In one embodiment, the method includes the steps of creating a fibrin aggregate...
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7407626 |
Composition and method of use of medical test kit
A medical test kit includes a glucose testing composition, a protein testing composition, a bilirubin testing composition, a bilinogen testing composition, an amylase testing composition, a blood...
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7405055 |
Method and device for predicting physiological values
The invention relates generally to methods, systems, and devices for measuring the concentration of target analytes present in a biological system using a series of measurements obtained from a...
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7397026 |
Efficient electron transfer dissociation for mass spectrometry
The present invention relates to, inter alia, methods and apparatuses for electron transfer dissociation (ETD) that vary the internal energy of precursor ions for ETD. The methods and apparatuses...
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7390663 |
Process, composition and kit for providing a stable whole blood calibrator/control
The present invention is directed toward a stable calibrator and/or control, kit and process for using in a glucose monitoring instrumentation. Principally, the instant invention teaches a...
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7385185 |
Molecular activation for tandem mass spectroscopy
In a tandem mass spectrometer means are provided for molecular activation of ions prior to fragmentation. An embodiment of a tandem mass spectrometer comprises a first collision cell receiving...
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7384791 |
Method of analyzing blood
A method of analyzing blood includes delivering a blood sample to a test device, applying a spatially varying electric field to the blood sample to provide a depleted cell concentration in a...
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7374719 |
Test strip for determining concentration of multiple analytes in a single fluid sample
A multilayer test strip that measures concentrations of multiple analytes from a single whole blood sample. The test strip includes a test matrix of several layers held together in constant contact...
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7335286 |
Immersion sensor for measuring the concentration of an analyte with the help of an oxidase
The invention relates to measuring the concentration of analytes with the aid of an oxidase in an immersion sensor situated in a fluid or in a matrix containing fluid. Oxygen diffuses into the...
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7332355 |
Method and compositions for the detection of protein glycosylation
The invention provides methods and compositions for the rapid and sensitive detection of post-translationally modified proteins, and particularly of those with post-translational glycosylations....
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7323315 |
Method for reducing effect of hematocrit on measurement of an analyte in whole blood
A method for determining the presence and/or amount of an analyte in a sample of whole blood comprises the step of treating the sample with a nonlytic hypertonic salt composition to reduce the...
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7291256 |
Mediator stabilized reagent compositions and methods for their use in electrochemical analyte detection assays
Mediator stabilized reagent compositions and methods for their use in electrochemical analyte determination assays are provided. The subject reagent compositions include an enzyme, a redox mediator...
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7285403 |
Xylose-fermenting recombinant yeast strains
Disclosed are xylose-fermenting recombinant yeast strains expressing xylose reductase, xylitol dehydrogenase, and xylulokinase and having reduced expression of PHO13 or a PHO13 ortholog, as well as...
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7256047 |
Measurement of gluconeogenesis and intermediary metabolism using stable isotopes
The present invention provides a combination of carbon-13 and deuterium metabolic tracers and methods that when used in conjunction with nuclear magnetic resonance spectroscopy, provide a...
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7244582 |
Immobilized carbohydrate biosensor
A biosensor in which a carbohydrate or a derivative of a carbohydrate is used to generate a detectable signal by way of the specific binding to a protein, a virus or a cell.
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7244581 |
Glucose dehydrogenase
Disclosed is a modified glucose dehydrogenase having pyrroloquinoline quinone as a coenzyme, wherein one or more amino acid residues in a region of amino acid 349-377 of water-soluble PQQGDH...
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7235378 |
Method of selectively determining glycated hemoglobin
A method of determining glycated hemoglobin is provided, by which a ratio of the glycated hemoglobin in a sample can be determined accurately and easily. The ratio of glycated hemoglobin can be...
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7229783 |
Method for monitoring hygiene
A test method and test device for hygiene monitoring of a test sample from a biological material or a surface with a biological material to detect the presence of phosphate and glucose as a measure...
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7222024 |
Method for determining the concentration of blood glucose
The present invention provides a method for determining concentration of blood glucose by using the change in the rising time. The chemical reaction between the blood glucose and enzyme within the...
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7205127 |
Methods of treating insulin resistance with an inhibitor of an NAD(P)H oxidase
The present invention relates to the use of NAD(P)H oxidase inhibitors to increase cellular uptake of glucose and in the treatment and/or prevention of diseases caused by insulin resistance or...
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7195923 |
Ratiometric determination of glycated protein
The present invention provides methods for determining a ratio of an amount of a glycated form of a protein to a total amount of the protein in a sample containing the glycated protein, the...
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