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8173384 Methods for analyzing or processing a heparin sample  
The invention relates to methods and products for analyzing or processing a heparin sample. In one embodiment, the methods comprise contacting the sample with heparinase I, heparinase II and...
8163496 Methods and kits for measuring von Willebrand factor  
Methods and kits for measuring levels of von Willebrand factor function in a sample without using a platelet aggregation agonist, such as ristocetin, comprising recombinant glycoprotein Ibα having ...
8163513 Method for determining the total clotting activity of a blood or plasma sample  
The invention relates to a method for determining the total clotting activity of a blood or plasma sample, characterized in that a highly specific, reversible thrombin inhibitor is added to a blood...
8133696 Method for determining thrombin activity  
Methods and kits to determine thrombin activity are provided. They have the great advantage that there is no need to measure the whole calibrator curve in each individual medium, since a...
8129135 Method for diagnosing cardiovascular diseases  
Method for diagnosing a cardiovascular disease in an individual comprising the steps of: providing a sample of an individual; determining the amount of cytokeratin-18 (CK-18) or fragments thereof...
8129195 Method for the production of an analytical element  
A method is provided for producing an analytical element comprising at least one test field for analyzing a liquid sample, wherein provision is made for a carrier on which a polymer fabric is...
8124025 Membrane system for blood coagulation testing  
Articles for testing a coagulation process in whole blood.
8114633 Methods for differentiating plasma-derived protein from recombinant protein in a sample  
The present invention relates, in general, to methods for detecting and quantitating plasma-derived protein and recombinant protein in a sample based on the difference in protein glycosylation,...
8076144 Protocol for risk stratification of ischemic events and optimized individualized treatment  
A hemostasis analyzer, such as the Thrombelastograph® (TEG®) hemostasis analyzer is utilized to measure continuously in real time, the hemostasis process from the initial fibrin formation, t...
8062591 Clinical laboratory test apparatus and clinical laboratory test system  
The clinical laboratory test apparatus includes: an analyzing unit for analyzing a specimen; a reception part for receiving specimen information before analysis of the specimen; a discrimination...
8058023 Assessment of cardiac health and thrombotic risk in a patient  
The invention features methods and compositions for assessing risk, particularly immediate risk, of thrombotic events in patients with suspected or known vascular disease, and more particularly to...
8048990 Modified vitamin K-dependent polypeptides  
The invention provides vitamin K-dependent polypeptides with enhanced membrane binding affinity. These polypeptides can be used to modulate clot formation in mammals. Methods of modulating clot...
8021854 Method of treating vascular disease  
A method for attenuating the incidence and severity of endovascular disease, arrhythmias and malignancy via a reduction in the total circulating platelet volume is presented. The method will...
8008086 Protocol for monitoring direct thrombin inhibition  
A hemostasis analyzer, such as the Thrombelastograph® (TEG®) hemostasis analyzer is utilized to measure continuously in real time, the hemostasis process from the initial fibrin formation, t...
7981597 Method for preparing agglutinatable, fixed platelet fragments  
The present invention relates to a method for preparing agglutinatable platelet fragments, in which native platelets are treated with ultrasound and a fixative. The platelet fragments are suitable...
7977106 Method for assaying coagulation in fluid samples  
This invention is a disposable cartridge for use at the patient side to perform traditional coagulation assays on fresh whole blood or blood derivative samples. The cartridge, in use with an...
7947505 Method for testing efficacy of antithrombotic agent  
The present invention provides a method for testing quickly and easily the manner in which an antithrombotic agent inhibits the acceleration of blood coagulation when a platelet agonist causes...
7943333 Diagnostic method for identifying carriers of the Marburg I variant of factor VII-activating protease (FSAP) on the basis of differential modulation of FSAP activity  
The present invention relates to a diagnostic method for identifying persons with genetically related hetero- or homozygous expression of the MR I variant of factor VII-activating protease (FSAP)....
7939288 Method for differentiating between factor XIII deficiency states and fibrinogen deficiency states by means of thrombelastographic techniques  
The invention relates to a method for determining a factor XIII deficiency, a method for determining a fibrinogen deficiency, and a method for differentiating between a factor XIII deficiency and a...
7939329 Protocol for risk stratification of ischemic events and optimized individualized treatment  
A hemostasis analyzer, such as the Thrombelastograph® (TEG®) hemostasis analyzer is utilized to measure continuously in real time, the hemostasis process from the initial fibrin formation, t...
7935498 Methods for identifying patients with increased risk of an adverse cardiovascular event  
Methods, compositions and kits are disclosed for identifying patients with an increased risk of experiencing an adverse cardiovascular event where the patient is undergoing aspirin antiplatelet...
7927626 Process of making flowable hemostatic compositions and devices containing such compositions  
The present invention is directed to processes of making flowable hemostatic compositions and devices that include the flowable hemostatic composition disposed therein, where a volume of a...
7923255 Method of detecting platelet thrombosis or organ failure  
A method of detecting platelet thrombosis or organ failure in a patient suffering from disseminated intravascular coagulation (DIC) or systemic inflammatory response syndrome (SIRS), comprising...
7923217 Specificity in the determination of antithrombin  
Methods and reagents for determining antithrombin III (AT) in body fluids by adding an AT binding partner to the sample and determining the free AT binding partner.
7906299 Assay for low molecular weight heparin  
A prothrombin time reagent for determination of low molecular weight heparin in fresh whole blood and in anti-coagulant treated blood is provided. The reagent is composed of recombinant animal...
7897333 Reagent for measuring clotting time and method for manufacturing the reagent  
A reagent for measuring clotting time is described. The reagent comprises a complex of a phospholipid and a recombinant tissue factor obtained by using an insect or a cultured insect cell as a...
7883698 Isolation and preservation of fetal hematopoietic and mesencymal system cells from non-controversial materials and/or tissues resulting from miscarriages and methods of therapeutic use  
The present invention is directed to compositions of fetal hematopoietic stem and progenitor cells and stromal (mesencymal) cells derived from second trimester (16-20 weeks gestation) miscarriages,...
7867771 Reagent for measuring clotting time and method for stabilizing tissue factor  
The present invention provides a reagent for measuring clotting time including a nonionic surfactant, a nickel ion and a tissue factor. A method for stabilizing a tissue factor, and use of a...
7829294 Anti-human soluble fibrin monoclonal antibody and immunological assay method using the antibody  
The present invention is directed to a monoclonal antibody against a soluble fibrin, which specifically recognizes a conformation-changed site newly occurred in a C-terminal region of an Aα-chain ...
7807107 Particle agglutination-evaluating container  
A particle agglutination-evaluating container for immunological analysis, based on an agglutinate formed in an agglutination reaction between an antibody- or antigen-containing sample and...
7803569 Marburg I mutant of factor VII activating protease (FSAP) as risk factor for arterial thrombosis and methods of detecting FSAP and FSAP mutations  
An arterial thrombosis risk factor comprising one or more of the identified mutants of coagulation factor VII activating protease (FSAP) is described. In addition, diagnostic determination methods...
7803570 Method for determining the concentration of thrombin inhibitors  
The invention relates to a method for determining the concentration of thrombin inhibitors in a non-turbid body liquid or a non-turbid extract from a body liquid. It comprises the following steps....
7790409 Blood coagulation accelerator and container for blood examination  
The present invention provides a blood coagulation accelerator excellent under severe conditions at ordinary or higher temperatures and capable of exhibiting high blood coagulation performance...
7790410 Method and apparatus for determining hemocompatibility  
Provided herein are techniques for screening materials for hemocompatibility. Hemocompatible materials may be advantageous when incorporated into devices that may come into direct contact with...
7785891 Device and methods for identifying and treating aspirin non-responsive patients  
The present invention relates to methods and compositions for identifying and treating subjects in need of antithrombotic therapies but who are not responsive to aspirin.
7785820 Method for automatically determining the endogenous thrombin potential  
The present invention relates to a method for automatically determining the endogenous thrombin potential of a blood or plasma sample.
7771996 FVII or FVIIa variants  
Variants of FVII or FVIIa comprising at least one amino acid modification in position 196, 237 or 341 relative to hFVII or hFVIIa. The variants exhibit an increased clotting activity, i.e. reduced...
7767459 Method for determining prothrombin time  
A method for determining prothrombin time of a plasma or whole blood sample includes measuring prothrombin time for at least two different dilutions for a test sample to determine tmin or INRmin....
7767458 Method for determining coagulation activation and device for carrying out said method  
A method is disclosed of assaying circulating microparticles contained in a sample of whole blood or blood plasma from a patient to determine the patient's ability to generate thrombin or Factor Xa...
7759082 Electroprocessed fibrin-based matrices and tissues  
The invention is directed to formation and use of electroprocessed fibrin as an extracellular matrix and, together with cells, its use in forming engineered tissue. The engineered tissue can...
7759083 Screening method for a growth inhibitor or promoter of a vascular smooth muscle cell  
It was found that TAT which has not been known biological activity has a role as a new blood vessel smooth muscle proliferation factor, and then a screening method vascular of an inhibitor or...
7754489 Protocol for risk stratification of ischemic events and optimized individualized treatment  
A hemostasis analyzer, such as the Thrombelastograph® (TEG®) hemostasis analyzer is utilized to measure continuously in real time, the hemostasis process from the initial fibrin formation, t...
7745224 Procedure for the standardization of coagulation tests  
The present invention lies in the field of coagulation diagnosis and relates to a procedure for the standardization of coagulation tests, where calibrators are used to which a discrete standard...
7741124 Detection procedures for fibrinogen and/or fibrinogen derivatives  
Described are determination procedures for fibrinogen and/or fibrinogen-derivatives by matrix-independent turbidimetry. In the FIFTA called procedure the fibrinogen activity is preferably...
7732213 Method of evaluating patient hemostasis  
A hemostasis analyzer, such as the Thrombelastograph® (TEG®) hemostasis analyzer is utilized to measure continuously in real time, the hemostasis process from the initial fibrin formation, t...
7727736 Soluble phospholipids for use in clotting factor assays  
The present invention provides a soluble phospholipid reagent and assays of clotting activity using the same. The methods of the invention can be used to carry out any clotting assay or other assay...
7723064 Methods for monitoring patients for efficacy of an antiplatelet therapy regimen  
Methods are disclosed for monitoring patients utilizing Mean Platelet Component values during therapeutic intervention.
7718412 Hemostatic compositions containing sterile thrombin  
The present invention includes sterilized hemostatic compositions that contain a continuous, biocompatible liquid phase having a solid phase of particles of a biocompatible polymer suitable for use...
7718763 Substrate polyeptides for von Willebrand factor cleaving protease ADAMTS-13  
The present invention relates to specific substrates for a von Willebrand factor cleaving enzyme, ADAMTS-13, as well as to diagnosis of ADAMTS-13 deficient patients, diagnostic compositions, and...
7682808 Coagulation and fibrinolytic cascades modulator  
A thromboplastin reagent comprises (i) TF, (ii) a phospholipid, and (iii) a polyP TFPI blocker.