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9005939 Protoilludene synthase  
The present invention relates to an isolated, recombinant or synthetic polynucleotide encoding a polypeptide with protoilludene synthase activity and comprising a sequence selected from the group...
8993269 Glucosyl stevia composition  
Glucosyl stevia compositions are prepared from steviol glycosides of Stevia rebaudiana Bertoni. The glucosylation was performed by cyclodextrin glucanotransferase using the starch as source of...
8927238 Method for producing patchoulol and 7-epi-alpha-selinene  
A method of producing patchoulol and 7-epi-α-selinene by contacting at least one polypeptide with farnesyl phyrophosphate (fpp). The method may be carried out in vitro or in vivo to produce...
8911971 Glucosyl stevia composition  
Glucosyl stevia compositions are prepared from steviol glycosides of Stevia rebaudiana Bertoni. The glucosylation was performed by cyclodextrin glucanotransferase using starch as the source of...
8889381 Diterpene synthases and method for producing diterpenoids  
Provided herein are diterpene synthases (diTPS) and methods for producing diterpenoids. Also provided herein are nucleic acid sequences encoding diTPS, diTPS amino acid sequences, diTPS proteins,...
8853217 Compounds useful as inhibitors of ATR kinase  
The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this...
8846686 Compounds useful as inhibitors of ATR kinase  
The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this...
8735101 Glucosyl stevia composition  
Glucosyl stevia compositions are prepared from steviol glycosides of Stevia rebaudiana Bertoni. The glucosylation was performed by cyclodextrin glucanotransferase using the starch as source of...
8669077 Glucosyl Stevia composition  
Glucosyl stevia compositions are prepared from steviol glycosides of Stevia rebaudiana Bertoni. The glucosylation was performed by cyclodextrin glucanotransferase using the starch as source of...
8647844 Glucosyl stevia composition  
Glucosyl stevia compositions are prepared from steviol glycosides of Stevia rebaudiana Bertoni. The glucosylation was performed by cyclodextrin glucanotransferase using the starch as source of...
8530205 Buffer composition for catalyzing the preparation of calcitriol or calcifediol and method for preparing calcitriol or calcifediol using same  
The present invention relates to a buffer composition for promoting production of calcitriol or calcifediol, and a method for producing calcitriol or calcifediol using the same. More particularly,...
8318459 Glucosyl stevia composition  
Glucosyl stevia compositions are prepared from steviol glycosides of Stevia rebaudiana Bertoni. The glucosylation was performed by cyclodextrin glucanotransferase using the starch as source of...
8273708 Methods of treatment of ocular surface pathologies  
The invention concerns compositions and methods for treating and/or preventing ocular pathologies. The invention also concerns compositions and methods enabling the regulation of paracellular...
8257948 Method of preparing alpha-glucosyl Stevia composition  
Glucosyl stevia compositions are prepared from steviol glycosides of Stevia rebaudiana Bertoni. The glucosylation was performed by cyclodextrin glucanotransferase using the starch as source of...
8148119 Hydroxylase gene and use thereof  
A vitamin D3 hydroxylase is purified from Pseudonocardia autotrophica cell, and a primer is designed based on amino acid sequence obtained from hydroxylase. Subsequently, PCR is conducted using...
7972821 Production of functional proteins: balance of shear stress and gravity  
A method for the production of functional proteins including hormones by renal cells in a three dimensional culturing process responsive to shear stress uses a rotating wall vessel. Natural...
7910334 Biotransformation of colchicinoid compounds  
The present invention relates to a biotransformation process, effected by means of selected microbial strains, for the preparation of 3-O-glycosyl derivatives of colchicinoid compounds.
7790425 Saponin-decomposing enzyme, gene thereof and large-scale production system for producing soyasapogenol B  
The present invention provides a protein having saponin-decomposing activity, more specifically a protein which can decompose a glycoside having soyasapogenol B as an aglycone to produce...
7556948 Method for producing crystallized pleuromutilins  
Invented are non-peptide TPO mimetics. Also invented is a method of treating thrombocytopenia, in a mammal, including a human, in need thereof which comprises administering to such mammal an...
7432102 Transformants producing substance pf1022 derivatives, methods for producing the same, and novel biosynthesis genes  
An objective of the present invention is to provide a method for producing substance PF1022 derivatives, in particular PF1022-220 and PF1022-260, by a direct fermentation method, and a...
7354747 Carbohydrate derived protein resistant biomaterial  
Carbohydrate-derived side-chain polyethers that may be synthesized by condensation polymerization of monomers derived from natural occurring carbohydrates. These compounds are protein resistant,...
7294492 Process for the manufacture of spiroketals  
The present invention is directed to the use of yeasts to produce spiroketal fragrance materials. The preferred yeasts used in the method of the invention are Bensingtonia ciliate and Cryptococcus...
7125692 Process for producing monomer  
A process for producing a monomer for resists represented by the following general formula 1: wherein R1 represents hydrogen or an optionally substituted alkyl group; R2, R3 and R4 each...
6872517 Early diagnosis of cancerous and precancerous conditions by leakage of signature peptides and carbohydrates into the bloodstream  
The present invention involves the early diagnosis of cancerous or precancerous conditions in the gastrointestinal tract by detection of a backleak of signature proteins or carbohydrates in a...
6589765 Mass production of paclitaxel by changing the temperature of the medium during the plant cell culture  
The present invention relate to a method to increase the production level of paclitaxel by changing the temperature during the plant cell culture. According to the present invention, the...
6586201 Method of chromatographic isolation for non-glyceride components  
A method of chromatographic isolation for non-glyceride components (squalenes, carotenes, vitamin E, sterols and/or the like) from a non-glyceride components-comprising compound by the steps of a....
6479657 Crystalline 1-kestose and process for preparing the same  
A process for producing crystal 1-kestose wherein granular crystal 1-kestose in the form of large crystals can be produced at a high yield is disclosed. A highly pure solution of 1-kestose is...
6428989 Method for producing taxane-type diterpenes  
The present invention discloses a method for producing a taxane-type diterpene(s) by culturing cells of a taxane-type diterpene-producing plant, comprising one or both of the the following steps...
RE37206 Gene encoding glycosyltransferase and its uses  
This invention relates to glycosyltransferase, genes encoding glycosyltransferase, recombinant vectors having such a gene, host cells transformed with such a recombinant vector, and uses thereof....
6046041 Method for producing marine-derived compounds and novel compounds produced therefrom  
A fortified enzyme preparation of the gorgonian Pseudopterogorgia americana or Pseudopterogorgia elisabethae has been developed which efficiently transforms a variety of precursor molecules, e.g.,...
5928910 Antifungal substances BE-49385 and process for their production  
The present invention relates to a compound represented by the general formula (I): ##STR1## wherein R1 is a hydrogen atom, or ##STR2## and R2 is a hydrogen atom or OH and R2 is a hydrogen atom or...
5925550 Method for selectively increasing the ratio of single major components of antibiotic A/16686 complex  
The present invention relates to a method for selectively enhancing the production of factors A2 and/or A3 of antibiotic A/16686 either to isolate these single components or to enrich the complex...
5861277 Methods and compositions for enhancing the expression of genes in plants  
Disclosed are methods of increasing exogenous protein expression in a cell or a transgenic plant. Constructs, i.e., vectors, DNA fusions and polynucleotides, for use in conjunction with the...
5840683 Peptides inhibiting the oncogenic action of p21 ras  
The present invention provides peptides and cyclized peptides which inhibit the oncogenic and/or transforming activity of the p21 ras protein, pharmaceutical compositions containing at least one...
5801023 Antiparasitic pyrrolobenzoxazine compounds  
This invention provides compounds of the following chemical formula or their pharmaceutically-acceptable salts: ##STR1## wherein R is hydrogen or chloro. Also, the present invention provides a...
5773264 Process for the production of 17 α-hydroxy-3-methoxy-8,14-seco-1,3,5(10),9(11)estratetraen-14-one by reduction of the corresponding 17-one compound  
A process for the production of 17α-hydroxy-3-methoxy-8,14-seco-1,3,5 (10),9(11)estratetraen-14-one by fermentation of 3-methoxy-8,14-seco-1,3,5(10),9(11) -estratetraene-14,17-dione with a live...
5763234 Secosteroids, and method for producing same  
A fortified enzyme preparation of the gorgonian Pseudopterogorgia americana has been developed which efficiently transforms a variety of sterols to their 9(11)-secosteroid derivative in high...
5747303 Intermediates of peptide antagonists of neurotensin  
The invention is directed to a novel compound of formula ##STR1## in which R is a hydroxyl, alkyloxy, phenylalkyloxy or --NH--CH2 --COOH radical, R' and R" are identical and are each a hydroxy or...
5593870 Process for producing frenolicin B  
The present invention is directed to a process for producing frenolicin B. The process comprises fermenting a broth so as to produce frenolicin, said broth having a microorganism capable of...
5563054 Process for preparation of benzo[B]thiophene glucuronides  
The present invention provides a biotransformation process for preparing a compound of the formula ##STR1## wherein R1 and R2 are hydrogen or a β-glucuronide group of the formula ##STR2## provided...
5492819 Recovery of insoluble biosynthetic products  
There is disclosed a process for the recovery of an insoluble fermentation product from a solid phase cell mass, the process comprising treating the fermentation broth to solubilize the cell mass...
5474923 Method for the biological preparation of hydroxyvitamin D compounds  
A method for introducing hydroxyl groups into vitamin D compound at the 1α- and/or 25-positions in the presence of a cyclodextrin compound by the use of a reaction mixture containing a...
5444087 Manumycin compounds  
Manumycin C, Manumycin D and Manumycin E, obtainable by cultivation of a strain of Streptomyces sp. A.T.C.C. No. 55484, oxidized derivatives thereof and salts and prodrugs of these compounds. The...
5431896 Microbial immunoregulant  
Described is a new immunosuppressant, L-687,819, a C-31 demethylated derivative of L-683,795 (FK-523), produced under fermentation conditions utilizing the new mutant microorganism, Streptomyces...
5403728 Microbial process for preparing mevinolin by a strain of aspergillus  
The invention refers to a new microbial process for preparing β,δ-dihydroxy-7-[1,2,6,7,8,8a-hexahydro-2.6-dimethyl-8-(2-me thy l-butyryloxy)-naphthalen-1-yl]-heptanoic acid δ-lactone of formula...
5338845 Aspergillus species, cyclic dimeric dipeptide derivative substance P antagonist biosynthetic products thereof, and process for preparation thereof  
A novel Aspergillus species, cyclic dimeric dipeptide derivatives which are biosynthetic products thereof and are useful as Substance P antagonists and therefore as analgesic and/or...
5316939 Microorganism belonging to the genus Rhodococcus, and process for producing sec-cedrenol and cedrenone  
A biological pure culture of a microorganism belonging to the genus Rhodococcus and being capable of oxidizing the allyl position of α-cedrene, a process for producing sec-cedrenol comprising...
5302522 Process for the production of sec-cedrenol and cedrenone from α-cedrene by rhodococcus  
A biological pure culture of a microorganism belonging to the genus Rhodococcus and being capable of oxidizing the allyl position of α-cedrene, a process for producing sec-cedrenol comprising...
5290698 Streptoverticillium ferm P-10489 which produces antitumor agent BE-13793C  
A novel antitumor substance BE-13793C or a pharmaceutically acceptable salt thereof, which is represented by the following formula: ##STR1## an anticancer agent comprising the novel substance or a...
5248601 Process for preparing L(-)-carnitine chloride  
A biotechnological process for preparing L(-)-carnitine chloride, having the formula ##STR1## comprising: (a) reacting a racemic ester of (R,S)-3,4-epoxybutyric acid having the formula ##STR2##...

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