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7611670 |
Quantitative analysis of a biological sample of unknown quantity
Disclosed is a method for testing a modified specimen such as a dried blood spot, plasma or serum specimen, for an analyte of interest, such as cholesterol. In accordance with the disclosed subject...
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7575884 |
Test piece for measuring high-density lipoprotein (HDL) cholesterol
The present invention relates to a test piece having a simple structure, by which HDL cholesterol can be measured easily using a small amount of specimen. A reagent layer ( 2 ) is formed on a...
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7527932 |
Method of using physiological markers to estimate cardiovascular risk
An individual's risk profile for developing a cardiovascular disorder or for experiencing a cardiovascular event is determined by 1) measuring levels of certain stress-evoked proteins including...
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7507551 |
Multiple quantification method for cholesterol in low-density lipoproteins
The present invention is intended to provide a method for simultaneously measuring cholesterol in low density lipoprotein and total cholesterol as test components in blood. Specifically, a method...
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7491542 |
Test device for determining the concentration of LDL-cholesterol in a sample
The present invention provides a test device for determining the concentration of LDL-cholesterol in a sample. The test device has a continuous solid surface with at least one reaction area on the...
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7402404 |
Assay method for measurement of net cholesterol flux
The present invention relates to an assay for determining net cholesterol flux from lipid loaded cells in the presence of an acceptor (e.g., serum). The present invention also relates to a method...
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7361482 |
Method for detecting intracellular cholesterol
The present invention relates to a method of detecting intracellular cholesterol. The method provides contacting a permeabilized cell with labeled cθ complex. Methods of using this detection...
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7348158 |
Method of quantifying cholesterol in high density lipoprotein and reagent compositions
A method for specifically quantifying HDL cholesterol in which cholesterol in lipoproteins other than HDL is erased in the first step, and HDL cholesterol is specifically quantified in the second...
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7335483 |
Method of pretreatment of sample for quantitating cholesterol and method for quantitating cholesterol in specific lipoproteins by using the same
A method of a pretreatment of a sample for quantitating cholesterol characterized by, before measuring cholesterol contained in specific lipoproteins, treating the sample containing lipoproteins...
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7279296 |
Compositions and methods for lipoprotein uptake assays
Provided herein are compositions and methods for lipoprotein uptake assay. These compositions and methods may be used for the lipoprotein uptake assays, including high-throughput assays. The...
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7270971 |
Fluorescence assay for measuring the rate of cholesterol ester transfer
An improved method of obtaining fluorescence measurements which may be used as a measure of the CETP-catalyzed rate of transfer of a lipophilic non-polar fluorescent cholesteryl ester between...
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7250304 |
Functional assay of high-density lipoprotein
This invention provides novel assays that are prognostic and/or diagnostic for atherosclerosis or risk of atherosclerosis. It was discovered that high density lipoprotein (HDL) or components...
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7238494 |
Direct assay of cholesterol in skin samples removed by tape stripping
Skin cholesterol is measured by applying an adhesive tape onto a selected area of the skin to adhere the tape to the selected skin area and stripping the tape off the selected skin area to obtain a...
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7223546 |
Method for measuring the amount of constituent contained in a specific lipoprotein
There is provided a method and kit for measuring the amount of an objective constituent contained in a specific lipoprotein in a biological sample such as serum and plasma, specifically for...
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7208287 |
Reagent set and method for detecting cholesterol in a high-density lipoprotein or low density lipoprotein
A method for quantitating a specific component in lipoproteins contained in a biological sample, for example, HDL (high-density lipoprotein), LDL (low-density lipoprotein) or VLDL (very low-density...
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7202047 |
Aqueous method for determining cholesterol in remnant-like particles using cholesterol esterase, phospholipase, surfactant and cholesterol oxidase or dehydrogenase
The present invention provides a simple and sensitive aqueous method for determining cholesterol in remnant-like particles in a biological sample without the separation of components of the sample....
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7179612 |
Method for detecting a lipoprotein-acute phase protein complex and predicting an increased risk of system failure or mortality
A method for diagnosing a condition of a patient involves the steps of (a) adding one or more reagents to a test sample from a patient, the test samples comprising at least part of a blood sample...
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7087397 |
Method for determining HDL concentration from whole blood or plasma
A multilayer test strip and method of using the test strip for determining concentration of HDL cholesterol in a whole blood sample. The inventive test strip includes a two-stage blood separation...
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7081509 |
Method for producing highly functional, hyper branched polyester by means of enzymatic esterification
The present invention relates to a process for preparing highly functional hyperbranched polyesters which comprises reacting a reaction solution comprising solvent and
(a) one or more dicarboxylic...
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7074581 |
Reagent for assaying lipid
Effective stabilizing amount at least of one antioxidant is added to a composition containing an esterase and surfactant(s).
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7060452 |
Assay method for measurement of net cholesterol flux
The present invention relates to an assay for determining net cholesterol flux from lipid loaded cells in the presence of an acceptor (e.g., serum). The present invention also relates to a method...
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7052864 |
Bioanalytical measuring method using oxidases and lanthanoid-ligand complexes
The present invention concerns biological methods of determination using enzymes from the group of oxidases and using optical indicators from the group of lanthanoid-ligand complexes.
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7049130 |
Diagnostic sanitary test strip
An improved multi-layered diagnostic sanitary test strip for receiving a heterogenous fluid, such as whole blood, to test for presence and/or amount of a suspected analyte in the fluid by...
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7049086 |
High-throughput screening assay for cholesterol inhibitors and inhibitors identified thereby
The present invention provides a high-throughput screening assay to identify test agents as cholesterol inhibitors via mutant NCP1 mammalian cells. Also provided are cholesterol inhibiting agents...
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7026111 |
Methods and reagents for improved cell-based assays
The ability to efficiently determine the state of enzyme expression in cells has long been desired as material to the diagnosis of disease. This invention relates to cytoenzymology, and more...
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6987001 |
Methods and compositions using stearoyl-CoA desaturase to identify triglyceride reducing therapeutic agents
The use of screening assays based on the role of human stearoyl-CoA desaturase-1 (“hSCD1”) in human diseases, disorders or conditions relating to serum levels of triglyceride, VLDL, HDL, LDL,...
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6986998 |
Method of analyzing components in biological samples
There is provided a method for a selective assay of component, particularly cholesterol, in very low-density lipoprotein (VLDL) which is one of serum lipoproteins. In the assay, an enzymatic...
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6979552 |
Method of lipid assay and reagent for use therein
A method of lipid assay characterized by assaying the lipids contained in a blood component in the presence of an organic silicon compound. The method can cause specific conditions for direct...
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6974676 |
Assay methods for transfer proteins that normalize for acceptor concentration
A method to measure protein wherein said method internally controls for factors that affects protein activity such as substrate concentration.
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6939682 |
Test piece for assaying high density lipoprotein (HDL) cholesterol
The present invention relates to a test piece having a simple structure, by which HDL cholesterol can be measured easily using a small amount of specimen. A reagent layer ( 2 ) is formed on a...
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6893830 |
Method of screening oxysterol activation of LXRα
The present invention provides a method of screening for agonists of an oxycholesterol activator of LXRα transcription, comprising the steps of: introducing a reporter construct and an LXR...
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6861233 |
Method of screening for triacyglycerol hydrolase inhibitors
The invention relates to methods of identifying therapeutic agents which inhibit triacyglycerol hydrolase (TGH) activity, defined as TGH inhibitors, which are useful in the treatment of conditions...
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6846636 |
Methods and compositions for HDL holoparticle uptake receptor
The present invention provides an isolated mammalian receptor which specifically binds a high density lipoprotein holoparticle, comprising a subunit of approximately 45-600 kDa molecular weight and...
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6844149 |
Method, system, and apparatus for measurement and recording of blood chemistry and other physiological measurements
A multi-component test strip for analyzing a plurality of blood components in a single blood sample. The test strip comprises a porous medium having a sample receiving region, and two or more...
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6794157 |
Methods for fractional quatification of cholesterol in lipoproteins and quantification reagents
The present invention provides a method for the quantitative determination of cholesterol in low density lipoproteins and a reagent kit for use therein. The present invention also provides a method...
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6764828 |
Method for quantitatively determining LDL cholesterols
A method for quantitatively determining LDL cholesterol, including the steps of adding to serum a surfactant selected from among polyoxyethylenealkylene phenyl ethers and polyoxyethylenealkylene...
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6756510 |
Making a variety of L-lysine feed supplements
Liquid lysine can be made with almost any particular specification that may be reasonably expected. A multistep process for producing lysine includes at least: fermentation, ultrafiltration,...
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6689618 |
Method and test strip of detecting oxidizing adulterant in urine
A single reagent system and a method to detect and measure oxidizing adulterants in bodily fluid being screened for drugs of abuse are disclosed. The system comprising a strip containing 0.05 to...
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6673555 |
Methods of using SCAP antagonists
The invention relates to a method for screening therapeutic agents, defined as SCAP antagonists, for use in combating diseases associated with elevated lipid levels, said method comprising...
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6660491 |
Process for producing dietary sterol fatty acid esters
A process for enzymatically producing, from a vegetable oil deodorizer distillate, a dietary sterol fatty acid ester superior in flavor qualities (e.g., color, odor and taste) and safety and...
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6613539 |
Method and apparatus for simultaneously testing a plurality of compounds to detect their activity
Described is a method of simultaneously testing a plurality of compounds for activity comprising the steps of: (a) placing a plurality of the compounds into at least two arrays, each having a...
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6605440 |
Method for determining analyte level
A multilayer analytical element for determining a level of an analyte on a substrate and adapted for use with hydrogen peroxide and an affinity-enzymatic compound of formula A-C-B, wherein A is a...
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6602710 |
Screening method for SREBP pathway-specific inhibitors
This invention provides a screening method for sterol regulatory element binding protein (SREBP) pathway-specific inhibitors using a mutant cultured cell, as well as therapeutic agents for...
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6506570 |
Method of sorting birds in ovo
A method of determining the gender of a bird in ovo comprises detecting the presence or absence of an elevated level of a sex-related hormone in the extra-embryonic fluid of the bird egg, and then...
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6498019 |
Lecithin-cholesterol acyltransferase protein
This invention relates to a novel protein having a lecithin-cholesterol acyltransferase-like activity, etc. or its salt, a precursor protein of the protein or its salt, a partial peptide of the...
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6479249 |
Method of determining cholesterol content of high-density lipoproteins
Disclosed is a method for quantifying cholesterol in HDL, which does not require complex fragmentation and separation operations, and by which the HDL cholesterol in test samples containing HDL and...
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6410253 |
Cholesterol oxidase
A process for producing cholesterol oxidase from a recombinant microorganism, the microorganism itself and its recombinant plasmid are disclosed. The cholesterol oxidase has a particular amino acid...
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6383819 |
Method for determining cholesterol and sensor applicable to the same
The present disclosure relates to a method for determining cholesterol in low density lipoprotein comprising the steps of (a) measuring total cholesterol level in a sample containing at least high...
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6379883 |
Microfabricated aperture-based sensor
A chemical sensor includes an enzyme layer, a diffusion layer and an analyte barrier layer positioned over the diffusion layer. Apertures are formed by microfabrication in the analyte barrier layer...
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6365363 |
Method of determining skin tissue cholesterol
A method of determining skin tissue cholesterol includes preparing a section of skin surface, applying a dosed amount of an enzyme-containing mixture onto the skin, exposing, evaluating the...
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