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6913909 |
Nucleotide sequences coding for the thrE gene and process for the enzymatic production of L-threonine using coryneform bacteria
The invention relates to preferably recombinant DNA derived from Corynebacterium and replicable in coryneform microorganisms, which contains at least one nucleotide sequence that codes for the...
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6913908 |
Methods of making L-amino acids in coryneform using the sigE gene
The present invention relates lo an isolated polynucleotide from Corynebacterium glutamicum comprising a polynucleotide sequence chosen from the group c insisting of (a) a polynucleotide which is...
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6902927 |
Enzymatic process for the enantiomeric resolution of amino acids
An enzymatic process permitting the enantiomeric resolution of amino acids is provided. More specifically, this process for separating the enantiomers of an amino acid comprises treating a racemic...
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6902915 |
Heat-stable D-aminoacylase
The present invention provides a novel D-aminoacylase, as well as method for producing a D-amino acid using the same. In order to achieve the above objective, the present inventors have succeeded...
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6902916 |
Nucleotide sequences coding for the 1ysR1 gene
The present invention relates to polynucleotides corresponding to the lysR1 gene and which encode a LysR1 transcriptional regulator, methods of producing L-amino acids, and methods of screening for...
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6887691 |
DNA coding for protein which confers on bacterium Escherichia coli resistance to L-homoserine, and method for producing L-amino acids
A bacterium which has an ability to produce an amino acid and in which a novel gene (rhtB) coding for a protein having an activity of making a bacterium having the protein L-homoserine-resistant is...
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6872553 |
Nucleotide sequences which code for the pck gene
The invention relates to isolated nucleotide sequences from Coryneform bacteria which code for the pck gene encoding the enzyme phosphoenol pyruvate carboxykinase (PEP carboxykinase). The invention...
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6869788 |
DNA encoding novel D-aminoacylase and process for producing D-amino acid by using the same
This invention provides a novel D-aminoacylase obtained by cloning a DNA encoding the novel D-aminoacylase from Methylobacterium mesophilicum MT 10894, etc. and which shows sufficiently high...
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6852516 |
Method for producing L-glutamic acid by fermentation
A coryneform bacterium which has enhanced intracellular pyruvate carboxylase activity obtained by increasing copy number of a gene encoding the intracellular pyruvate carboxylase, or by enhancing...
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6838267 |
Nucleotide sequences coding for the ccpA1 gene
The present invention provides isolated polynucleotides containing a polynucleotide sequence which is:
a) polynucleotide which is identical to the extent of at least 70% to a polynucleotide...
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6830903 |
Methods for producing L-amino acids using a corynebacterium glutamicum with a disrupted pgi gene
The present invention relates, in general, to a method of producing L-amino acids comprising culturing altered bacterial cells having increased amounts of NADPH as compared to unaltered bacterial...
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6830904 |
Methods for producing diastereomers of isoleucine
Methods for producing single diastereomers of isoleucine in high stereochemical purity are provided. D-isoleucine is produced by converting (R)-2-methylbutyraldehyde to a diastereomeric mixture of...
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6828119 |
Enzymatic deprotection of amines and hydroxides
Provided is a method of deprotecting a hydroxide or amine protected with a group of formula ArC*(R)H—(CH 2 ) n —O—C(═O)— where the substituents are as described below, the method...
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6825014 |
Process for the preparation of allysine acetal
The present invention relates to the preparation of compounds of formula (I): from the corresponding hydantoins by means of an enzymatic process. The L-compound is preferably formed.
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6812016 |
Nucleotide sequences which code for the metY gene
The present invention relates to isolated polynucleotides which encode proteins with O-acetylhomoserine sulfhydrylase, vectors and cells containing the polynucleotides as well as methods of...
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6812006 |
Nucleotide sequences which code for the lysR3 gene
The present invention relates to polynucleotides corresponding to the lysR3 gene and which encode a LysR3 transcriptional regulator, methods of producing L-amino acids, and methods of screening for...
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6808914 |
Process for the preparation of L-amino acids by fermentation and nucleotide sequences coding for the accDA gene
The invention relates to nucleotide sequences coding for the accDA gene and to a process for the preparation of L-amino acids, especially L-lysine, by fermentation using corynebacteria in which the...
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6806068 |
Nucleotide sequences which encode the pfk gene
The present invention is directed to nucleotide sequences coding for phosphofructokinase which have been derived from Corynebacterium glutamicum . The invention also encompasses methods for...
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6800465 |
D-hydantoinase from Ochrobactrum anthropi
The present invention relates to a novel D-hydantoinase from Ochrobactrum anthropi that enantio-selectively hydrolyzes D-hydantoins to their corresponding D-N-carbamoyl-amino acids; nucleic acids...
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6800464 |
Arthrobacter D-carbamoylase and methods of preparing enantiomerically enriched D-amino acids
The present invention relates to a new D-carbamoylase and the gene sequences which code for this from the organism Arthrobacter crystallopoietes DSM 20117. Plasmids, vectors, microorganisms,...
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6780633 |
Methods for producing optically active amino acids
A method for producing from one of the optical isomers (optical isomer I) of an amino acid represented by Formula (1):R—CH(NH 2 )—COOH (1), wherein R is defined in the specification, the other...
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6777206 |
Nucleotide sequences which code for the RodA protein
The invention provides nucleotide sequences from Coryneform bacteria which code for the RodA protein and a process for the fermentative preparation of amino acids using bacteria in which the rodA...
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6777229 |
Plasmids from Corynebacterium glutamicum and use thereof
This invention relates to the mutually compatible plasmids pTET3 and pCRY4, isolated from the strain of Corynebacterium glutamicum deposited under DSM number 5616, wherein plasmid pTET3 is...
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6767725 |
Acetyl amino acid racemase from amycolatopsis orientalis for racemizing carbamoyl amino acids
The invention relates to the use of the N-acetyl amino acid racemase from Amycolatopsis orientalis subspecies lurida for the racemiszation of N-carbamoyl amino acids. This use permits the 100%...
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6759218 |
Nucleotide sequences coding for the glbO gene
The present invention provides an isolated polynucleotide containing a polynucleotide sequence selected from the group a) polynucleotide which is at least 70% identical to a polynucleotide which...
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6756216 |
Process for producing non-proteinogenic L-amino acids by fermentation
Process for production of non-protenogenic L-amino acids by direct fermentation of a microorganism strain known per se having a deregulated cysteine metabolism in a manner known per se, which...
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6713288 |
Whole cell catalysts
A microorganism is described which is transformed with DNAs which encode a hydantoinnase, a racemase, and a carbamoylase. As a result, the microorganism is able to degrade hydantoins directly to...
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6713289 |
Nucleotide sequences which code for the eno gene
The present invention is directed to nucleotide sequences coding for a bacterial enolase enzyme. These sequences may be used in improved methods for the fermentative preparation of amino acids...
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6706517 |
Method for producing L-amino acids by fermentation
The present invention provides an industrially efficient method for producing an L-amino acid useful as medicament, chemical agent, food material and feed additive, and the method comprising...
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6686181 |
Method for the production of L-amino acids from their racemic N-aceytyl-D, L-derivatives by enzymatic racemate cleavage by means of isolated recombinant enzymes
Process for the preparation of L -amino acids from their racemic N-acetyl-D,L derivatives by enzymatic resolution by means of isolated, recombinant enzymes A process for the preparation of...
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6680186 |
Nucleotide sequences which encode plsC gene
The present invention relates to polynucleotides corresponding to the plsC gene and which encode 1-acyl-SN-glycerol-3-phosphate acyltransferase, methods of producing L-amino acids, and methods of...
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6667166 |
Processes for preparing D-pantothenic acid using coryneform bacteria
The present invention provides processes for preparing D-pantothenic acid using Coryneform bacteria having an enhanced pfkA gene.
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6664083 |
Methods for racemizing N-acylamino acids and producing optically active amino acids
A method for racemizing with N-acylamino acid racemase (NAAR) derived from Sebekia benihana and a method for producing optically active amino acids using the racemaization method are provided....
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6660504 |
Process for exchanging bases in phospholipids
The present invention provides a process for preparing a phospholipid in an aqueous system in which hydrolysis is extremely controlled, and the synthetic yield is improved. A process for...
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6656710 |
Process for the production of amino acids using racemase and acylase
The present invention relates to the processes of racemization and deprotection of special N-protected amino acids in the acylase/racemase system for the total conversion of special N-protected...
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6653111 |
Bacterial strain of Escherichia coli BKIIM B-3996 as the producer of L-threonine
The present invention provides a method for deriving an E. coli strain which produces L-theronine from E.coli strain VNIIgenetika 472T23 by transducing with bacteriophage P1 which bears a...
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6649379 |
Method and deregulated enzyme for threonine production
Mutagenesis of the gene encoding homoserine dehydrogenase (hom) for production of the amino acid threonine is described. The mutation causes an alteration in the carboxy terminus of the enzyme that...
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6632644 |
Nucleotide sequences which code for the zwa1 gene
The invention relates to an isolated polynucleotide comprising a polynucleotide sequence chosen from the group consisting of a) polynucleotide which is identical to the extent of at least 70% to a...
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6620598 |
Process for preparing O-acetyl-L serine by fermentation
A process is provided for the fermentative preparation of O-acetyl-L-serine. A microorganism strain, which is derived from a wild type and which exhibits an increased endogenous formation of...
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6617139 |
Amidase gene
The present invention relates to a novel protein having amidase activity that stereoselectively hydrolyzes α-amino acid amides and α-hydroxy acid amides, and a gene encoding said protein.
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6596516 |
Process for the fermentative preparation of L-amino acids using coryneform bacteria
A process for the preparation of L-amino acids, in which the following steps are carried out, a) fermenting the desired L-amino acid-producing bacteria in which at least the glyA gene is...
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6586214 |
Method for increasing the metabolic flux through the pentose phosphate cycle in coryneform bacteria by regulation of the phosphoglucose isomerase (pgi gene)
The present invention is directed to isolated polynucleotides coding for phosphoglucose isomerase (pgi) from coryneform bacteria. In addition, the invention includes methods for increasing the...
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6582940 |
Method for producing calcium pantothenate
A method for preparing nondeliquescent crystalline calcium pantothenate which comprises the steps of: (1) stirring a supersaturated aqueous solution containing calcium pantothenate in a ratio of...
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6582939 |
Process for the preparation of alkaline earth salts of D-pantothenic acid
The preparation of alkaline earth salts of D-pantothenic acid, in which the fermentation is carried out in the presence of alkaline earth compounds.
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6579699 |
Method for producing fermentative product and stress-resistant microorganism
A method for producing a fermentative product by utilizing a microorganism, the method comprising culturing the microorganism in a medium to produce and accumulate the fermentative product in the...
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6579705 |
Process for preparing non-proteinogenic L-amino acids
Process is provided for preparing a non-proteinogenic L-amino acid by means of an enzymic biotransformation in which O-acetyl-L-serine is reacted with a nucleophilic compound, while using an...
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6569650 |
Process for the fermentative preparation of metabolic products and for the nucleotide sequences encoding for the sod gene
The present invention is directed to nucleotide sequences coding for the superoxide dismutase (sod) gene from Corynebacterium melassecola . It includes processes for the fermentative preparation...
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6566105 |
Process for the production of D-α-amino acids
A process is described for the production of D-α-amino acids by the stereospecific conversion of racemic mixtures of 5-substituted hydantoins using a microorganism transformed with a plasmid which...
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6551803 |
Method for purification of amino acid containing solutions by electrodialysis
A process is described for purifying an amino acid-containing solution by means of electrodialysis, wherein an amino acid-containing solution is employed which is obtained from the fermentation for...
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6546074 |
Protein crystal structure and method for identifying protein modulators
A method of identifying an agent compound (such as an inhibitor) which modulates asparate decarboxylase (ADC) activity. The method comprises the steps of: a) providing a model of a binding cavity...
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