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7595169 |
Method for determining percent platelet aggregation
A method for obtaining a percent aggregation or inhibition of platelets resulting from anti-platelet using a single blood sample is achieved. An assay device is provided. The assay device has...
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7588942 |
Standard/reference/control for blood coagulation testing
A whole-blood-based substitute composition that is useful in coagulation assays as a standard, reference, control, calibrator, linearity verifier, or training material is prepared by combining a...
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7585642 |
Methods for evaluating the quality of a heparin sample
The invention relates to methods and products for characterizing and using polysaccharides. Low molecular weight heparin products and methods of use are described. Methods for characterizing purity...
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7557188 |
Methods of treating blood coagulation disorders using a pharmaceutical preparation comprising vWF propeptide
Described is a pharmaceutical preparation for treating blood coagulation disorders comprising an effective amount of vWF propeptide as well as a method for producing such a preparation.
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7544660 |
Factor VIII polypeptide having factor VIII:C activity
Factor VIII polypeptides having FVIII:C activity that contain modifications in the A3 and/or C1 and/or C2 domains of the sequence of the light chain of Factor VIII, characterized by the binding...
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7510879 |
Detection procedures for fibrinogen and/or fibrinogen derivatives
Described are determination procedures for fibrinogen and/or fibrinogen-derivatives by matrix-independent turbidimetry. In the FIFTA called procedure the fibrinogen activity is preferably...
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7498146 |
Stable factor VIII/von willebrand factor complex
There are disclosed a stable factor VIII/vWF-complexes, particularly comprising high-molecular vWF multimers, being free from low-molecular vWF molecules and from proteolytic vWF degradation...
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7494782 |
Assay for measuring factor viia-antithrombin complexes
A method for determining the concentration of factor VIIa-antithrombin complexes is disclosed which has application to estimating the level of intravascular exposure of tissue factor, assessing...
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7470519 |
Methods for detecting TAFIa or TAFIai
The invention relates to a diagnostic assay for selectively measuring levels of the 35kD form of thrombin-activatable fibrinolysis inhibitor (TAFIa or TAFIai), or a derivative or variant thereof,...
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7442514 |
Mutants of the factor VII-activating protease and detection methods using specific antibodies
Mutants of the DNA sequence coding for the protease (FSAP) which activates blood clotting factor VII and single-chain plasminogen activators, the mutants comprising a G/C base exchange at...
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7439069 |
Blood coagulation test cartridge, system, and method
A system and method for determining a coagulation time, e.g., thrombin time, PT, aPTT, and ACT, of a blood sample deposited in a test cartridge is disclosed. The test cartridge includes a blood...
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7432352 |
Hybrid molecules having Factor VII/VIIa activity
The present invention relates to novel human coagulation Factor VII/VIIa proteins having coagulant potential/activity as well as pharmaceutical compositions comprising the proteins, uses thereof,...
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7422905 |
Blood coagulation test cartridge, system, and method
A system and method for determining a coagulation time, e.g., TT, PT, aPTT, and ACT, of a test sample deposited in a test cartridge is disclosed. A cartridge housing having upper and lower major...
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7399637 |
Blood coagulation test cartridge, system, and method
A system and method for determining a coagulation time, e.g., TT, PT, aPTT, and ACT, of a blood test sample deposited in a test cartridge is disclosed. A cartridge housing having upper and lower...
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7399604 |
Methods and products related to evaluating the quality of a polysaccharide
The invention relates to methods and products for characterizing and using polysaccharides. Low molecular weight heparin products and methods of use are described. Methods for characterizing purity...
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7381536 |
Assessment of cardiac health and thrombotic risk in a patient
The invention features methods and compositions for assessing risk, particularly immediate risk, of thrombotic events in patients with suspected or known vascular disease, and more particularly to...
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7378393 |
Recombinant anticoagulant proteins
Novel recombinant anticoagulation proteins, methods of their use and methods of their production are described. In particular, recombinant fusions of annexin V (ANV) and Kunitz protease inhibitors...
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7361306 |
Device and method for measuring coagulation time and platelet activity
The present invention refers to a novel device for measuring coagulation time and platelet activity wherein the patient can measure his or her coagulation time and platelet activity without the aid...
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7357916 |
Method for creating a uniform vascular wound in zebrafish or zebrafish larva
Disclosed are improved methods for creating a uniform vascular wound in a zebrafish larva or zebrafish. The methods illustratively include subjecting a zebrafish larva to laser irradiation in an...
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7323315 |
Method for reducing effect of hematocrit on measurement of an analyte in whole blood
A method for determining the presence and/or amount of an analyte in a sample of whole blood comprises the step of treating the sample with a nonlytic hypertonic salt composition to reduce the...
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7316911 |
Method for treatment of indwelling catheter occlusion using fibrinolytic metalloproteinases
A method is provided for the localized intravascular administration of a fibrinolytic metalloproteinase to a human subject in amounts that are both safe and effective to lyse an occluding...
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7314728 |
Methods of treating peripheral arterial occlusions
A method is provided for the localized intravascular administration of a fibrinolytic metalloproteinase to a human subject in amounts that are both safe and effective to lyse an occluding...
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7314616 |
Additive containing an anti-fungal amount of a salt of formic acid
An additive for controlling the growth of spores of a fungi growth which is adapted to be added to an aqueous system comprising a salt of formic acid. The salt of formic acid is a metal salt or an...
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7309607 |
Method and device for monitoring platelet function
The invention provides a method of monitoring platelet function in a mammal by passing blood removed from the body of the mammal through a passageway to contact an obstruction or irregularity in...
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7297551 |
Recombinant proteins and peptides for endotoxin biosensors, endotoxin removal, and anti-microbial and anti-endotoxin therapeutics
Recombinant fragments of Factor C are disclosed. These proteins and peptides show great potency in recognizing, binding to, neutralizing and removing endotoxin. These molecules can thus be used for...
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7294479 |
Compositions, kit and one-step method for monitoring compounds having anti-factor Xa and/or anti factor IIa activities
Provided are compositions and methods for accurate determination of the concentration of anticoagulant in a sample such as a blood or plasma sample. The compositions can contain a Factor X compound...
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7276376 |
Analyzing method of a blood coagulation reaction
An analyzing method of a blood coagulation reaction by detecting an optical change of a blood sample with an elapse of time, the method includes: setting at least one checkpoint or check region...
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7270972 |
Process for producing subunit peptide originating in polymer protein
It is provided a method for producing a subunit peptide originating from an oligomeric protein having disulfide bonds within a subunit and between subunits. The method comprises producing a subunit...
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7252959 |
Assays for diagnosis of thrombophilic disease
The present invention provides methods for diagnosing and/or monitoring thrombophilic disease in a patient that can result from the antiphospholipid antibody syndrome (aPL syndrome). The methods of...
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7235377 |
Global test of the hemostatic system
The instant invention describes a method for establishing the hemostatic competence of blood, wherein the steps of the method include obtaining a blood sample from a subject, contacting the blood...
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7220553 |
Use of Russell's viper venom-induced plasma factor Xa activity to monitor the activity of factor Xa inhibitors
The invention relates to a method of monitoring the effect of a direct of indirect Factor Xa inhibitors comprising the steps of collecting a plasma sample from a patient, adding a solution of...
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7208288 |
Methods for enhancing the lysis of coagulated blood with apolipoprotein E2 phenotype
Methods for enhancing the lysis of coagulated blood comprise administering to coagulated blood a combination of clot clysis agent and a lysis enhancing amount of apolipoprotein E2 (Apo E2) or a...
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7202048 |
Onset of force development as a marker of thrombin generation
Platelet contractile force (PCF) is used as a surrogate marker of thrombin generation. PCF generation occurs concomitant with the burst of prothrombin fragment F 1+2 release. The time between assay...
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7192726 |
Method of using platelet contractile force and whole blood clot elastic modulus as clinical markers
Platelet contractile force and/or clot elastic modulus measurements are used to identify patients at risk for atherosclerosis or for bleeding during surgical procedures or other applications....
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7179652 |
Protocol for monitoring platelet inhibition
A hemostasis analyzer, such as the Thrombelastograph® (TEG®) hemostasis analyzer is utilized to measure continuously in real time, the hemostasis process from the initial fibrin formation,...
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7172878 |
Method for determining the concentration of thrombin inhibitors and kits therefor
The invention relates to a method for determining the concentration of thrombin inhibitors in a non-turbid body liquid or a non-turbid extract from a body liquid. It comprises the following steps....
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7169572 |
Assays for determining anticoagulant cofactor activity
Methods are disclosed for determining, in a sample derived from a human, the functional activity of a component of the human blood coagulation system, which activity can be correlated to conversion...
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7135305 |
Methods for controlling the lysis of coagulated blood with apolipoprotein e4 phenotype
Methods for inhibiting lysis of coagulated blood and reducing risk of excessive lysis comprising administration of lysis-inhibiting amounts of apolipoprotein E4, and methods for inhibiting lysis of...
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7118880 |
Kits for screening for blood coagulation disorders
In vitro methods for qualitative screening and/or quantitative determination of the functional activity of components of the Protein C anticoagulant pathway of blood coagulation are described. The...
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7087722 |
Fibrin binding domain polypeptides and uses and methods of producing same
This invention provides an imaging agent which comprises a polypeptide labeled with an imageable marker, such polypeptide having an amino acid sequence substantially present in the fibrin binding...
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7084113 |
Protein having antithrombotic activity and method for producing the same
A method for producing a protein having an antithrombotic activity, which comprises replacing, in a protein that has an amino acid sequence having a homology of not less than 30% to the amino acid...
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7083937 |
Methods and products related to the analysis of polysaccarides
The invention relates to methods and products for characterizing and using polysaccharides. Low molecular weight heparin products and methods of use are described. Methods for characterizing purity...
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7074582 |
Method for assessing coagulation
A method for assessing coagulation in a test sample is provided wherein an activator is added to a test sample in an amount sufficient to trigger a thrombin explosion dependent on propagation phase...
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7060505 |
Assay device
An assay device and method are provided which allow the determination of the presence or absence of at least one analyte in a test sample, while providing specific identification of the test...
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7056722 |
Apparatus and method of preparation of stable, long term thrombin from plasma and thrombin formed thereby
A sterile method for preparing stable thrombin component from a single donor's plasma in which the thrombin component is harvested simultaneously from the clotting and adhesive proteins component...
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7049087 |
Method for manufacturing a tissue factor-based prothrombin time reagent
A method for manufacturing a tissue factor-based prothrombin-time reagent includes combining predetermined quantities of tissue factor (TF), phospholipid and detergent-containing buffer to create a...
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7041458 |
Methods and reagents for determining protein S
The present invention relates to an assay for free protein S comprising the addition of a ligand specific for free protein S to a biological fluid sample to form a protein S/ligand complex, and...
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7026129 |
IG lambda biopolymer markers predictive of Alzheimers disease
The instant invention involves the use of a combination of preparatory steps in conjunction with mass spectroscopy and time-of-flight detection procedures to maximize the diversity of biopolymers...
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7026111 |
Methods and reagents for improved cell-based assays
The ability to efficiently determine the state of enzyme expression in cells has long been desired as material to the diagnosis of disease. This invention relates to cytoenzymology, and more...
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7011956 |
Thrombotic episode risk assays using oxidized phospholipids
An assay to assess thrombotic risk in which oxidized lipids comprising phospholipids are utilized as a membrane source in a clotting assay and the results compared to an assay in which unoxidized...
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