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7611873 |
Method for producing L-methionine by fermentation
L-Methionine is produced by culturing a microorganism which is deficient in repressor of L-methionine biosynthesis system and/or enhanced intracellular homoserine transsuccinylase activity is...
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7611872 |
Method for the production of D-pantothenic acid and/or salts thereof via purification by nanofiltration as adjunct for animal feedstuffs
The invention relates to an improved method for the production of D-pantothenic acid and/or salts thereof and use thereof as adjunct for animal feedstuffs.
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7608248 |
Stable isotope-labeled aromatic amino acids, method for incorporating the same in target protein and method for NMR-structural analysis of proteins
The present invention herein provides, for instance, a stable isotope-labeled phenylalanine wherein a carbon atom of the phenyl group linked to an amino acid residue is 13 C, 2 to 4 carbon atoms...
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7608191 |
Production of a fermentation product
A process of separating suspended solids from a fermentation liquor by subjecting the liquor to a solids-liquid separation stage, wherein the fermentation liquor is produced in a fermentation...
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7598062 |
Process for the production of L-amino acids using strains of the family enterobacteriaceae that contain an attenuated fruR gene
A process for the production of L-amino acids, in particular L-threonine, in which the following steps are carried out:
(a) fermentation of the microorganisms of the family...
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7588923 |
Method to increase the yield and improve purification of products from transaminase reactions
A process for producing high yields of enantioselective amino acids and chiral amines by reacting a keto acid or ketone and an amino acid donor in the presence of a transaminase biocatalyst to...
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7585650 |
Alleles of the zwf gene from coryneform bacteria
The invention relates to mutants and alleles of the zwf gene of coryneform bacteria, which encode variants of the Zwf subunit of glucose 6-phosphate dehydrogenase (EC: 1.1.1.49), and to processes...
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7582454 |
5-substituted hydantoin racemase, DNA coding for the racemase, and processes for producing optically active amino acids
The present invention relates to a 5-substituted hydantoin racemase, which efficiently catalyzes racemization reactions at a high optimum temperature for racemization reactions, DNA coding for the...
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7582444 |
Use of flocculating agents for separating the solid residue in hydrolysed fermentation substrates
Process for improving the separation efficiency of residual solid matter from the liquid phase of an aqueous acid hydrolysate of a naturally occurring polysaccharide comprising dissolved sugars,...
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7582215 |
Production of a fermentation product
A process of separating suspended solids from a fermentation liquor by subjecting the liquor to a solids-liquid separation stage, wherein the fermentation liquor is produced in a fermentation...
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7575905 |
Process for L-amino acid production using enterobacteriaceae strains with enhanced yibD
The invention relates to a process for the preparation of L-amino acids by the fermentation of recombinant microorganisms of the family Enterobacteriaceae. The microorganisms produce the desired...
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7572455 |
Vaccine comprising an attenuated pestivirus
Attenuated pestiviruses, in particular attenuated BVDV, wherein at least one mutation is in the coding sequence for glycoprotein E rns and at least another mutation in the coding sequence for N...
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7563602 |
Alleles of the GND gene from coryneform bacteria
The invention relates to mutants and alleles of the gnd gene from coryneform bacteria coding for 6-phosphogluconate dehydrogenases which contain at position 329 or a comparable position of the...
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7556947 |
Method for producing β-hydroxy amino acid and enzyme used therefor
A method for producing β-hydroxy amino acid and its optically-active isomer is provided. The β-hydroxy amino acid is produced by reacting a predetermined D-α-amino acid and 5,10-methylene...
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7553645 |
Process for preparing L-amino acids using improved strains of the Enterobacteriaceae family
The invention relates to a process for preparing L-amino acids by fermenting recombinant microorganisms of the Enterobacteriaceae family in which the ytfQ-ORF is overexpressed.
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7550277 |
D-amino acid dehydrogenase and method of making D-amino acids
Polypeptides capable of catalyzing the reductive amination of a 2-ketoacid to its corresponding D-amino acid are provided. The polypeptides can be prepared by mutagenesis of, e.g., a...
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7547531 |
L-amino acid producing microorganism which has been modified to inactive the fimH gene, and a method for producing I-amino acid
An L-amino acid producing bacterium of the Enterobacteriaceae family is described, wherein the bacterium has been modified so as to not produce type I fimbrial adhesin protein is cultured in a...
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7534590 |
Method for producing monatin
A solution to be treated containing monatin and impurities is treated with a nonpolar resin having aromatic rings, whereby monatin is separated from the solution. Treatment with the nonpolar resin...
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7531332 |
Method for producing a lower alkyl ester of α-L-aspartyl-L-phenylalanine using Escherichia bacteria
A method for producing an L-amino acid, such as L-phenylalanine and L-threonine, is provided using an Escherichia bacterium, wherein the L-amino acid productivity of said bacterium is enhanced by...
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7527950 |
Method for producing an L-amino acid by enhancing expression of the yfiK gene in an Escherichia bacterium
A bacterium belonging to the genus Escherichia which has an ability to produce an L-amino acid, wherein the ability to produce the L-amino acid is increased by increasing expression of the yfiK...
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7524657 |
Alleles of the sigA gene from coryneform bacteria
The invention relates to alleles of the sigA gene from coryneform bacteria which code for sigma factors A and a process for the fermentative preparation of L-lysine using bacteria which contain...
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7504242 |
Process for the fermentative production of amino acids using coryneform bacteria in which OpcA gene expression is amplified
The present invention relates to polynucleotides that encode proteins having OpcA enzymatic activity. These polynucleotides can be used for increasing lysine biosynthesis in Coryneform glutamicum.
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7501282 |
Plasmid autonomously replicable in Enterobacteriaceae family
A gene isolated from a microorganism selected from the group consisting of Pantoea bacteria, Erwinia bacteria, and Enterobacter bacteria, and encoding a Rep protein or a homologue thereof is...
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7494801 |
Method of selecting Escherichia coli strain which highly expresses exogenous genes, Escherichia coli mutant strains selected by this method and process for producing enzymes and compounds using the same
The invention relates to a selection method of an Escherichia coli mutant strain which expresses an exogenous gene at a high level, wherein stress resistance such as hydrogen peroxide...
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7491519 |
Bacterium having ability to produce L-glutamic acid, L-proline or L-arginine and method for producing L-glutamic acid, L-proline or L-arginine
L-Glutamic acid, L-proline or L-arginine is produced by culturing a bacterium belonging to the genus Escherichia , which is L-isoleucine auxotrophic and has ability to produce L-glutamic acid,...
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7470524 |
Method for producing L-amino acids using bacteria of the Enterobacteriaceae family
There is disclosed a method for producing an L-amino acid, for example L-threonine, L-lysine, L-histidine, L-phenylalanine, L-arginine, L-tryptophan or L-glutamic acid, using a bacterium of the...
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7468262 |
Polynucleotides encoding useful polypeptides in corynebacterium glutamicum ssp. lactofermentum
The present invention provides novel polypeptides and polynucleotides useful as biotechnological tools, specifically identified in a coryneform bacterium Corynebacterium glutamicum ssp. ...
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7455997 |
Production of fermentation product
A process of producing fermentation product comprising the steps of, (i) forming an acidified suspension of particulate plant derived material comprising a first polysaccharide which is more...
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7452704 |
Dehydrogenase and a gene encoding the same
The object of the present invention is to provide a novel dehydrogenase having a property which is different from that of known dehydrogenases. The present invention provides a dehydrogenase having...
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7449325 |
Process for enzymatically producing either optically active N-substituted β-amino acids or esters thereof or optically active N-substituted 2-homopipecolic acids or esters thereof
The present invention discloses a process which comprises selectively hydrolyzing one enantiomer of racemic mixtures of an N-substituted β-amino acid alkyl ester or N-substituted 2-homopipecolic...
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7445915 |
Mutant isopropylmalate isomerase
The present invention provides a polypeptide comprising an amino acid sequence in which at least one amino acid is deleted, substituted or added in an amino acid sequence of isopropylmalate...
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7442529 |
Fluorescent probes for biological studies
The present invention provides fluorescent compounds of formula (I)
and methods monitoring protein-protein interactions.
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7439050 |
Corynebacterium glutamicum genes encoding diaminopimelate epimerase
Isolated nucleic acid molecules, designated MP nucleic acid molecules, which encode novel MP proteins from Corynebacterium glutamicum are described. The invention also provides antisense nucleic...
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7432087 |
Method for preparing (2S, 3R, 4S)-4-hydroxyisoleucine and analogues thereof
The invention concerns a method for preparing a-amino acids of general formula (2S-1) wherein: the group R1 represents a hydrogen atom, a group protecting the amino group or a group of formula...
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7432086 |
L-amino acid amide asymmetric hydrolase and DNA encoding the same
A recombinant microorganism is produced by introducing a DNA encoding an enzyme which hydrolyzes an amido bond of L-amino acid amide, especially L-2-alkylcysteine amide, and L-amino acid is...
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7432085 |
Method for producing L-amino acid
In a method for producing an L-amino acid by culturing a microorganism having an ability to produce an L-amino acid in a medium to produce and accumulate the L-amino acid in the medium and...
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7427496 |
Anti-cancer compounds
The invention provides bradykinin antagonists and pharmaceutically acceptable salts thereof having anti-cancer activity. These anti-cancer compounds are particularly useful for inhibiting the...
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7416864 |
Method for treating dyskinesia
The present invention is directed to the use of a class of peptide compounds for treating primary or/and secondary dyskinesias such as tardive dyskinesia.
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7399617 |
Method for producing an L-amino acid in an Escherichia bacterium via altering expression levels of target proteins
A bacterium belonging to the genus Escherichia which has an ability to produce an L-amino acid, wherein the ability to produce the L-amino acid is increased by increasing expression of an L-amino...
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7399616 |
Enzymatic synthesis of Nα-acyl-L-arginine esters
The invention relates to a process for preparing a Na-acyl-L-arginine ester, derived from fatty acids and esterified dibasic amino acids, according to the following formula (I), where: X— is...
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7396665 |
Method of producing FR901228
Depsipeptides and congeners thereof are disclosed having structure (I), wherein m, n, p, q, X, R1, R2 and R3 are as defined herein. These compounds, including FR901228, have activity as, for...
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7393679 |
Whole cell catalyst
A whole cell catalyst is described comprising a hydantoinase, a racemase and a carbamoylase. Thus this catalyst is able to degrade hydantoins directly into the amino acids. Additionally, a process...
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7381548 |
Method for producing L-amino acid using bacterium of Enterobacteriaceae family having expression of yafA gene attenuated
The present invention provides a method for producing an L-amino acid using a bacterium of the Enterobacteriaceae family, particularly a bacterium belonging to genus Escherichia or Pantoea ,...
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7378267 |
Method for L-threonine production
A method for producing L-threonine using a microorganism is provided. In the method, the threonine dehydratase (tdc) gene existing in the genomic DNA of the microorganism is partially deactivated...
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7371555 |
Polypeptides having α-H-α-amino acid amide racemase activity and nucleic acids encoding the same
The invention relates to isolated polypeptides having α-H-α-amino acid amide racemase activity and nucleic acids encoding the same. The invention also relates to vectors and host cells comprising...
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7371549 |
Aldolase, and method for producing optically active IHOG and monatin
The present invention relates to a method for producing optically active IHOG, which can in turn be used for the production of monatin. The present invention further relates to a method for...
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7364889 |
Catalytically active peptides
A catalytically active peptide comprising an imidazole function in position i flanked by at least one functional group to be amidated in position i+3+4k, where k is an integer equal to or higher...
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7364875 |
Method for producing medical and commercial grade poly-gamma-glutamic acid of high molecular weight
Methods for producing high molecular weight poly-gamma-glutamic acid (PGA). The PGA is produced by fermentation, and purified by use of tangential flow filtration, followed by diafiltration, as...
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7361490 |
DNA encoding hydantoinase, DNA encoding N-carbamyl-L-amino acid hydrolase, recombinant DNA, transformed cell, method of producing protein and method of producing optically active amino acid
The present invention provides a method of producing optically active amino acids from 5-substituted hydantoin by isolating a hydantoinase gene and an N-carbamyl-L-amino acid hydrolase gene...
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7351571 |
Process for the production of β-amino acids using acylase
The present invention relates to a Variovorax sp. which produces an acylase having an asymmetric hydrolysis activity on an N-acetyl β-amino acid to selectively produce an R-β-amino acid, and a ...
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