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7459294 Method of producing a compound by fermentation  
During the production of a product compound by fermentation, the concentration of a precursor compound is maintained within a pre-selected concentration range by having an adsorbent resin in...
7439045 pH controlled fermentation process for pseudomonic acid production  
An improved fermentation process for preparing pseudomonic acid A (mupirocin) is disclosed. The metabolically controlled fermentation process provides culturing a Pseudomonas sp. strain in a...
7419751 Titanylphthalocyanine crystal and method of producing the titanylphthalocyanine crystal, and electrophotographic photoreceptor, method, apparatus and process cartridge using the titanylphthalocyanine crystal  
A titanylphthalocyanine crystal having an X-ray diffraction spectrum having plural diffraction peaks and a primary particle diameter not greater than 0.2 μm, wherein a maximum diffraction peak is...
7405063 Biooxidation capabilities of Candida sp  
A bioprocess for producing carboxylic acids, alcohols and aldehydes is provided by culturing Candida sp. in a fermentation medium containing various defined substrates.
7396667 Enzymatic depolymerization process of polylactic acid, and producing process of polylactic acid using depolymerization product  
A depolymerizing process of polylactic acid, wherein the polylactic acid is depolymerized in the presence of a hydrolase in an organic solvent or a supercritical fluid, thereby producing a...
7264951 Enhanced production of taxol and taxanes by cell cultures of Taxus species  
This invention provides methods whereby taxol, baccatin III, and other taxol-like compounds, or taxanes, can be produced in very high yield from all known Taxus species, e.g., brevifolia,...
7217558 Microorganism producing 5'xanthylic acid  
The invention relates to Corynebacterium ammoniagenes CJXOL 0201 KCCM 10447 producing 5′-xanthylic acid. More specifically, the invention relates to Corynebacterium ammoniagenes CJXOL 0201...
7202063 Processes for the production of rhamnolipids  
A process for producing rhamnolipids involving culturing Pseudomonas chlororaphis strain NRRL B-30761 in a first aqueous culture medium containing about 0.3% NH 4 H 2 PO 4 , about 0.2% K 2 HPO 4...
7169591 Preparation of enantio-specific epoxides  
A method for converting alkenes into epoxides and, particularly, to convert alkenes into enantio-specific epoxides by the use of enzymes which may be in their naturally-occuring (native) form or in...
7141412 Process for preparing optically active 3-hydroxypyrrolidine derivatives by enzymatic hydroxylation  
A process for the preparation of optically active 3-hydroxypyrrolidine or N-substituted 3-hydroxypyrrolidines, wherein an oxygen atom is inserted stereoselectively into the corresponding...
7129067 Method for producing lactone  
This invention relates to a method for producing a lactone comprising culturing Candida sorbophila in a medium containing at least one selected from the group consisting of a hydroxy fatty acid,...
7063977 Enzymatic resolution of t-butyl taxane derivatives  
A method for the resolution of a mixture of the cis or trans enantiomers of a compound of the formula wherein R 1 is —O—C(O)alkyl, —O—C(O)aryl or —O—C(O)cycloalkyl by contacting...
7060477 Epoxide hydrolases of aspergillus origin  
The invention concerns proteins of fungal origin having an epoxide hydrolase activity, such as those obtained in essentially pure form by extraction from fungi cells, or by culturing in host cells...
7060471 Stereoselective chemoenzymatic process for the preparation of optically enriched phenylglycidates as precursors of taxol side chain  
The present invention relates to a novel and efficient chemoenzymatic process of preparation of optically active trans alkyl phenylglycidates. The invention particularly discloses a novel process...
7052886 Process for the isolation of lovastatin  
The process for the preparation and isolation of the hypolipaemic active substance lovastatin in substantially pure form having a purity of at least 95% which comprises lactonizing the mevinolinic...
7052885 Process for preparing heterocyclic (R)- and (S)-cyanohydrins  
A process for preparing enantiomer-enriched heterocyclic (R)- and (S)-cyanohydrins of the formula (I), where R1, R2, R3, R4 independently of one another are H, an unsubstituted or substituted C...
6951745 Polyhydroxyalkanoate-containing structure and manufacturing method thereof  
A method for manufacturing polyhydroxyalkanoate-containing structure, at least a part of a base material surface of the structure being coated with polyhydroxyalkanoate, the method comprises the...
6939978 Production of taxol and taxanes  
A high yield, economical process for purifying taxanes from yew biomass is disclosed. The process does not require initial liquid:liquid portioning of the crude extract to separate highly polar...
6927047 Manufacture and purification of mycophenolic acid  
The present invention provides an improved method for the manufacture of Mycophenolic acid by solid substrate fermentation of Pencillium brevi-campactum , in a contained bioreactor under optimal...
6924129 Enzyme-catalyzed esterification of pendant carboxylic acid groups  
A method for enzymatically synthesizing a polymer by combining a preselected quantity of an enzyme, a first reactant selected from polymers with at least one carboxylic acid pendant group, a second...
6905875 Non-disruptive three-dimensional culture and harvest system for anchorage-dependent cells  
A non-disruptive three-dimensional culture system allows cell growth and proliferation in three dimensions, permitting cell splitting without subjecting cells to disruptive conditions that affect...
6903225 Process for producing optically active 2-[6-(hydroxymethyl)-1,3-dioxan-4-yl]acetic acid derivatives  
This invention provides a process for producing optically active 2-[6-(hydroxymethyl)-1,3-dioxan-4-yl]acetic acid derivatives, which are of value as intermediates of drugs, from inexpensive...
6872788 Production method of polyester containing epoxy group in side chain and production method of crosslinked polymer  
A method is provided which biosynthesizes a PHA having an epoxy group on a side chain with improved physicochemical properties. Specifically, a method of producing a polyester containing an epoxy...
6852315 Epoxidation of carbon-carbon double bond with membrane bound peroxygenase  
A method has been discovered for the epoxidation of a compound having at least one carbon-carbon double bond, the method involves reacting a compound having at least one carbon-carbon double bond,...
6844174 Fermentation process for lipstatin and method of extracting lipstatin from a fermentation broth  
The present invention provides a fermentation process for producing lipstatin comprising the steps of: a) preparing a fermentation medium containing a lipstatin-producing microorganism comprising...
6828115 Epoxide hydrolases from streptomyces  
A description is given of epoxide hydrolases from bacteria of the genus Streptomyces , a novel process for the enzymatic separation of epoxide enantiomeric mixtures, of a novel detection method...
6759539 Process for isolation and purification of paclitaxel from natural sources  
Disclosed is a process for isolating and purifying paclitaxel from a natural resource of taxanes, comprising the steps of (a) washing a raw material comprising paclitaxel with water in order to...
6734314 Preparation of orlistat and orlistat crystalline forms  
The present invention is directed to a process of converting lipstatin to orlistat by catalytic hydrogenation. The present invention further discloses novel crystalline solid orlistat forms,...
6638742 Methods for obtaining taxanes  
Methods for obtaining taxanes from novel sources are disclosed. Angiosperms other than hazelnut and the gymnosperm ginkgo have been discovered to be sources of taxane, including paclitaxel. Taxane...
6620599 Process for the production of a biologically active phenolic compound(&plus ) catechin  
The invention provides a process for the production of a biologically active phenolic compound (+) catechin from Taxus wallichiana tissue cultures, said process comprising the steps of (a)...
6596518 Percyquinnin, a process for its production and its use as a pharmaceutical  
The present invention relates to a compound named Percyquinnin that is obtainable by cultivating a basidiomycetes Stereum complicatum (DSM 13303), and to its pharmaceutically acceptable salts....
6589765 Mass production of paclitaxel by changing the temperature of the medium during the plant cell culture  
The present invention relate to a method to increase the production level of paclitaxel by changing the temperature during the plant cell culture. According to the present invention, the production...
6562602 Fermentation and purification of mycolactones  
Fermentation based methods for producing mycolactones allows one to produce large quantities of mycolactones, which can be purified by extraction and chromatography to yield pure preparations of...
6541242 Enzymatic processes for the resolution of enantiomeric mixtures of compounds useful as intermediates in the preparation of taxanes  
Methods for the enzymatic resolution of mixtures of enantiomers, such as β-lactam compounds, which may be employed as intermediates in the preparation of taxanes bearing a C-13 sidechain...
6528301 Paclitaxel production by actinomycetes  
The present invention related to microorganisms producing taxanes, such as paclitaxel or related taxanes, to the use of said microorganisms for the production of taxanes, and to the procedure for...
6514732 Process for preparing baccatin  
A process for preparing baccatin and/or baccatin derivatives is described in which 10-deacetylbaccatin or a 10-deacetylbaccatin derivative is reacted in the presence of an isolated enzyme and an...
6509177 Process for the preparation of pseudomonic acid A antibiotic by microbiological method  
A procedure for the preparation of pseudomonic acid A comprising submerged cultivation of a Pseudomonas bacterium strain capable of biosynthesis of the substantially pure pseudomonic acid A in...
6500651 Metabolic controlled fermentation procedure for the manufacture of lovastatin hydroxy acid  
A method for producing mevinolin by a microorganism in a fermentation process having a seed culture stage and a main fermentation stage, including a) cultivating a microorganism biomass in the...
6465221 Method of producing a taxane-type diterpene  
The present invention relates to a method of producing a taxane-type diterpene wherein a cell and/or a tissue of a plant which produces the taxane-type diterpene is cultured in the presence of at...
6458568 Method for the production of baccatin-III by enzymatic synthesis  
A method for the continuous synthesis of baccatin-III is performed by means of the enzymatic acetylations of 10-deacetyl baccatin-III (10-DAB) in an enzyme reactor. This objective is accomplished...
6440709 Production of isochroman compounds by culturing Penicillium  
This invention relates to the isochroman compound of formula (I) and its pharmaceutically acceptable salts, which are useful as an amyloid aggregation inhibitor and for treating Alzheimer's...
6428989 Method for producing taxane-type diterpenes  
The present invention discloses a method for producing a taxane-type diterpene(s) by culturing cells of a taxane-type diterpene-producing plant, comprising one or both of the the following steps...
6388097 Process for the preparation of β hydroxy-&dgr lactone using novel intermediates  
The present invention relates to a process for the preparation of optically active 6-hydroxymethyl-4-tert-butyldimethylsilyloxy)-(4S,6R)-tetrah ydro-2H-2-pyranone (β Hydroxy δ Lacone) and the...
6379935 Method of producing α-halo-α,β-saturated carbonyl compounds from the corresponding α,β-unsaturated compounds  
A method of producing an α-halo-α,β-saturated carbonyl compound from an α-halocarbonyl compound having an α, β-carbon-carbon double bond by reducing said α,β-carbon-carbon double bond using...
6368835 Process for producing a lactone using corynebacterium sp. NK-1 (FERM BP-6329)  
A flavoring solution for making pickles having a flavor of foods pickled in rice bran paste, a clear bran pickles flavoring solution, processes for producing the flavoring solutions, a process for...
6348337 Process for the preparation of C-4 deacetyltaxanes  
A process useful for the preparation of intermediates in synthesis or semi-synthesis of paclitaxel analogs wherein a starting taxane such as 10-deacetylbaccatin III is deacetylated at the C-4...
6337410 Antibiotic TKR459, production method, and microorganism  
The present invention has its object to provide a noble antifungal substance which is use of as clinical medicine in the therapy of fungal infectious diseases. The present invention is related to...
6261826 Antibiotic TKR2648 and process for producing the same  
Antibitic TKR2648 having the following chemical formula (I) or its pharmacologically acceptable salt. ##STR1##
6261813 Two step enzymatic acylation  
A method for derivatizing a compound having a hydroxyl group by back to back acylation is provided. The compound is acylated with a bifunctional acyl donor in the presence of a hydrolase to form an...
6248572 Production of taxol from taxus plant cell culture adding silver nitrate  
The present invention provides a method for mass production of taxol which comprises adding sugar into a culture medium containing sugar in the course of semicontinuous culture of Taxus genus plant...
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