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7618798 |
Alginate gel scaffold having a plurality of continuous parallel microtubular copper capillaries
The invention relates to mutants and alleles of the coryneform bacterium mqo gene which encodes malate quinone oxidoreductases which contain any amino acid apart from L-serine at position 111, or a...
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7598062 |
Process for the production of L-amino acids using strains of the family enterobacteriaceae that contain an attenuated fruR gene
A process for the production of L-amino acids, in particular L-threonine, in which the following steps are carried out:
(a) fermentation of the microorganisms of the family...
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7588923 |
Method to increase the yield and improve purification of products from transaminase reactions
A process for producing high yields of enantioselective amino acids and chiral amines by reacting a keto acid or ketone and an amino acid donor in the presence of a transaminase biocatalyst to...
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7585650 |
Alleles of the zwf gene from coryneform bacteria
The invention relates to mutants and alleles of the zwf gene of coryneform bacteria, which encode variants of the Zwf subunit of glucose 6-phosphate dehydrogenase (EC: 1.1.1.49), and to processes...
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7582454 |
5-substituted hydantoin racemase, DNA coding for the racemase, and processes for producing optically active amino acids
The present invention relates to a 5-substituted hydantoin racemase, which efficiently catalyzes racemization reactions at a high optimum temperature for racemization reactions, DNA coding for the...
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7572607 |
Polypeptides and biosynthetic pathways for the production of monatin and its precursors
Methods and compositions that can be used to make monatin from glucose, tryptophan, indole-3-lactic acid, indole-3-pyruvate, and 2-hydroxy 2-(indol-3-ylmethyl)-4-keto glutaric acid, are provided....
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7563602 |
Alleles of the GND gene from coryneform bacteria
The invention relates to mutants and alleles of the gnd gene from coryneform bacteria coding for 6-phosphogluconate dehydrogenases which contain at position 329 or a comparable position of the...
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7534590 |
Method for producing monatin
A solution to be treated containing monatin and impurities is treated with a nonpolar resin having aromatic rings, whereby monatin is separated from the solution. Treatment with the nonpolar resin...
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7504242 |
Process for the fermentative production of amino acids using coryneform bacteria in which OpcA gene expression is amplified
The present invention relates to polynucleotides that encode proteins having OpcA enzymatic activity. These polynucleotides can be used for increasing lysine biosynthesis in Coryneform glutamicum.
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7470524 |
Method for producing L-amino acids using bacteria of the Enterobacteriaceae family
There is disclosed a method for producing an L-amino acid, for example L-threonine, L-lysine, L-histidine, L-phenylalanine, L-arginine, L-tryptophan or L-glutamic acid, using a bacterium of the...
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7452704 |
Dehydrogenase and a gene encoding the same
The object of the present invention is to provide a novel dehydrogenase having a property which is different from that of known dehydrogenases. The present invention provides a dehydrogenase having...
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7445915 |
Mutant isopropylmalate isomerase
The present invention provides a polypeptide comprising an amino acid sequence in which at least one amino acid is deleted, substituted or added in an amino acid sequence of isopropylmalate...
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7432085 |
Method for producing L-amino acid
In a method for producing an L-amino acid by culturing a microorganism having an ability to produce an L-amino acid in a medium to produce and accumulate the L-amino acid in the medium and...
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7381548 |
Method for producing L-amino acid using bacterium of Enterobacteriaceae family having expression of yafA gene attenuated
The present invention provides a method for producing an L-amino acid using a bacterium of the Enterobacteriaceae family, particularly a bacterium belonging to genus Escherichia or Pantoea ,...
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7361490 |
DNA encoding hydantoinase, DNA encoding N-carbamyl-L-amino acid hydrolase, recombinant DNA, transformed cell, method of producing protein and method of producing optically active amino acid
The present invention provides a method of producing optically active amino acids from 5-substituted hydantoin by isolating a hydantoinase gene and an N-carbamyl-L-amino acid hydrolase gene...
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7335496 |
Method for producing target substance
A target substance is produced by culturing a bacterium which has the ability to produce the target substance in a medium to cause accumulation of said target substance in the medium and collecting...
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7311836 |
Process for producing amino acid or salt thereof by column technique and production apparatus thereof
According to the process for producing amino acid or salt thereof in the present invention, in the adsorption step, an amino acid-containing aqueous solution is fed into a pressure tight column so...
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7303900 |
Methods for the production of tyrosine, cinnamic acid and para-hydroxycinnamic acid using recombinant microorganisms
Genes encoding phenylalanine ammonia-lyase (PAL), tyrosine ammonia lyase (TAL) and phenylalanine hydroxylase (PAH) have been introduced into a host organism for the production of...
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7300776 |
L-amino acid-producing bacterium and a method for producing L-amino acid
An L-amino acid-producing strain of Escherichia coli is bred by modifying an Escherichia coli K12 strain or a derivative thereof so as to become resistant to L-valine and have an ability to...
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7300775 |
Methods for producing α-substituted carboxylic acids using nitrilases and strecker reagents
In accordance with the present invention there are provided methods for producing enantiomerically pure α-substituted carboxylic acids, such as, for example, α-amino acids and α-hydroxy acids,...
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7288403 |
Anthranilate synthase gene and method for increasing tryptophan production
The present invention provides a method for conferring tolerance to an amino acid analog of tryptophan to a plant and/or altering the tryptophan content of a plant by introducing and expressing an...
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7282356 |
D-aminoacylase mutants
The present invention provides mutant D-aminoacylases and use thereof. The mutant D-aminoacylases are hard to be inhibited by the substrate and, comprise the amino acid sequences of the...
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7259003 |
Escherichia bacteria transformed with a yedA homolog to enhance L-amino acid producing activity, and methods for producing an L-amino acid using same
A method for producing an L-amino acid, such as L-phenylalanine or L-threonine, is provided using a bacterium belonging to the genus Escherichia , wherein the L-amino acid productivity of said...
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7256024 |
Tyrissamycin antibiotic
A novel tyrosyl diester antibiotic is obtained from fermentation of a recombinant strain of Streptomyces lividans designated Stretomyces lividans WD 15684 (ATCC-202143). The new antibiotic,...
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7223588 |
Microorganisms and methods for overproduction of DAHP by cloned Pps gene
Genetic elements comprising expression vectors and a gene coding for phosphoenol pyruvate synthase is utilized to enhance diversion of carbon resources into the common aromatic pathway and pathways...
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7214526 |
Alleles of the mqo gene from coryneform bacteria
The invention relates to mutants and alleles of the coryneform bacterium mqo gene which encodes malate quinone oxidoreductases which contain any amino acid apart from L-serine at position 111, or a...
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7179623 |
Method of producing amino acids using E. coli transformed with sucrose PTS genes
Amino acids such as threonine, homoserine, isoleucine, lysine, valine and tryptophan are produced using a bacterium belonging to the genus Escherichia which has been constructed from a sucrose...
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7160703 |
Nucleotide sequences coding for the PtsI protein
The present invention provides nucleotide sequences from Coryneform bacteria which code for the PtsI protein and a process for the fermentative preparation of amino acids using bacteria in which...
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7157251 |
Process for the racemization of N-protected amino acids using racemase
The present invention relates to the processes of racemization and deprotection of special N-protected amino acids in the acylase/racemase system for the total conversion of special N-protected...
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7129059 |
Process for the preparation of compounds with enhanced optical purity
A process for preparation of a compound with enhanced optical purity is disclosed wherein a mixture of the enantiomers of a chiral amine is brought into contact with an enzyme having peptide...
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7115412 |
Process for the preparation of optically active 7-substituted-3-(2-aminopropyl)indole derivatives and intermediates therefor
Disclosed are a process for preparation of an optically active 7-substituted 3-(2-aminopropyl)indole compound and an intermediate therefor. In the above preparation process, 7-substituted indole is...
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7105326 |
Methods for the production of tyrosine, cinnamic acid and para-hydroxycinnamic acid
Genes encoding phenylalanine ammonia-lyase (PAL), tyrosine ammonia lyase (TAL) and phenylalanine hydroxylase (PAH) have been introduced into a host organism for the production of...
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7098020 |
DNA encoding hydantoinase, DNA encoding N-carbamyl-L-amino acid hydrolase, recombinant DNA, transformed cell, method of producing protein, and method of producing optically active amino acid
The present invention provides a method of producing optically active amino acids from 5-substituted hydantoin by isolating a hydantoinase gene and an N-carbamyl-L-amino acid hydrolase gene...
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7097999 |
Method for producing target substance using microorganisms with reduced interactions between MalK and IIAGlc
The present invention describes a method for producing a target substance by utilizing a microorganism comprising culturing the microorganism in a medium, allowing the target substance to...
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7074602 |
Method for producing L-threonine
An L-threonine-producing Escherichia coli strain and a method for producing the same are provided. The Escherchia coli strain contains chromosomal DNA with inactivated metJ gene. Therefore,...
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7045320 |
Methods for producing L-amino acids
A bacterium belonging to the genus Escherichia having an ability to produce an L-amino acid is cultured in a medium containing fructose as a main carbon source, preferably a medium containing a...
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7018817 |
Process for the preparation of compounds with enhanced optical purity
Process for the preparation of a compound with enhanced optical purity wherein a mixture of the enantiomers of a chiral compound of formula 1
wherein:
R 1 represents an alkyl or an aryl group...
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6962794 |
Application of glucose transport mutants for production of aromatic pathway compounds
This invention describes methods for enhancing carbon flow into a pathway of a host cell to enhance the biosynthetic production of compounds therefrom, the host cells being selected based on being...
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6960455 |
Methods of making amino acids using E. coli transformed with csc genes
An amino acid such as threonine, homoserine, isoleucine, lysine, valine and tryptophan is produced using a bacterium belonging to the genus Escherichia which has been constructed from sucorse...
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6953677 |
Recombinant L-N-carbamoylase from Arthrobacter aurescens and method of producing L-amino acids therewith
A novel rec-L-N-carbamoylase from Arthrobacter aurescens and its method of use for producing L-amino acids. The recombinantly produced L-carbamoylase is unexpectedly stable, so that an industrial...
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6902915 |
Heat-stable D-aminoacylase
The present invention provides a novel D-aminoacylase, as well as method for producing a D-amino acid using the same. In order to achieve the above objective, the present inventors have succeeded...
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6869788 |
DNA encoding novel D-aminoacylase and process for producing D-amino acid by using the same
This invention provides a novel D-aminoacylase obtained by cloning a DNA encoding the novel D-aminoacylase from Methylobacterium mesophilicum MT 10894, etc. and which shows sufficiently high...
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6808914 |
Process for the preparation of L-amino acids by fermentation and nucleotide sequences coding for the accDA gene
The invention relates to nucleotide sequences coding for the accDA gene and to a process for the preparation of L-amino acids, especially L-lysine, by fermentation using corynebacteria in which the...
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6686181 |
Method for the production of L-amino acids from their racemic N-aceytyl-D, L-derivatives by enzymatic racemate cleavage by means of isolated recombinant enzymes
Process for the preparation of L -amino acids from their racemic N-acetyl-D,L derivatives by enzymatic resolution by means of isolated, recombinant enzymes A process for the preparation of...
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6656710 |
Process for the production of amino acids using racemase and acylase
The present invention relates to the processes of racemization and deprotection of special N-protected amino acids in the acylase/racemase system for the total conversion of special N-protected...
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6617127 |
Synthesis and recovery of aspartame involving enzymatic deformylation step
The invention relates to the synthesis of aspartame involving enzymatic deformylation of an N-formyl-α-L-aspartyl-L-phenylalanine compound by treatment with an enzyme having formylmethionyl...
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6551816 |
Enzymatic method for preparing synthesis intermediates
The invention concerns a method for preparing α-phenylalanine ester with substantially enantiomeric purity of formulae (I) and (II) wherein Alk represents a linear or branched C 1 -C 6 alkyl...
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6551803 |
Method for purification of amino acid containing solutions by electrodialysis
A process is described for purifying an amino acid-containing solution by means of electrodialysis, wherein an amino acid-containing solution is employed which is obtained from the fermentation for...
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6515201 |
Anthranilate synthase gene and method of use thereof for conferring tryptophan overproduction
The present invention provides a method for conferring tolerance to an amino acid analog of tryptophan to a plant and/or altering the tryptophan content of a plant by introducing and expressing an...
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6444450 |
Large-scale production of polyphenols or polyaromatic amines using enzyme-mediated reactions
A process for large-scale, low cost, batch or continuous production of polyphenols using enzyme-mediated reactions and methods for recycling non-consumed reactants.
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