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7595169 Method for determining percent platelet aggregation  
A method for obtaining a percent aggregation or inhibition of platelets resulting from anti-platelet using a single blood sample is achieved. An assay device is provided. The assay device has...
7588942 Standard/reference/control for blood coagulation testing  
A whole-blood-based substitute composition that is useful in coagulation assays as a standard, reference, control, calibrator, linearity verifier, or training material is prepared by combining a...
7585642 Methods for evaluating the quality of a heparin sample  
The invention relates to methods and products for characterizing and using polysaccharides. Low molecular weight heparin products and methods of use are described. Methods for characterizing purity...
7557188 Methods of treating blood coagulation disorders using a pharmaceutical preparation comprising vWF propeptide  
Described is a pharmaceutical preparation for treating blood coagulation disorders comprising an effective amount of vWF propeptide as well as a method for producing such a preparation.
7544660 Factor VIII polypeptide having factor VIII:C activity  
Factor VIII polypeptides having FVIII:C activity that contain modifications in the A3 and/or C1 and/or C2 domains of the sequence of the light chain of Factor VIII, characterized by the binding...
7510879 Detection procedures for fibrinogen and/or fibrinogen derivatives  
Described are determination procedures for fibrinogen and/or fibrinogen-derivatives by matrix-independent turbidimetry. In the FIFTA called procedure the fibrinogen activity is preferably...
7498146 Stable factor VIII/von willebrand factor complex  
There are disclosed a stable factor VIII/vWF-complexes, particularly comprising high-molecular vWF multimers, being free from low-molecular vWF molecules and from proteolytic vWF degradation...
7494782 Assay for measuring factor viia-antithrombin complexes  
A method for determining the concentration of factor VIIa-antithrombin complexes is disclosed which has application to estimating the level of intravascular exposure of tissue factor, assessing...
7470519 Methods for detecting TAFIa or TAFIai  
The invention relates to a diagnostic assay for selectively measuring levels of the 35kD form of thrombin-activatable fibrinolysis inhibitor (TAFIa or TAFIai), or a derivative or variant thereof,...
7442514 Mutants of the factor VII-activating protease and detection methods using specific antibodies  
Mutants of the DNA sequence coding for the protease (FSAP) which activates blood clotting factor VII and single-chain plasminogen activators, the mutants comprising a G/C base exchange at...
7439069 Blood coagulation test cartridge, system, and method  
A system and method for determining a coagulation time, e.g., thrombin time, PT, aPTT, and ACT, of a blood sample deposited in a test cartridge is disclosed. The test cartridge includes a blood...
7432352 Hybrid molecules having Factor VII/VIIa activity  
The present invention relates to novel human coagulation Factor VII/VIIa proteins having coagulant potential/activity as well as pharmaceutical compositions comprising the proteins, uses thereof,...
7422905 Blood coagulation test cartridge, system, and method  
A system and method for determining a coagulation time, e.g., TT, PT, aPTT, and ACT, of a test sample deposited in a test cartridge is disclosed. A cartridge housing having upper and lower major...
7399637 Blood coagulation test cartridge, system, and method  
A system and method for determining a coagulation time, e.g., TT, PT, aPTT, and ACT, of a blood test sample deposited in a test cartridge is disclosed. A cartridge housing having upper and lower...
7399604 Methods and products related to evaluating the quality of a polysaccharide  
The invention relates to methods and products for characterizing and using polysaccharides. Low molecular weight heparin products and methods of use are described. Methods for characterizing purity...
7381536 Assessment of cardiac health and thrombotic risk in a patient  
The invention features methods and compositions for assessing risk, particularly immediate risk, of thrombotic events in patients with suspected or known vascular disease, and more particularly to...
7378393 Recombinant anticoagulant proteins  
Novel recombinant anticoagulation proteins, methods of their use and methods of their production are described. In particular, recombinant fusions of annexin V (ANV) and Kunitz protease inhibitors...
7361306 Device and method for measuring coagulation time and platelet activity  
The present invention refers to a novel device for measuring coagulation time and platelet activity wherein the patient can measure his or her coagulation time and platelet activity without the aid...
7357916 Method for creating a uniform vascular wound in zebrafish or zebrafish larva  
Disclosed are improved methods for creating a uniform vascular wound in a zebrafish larva or zebrafish. The methods illustratively include subjecting a zebrafish larva to laser irradiation in an...
7323315 Method for reducing effect of hematocrit on measurement of an analyte in whole blood  
A method for determining the presence and/or amount of an analyte in a sample of whole blood comprises the step of treating the sample with a nonlytic hypertonic salt composition to reduce the...
7316911 Method for treatment of indwelling catheter occlusion using fibrinolytic metalloproteinases  
A method is provided for the localized intravascular administration of a fibrinolytic metalloproteinase to a human subject in amounts that are both safe and effective to lyse an occluding...
7314728 Methods of treating peripheral arterial occlusions  
A method is provided for the localized intravascular administration of a fibrinolytic metalloproteinase to a human subject in amounts that are both safe and effective to lyse an occluding...
7314616 Additive containing an anti-fungal amount of a salt of formic acid  
An additive for controlling the growth of spores of a fungi growth which is adapted to be added to an aqueous system comprising a salt of formic acid. The salt of formic acid is a metal salt or an...
7309607 Method and device for monitoring platelet function  
The invention provides a method of monitoring platelet function in a mammal by passing blood removed from the body of the mammal through a passageway to contact an obstruction or irregularity in...
7297551 Recombinant proteins and peptides for endotoxin biosensors, endotoxin removal, and anti-microbial and anti-endotoxin therapeutics  
Recombinant fragments of Factor C are disclosed. These proteins and peptides show great potency in recognizing, binding to, neutralizing and removing endotoxin. These molecules can thus be used for...
7294479 Compositions, kit and one-step method for monitoring compounds having anti-factor Xa and/or anti factor IIa activities  
Provided are compositions and methods for accurate determination of the concentration of anticoagulant in a sample such as a blood or plasma sample. The compositions can contain a Factor X compound...
7276376 Analyzing method of a blood coagulation reaction  
An analyzing method of a blood coagulation reaction by detecting an optical change of a blood sample with an elapse of time, the method includes: setting at least one checkpoint or check region...
7270972 Process for producing subunit peptide originating in polymer protein  
It is provided a method for producing a subunit peptide originating from an oligomeric protein having disulfide bonds within a subunit and between subunits. The method comprises producing a subunit...
7252959 Assays for diagnosis of thrombophilic disease  
The present invention provides methods for diagnosing and/or monitoring thrombophilic disease in a patient that can result from the antiphospholipid antibody syndrome (aPL syndrome). The methods of...
7235377 Global test of the hemostatic system  
The instant invention describes a method for establishing the hemostatic competence of blood, wherein the steps of the method include obtaining a blood sample from a subject, contacting the blood...
7220553 Use of Russell's viper venom-induced plasma factor Xa activity to monitor the activity of factor Xa inhibitors  
The invention relates to a method of monitoring the effect of a direct of indirect Factor Xa inhibitors comprising the steps of collecting a plasma sample from a patient, adding a solution of...
7208288 Methods for enhancing the lysis of coagulated blood with apolipoprotein E2 phenotype  
Methods for enhancing the lysis of coagulated blood comprise administering to coagulated blood a combination of clot clysis agent and a lysis enhancing amount of apolipoprotein E2 (Apo E2) or a...
7202048 Onset of force development as a marker of thrombin generation  
Platelet contractile force (PCF) is used as a surrogate marker of thrombin generation. PCF generation occurs concomitant with the burst of prothrombin fragment F 1+2 release. The time between assay...
7192726 Method of using platelet contractile force and whole blood clot elastic modulus as clinical markers  
Platelet contractile force and/or clot elastic modulus measurements are used to identify patients at risk for atherosclerosis or for bleeding during surgical procedures or other applications....
7179652 Protocol for monitoring platelet inhibition  
A hemostasis analyzer, such as the Thrombelastograph® (TEG®) hemostasis analyzer is utilized to measure continuously in real time, the hemostasis process from the initial fibrin formation,...
7172878 Method for determining the concentration of thrombin inhibitors and kits therefor  
The invention relates to a method for determining the concentration of thrombin inhibitors in a non-turbid body liquid or a non-turbid extract from a body liquid. It comprises the following steps....
7169572 Assays for determining anticoagulant cofactor activity  
Methods are disclosed for determining, in a sample derived from a human, the functional activity of a component of the human blood coagulation system, which activity can be correlated to conversion...
7135305 Methods for controlling the lysis of coagulated blood with apolipoprotein e4 phenotype  
Methods for inhibiting lysis of coagulated blood and reducing risk of excessive lysis comprising administration of lysis-inhibiting amounts of apolipoprotein E4, and methods for inhibiting lysis of...
7118880 Kits for screening for blood coagulation disorders  
In vitro methods for qualitative screening and/or quantitative determination of the functional activity of components of the Protein C anticoagulant pathway of blood coagulation are described. The...
7087722 Fibrin binding domain polypeptides and uses and methods of producing same  
This invention provides an imaging agent which comprises a polypeptide labeled with an imageable marker, such polypeptide having an amino acid sequence substantially present in the fibrin binding...
7084113 Protein having antithrombotic activity and method for producing the same  
A method for producing a protein having an antithrombotic activity, which comprises replacing, in a protein that has an amino acid sequence having a homology of not less than 30% to the amino acid...
7083937 Methods and products related to the analysis of polysaccarides  
The invention relates to methods and products for characterizing and using polysaccharides. Low molecular weight heparin products and methods of use are described. Methods for characterizing purity...
7074582 Method for assessing coagulation  
A method for assessing coagulation in a test sample is provided wherein an activator is added to a test sample in an amount sufficient to trigger a thrombin explosion dependent on propagation phase...
7060505 Assay device  
An assay device and method are provided which allow the determination of the presence or absence of at least one analyte in a test sample, while providing specific identification of the test...
7056722 Apparatus and method of preparation of stable, long term thrombin from plasma and thrombin formed thereby  
A sterile method for preparing stable thrombin component from a single donor's plasma in which the thrombin component is harvested simultaneously from the clotting and adhesive proteins component...
7049087 Method for manufacturing a tissue factor-based prothrombin time reagent  
A method for manufacturing a tissue factor-based prothrombin-time reagent includes combining predetermined quantities of tissue factor (TF), phospholipid and detergent-containing buffer to create a...
7041458 Methods and reagents for determining protein S  
The present invention relates to an assay for free protein S comprising the addition of a ligand specific for free protein S to a biological fluid sample to form a protein S/ligand complex, and...
7026129 IG lambda biopolymer markers predictive of Alzheimers disease  
The instant invention involves the use of a combination of preparatory steps in conjunction with mass spectroscopy and time-of-flight detection procedures to maximize the diversity of biopolymers...
7026111 Methods and reagents for improved cell-based assays  
The ability to efficiently determine the state of enzyme expression in cells has long been desired as material to the diagnosis of disease. This invention relates to cytoenzymology, and more...
7011956 Thrombotic episode risk assays using oxidized phospholipids  
An assay to assess thrombotic risk in which oxidized lipids comprising phospholipids are utilized as a membrane source in a clotting assay and the results compared to an assay in which unoxidized...