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8980587 Process for producing reveromycin A or a synthetic intermediate thereof, process for producing compounds containing a spiroketal ring and novel antineoplastics, fungicides and therapeutic agents for bone disorders  
A bacterium belonging to the genus Streptomyces having an ability to produce reveromycin A or a synthetic intermediate thereof, the bacterium being modified so as to increase expression of revQ...
8940789 Neurite elongation agent, memory-improving agent and anti-Alzheimer agent comprising 4′-demethylnobiletin or 4′-demethyltangeretin as active ingredient, and process for production of the compound  
A method for producing 4′-demethylnobiletin or 4′-demethyltangeretin including fermenting a skin derived from at least one citrus fruit selected from citrus fruits belonging to section Acrumen in...
8927237 Method for producing acyloxypyranone compound, method for producing alkyne compound, and method for producing dihydrofuran compound  
An acylating agent and a hydrolase are caused to act on a hydroxypyranone represented by formula (I) in a water-containing organic solvent, to thereby produce an acyloxypyranone compound...
8765445 Equol-producing lactic acid bacteria-containing composition  
The present invention provides an equol-producing lactic acid bacteria-containing composition comprising, as an essential component thereof, a lactic acid bacterial strain belonging to the genus...
8735137 Use of Saccharomyces cerevisiae SUC2 gene in Yarrowia lipolytica for sucrose utilization  
Disclosed herein are transformed Yarrowia lipolytica comprising an exogenous polynucleotide encoding a polypeptide having sucrose invertase activity. Also disclosed are methods of using the...
8709764 Enzymatic demethylation of flavonoids  
The invention discloses the demethylation of 5-methoxyflavonoids by bacterial enzymes, the use of these enzymes in the production of phytoestrogens in vitro, and in pharmaceutical compositions in...
8673967 Process  
A process for producing a composition comprising at least 3% by weight of total tocopherols and tocotrienols comprises: providing a product obtained from palm oil comprising tocopherols and...
8597915 Process for the reduction of cinnamaldehyde derivative employing enoate reductases  
The present invention relates to a novel enzymatically catalyzed method for the production of asymmetric aromatic aldehydes in an aqueous reaction medium containing certain organic co-solvents.
8426189 Soybean-based fermentation media, methods of making and use  
Fermentation media containing an isoflavone-depleted soybean meal or isoflavone-depleted soybean meal product and at least one exogenous added ingredient that comprises a substrate for microbial...
8420833 Producing biofuels using polyketide synthases  
The present invention provides for a non-naturally occurring polyketide synthase (PKS) capable of synthesizing a carboxylic acid or a lactone, and a composition such that a carboxylic acid or...
8383382 Variant LovD polypeptides and their uses  
The present disclosure provides acyltransferases useful for synthesizing therapeutically important statin compound.
8268595 Integrated methods for processing palm fruit bunches  
This invention is directed to an integrated method for the processing of palm fruit bunches to oil and other products. The method comprises inter alia separating palm fruit carrying bunches into...
8030432 Copolymerization of hydroxytyrosol with flavonoids mediated by horseradish peroxidases  
The present invention provides a method of producing a copolymer of hydroxytyrosol, or its derivative, and at least one flavonoid comprising reacting hydroxytyrosol monomers or derivative with at...
7982057 Compound of stemphones and production thereof  
The present invention relates to novel compound of stemphones obtained by culturing microorganism belonging to genus Aspergillus and having ability to produce compound of stemphones selected from...
7955824 Methods of making epothilones  
The invention provides novel compounds that may be used as intermediates in the preparation of epothilones, epothilone analogs and derivative, as well as new synthetic methods for producing the...
7897370 Process for producing HMG-CoA reductase inhibitor  
The present invention relates to a protein derived from a microorganism belonging to the genus Bacillus, which has an activity of hydroxylating a compound represented by the formula (I-a): wherein...
7888083 Process for the preparation of dihydroxy esters and derivatives thereof  
A process is provided for the preparation of a compound of formula (1) wherein R and R′ represent optionally substituted hydrocarbyl groups and X represents a hydrocarbyl linking group. The...
7868138 Methods for generating polynucleotides having desired characteristics by iterative selection and recombination  
A method for DNA reassembly after random fragmentation, and its application to mutagenesis of nucleic acid sequences by in vitro or in vivo recombination is described. In particular, a method for...
7807422 Production of flavonoids by recombinant microorganisms  
Methods and compositions are provided for production of flavonoids in microbial hosts. The compositions comprises a set of genes which encode for enzymes involved in one or more steps in the...
7794991 Stemphones and production thereof  
The present invention relates to novel stemphones having enhancing effect of β-lactam antibiotic used as an antibacterial agent, and a process for production thereof. The process is comprised of...
7700329 Methods for making simvastatin and intermediates  
The invention provides synthetic chemical and chemoenzymatic methods of producing simvastatin and various intermediates. In one aspect, enzymes such as hydrolases, e.g., esterases, are used in the...
7700551 Hydrolysable polymeric FMOC-linker  
The invention relates to Fmoc (9-fluorenyl-methoxycarbonyl)-based polymeric conjugates. These conjugates are useful for extending the in-vivo circulation of protein and peptide drugs.
7663219 Semiconductor device and method of manufacturing the same  
A semiconductor device includes a semiconductor package, a circuit board and an interval maintaining member. The semiconductor package has a body and a lead protruded from the body. The circuit...
7560287 Long wavelength engineered fluorescent proteins  
Engineered fluorescent proteins, nucleic acids encoding them and methods of use are provided.
7439046 Process for the preparation of 2,4-dideoxyhexoses and 2,4,6-trideoxyhexoses  
The invention relates to a process for the preparation of a 2,4-dideoxyhexose or a 2,4,6-trideoxyhexose from a substituted or unsubstituted carbonyl compound with at least 2 carbon atoms and at...
7439045 pH controlled fermentation process for pseudomonic acid production  
An improved fermentation process for preparing pseudomonic acid A (mupirocin) is disclosed. The metabolically controlled fermentation process provides culturing a Pseudomonas sp. strain in a...
7432089 DNA encoding favin-adenine-dinucleotide-dependent-D-erythronate-4-phosphate-de-hydrogenase, pdxR, and microbial production of vitamin B6  
The present invention relates to a DNA encoding a novel flavin adenine dinucleotide (FAD)-dependent D-erythronate 4-phosphate (EN4P) dehydrogenase originated from Sinorhizobium meliloti, which is...
7416865 Process for the preparation of dihydroxy esters and derivatives thereof  
A process is provided for the preparation of a compound of formula (1) wherein R and R′ represent optionally substituted hydrocarbyl groups and X represents a hydrocarbyl linking group. The...
7396667 Enzymatic depolymerization process of polylactic acid, and producing process of polylactic acid using depolymerization product  
A depolymerizing process of polylactic acid, wherein the polylactic acid is depolymerized in the presence of a hydrolase in an organic solvent or a supercritical fluid, thereby producing a...
7338791 Production of flavonoids by recombinant microorganisms  
Methods and compositions are provided for production of flavonoids in microbial hosts. The compositions comprises a set of genes which encode for enzymes involved in one or more steps in the...
7202062 Strains of Saccharaothrix, process for producing pravastain using the strains and isolation process of (HMG)-CoA reductase  
The present invention provides two new microorganism strains of Saccharothrix, designated as YS-44442 and YS-45494, a process of producing pravastatin using the strains, and an improved process...
7129067 Method for producing lactone  
This invention relates to a method for producing a lactone comprising culturing Candida sorbophila in a medium containing at least one selected from the group consisting of a hydroxy fatty acid, a...
7125692 Process for producing monomer  
A process for producing a monomer for resists represented by the following general formula 1: wherein R1 represents hydrogen or an optionally substituted alkyl group; R2, R3 and R4 each...
7118895 Process for producing aglycon by using diglycosidase and flavor-improved food containing the aglycon and converting agent to be used in the process  
A physiologically active substance of aglycon type, in particular, aglycon isoflavone, can be efficiently produced, without resort to any acid/alkali treatment or fermentation and substantially...
7078223 Process for the preparation of pseudomonic acid a antibiotic by microbiological method  
A procedure for the preparation of pseudomonic acid A comprising submerged cultivation of a Pseudomonas bacterium strain capable of biosynthesis of the substantially pure pseudomonic acid A in...
7067290 Method for production of polyketides  
A method for the production of a polyketide by fermentation comprising the steps of growing a culture of a polyketide-producing organism at a pH value conducive to cell growth for a time...
7056540 Enzymatic process for the preparation of optically active alcohols from ketones using tuberous root Daucus carota  
The present invention relates to an enzymatic process for the preparation of optically active chiral alcohols using tuberous root Daucus carota; particularly invention relates to an enzymatic...
7052886 Process for the isolation of lovastatin  
The process for the preparation and isolation of the hypolipaemic active substance lovastatin in substantially pure form having a purity of at least 95% which comprises lactonizing the mevinolinic...
7052885 Process for preparing heterocyclic (R)- and (S)-cyanohydrins  
A process for preparing enantiomer-enriched heterocyclic (R)- and (S)-cyanohydrins of the formula (I), where R1, R2, R3, R4 independently of one another are H, an unsubstituted or substituted...
7049111 Process for producing HMG-CoA reductase inhibitor  
The present invention relates to a protein derived from a microorganism belonging to the genus Bacillus, which has an activity of hydroxylating a compound represented by the formula (I-a): wherein...
7033621 Isoflavone compositions produced from legumes  
Processes for the production of isoflavones are described wherein plant material from plants of the genus leguminosae are contacted with water, an enzyme which cleaves isoflavone glycosides to the...
6946270 Process for producing HMG-CoA reductase inhibitors  
The present invention relates to a process for producing a compound (II-a) or a compound (II-b), each of which is a hydroxylated product of a compound represented by the formula (I-a) (hereinafter...
6936731 Pravastatin sodium substantially free of pravastatin lactone and epi-pravastatin, and compositions containing same  
The present invention provides pravastatin sodium substantially free of pravastatin lactone and epiprava, the C-6 epimer of pravastatin. The present invention further provides a novel process for...
6903227 Synthesis of 2-acyl substituted chromanes and intermediates thereof  
Novel processes for producing enantiomerically enriched and enantiomerically pure compositions of 2-acyl substituted chromane compounds, and 2-acylchromane compounds that are intermediates for...
6844174 Fermentation process for lipstatin and method of extracting lipstatin from a fermentation broth  
The present invention provides a fermentation process for producing lipstatin comprising the steps of: a) preparing a fermentation medium containing a lipstatin-producing microorganism comprising...
6825015 Process for the obtaining of HMG-COA reductase inhibitors of high purity  
A process for the isolation and purification of HMG-CoA reductase inhibitors from a mycelium biomass is described, which process comprises: clarifying a mycelium broth and concentrating the...
6812007 Process for the isolation and purification of mevinolin  
In a process for preparing mevinolin by fermentation of a biomass in a fermentation liquor, which includes dissolving mevinolin from the biomass into the fermentation liquor, and separating the...
6790968 Substance FKI-0076 and process for producing the same  
A microorganism having ability to produce FKI-0076 substance represented by the following formula [I] is cultured in a medium allowing for the accumulation of FKI-0076 substance in the culture...
6777211 Process for producing hydroxylated fatty acid and delta-lactone  
The process which comprises causing cells or a culture of a microorganism having the activity to introduce hydroxy into the [n-5]-position (n is an even number of 10 or more) and hydrogen into the...
6716609 Polypeptides having α-hydroxy-&ggr -carboxymuconic acid-&egr -semialdehyde dehydrogenase activity  
α-Hydroxy-γ-carboxymuconic acid-ε-semialdehyde dehydrogenase, a gene encoding the enzyme, a recombinant vector containing the gene and a transformant carrying the gene, and processes for producing...

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