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5059712 |
Isolating aminoarginine and use to block nitric oxide formation in body
Pharmaceutically pure physiologically active N G -aminoarginine (i.e., the L or D,L form) or pharmaceutically acceptable salt thereof is administered in a nitric oxide synthesis inhibiting amount...
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5053328 |
Process for the fermentative preparation of L-amino acids from α-keto carboxylic acids
The preparation of an L-amino acid, particularly valine, leucine, isoleucine, alanine and phenylalanine, from the corresponding α-keto carboxylic acid by bacterial fermentation in the presence of...
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5041375 |
Method of producing carnitine
This invention relates to a method for producing carnitine comprising contacting, in a reaction medium, carnitinenitrile with (A) a nitrilase capable of hydrolyzing carnitinenitrile to form...
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5024945 |
Process for obtaining sarcosine oxidase from microorganisms
The present invention provides a process for obtaining sarcosine oxidase from micro-organisms by culturing thereof and obtaining the enzyme from the biomass or from the culture broth, wherein a...
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5017480 |
Process for recovering L-amino acid from fermentation liquors
A process for recovering a high-purity L-amino acid from a fermentation liquor obtained by fermentation or an enzymic method, which comprises removing the impurities contained in said fermentation...
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5001258 |
Antibiotic, fumifungin, a microbial process for the preparation thereof, and the use thereof as a pharmaceutical
Fumifungin, a compound of the formula ##STR1## can be isolated from the culture broth of fungus culture No. Y-83,0405 (DSM 4152), and has bactericidal and fungicidal properties.
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4997754 |
Process for recovering L-amino acids from fermentation liquors containing them
A process for recovering a high-purity L-amino acid from a fermentation liquor obtained by fermentation or an enzymic method, which comprises removing the impurities contained in said fermentation...
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4994381 |
N-[[6 -methoxy-5-(trifluoromethyl)-1-naphthalenyl]-thioxomethyl]-N-methylglycin e S-oxide and the amide thereof
Disclosed herein are N-[[6-methoxy-5-(trifluoromethyl)-1-naphthalenyl]-thioxmethy
l]-N-methylgly cine S-oxide (tolrestat S-oxide) and the amine thereof and methods of their preparation. The...
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4990448 |
Bu-4061T
A new antibiotic designated BU-4061T is produced by fermentation of actinomycete strain Q996-17 (ATCC-53904). The BU-4061T antibiotic exhibits both in vitro and in vivo antitumor activity.
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4980284 |
Method of preparing D-α-amino acids
A substantial elevation of the space-time yield is achieved in the preparation of D-α-amino acids by means of the biotransformation of hydantoins which are monosubstituted in the 5-position in an...
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H000819 |
Palladium-109 labeled anti-melanoma monoclonal antibodies
Palladium-109, a beta-emitting radionuclide, when chelated to anti-melanoma monoclonal antibody demonstrates high uptake in melanoma and thus is useful for tumor therapy.
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4929551 |
Process for producing L(-)-tetrahydrofolic acid
The invention relates to a process for producing L(-)-tetrahydrofolic acid which comprises allowing dihydrofolate reductase to act upon dihydrofolic acid in the presence of (1) NADP or NADPH, and...
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4880737 |
Process for the preparation of L-alpha-amino acid and d-alpha-amino acid amide
The invention relates to a process for preparation of L-α-amino acid and D-α-amino acid amide from DL-α-amino-acid amide by contacting the DL-α-amino acid amide in an aqueous solution with an...
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4880738 |
Production of amino acids using coupled enzyme systems
A biocatalytic method for producing a desired amino acid is disclosed. The method involves contacting a 2-ketoacid corresponding to the desired amino acid with lactic acid, aspartic acid and...
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4859591 |
Transamination process for producing amino acids
A process is disclosed for catalyzing the transamination of an amino acid precursor to the corresponding L-amino acid by using aspartic acid as the amino donor and by adding certain multivalent...
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4849345 |
L-phenylalanine dehydrogenase and use thereof
New L-phenylalanine dehydrogenases produced by a microorganism belonging to the genus Sporosarcina or Bacillus, new microorganisms capable of l-phenylalanine dehydrogenase and belonging to the...
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4826766 |
Production of amino acids using coupled aminotransferases
This invention relates to a process for producing a desired alpha-amino acid, AA d , or a derivative thereof. The process comprises: (a) reacting a first alpha-amino acid, AA NH s ; a first...
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4812406 |
Process for preparing optically active hydantoins
A process for preparing optically active hydantoins having the general formula (II): ##STR1## wherein R 1 and R 2 , which are different from each other, are independently alkyl group, aralkyl...
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4810647 |
Process of producing ethanol and various other by-products from cereals
The present invention is related to a process of producing ethanol and gluten from cereals especially from wheat, which comprises the steps if: (a) crushing cereals and soaking the thus crushed...
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4783402 |
Production of primary or secondary alcohol derivatives of phospholipids by the enzymatic technique
A process for producing a primary or secondary alcohol derivative of a phosopholipid which comprises reacting the phospholipid with a primary or secondary alcohol in the presence of phospholipase DM.
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4782019 |
Enzymatic production of sphingophospholipid derivatives
A process for producing a sphingophospholipid derivative comprising reacting a sphingophospholipid with a specified compound having an alcoholic hydroxyl group selected from the group consisting of...
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4782020 |
Process for the continuous enzymatic conversion of alpha-hydrocarboxylic acids into the corresponding optically active alpha-aminocarboxylic acids
α-Hydroxycarboxylic acids are continuously converted into the corresponding optically active α- aminocarboxylic acids. The conversion is carried out in a membrane reactor in the presence of...
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4782021 |
Method of producing L-serine
This invention is a method of producing L-serine by causing glycine to react with formaldehyde by using the culture solution or the microbe cells of a microorganism belonging to the genus...
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4757009 |
Recombinant DNA having a phosphoenol pyruvate carboxylase gene inserted therein, bacteria carrying said recombinant DNA and a process for producing amino acids using said bacteria
A recombinant DNA molecule comprising a plasmid vector having operationally inserted therein a gene coding for phosphoenol pyruvate carboxylase is disclosed along with bacteria containing this...
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4745061 |
Novel d-aminoacid transaminase and its use
A D-aminoacid transaminase which converts CPC with Δ-keto acids into Δ-ketoadipinyl-7-ACA can be isolated from Bacillus Licheniformis ATCC 9945. This transamination can be applied to other...
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4708936 |
Process for the continuous production of L-carnitine
Process for the continuous production of L-carnitine by the microbiological method. A microorganism of the strain DSM No. 3225 (HK 1331b) type is cultivated in a bioreactor with crotonobetaine...
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4705752 |
Process for the enzymatic hydrolysis of D-α-amino-acid amides
Process for the enzymatic hydrolysis of a D-α-amino-acid amide to the corresponding D-α-amino-acid, wherein an aqueous solution of the D-α-amino-acid amide is contacted with an...
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4670395 |
Enantioselective hydrolysis of N-acylamino acid esters using a combined enzyme system
Disclosed is combination of an acylase and esterase for selective enzymatic hydrolysis of only the L-isomer of an L and D mixture of αN-acyl-α-amino acid ester whose alpha carbon atom is chiral...
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4666840 |
Process for the preparation of L-α-aminoacids
The process of the invention is useful for the preparation of L-α-aminoacids and is based on the use of an N-carbamyl-α-aminoacid compound which is contacted with a E.C.3.5.2.2, a...
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4647693 |
Antibiotics DO-248-A and B and process for preparing the same
Antibiotics DO-248-A and DO-248-B of the following Formula I: ##STR1## wherein R is ethyl or isopropyl, have antibacterial activity against acid-fast bacteria. DO-248-A, DO-248-B, or their...
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4608340 |
Immobilized aminoacylase enzyme
Immobilized aminoacylase having high specific activity is obtained by covalent bonding of aminoacylase to a partially hydrolyzed Akrilex P type acrylamide-N,N 1 -methylene-bis (acrylamide)...
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4607011 |
Accumulation and isolation of N-acylphosphatidylserine
A phospholipid mixture, rich in N-acylphosphatidylserine (NAPS), is produced by growth of certain bacterial cultures in media containing effective amounts of tris (hydroxymethyl) aminomethane. NAPS...
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4525454 |
Production of L-4-phenyl-2-aminobutanoic acid by transamination
A process is described for producing L-4-phenyl-2-amino butanoic acid. The process comprises reacting 4-phenyl-2-oxobutanoic acid or an ester thereof with L-aspartic acid in the presence of...
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4518692 |
Production of L-amino acids by transamination
A process is described for producing alpha amino acids or derivatives thereof. The process comprises reacting an alpha-keto acid with L-aspartic acid in the presence of transaminase enzyme to...
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4427658 |
Total enzymatic hydrolysate from whey proteins and process of obtaining the same
A total enzymatic hydrolysate from whey proteins is disclosed comprising peptidic hydrolysate with substantially no residual proteins, at least 50% of the peptides containing 2 to 5 amino acids. 70...
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4418146 |
Preparation of D-N-carbamyl-α-aminoacids and micro-organisms for carrying out this preparation
A process for the preparation of D-carbamyl-α-aminoacids of the formula ##STR1## where R has the meanings given in the description, by enzymatic cleavage of the corresponding hydantoins by means...
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4415657 |
Process for preparation of an optically active monoalkyl ester of β-(S)-aminoglutaric acid
A process is disclosed in which an optically active monoalkyl ester of β-(S)-aminoglutaric acid is prepared by subjecting a dialkyl ester of β-protected aminoglutaric acid to the action of a...
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4411991 |
Process for fermentative production of amino acids
A process is disclosed in which an amino acid-producing microorganism having an ability to assimilate lactic acid is aerobically cultivated in the presence of at least one lactic acid microorganism...
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4390626 |
Immobilized aminoacylase
An immobilized aminoacylase is prepared by bonding aminoacylase to a water-insoluble porous anion exchanger such as a porous phenolic resin, porous styrene resin, porous silica or porous glass...
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4389489 |
Optically pure heterocyclic aminoacid compounds, a process for their use for the synthesis of medicaments
The invention relates to optically pure heterocyclic amino acid compounds of the Formula I, as described hereinabove as well as a process for their preparation involving subject D, L-compounds to...
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4389488 |
Process for the enzymatic preparation of L-2-amino-4-methylphosphinobutyric acid
A process for the enzymatic preparation of L-2-amino-4-methylphosphinobutyric acid by enzymatic cleavage of the corresponding N-arylacetyl derivatives using penicillin-G-acylase.
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4312948 |
Enzymic microbiological process for producing optically active aminoacids starting from hydantoins and/or racemic carbamoyl derivatives
A method is disclosed for producing D-aminoacids from racemic mixtures of N-carbamoyl derivatives of such acids or from the corresponding hydantoins wherein the racemic compounds are subjected to...
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4286060 |
Process for production of an amino acid
The process according to the invention comprises submerged cultivation of microorganisms producing an amino acid in a nutrient media including nitrogen, mineral salts and a source of carbon - a...
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4271269 |
Regeneration of an enzyme immobilizate
An enzyme immobilizate comprising an amorphous siliceous support to which an enzyme is bonded by adsorption via an amino alkoxy silane is regenerated after the enzyme has become inactive by...
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4251631 |
Cross-linked enzyme membrane
A cross-linked enzyme membrane is prepared by directly adsorbing enzymes into the pores of a microporous non-fibrous filter membrane made of a silica modified vinylchloride polymer and then...
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4248967 |
Enzymic complexes adapted to convert racemic hydantoins into optically active aminoacids, and their applications
Enzymic complexes deriving from micro-organisms belonging to the Bacillaceae family using an hydantoin or a derivative thereof as inductor of the enzymic activity are used for hydrolysing racemic...
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4242452 |
Process for preparing N-carbamoyl-D-thienylglycines
A process for preparing N-carbamoyl-D-(2-thienyl or 3-thienyl)glycine by subjecting 5-(2-thienyl or 3-thienyl)hydantoin to the action of a cultured broth, cells or treated cells of microorganisms...
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4237227 |
Process for preparing D-N-carbamoyl-α-amino acids
A process for preparing D-N-carbamoyl-α-amino acids by subjecting 5-substituted hydantoins to the action of a cultured broth, cells or treated cells of microorganisms having an ability in...
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4232006 |
Antibiotic W-10 complex, antibiotic 20561 and antibiotic 20562 as antifungal agents
A novel antibiotic complex exhibiting antifungal activity is produced by fermenting a novel species of bacteria from the genus Aeromonas, the bacterium being herein designated Aeromonas sp. W-10....
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4211840 |
Method for producing D-α-amino acid
D-α-amino acids are produced by contacting a 5-substituted hydantoin with an effective amount of an enzyme capable of converting the 5-substituted hydantoin to the D-α-amino acid produced by a...
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