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8153406 |
Microorganism
A microorganism which is Rhodococcus rhodochrous strain NCIMB 41164 or a mutant thereof. A method of culturing the microorganism in a culture medium comprising urea or urea derivative is claimed. A...
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8143033 |
Process for producing (meth)acrylamide
A process for producing (meth)acrylamide using a microbial catalyst, wherein production steps can be simplified and production cost can be reduced. The process for producing (meth)acrylamide of the...
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8062870 |
Enantiomerically resolving acyloxyalkyl thiocarbonates used in synthesizing acyloxyalkyl carbamate prodrugs
Methods of enzymatically resolving acyloxyalkyl thiocarbonates useful in the synthesis of acyloxyalkyl carbamate prodrugs are disclosed.
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8003771 |
Compositions, probes and conjugates and uses thereof
The present invention relates to compositions useful as probes and in other applications and methods of their use. In some embodiments, nucleotides are prepared and functionalized with dyes. In...
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7993886 |
Catalyzed preparation of (meth)acrylates of N-hydroxyalkylated amides
The claimed invention relates to a process for preparing (meth)acrylates of N-hydroxyalkylated amides, in which open-chain N-hydroxyalkylated amides are esterified with (meth)acrylic acid or...
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7943359 |
Polynucleotides which code for cyanide-tolerant nitrile hydratase and compositions thereof
Disclosed herein are cyanide-tolerant nitrile hydratases especially from Pseudomonas putida or Pseudomonas marginalis strains which exhibit increased cyanide tolerance. Also disclosed are methods...
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7906596 |
Processes for enzymatic synthesis of poly(oxyalkylene)acrylamides
Processes for enzymatic synthesis comprising: (a) providing an aliphatic poly(oxyalkylene)amine; and (b) reacting the aliphatic poly(oxyalkylene)amine with a reactant selected from the group...
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7838271 |
Microbiological method for producing amides
The present invention provides for microorganisms capable of tolerating acetonitrile concentrations of at least 3 M, enzyme extracts obtainable from these microorganisms, a nitrile hydratase...
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7829657 |
Polycationically charged polymer and the use of the same as a carrier for nucleic acid
Disclosed is a composition for the delivery of nucleic acid to target cells or tissues, which comprises a polycationically charged polymer as a carrier of nucleic acid. The polycationically charged...
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7820416 |
Process for producing amide compound and acrylamide polymer
In a method for producing an amide compound of the present invention including obtaining an amide compound from a nitrile compound using a microbial catalyst and transferring a solution containing...
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7816106 |
Manufacture of amides
A method of producing an amide from the corresponding nitrile comprising the following steps, i) providing a microorganism capable of producing a nitrile hydratase biocatalyst, ii) culturing the...
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7749739 |
Process for producing amide compound using microbial catalyst
This invention relates to a process for producing an amide compound from a nitrile compound using a microbial catalyst, wherein a microbial cell having nitrile hydratase activity of 50 U or higher...
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7741097 |
Process for the preparation of amides
A novel biotechnological process for the preparation of nitriles, starting from amides, is described. Micro-organisms of the genus Amycolatopsis, Actinomadura or Rhodococcus are employed for this...
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7700330 |
Method of purifying amide compound
The invention is to provide a process for effectively removing impurities contained in an amide compound-containing solution by making an amide compound-containing solution, particularly an amide...
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7687553 |
Method for treating bone cancer pain or chemotherapy induced pain
The present invention is directed to the use of a class of peptide compounds for treating tumor pain, in particular bone cancer pain, for treating chemotherapy-induced pain and for treating...
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7674924 |
Compositions, probes, and conjugates and uses thereof
The present invention relates to compositions useful as probes and in other applications and methods of their use. In some embodiments, nucleotides are prepared and functionalized with dyes. In...
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7666635 |
Process for the preparation of amides
A novel biotechnological process for the preparation of nitriles, starting from amides, is described. Micro-organisms of the genus Amycolatopsis, Actinomadura or Rhodococcus are employed for this...
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7612030 |
Enzymatic production of peracids using perhydrolytic enzymes
A process is provided to produce a concentrated aqueous peracid solution in situ using at least one enzyme having perhydrolase activity in the presence of hydrogen peroxide (at a concentration of...
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7592165 |
Process for the enzymatic preparation of an amide from a nitrile
Disclosed herein are cyanide-tolerant nitrile hydratases especially from Pseudomonas putida or Pseudomonas marginalis strains which exhibit increased cyanide tolerance. Also disclosed are methods...
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7592164 |
Process for preparing unsaturated amides and carboxylic acids
A process of producing an amide from a nitrile by the action of a nitrile hydratase enzyme or ammonium salt of an ethylenically unsaturated carboxylic acid from an amide by the action of amidase...
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7556956 |
Enzymes for the preparation of amides
A novel biotechnological process for the preparation of nitriles, starting from amides, is described. Micro-organisms of the genus Amycolatopsis, Actinomadura or Rhodococcus are employed for this...
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7553646 |
Microbial sulfoxidation and amidation of benzhdrylsulfanyl carboxylic acids and uses thereof
The present invention provides novel methods for the synthesis of racemic and enantiomers of modafinil via microbial oxidation-amidation transformation. The methods include the successive...
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7491521 |
Rhodococcus nitrile hydratase
The invention relates to a Rhodococcus polynucleotide cluster which contains nucleotide sequences which encode polypeptides having the activity of a nitrile hydratase, of an auxiliary protein P15K...
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7445793 |
Support for tissue regeneration and process for producing the same
The present invention provides a scaffold in which cells can be stably retained and grafted in a uniform distribution state in the culture, preferable proliferation ability and viability can be...
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7399616 |
Enzymatic synthesis of Nα-acyl-L-arginine esters
The invention relates to a process for preparing a Na-acyl-L-arginine ester, derived from fatty acids and esterified dibasic amino acids, according to the following formula (I), where: X— is B...
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7344868 |
Method for synthesizing ceramide-type compounds
The invention relates to the fields of fatty substance chemistry, specifically of the ceramide-type compound synthesis. The invention resides substantially in the synthesis of ceramide-type...
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7316918 |
Process for the preparation of (−) modafinil
An enzymatic process for the preparation of intermediates useful in the synthesis of (−) modafinil.
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7309590 |
Method for producing an aqueous acrylamide solution with a biocatalyst
The invention relates to a method and device for producing an aqueous acrylamide solution by hydrating acrylonitrile in an aqueous solution while in the presence of a biocatalyst.
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7244595 |
Method of maintaining or improving a nitrile hydratase activity
The object of this invention is to provide a method which not only maintains the nitrile hydratase activity of a nitrile hydratase-containing cell or a treated material of the cell under conditions...
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7241602 |
Nucleic acid sequences encoding enantioselective amidases
The invention relates to nucleic acid sequence encoding enantioselective amides with an amino acid sequence of SEQ ID NO: 2. The invention also relates to a process for fermentation, comprising a...
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7238503 |
Process for making fluoroleucine ethyl esters
The instant invention describes a novel reaction that includes spontaneous racemization of an azalactone via enol tautomerization. This racemization results in improved yield and ee over other...
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7208631 |
2-alkylcysteinamide or salt thereof, process for producing these, and use of these
A process for producing a 2-alkylcysteinamide, which comprises hydrolysis of a 4-alkylthiazolidine-4-carboxamide represented by the general formula (2) or a salt thereof: wherein R represents a...
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7205133 |
Process for producing acrylamide using a microbial catalyst having been washed with aqueous acrylic acid solution
Provided is a process for producing acrylamide with good storage stability and improved acrylamide polymer physical properties using a microbial catalyst. A microbial catalyst having catalytic...
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7189543 |
Method for producing cadaverine dicarboxylate
Cadaverine dicarboxylate is produced by performing an enzymatic decarboxylation reaction of a lysine solution while adding a dicarboxylic acid containing 4 to 10 carbons to the lysine solution to...
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7129059 |
Process for the preparation of compounds with enhanced optical purity
A process for preparation of a compound with enhanced optical purity is disclosed wherein a mixture of the enantiomers of a chiral amine is brought into contact with an enzyme having peptide...
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7129217 |
Aqueous acrylamide solution containing saccharide
This invention provides an aqueous solution of acrylamide that is useful as a starting material for high-quality polyacrylamide. Starting materials for polyacrylamide are an aqueous solution of...
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7078199 |
Method of manufacturing compound with biocatalyst by using controlled reaction temperature
Provided is a method for producing a compound using a biocatalyst. In the method for continuously producing a compound using a biocatalyst in one or a plurality of reaction tanks, the downstream...
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7056707 |
Bioactive compound and its isolation and method of treatment for lipoxygenase inhibition and as free radical scavenging agent
The present invention relates to a novel compound having a molecular formula C13H15NO5 having molecular structure of Formula I and a process for the isolation of said compound. The present...
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7049107 |
Method of producing phosphatidylserine
A novel method of producing PS is described herein. The method first involves producing PLD enzyme through the use of enzyme-producing microorganisms. The PLD enzyme is reacted with a lecithin and...
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7015309 |
Pyrrhocoricin-derived peptides, and methods of use thereof
Modifications of the peptide pyrrhocoricin permit the production of a variety of anti-bacterial or anti-fungal peptides having general formula...
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7005281 |
Enzymatic process for preparing organosilicon group containing photoinitiators
The invention relates to a process for preparing organosilicon group containing photoinitiators of the formula (I), wherein m is a number from 1 to 200; q is 0 or 1; A is IN-C(O)—O—CHR3—Y— or IN-C...
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6955911 |
Method of culturing microorganism
In cultivating a microorganism having nitrile hydratase production ability, by allowing at least one of a ketose, such as fructose, and a sugar alcohol, such as mannitol, to be present, growth...
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6951746 |
Method of manufacturing polyamine composition
After yeast somatic components are digested with nuclease or hydrolyzed with alkali, polyamine is recovered to obtain a polyamine composition in volume efficiently at a high recovery rate from...
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6900037 |
Method for producing amide compounds
The present invention provides a method for producing amide compounds using hydroxyl nitrile compounds and microorganisms and/or enzymatically active material having cyanide-resistant nitrile...
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6897058 |
Method for the preparation of enantiomerically enriched amines
Method for the preparation of an enantiomerically enriched acylated amine wherein a phenylacetic acid derivative is brought into contact with a mixture of enantiomers of an amine H2NCR1R2R3, in...
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6858414 |
Multistage process for the preparation of highly pure deferoxamine mesylate salt
The present invention provides a purification process whereby deferoxamine B produced by a microorganism and in mixture with other polyhydroxamates produced by the microorganism may be converted...
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6849432 |
Process for producing amide compounds
The invention is a process for continuously producing an amide compound by reacting a microorganism fungus body containing nitrile hydratase or a processed product of the microorganism fungus body...
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6743608 |
Process for the preparation of substituted 3-phenyl-propanoic acid esters and substituted 3-phenyl-propanoic acids
The present invention relates to a process comprising hydrolysis or trans esterification of one of the two enantiomeric forms of a racemic or enantiomerically enriched ester of formula I or IV by a...
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6699682 |
Assay for inhibitors of fatty-acid amide hydrolase
The soporific activity of cis-9,10-octadecenoamide and other soporific fatty acid primary amides is neutralized by hydrolysis in the presence of fatty-acid amide hydrolase (FAAH). Hydrolysis of...
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6699695 |
Rhodococcus microorganisms and process for producing amide compounds
A nitrile compound having a complicated structure (e.g., 2-hydroxy-4-methylthiobutyronitrile) is converted into an amide compound with high production efficiency, by using a novel microorganism of...
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