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8685683 Method for production of vitamin C and or 2-Keto-L gulonic acid  
The present invention relates to newly identified genes that encode proteins that are involved in the synthesis of L-ascorbic acid (hereinafter also referred to as Vitamin C) and/or...
8497101 Use of a new gene coding for a new member of the MCM2-8 family in pharmaceutical compositions  
The use of the human or animal MCM9 gene, or parts of the gene, or transcripts thereof, or antisense nucleic acids able to hybridize with part of the gene or transcripts, or silencing RNA derived...
7960152 Methods for production of xylitol in microorganisms  
The invention provides biosynthetic routes to xylitol production that do not require pure D-xylose for synthesis and that can utilize inexpensive substrates such as hemicellulose hydrolysates.
7135315 Aldehyde dehydrogenase gene  
The present invention relates to a novel DNA which encodes aldehyde dehydrogenase (SNDH), an expression vector containing the DNA and recombinant organisms containing said DNA. Furthermore, the...
7109004 Process for reducing an alpha-keto ester  
A process for preparing (R)-hydroxy ester (II) from alpha-keto ester I comprising adding the alpha-keto ester I to a mixture comprising the ketoreductase enzyme and non-ketoreductase enzyme...
7091013 Process for the manufacture of 2-keto-L-gulonic acid  
The present invention discloses a process for producing sodium 2-keto-L-gulonate from sorbitol and recovering 2-keto-L-gulonic acid in high recovery yields, by controlled cation exchange treatment...
7033804 Methods for the production of products in host cells  
The invention provides methods and host cells for the production of ascorbic acid intermediates. The invention also provides host cells having a modification in a polynucleotide that uncouples the...
6824996 Production of ascorbic acid  
The present invention provides for the production of ASA from yeast capable of producing ASA from KLG. The present invention provides methods for the production of ASA as well as recombinant yeast...
6730503 Alcohol/aldehyde dehydrogenase  
The present invention is directed to a recombinant enzymes having alcohol and aldehyde dehydrogenase activity which comprises one or mom recombinant polypeptides selected from the group consisting...
6670505 Process for the recovery of organic acids from aqueous solutions  
A process for recovering a desired organic acid from a solution includes the steps of: providing an aqueous solution including at least one desired organic acid or its acid anion; adjusting the...
6399340 Vector derivatives of gluconobacter plasmid pF4  
A DNA derived from plasmid pF4, which contains a region involved in the control of autonomous replication in a bacterial cell belonging to the genus Gluconobactor, with or without a part of the...
6271006 Enzymatic process for the manufacture of ascorbic acid, 2-keto-L-gulonic acid and esters of 2-keto-L-gulonic acid  
The present invention is directed toward efficient, high-yield processes for making ascorbic acid, 2-keto-L-gulonic acid, and esters of 2-keto-L-gulonic acid. The processes comprise reacting the...
6238897 Continuous process for producing 2-keto-L-gulonic acid  
A process for the continuous production of 2-keto-L-gulonic acid or a salt thereof from D-sorbitol by fermentation with microorganisms in a nutrient medium containing D-sorbitol that is incubated...
6187570 Electrodialysis methods for purification and recovery of gluconic acid derivatives  
A process for purifying and concentrating a gluconic acid derivative, such as 2-keto-L-gulonic acid, comprising introducing a non-viable and/or acidified fermentation medium or an in-vitro reactor...
5998180 Nitrilase from Rhodoccus rhodochrous for converting acrylonitrile directly to acrylic acid  
Nitrilase enzymes are provided which have Km at pH 7.0 for acrylonitrile of 500 μM or below. The enzymes also have Ki at pH 7.0 for ammonium acrylate of at least 100 mM. In particular, the...
5989891 Bacterial stains and use thereof in fermentation processes for 2-keto-L-gulonic acid production  
The present invention relates to a process for the production of 2-keto-L-gulonic acid by fermentative conversion of L-sorbose and/or D-sorbitol. The present invention further relates to novel...
5932463 Gluconobacter alcohol/aldehyde dehydrogenase  
The present invention relates to a novel alcohol/aldehyde dehydrogenase (hereinafter referred to as AADH), a process for producing the same and a process for producing aldehydes, carboxylic acids...
5916785 Process of oxidizing alcohols or carboxylic acids with alcohol/aldehyde dehydrogenase from gluconobacter  
The present invention relates to a novel alcohol/aldehyde dehydro-genase (hereinafter referred to as AADH), a process for producing the same and a process for producing aldehydes, carboxylic acids...
5900370 Process for the production of ascorbic acid with prototheca  
The present invention is directed to methods for the production of ascorbic acid by culturing organisms of the genus Prototheca and recovering ascorbic acid from the fermentation medium.
5888786 Method for producing 2-keto-L-gulonic acid  
An expression vector containing both a DNA encoding an L-sorbose dehydrogenase and a DNA encoding an L-sorbosone dehydrogenase; a transformant having an ability to produce 2-keto-L-gulonic acid...
5834231 Bacterial strains and use thereof in fermentation process for 2-keto-L-gulonic acid production  
The present invention relates to a process for the production of 2-keto-L-gulonic acid by fermentative conversion of L-sorbose and/or D-sorbitol. The present invention further relates to novel...
5804423 Microbiological method of making 5-ketogluconate  
A method is disclosed for preparing 5-ketogluconate, which comprises the steps of: (a) genetically modifying a microorganism capable of microbiologically producing 5-ketogluconate to increase...
5795761 Mutants of 2,5-diketo-D-gluconic acid (2,5-DKG) reductase A  
Mutants of 2,5-diketo-D-gluconic acid reductase A an enzyme used to produce 2-keto-L-gluconic acid, a precursor of ascorbic acid (vitamin C), are prepared by site-directed mutagenesis. These...
5792631 Microbial process for the production of ascorbic acid using Chlorella protothecoides  
The present invention is directed to methods for the production of ascorbic acid by culturing organisms of the species C. protothecoides and recovering ascorbic acid from the fermentation medium.
5776742 Aldehyde dehydrogenase enzyme  
An aldehyde dehydrogenase having the physico-chemical properties: molecular weight: 91,000±5,000; substrate specificity:active on aldehyde compounds; inhibition: by Cu2+, Zn2+, Ni2 + and...
5759826 Process of preparing an organic acid  
A process is disclosed for preparing an organic acid and/or its salts from a solution obtained through fermentation. In this process, a pure carbohydrate-containing raw material is used. The...
5747306 Process for producing 2-keto-L-gulonic acid using electrodialysis  
In a microbial process for producing 2-keto-L-gulonic acid (hereinafter sometimes referred to as 2KGA) by fermentation or microbial cell reaction with at least one microorganism capable of...
5705373 Production of 2-keto-L-gulonic acid using pseudogluconobacter saccharoketogenes with recycling  
A method for producing 2-keto-L-gulonic acid (hereinafter referred to as 2KGA) which comprises (1) culturing a microorganism capable of producing 2KGA from L-sorbose, in a liquid culture medium...
5635611 Production of saccharide carboxylic acids  
A process for producing a saccharide carboxylic acid or a salt thereof characterized in that a microorganism belonging to the genus Pseudogluconobacter and capable of oxidizing a hydroxymethyl...
5541108 Gluconobacter oxydans strains  
A process for producing 2-keto-L-gulonic acid which comprises converting L-sorbose and/or D-sorbitol into 2-keto-L-gulonic acid with the aid of a microorganism or its cell free extract, said...
5521090 L-ascorbic acid containing biomass of chlorella pyrenoidosa  
Microalgal biomass that comprises cells of Chlorella pyrenoidosa which contain greater than 2.0% by dry weight of L-ascorbic acid (Vitamin C), microorganisms and processes that form the biomass,...
5474924 Method for producing 2-keto-L-gulonic acid  
2-keto-L-gulonic acid is in high yield produced by contacting a microorganism of the genus Pseudogluconobacter, either as it is or after processing, with L-sorbose.
RE34851 Biosynthesis of 2 keto-L-gulonic acid  
A process of producing 2-keto-L-gulonic acid from sorbose via a recombinant bacteria including expression vectors and probes for producing said recombinant bacteria.
5352599 Co-enzyme-independent L-sorbosone dehydrogenase of gluconobacter oxydans: isolation, characterization, and cloning and autologus expression of the gene  
A novel coenzyme independent L-sorbosone dehydrogenase originating from a microorganism belonging to the genus Gluconobacter oxydans which acts on L-sorbosone to produce 2-keto-L-gulonic acid.The...
5312741 Process for producing 2-keto-L-gulonic acid  
The present invention relates to a process for producing 2-keto-L-gulonic acid by fermentative conversion of D-sorbitol in high yield. 2-Keto-L-gulonic acid is an important intermediate for the...
5234819 Method for preparing 2,5-diketo-D-gluconic acid  
2,5-Diketo-D-gluconic acid is prepared in high yield and in high broth concentration by cultivating newly isolated microorganisms of genus Erwinia in an aqueous nutrient medium in the presence of...
5134077 Microorganisms of the genus Erwinia useful for preparing 2,5-diketo-D-gluconic acid  
2,5-Diketo-D-gluconic acid is prepared in high yield and in high broth concentration by cultivating newly isolated microorganisms of genus Erwinia in an aqueous nutrient medium in the presence of...
5085993 Coenzyme-independent L-sorbosone dehydrogenase from Pseudomonas putida  
A coenzyme-independent L-sorbosone dehydrogenase has been prepared from a microorganism belong to the genus Pseudomonas, which acts on L-sorbosone to produce 2-keto-L-gulonic acid. The enzyme is...
5077206 Process for preparing L-rhamnose  
The invention provides a process for preparing L-rhamnose by hydrolyzing a rhamnosidic bond of a glycoside having rhamnose in a terminal position, by enzymatically hydrolyzing the glucoside with...
5032514 Metabolic pathway engineering to increase production of ascorbic acid intermediates  
In recombinant microorganisms which were rendered capable of converting 2,5-diketo-D-gluconic acid (2,5-DKG) to 2-keto-L-gulonic acid (2-KLG) by transfer of genetic material, the secondary...
5008193 Ascorbic acid intermediates and process enzymes  
Methods for producing ascorbic acid using recombinant means comprising the transfer of genetic material by conjugation, a host cell lacking, entirely or to such an extent as not to be commercially...
5004690 Ascorbic acid intermediates and process enzymes  
A process for the preparation of 2-keto-L-gulonic acid (2-KLG) from 2,5-diketo-D-gluconic acid (2,5-DKG) using a DNA sequence encoding 2,5-DKG reductase. The 2-KLG is a precursor for the synthesis...
5001059 L-ascorbic acid production in microorganisms  
Improved production of ascorbic acid is obtained empolying Chlorella as a microorganism source and growing the culture under a controlled pattern of carbon source supply. Greatly improved ratios...
4990441 Process for separating 2-keto-L-gulonic acid from a fermented medium  
2-Keto-L-gulonic acid is separated from a fermented medium containing the calcium salt of 2-keto-L-gulonic acid, by carrying out the following operations: separation of insolubles; removal of...
4960695 Fermentation process to produce 2-keto-L-gluonic acid  
A process of producing 2-keto-L-gulonic acid by fermentative conversion of L-sorbose utilizing a fermentation system composed of component produced from a microorganism having the identifying...
4945052 Production of a Vitamin C precursor using genetically modified organisms  
An enzyme for conversion of 2,5-diketo-D-gluconate (2,5-DKG) to 2-keto-L-gulonic acid (2-KLG) and a genetically modified organism that expresses all the fermentation enzymes needed to convert...
4935359 Fermentation process  
Disclosed is a fermentation process for the conversion of L-sorbose to 2-keto-L-gulonic acid, which is characterized in that a mixed culture of microorganisms is used, which comprises...
4933289 Biologically pure cultures of Pseudomonas sorbosoxidans useful for producing 2-keto-L-gulonic acid  
2-Keto-L-gulonic acid is produced in a high yield by contacting L-sorbose with a microorganism of Pseudomonas sorbosoxidans, or a processed material thereof.
4916068 Bioconversion production of ascorbic acid with L-galactono-1,4-oxidase  
Processes for the bioconversion production of L-ascorbic acid (Vitamin C), and to microorganisms (e.g., Candida Norvegensis MF-56, ATCC 20686 and Candida Norvegensis MF-78, ATCC 20732) and...
4892823 Method for producing 2-keto-L-gulonic acid  
2-Keto-L-gulonic acid is produced in a high yield by contacting L-sorbose with a microorganism of Pseudomonas sorbosoxidans, or a processed material thereof.

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