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7572606 |
Biosyntheses of salinosporamide A and its analogs and related methods of making salinosporamide A and its analogs
Disclosed are methods of modulating biosynthesis of Salinosporamide A and its analogs, which are useful in treating cancer, inflammatory conditions, and/or infectious disease. The methods involve,...
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7563602 |
Alleles of the GND gene from coryneform bacteria
The invention relates to mutants and alleles of the gnd gene from coryneform bacteria coding for 6-phosphogluconate dehydrogenases which contain at position 329 or a comparable position of the...
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7556948 |
Method for producing crystallized pleuromutilins
Invented are non-peptide TPO mimetics. Also invented is a method of treating thrombocytopenia, in a mammal, including a human, in need thereof which comprises administering to such mammal an...
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7507564 |
Tiacumicin production
Methods, processes and materials for the production and recovery of Tiacumicins produced by culturing a microorganism belonging to the species Dactylosporangium aurantiacum subspecies ...
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7507560 |
Enzymatic production of macrocyclic amide oligomers
Hydrolytic enzymes capable of catalyzing amidation reactions can be used to produce cyclic amide oligomers from diesters and diamines. The cyclic amide oligomers are useful for the production of...
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7445916 |
Process for preparing rapamycin 42-esters and FK-506 32-esters with dicarboxylic acid, precursors for rapamycin conjugates and antibodies
Methods for the synthesis of regiospecific rapamycin 42-hemiesters and regiospecific FK506 32-esters with dicarboxylic acids is described. The methods involve catalyzing the reaction between a...
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7432088 |
Methods for the production of ansamitocins
A process of the large-scale fermentation of a highly productive ansamitocin-producing strains. A method for isolating crude ansamitocins. A method for purifying ansamitocins.
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7378268 |
Endophytic camptothecin and camptothecinoid producing fungi and process of producing the same
The present invention relates to a novel source of microorganism for production of Camptothecin and related camptothecinoids. The invention also discloses its isolation, screening for Camptothecin...
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7354747 |
Carbohydrate derived protein resistant biomaterial
Carbohydrate-derived side-chain polyethers that may be synthesized by condensation polymerization of monomers derived from natural occurring carbohydrates. These compounds are protein resistant,...
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7316917 |
Production of bicyclic-heteroaryl-2-carboxylic acids by selective enzymatic hydrolysis of a mixture of positional esters
The invention relates to an enzymatic process for the production of an intermediate, bicyclic-heteroaryl-2-carboxylic acid 7, of the formula
wherein X and Y are defined in the specification and...
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7279314 |
Chemical substance having morphogenetic and growth-accelerating activities
The present invention relates to a method of producing a novel chemical substance capable of inducing morphogenesis, promoting growth of marine foliate green alga that use the microorganisms, and a...
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7267968 |
Microbial n-and o-demethylation of a thebaine derivative
The invention provides a process for the N-demethylation or the N- and O-demethylation of a thebaine derivative which process comprises fermenting the derivative with a biocatalyst selected from...
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7252978 |
Method for producing L-arginine
L-Arginine is produced by culturing a microorganism which has L-arginine producing ability and has been modified so that expression of lysE gene should be enhanced, such a microorganism further...
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7244594 |
Microbial transformation method for the preparation of an epothilone
A microbial method for the preparation of an epothilone containing a terminal hydroxyalkyl group, comprising contacting at least one epothilone having a terminal alkyl group with an enzyme or...
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7241899 |
Methods for the preparation, isolation and purification of epothilone B, and X-ray crystal structures of epothilone B
The present invention relates to improved methods for the production, isolation and purification of epothilone B. These methods include, for example, a fermentation process for the production of...
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7192763 |
Streptomyces anulatus microorganism and a process for producing the substance GM-95
A compound which has the following formula (1),
a process for its production, a pharmaceutical composition comprising the compound as an active ingredient, a method of treating tumor which...
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7192750 |
Mutant Actinosynnema pretiosum strain with increased maytansinoid production
A microorganism that is a mutant bacterial strain of the species Actinosynnema pretiosum , designated PF4-4, (ATCC PTA-3921), being capable of producing maytansinoid ansamitocins such as...
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7132447 |
Substance FKI-1083 and process for producing the same
The present invention is comprised of culturing microorganism having ability to produce FKI-1083 substance represented by the formula:
in a medium, accumulating FKI-1083 substance in the...
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7052885 |
Process for preparing heterocyclic (R)- and (S)-cyanohydrins
A process for preparing enantiomer-enriched heterocyclic (R)- and (S)-cyanohydrins of the formula (I),
where R1, R2, R3, R4 independently of one another are H, an unsubstituted or substituted C...
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6929933 |
Riboflavin synthesis in yeast
The invention describes the riboflavin biosynthesis gene and gene products from yeast. Vectors and recombinant preparation processes for riboflavin are furthermore described. Specifically, the...
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6878534 |
Continuous fermentation process which is useful for the simultaneous optimal production of propionic acid and vitamin B12
The present invention relates to a fermentation process which is useful for the simultaneous production of propionic acid and vitamin B 12 , characterized in that it employs the culturing, on a...
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6844173 |
Strain of Streptomyces griseus
A microorganism strain which is Streptomyces griseus FERM BP-5420 and processes for preparing compounds by cultivating such microorganism strain.
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6818664 |
Angiogenesis inhibitor
A compound represented by the following formula (I) or a salt thereof and a medicament such as an angiogenesis inhibitor and an antitumor agent which comprises said compound or a physiologically...
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6818422 |
Substances K97-0239 and process for producing the same
A microorganism capable of producing substances K97-0239 comprising K97-0239A represented by the following formula [I]: and K97-0239B represented by the following formula [II]: is cultured in a...
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6767533 |
Use of a substance binding with the peripheral benzodiazepin receptor for treating skin stress
A composition containing a peripheral benzodiazepine receptor ligand for topical use in the treatment of cutaneous stress.
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6764842 |
Enantioselective bioreduction for the preparation of integrin receptor antagonist intermediates
The present invention relates to a novel enantioselective bioreduction using a yeast microorganism for the preparation of the chiral allylic alcohols of structural formula I (R is hydrogen or...
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6737256 |
Overcoming DAPA aminotransferase bottlenecks in biotin vitamers biosynthesis
A method is disclosed for the increased production of biotin and the biotin precursor dethiobiotin using a bacterium that produces a lysine-utilizing DAPA aminotransferase. This method involves the...
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6723894 |
Production of thebaine and oripavine
There is disclosed an improved poppy straw of a stably reproducing Papaver somniferum for the extraction of thebaine and/or oripavine, the threshed straw having thebaine and oripavine constituting...
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6627604 |
Memno peptides, process for their preparation and use thereof
The invention relates to novel peptide derivatives, called memno peptides, of the formula (I): wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 and (A)n have the meaning herein, obtainable...
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6620599 |
Process for the production of a biologically active phenolic compound(&plus ) catechin
The invention provides a process for the production of a biologically active phenolic compound (+) catechin from Taxus wallichiana tissue cultures, said process comprising the steps of (a)...
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6573074 |
Methods for ansamitocin production
Improved purification methods for ansamitocins are disclosed.
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6566106 |
Process for the isolation of clavulanic acid and of pharmaceutically acceptable salts thereof
A process for the isolation of clavulanic acid and pharmaceutically acceptable salts thereof, such as potassium clavulanate, from the aqueous fermentation broth of a clavulanic acid-producing...
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6562584 |
Bacterial strains for the production of 2-keto-L-gulonic acid
The present invention relates to novel bacterial strains useful for the production of 2-keto-L-gulonic acid. The present invention further relates to the use of these strains for the production of...
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6511820 |
Bacterial strains for the production of Pyrroloquinoline Quinone
The present invention relates to novel bacterial strains useful for the production of 2-keto-L-gulonic acid. The present invention further relates to the use of these strains for the production of...
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6482845 |
Method for inhibiting interleukin-2 production using tricyclo compounds
This invention relates to tricyclo compounds useful for treatment and prevention of resistance by transplantation, graft-versus-host diseases by medulla ossium transplantation, autoimmune diseases,...
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6440708 |
Fermentation of clavulanic acid at a controlled level of ammonia
A method for the production of clavulanic acid by the fermentation of a clavulanic acid producing microorganism at a controlled level of at least 50 mg/l ammonia has been provided for. Under the...
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6436681 |
Method for producing biotin
A gene construct comprising a biotin gene having the sequence SEQ ID No. 1 or SEQ ID No. 3, organisms which comprise this gene construct, the use of these sequences or of the gene construct for...
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6423530 |
Process for preparing FR900482 and compounds analogous thereto
A process for producing a compound of the general formula (I): (wherein R 1 represents hydrogen, a lower alkanoyl group or a lower alkyl group; R 2 and R 3 each represents hydrogen or a lower...
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6416762 |
Anti-picornaviral ligands via a combinatorial computational and synthetic approach
The present invention provides structure-based combinatorial libraries of compounds containing the functional group minima of picornaviruses including poliovirus and rhinovirus. The libraries can...
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6376222 |
Riboflavin production
The present invention provides a transformed yeast strain containing a DNA sequence transcriptionally linked to a promoter functional in such yeast cells, which when expressed in a suitable host...
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6372781 |
Compounds for treating gastroduodenal diseases
Spirolaxine, the compound of formula (I) wherein R is H, and the novel compounds of formula (I) wherein R is (C 1 -C 5 ) alkyl or CH 3 (CH 2 ) n CO and n is 1, 2, 3 or 4 are useful in treating...
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6361982 |
Regulatory gene for clavulanic acid biosynthesis
DNA comprising a regulatory gene for clavulanic acid biosynthesis. DNA is no greater than 7 kb in length and has the configuration of restriction sites shown in FIG. 1 or a fragment thereof. Use...
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6361979 |
Microbial conversion of 2-methylquinoxaline
The present invention relates to processes for the microbial oxidation of 2-methylquinoxaline to 2-quinoxalinecarboxylic acid which comprise contacting 2-methylquinoxaline with a microorganism, or...
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6361978 |
Production of biotin
The present invention provides processes for making biotin from desthiobiotin by either contacting desthiobiotin with an enzyme reaction mixture containing bioB gene product and nifU gene product...
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6350743 |
Cytotoxic pyridoacridine alkaloids
Shermilamine D, a novel cytotoxic pyridoacridine alkaloid of Formula 1, has been isolated from the tunicate Cystodytes violatinctus. The structure of the compound has been established on the...
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6316476 |
Heterocyclic compounds with antibacterial and antimycotic properties
The invention is drawn to novel antibiotics, XENORXIDES of formula shown below, wherein R 1 , R 2 =hydrogen, substituted or unsubstituted alkyl, cycloalkyl, acyl, aryl, aralkyl, or heterocyclyl...
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6284500 |
Microorganism resistant to threonine analogue and production of biotin
A microorganism resistant to a threonine analogue, which has a plasmid containing part or whole of a biotin operon; and a process for producing biotin, which comprises culturing a microorganism...
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RE37206 |
Gene encoding glycosyltransferase and its uses
This invention relates to glycosyltransferase, genes encoding glycosyltransferase, recombinant vectors having such a gene, host cells transformed with such a recombinant vector, and uses thereof....
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6235506 |
Process for the fermentative preparation of clavam derivatives whereby the levels of ammonia and urea in the fermentation medium are kept low
Improved methods for the preparation of clavams by fermentation of a clavam-producing organism in a suitable medium wherein the ammonium levels are kept low so as to avoid repression of enzymes,...
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6210935 |
Staurosporin biosynthesis gene clusters
The present invention relates especially to a DNA fragment that is obtainable from the gene cluster within the genome of Streptomyces or Actinomyces that is responsible for staurosporin...
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