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RE35230 |
Enantiomeric enrichment of cyanohydrins
A method of enantiomerically enriching chiral cyanohydrins is disclosed that involves selective cleavage of the unwanted enantiomer into its cleavage products HCN and the corresponding aldehyde or...
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5508180 |
Biocatalytic oxidation using soybean peroxidase
Biocatalytic oxidative processes wherein oxidizable substrates are reacted in the presence of soybean peroxidase are described. Preferred biocatalytic oxidative reactions include the oxidation of...
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5498625 |
Substantially pure enantieners of 2-azabicyclo(2.2.1)hept-5-en-3-one
Lactams of 1-amino-3-carboxylic acid cyclic compounds are produced in enantiomeric form, together with an enantiomer of the corresponding ring-opened amino-acid or ester, by reaction of the racemic...
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5444087 |
Manumycin compounds
Manumycin C, Manumycin D and Manumycin E, obtainable by cultivation of a strain of Streptomyces sp. A.T.C.C. No. 55484, oxidized derivatives thereof and salts and prodrugs of these compounds. The...
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5437991 |
Process for the synthesis natural aromatics
A novel method for the production of natural aromatic ester compounds such as methyl anthranilate, ethyl anthranilate butyl anthranilate methyl cinnamate and methyl salicylate comprises the...
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5431896 |
Microbial immunoregulant
Described is a new immunosuppressant, L-687,819, a C-31 demethylated derivative of L-683,795 (FK-523), produced under fermentation conditions utilizing the new mutant microorganism, Streptomyces...
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5422256 |
Production of anthranilic acid by a strain of Bacillus subtillis resistant to sulfaguanidine and fluorotryptophan
A strain of Bacillus subtilis which is a tryptophan auxotroph, resistant to sulfaguanidine and flourotryptophan and produces anthranilic acid in a nutrient solution containing L-tryptophan, and...
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5418161 |
Microbial degradation of indigo and indigo carmine with bacteria strain
Biologically pure strains of microorganisms capable of degrading indigo and indigo carmine are disclosed. A preferred strain is bacteria strain ATCC 55396. The bacteria is used for treating water...
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5395758 |
Process for production of amide compounds using agrobacterium radiobacter
There is disclosed a process for production of amide compounds which includes converting a nitrile compound into an amide compound using a cultured broth of bacterial cells, or bacterial cells or...
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5380654 |
Process for the preparation of epoxides of means of microorganisms
2,3-Epoxypropyl ethers valuable as intermediates for preparing medicaments and the like are prepared from the corresponding allyl ethers by means of epoxide-producing microorganisms belonging to...
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5360724 |
Process for the preparation of chiral 1-aryl-2-aminopropanes
One chiral form of a 1-aryl-2-aminopropane is produced in preference to its enantiomer by allowing a 1-arylpropan-2-one to react with a 1-amino-1-phenylethane of predominantly one chiral form and...
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5350871 |
Method of preparing optically active cyanohydrins
The invention relates to a method of preparing an optically active cyanohydrin by addition of hydrogen cyanide to a carbonyl compound, selected from aldehydes and ketones, in the presence of...
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5346816 |
Enzymatic process for the enantioselective preparation of optically active cyanohydrins
Enantioselective process for the preparation of the S enantiomer of an optically active cyanohydrin by reacting an aldehyde or an asymmetric ketone with a cyanide group donor in the presence of an...
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5316917 |
Automated analysis of free l-carnitine and total short-chain acylcarnitine
Disclosed is a method of assaying free L-carnitine and total short-chain acylcarnitine in blood. The method uses essentially protein-free samples of plasma or serum and comprises (a) obtaining a...
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5300430 |
Biocatalytic process for the production of L-(-)-carnitine from crotonobetaine and strains of proteus for use in said process
A process is described for stereospecifically hydrating crotonobetaine to L-(-)-carnitine via the action of an enzyme produced by four new strains of Proteus mirabilis (NRRL B-18480, NRRL B-18481,...
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5298409 |
Antibody-enhanced stereospecific hydrolyses
Hydrolyses of various chiral compounds are performed in stereospecific manner by antibodies generated from analogs of transition states of the compounds. The compounds susceptible to such...
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5290698 |
Streptoverticillium ferm P-10489 which produces antitumor agent BE-13793C
A novel antitumor substance BE-13793C or a pharmaceutically acceptable salt thereof, which is represented by the following formula: ##STR1## an anticancer agent comprising the novel substance or a...
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5290772 |
Immunosuppressant agent
Described is a process for producing an immunosuppressant, "demethimmunomycin" (L-683,7411) a C-31 demethylated analog of L-683,590 under fermentation conditions utilizing the microorganism,...
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5288624 |
Cercosporal fungicide compositions and methods of use
The present invention relates to a funcidally active principle (fungicidal agent) obtainable by cultivation of fungi of the genus Phaeoramularia or Cercospora. The principle can be used for...
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5278054 |
Process for the enzymatic hydrolysis of a carboxylic acid derivative
A process for the enzymatic hydrolysis of a carboxylic acid derivative by dissolving the carboxylic acid derivative in an organic solvent which is miscible with water only to a slight extent,...
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5275941 |
Process for the preparation of N-protected dialkyl (2S,3S)-3-ethylaspartates
The invention relates to a process for the preparation of N-protected dialkyl (2S,3S)-3-ethylaspartates or their salts from unpurified (2S,3S)-3-ethylaspartic acid obtainable by enzymatic amination...
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5275950 |
Process for the preparation of a renin inhibiting compound
Intermediates and a process for their preparation are disclosed which are useful for the preparation of a renin inhibiting compound of the formula: ##STR1## wherein R is a nitrogen-containing...
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5266463 |
Highly sensitive assay method for L-carnitine and composition for practicing same
A method of assaying L-carnitine in a specimen comprises reacting a specimen containing L-carnitine with: a) L-carnitine dehydrogenase having coenzymes of the thio-NAD group and of the NAD...
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5258292 |
Enzymic process for the synthesis of ammonium adipate
The invention relates to an enzymic process for the synthesis of ammonium adipate by the hydrolysis of adipamide and/or ammonium adipamate by means of a particular polypeptide or a recombinant...
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5248601 |
Process for preparing L(-)-carnitine chloride
A biotechnological process for preparing L(-)-carnitine chloride, having the formula ##STR1## comprising: (a) reacting a racemic ester of (R,S)-3,4-epoxybutyric acid having the formula ##STR2##...
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5238838 |
L-carnitine amidase produced by a microorganism
The microorganism DSM 6230 produces an enzyme, L-carnitine amidase. This microorganism and/or the enzyme which it produces can selectively hydrolyze L-carnitine amide and/or the L-component of...
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5223416 |
Process for producing R(-)-mandelic acid and derivatives thereof
A process for the predominantly producing R(-)-mandelic acid or a derivative thereof which comprises subjecting (i) R,S-mandelonitrile or a derivative thereof, or (ii) a mixture of prussic acid and...
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5217886 |
Method for the production of (-)-4-difluoromethyl-ornithine
The present invention is directed to a process for producing (-) 2-substituted-ornithines comprising contacting a 2-substituted-piperidone with L-α-E-aminocaprolactam-hydrolas in the presence of a...
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5210031 |
Process for the production of R(-)-4-halo-3-hydroxybutyronitrile
A process for the production of a 4-halo-3-hydroxybutyronitrile which comprises reacting an epihalohydrin with a halohydrin-halide-lyase originating from a microorganism selected from the group...
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5200330 |
Method for the preparation of methyl anthranilate
A process for the preparation of "natural" methyl anthranilate which comprises the microbial N-demethylation of methyl N-methyl-anthranilate is disclosed.
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5196327 |
Process for producing antifungal fermentation products and compositions thereof
A mixture of derivatives of 2-amino-3,4,5,14-tetrahydroxy-6-eicosenoic acid has been isolated from a culture medium after cultivation of microorganisms belonging to the genus Aspergillus. The...
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5188951 |
Enzymatic synthesis of soluble phosphatides from phospholipids
A method of preparing a soluble monovalent salt of a phosphatidyl ester which comprises reacting a phospholipid with a primary alcohol in the presence of an enzyme catalyst in a divalent cationic...
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5187093 |
Microorganisms useful in the process for the production of l-carnitine
Process for the production of L-carnitine utilizing a microorganism. The microorganism is cultivated with crotonobetaine and/or γ-butyrobetaine in the presence of a growth substrate. The enriched...
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5179014 |
Process for the preparation of amides using microorganisms
A process for the production of amides utilizing microorganisms is described, which comprises subjecting nitriles having from 2 to 6 carbon atoms to the action of a microorganism belonging to the...
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5177242 |
Process for preparing optically active cyanohydrins with enzymes
The reaction time and ease of handling of reactants in the known process of forming optically active (S)-cyanohydrins by reacting aldehydes with hydrocyanic acid in the presence of the enzyme...
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5169777 |
Composition of biologically pure cultures of Alcaligenes denitrificans denitrificans and a porous carrier useful for biodegradation
The present invention is a process of degrading 1,4-dibenz-oxazepine with a icroorganism enzymatically capable of converting the 1,4-dibenz-oxazepine into at least o-nitrophenol which is further...
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5166061 |
Process for the production of 4-halo-3-hydroxybutyronitrile with Corynebacterium or Microbacterium
A process for the production of a 4-halo-3-hydroxybutyronitrile which comprises reacting a 1,3-dihalo-2-propanol with a dehalogenating enzyme originating from a Corynebacterium or a Microbacterium...
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5162219 |
Preparation of amine-enriched proteins having an increased isoelectric point
Amine-enriched proteins, having an increased isoelectric point are provided by reacting a naturally occurring protein with an amide bond forming agent in the presence of a polyamine or a salt...
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5162212 |
Transaminase from E. coli DH-1 (ATCC 33849)
A new transaminase has been isolated from E. coli DH-1 (ATCC 33849). It is possible to use the transaminase with great efficiency to prepare L-phosphinothricin and gamma-aminobutyric acid from...
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5153125 |
Process for producing lysophospholipids-containing phospholipids with reduced neutral lipid content
Lysophospholipids-containing phospholipids with reduced neutral lipids content can be produced by a process which comprises subjecting neutral lipids- and lysophospholipids-containing phospholipids...
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5153127 |
AB-011 Antibiotics and process for producing them
The AB-011 Antibiotics and the main components thereof: AB-011a and AB-011b, obtained by the controlled aerobial cultivation of Streptomyces s.p. NCIB 12629 in an aqueous nutrient cultivation...
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5143828 |
Method for synthesizing an enzyme-catalyzed polymerized monolayer
A method for synthesizing enzyme-catalyzed polymers using the Langmuir-Blodgett technique. In one embodiment, the process comprises spreading one or more enzyme-polymerizable monomers on a...
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5135860 |
Process for preparing glyoxylic acid/aminomethylphosphonic acid mixtures
The invention provides a process for producing mixtures of glyoxylic acid and aminomethylphosphonic acid. The process comprises reacting glycolic acid and oxygen in an aqueous solution in the...
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5135858 |
Process for biological production of organic acids
An improved biological conversion of a nitrile such as acrylonitrile or a cyanopyridine into the corresponding carboxylic acid such as acrylic acid or a nicotinic acid by the action upon the...
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5122461 |
Preparation of pyrocatecholic compounds
The invention relates to a novel method for preparing pyrocatecholic compounds from monophenolic compounds using catalysis by monophenol monooxygenase in an aqueous solution containing metal ions....
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5122462 |
Process for the enzymatic preparation of optically-active cyanohydrins
The preparation of optically-active cyanohydrins from the corresponding oxo compounds is disclosed. The reaction of the oxo compounds with hydrocyanic acid is carried out in an organic solvent in...
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5116744 |
Microbial cyanide converting enzymes, their production and use
A novel cyanide converting enzyme, a "cyanidase" is described. The enzyme is extremely efficient in reducing substantial concentrations of cyanide to very low levels in a broad pH, and temperature...
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5098836 |
Deoxygenation in field preparation of polymers in aqueous solution
In a process for polymerizing monomers with free-radical initiators in aqueous solution to produce polymers useful in oil field applications, wherein said polymerization process employs an...
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5087614 |
Enzyme inhibitor and method of producing the same
Novel peptide analogues which exhibit inhibitory activity against aspartic proteinases, a novel species of actinomycetous microorganism which produces said novel peptide analogues, a process for...
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5079167 |
Method of racemate resolution
The invention relates to a method for resolving carbamate racemates of amino acids or norephedrine by enzmatic resolution.
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