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7354730 |
High-throughput assay of hematopoietic stem and progenitor cell proliferation
The present invention relates generally to kits that provide reagent mixes and instructions for the use thereof, in performing high-throughput assay methods that determine the proliferative status...
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7354729 |
High-throughput stem cell assay of hematopoietic stem and progenitor cell proliferation
The present invention relates generally to high-throughput assay methods that determine the proliferative status of hematopoietic stem and progenitor cells. The present invention further relates to...
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7297475 |
Medicament injection kit and medicament injection method
A medicament injection kit, for use in occluding a renal artery and a renal vein in a kidney and injecting a therapeutic medicament into the kidney so as to pressurize the kidney, includes: an...
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7288551 |
Solution for the preservation of hearts
The present invention is directed to preservation solutions for storing and perfusing a heart intended for transplantation to a patient requiring such implant. It was found that when cyclosporin is...
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7255983 |
Evaluation and preservation solution
An evaluation and preservation solution for human and animal organs, tissues and parts thereof is described, wherein it comprises serum albumin at a concentration of 55-105 g/L, a scavenger and...
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7220407 |
G-CSF therapy as an adjunct to reperfusion therapy in the treatment of acute myocardial infarction
The present invention relates to methods of using Granulocyte Colony Stimulating Factor (G-CSF) polypeptide in conjunction with reperfusion therapy in the treatment of acute myocardial infarction...
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7157221 |
Processes for making protein hydrolysates from animal peptone and for preserving mucosa
A process for hydrolyzing products with enzymatic activity remaining in peptone solutions after mucosa hydrolysis is provided along with a process for preserving mucosa tissue. Broadly, the...
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7063942 |
System and method to simulate hemodynamics
A system for hemodynamic simulation comprises a vessel having properties of a blood vessel, a reservoir containing a quantity of fluid, tubing connecting the vessel and reservoir, and at least one...
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7045279 |
Isolated perfused heart preparation and method of use
An isolated heart preparation in which essentially normal pumping activity of all four chambers of the heart is preserved, allowing for the use of the preparation in conjunction with investigations...
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7029839 |
Methods and solutions for storing donor organs
A method of preserving, storing and transplanting mammalian donor organs. The method includes the cooling of refrigeration preservation, loading pre-freezer preservation, cryopreservation and...
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7014990 |
Machine perfusion solution for organ and biological tissue preservation
Machine perfusion solutions for the presentation of organs and biological tissues prior to implantation, including a prostaglandin having vasodilatory, membrane stabilizing, platelet aggregation...
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7008591 |
Supercritical fluid extraction process for tissue preparation
The present invention provides methods for preparing tissue for incorporation into xenografts and bioprosthetic devices. The methods of the invention make use of supercritical fluids to remove...
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7005253 |
Cold storage solution for organ and biological tissue preservation
Cold storage solutions for the preservation of organs and biological tissues prior to implantation, including a prostaglandin having vasodilatory, membrane stabilizing, platelet aggregation...
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6994954 |
System for organ and tissue preservation and hypothermic blood substitution
A unified solution system for organ and/or tissue preservation and/or hypothermic blood substitution can be used to prepare multiple solutions for use in various stages of organ procurement,...
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6977140 |
Method for maintaining and/or restoring viability of organs
An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. The method includes perfusing the organ at hypothermic...
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6962775 |
Wound repair dressings and methods for their preservation
Methods and products relating the preservation of cultured mammalian epithelial or mesenchymal cells are provided. The methods involve the pre-treatment of epithelial cells with a solution...
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6962774 |
Method for dry-preserving multicellular organism tissue at ordinary temperatures
A tissue of a multicellular organism is gradually dried during cultivation. After the tissue has been completely dehydrated, water is added to the tissue for its recovery. The tissue of the...
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6953655 |
Compositions, methods and devices for maintaining an organ
Compositions, methods, systems/devices and media are provided for maintaining a harvested organ in a functioning and viable state prior to implantation. The organ perfusion apparatus includes a...
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6951712 |
Cryoprotective system comprising polymeric nano- or micro-particles
The present invention is directed to a cryoprotective system that comprises an aqueous solution containing polymeric nano- and micro-particles that exhibit a reversible temperature-dependent volume...
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6949335 |
Polyglycerol and lactose compositions for the protection of living systems from states of reduced metabolism
Polyglycerol, lactose, and a combination of polyglycerol and lactose are effective at preserving cells, tissues, and organs from damage due to hypothermic, ischemic, or other metabolic impairment,...
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6946241 |
Physiological medium for perfusing, preserving and storing isolated cell, tissue and organ samples
A physiological liquid medium is provided having the basic, synergistic components to allow its universal application in preserving cellular and functional integrity in vitro of different cell,...
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6939668 |
Compositions and methods for treatment of lung transplants
Methods and compositions for pre-treatment of lung transplants to reduce susceptibility to post-operative B. cepacia infection are provided. The methods and compositions employ saccharides,...
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6933103 |
Biocompatible tissue for therapeutic use and method of making same
A biocompatible graft material and a method for making the same are disclosed. The method of making the graft material involves freezing and subsequently thawing a donated tissue sample in a bleach...
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6924267 |
Methods and active substances for protecting organs
The present invention comprises a method of protecting organs or tissue susceptible to reperfusion-induced dysfunction after ischemia. The method comprises parenterally administering to a patient a...
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6916602 |
Methods of preserving functionality of an ovary, preserving fertility of a patient undergoing a treatment expected to cause sterility and assuring a supply of viable gametes for future use
A method of preserving functionality of an organ. The method includes removing a whole organ and associated vasculature, cryo-preserving the whole organ, allowing a period of time to elapse,...
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6905871 |
Apparatus for mechanical perfusion of donor's organ during its transport
The invention relates to an apparatus for mechanical organ perfusion during the transport phase of a donor organ, which apparatus comprises an organ receptacle for acommodating the organ,...
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6869758 |
Method and device for removal of cryoprotectant from cryopreserved biological cells and tissues
Novel methods and devices for removing cryoprotectant from cryoprotectant-containing liquids, and from cells residing therein, are disclosed. In one aspect, the method comprises passing the...
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6869757 |
Advantageous carrier solution for vitrifiable concentrations of cryoprotectants, and compatible cryoprotectant mixtures
Disclosed herein is a carrier solution for cryoprotectants that is useful for use with cells, tissues, and whole organs and for a variety of cryoprotectant solutions and that permits antinucleators...
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6864084 |
Bioreactor and method for fluidly suspending a product
A method for floating at least one substance for growing a tissue part in a bioreactor. The method includes providing at least one substance consisting of one of a tissue part, a scaffold having...
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6821779 |
Methods for storing neural cells
The instant methods pertain to improved methods for storing neural cells, preferably dissociated neural cells, prior to their use in transplantation and to the cells obtained using such methods....
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6811965 |
Kidney perfusion solution containing nitric oxide donor, inhibitor of NOS2, glutathione, gluconate and methods of use
A kidney perfusion solution which includes at least one gluconate salt; glutathione; a nitric oxide donor chemical and a chemical inhibitor selective for the inducible isoform of the enzyme nitric...
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6794124 |
Preservation solution
An improved preservation solution is described, which is intended for the preservation of organs and tissues, or parts thereof, from humans and animals. The improved preservation solution contains...
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6746836 |
Alpha-keratose as a blood plasma expander and use thereof
A plasma expander and blood substitute comprising a therapeutic amount if a solution of alpha-keratose, a soluble fraction of keratin, as an oncotic agent with nutrient growth properties suitable...
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6743575 |
Compositions and methods for the preservation of living tissues
The present invention provides solutions and methods for preserving living biological materials that enable organs, tissues and cells to be stored for extended periods of time with minimal loss of...
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6743574 |
Process for devitalizing soft-tissue engineered medical implants, and devitalized soft-tissue medical implants produced
The invention provides methodologies and apparatus for producing devitalized soft-tissue implants where the implant retains metabolically non-viable and/or reproductively non-viable cells, and...
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6696238 |
Transplant media
The present invention relates to media containing purified antimicrobial polypeptides, such as defensins, and/or cell surface receptor binding proteins. The media may also contain buffers,...
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6642045 |
System for exsanguinous metabolic support of an organ or tissue
An exsanguinous metabolic support system for maintaining an organ or tissue at a near normal metabolic rate is disclosed. The system employs a warm perfusion solution capable of supporting the...
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6632658 |
Bioreactor and method for fluidly suspending a product
The method for the holding in flotation of a substance such as a tissue part in a bioreactor ( 61 ) is characterized in that the substance ( 73 ) is acted upon with a fluid; and in that the flow of...
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6630154 |
Polymer formulations containing perfluorinated compounds for the engineering of cells and tissues for transplantation that improves cell metabolism and survival, and methods for making same
Disclosed and claimed are: a composition including at least one glycosaminoglycan, e.g., CIS, at least one perfluorinated substance and at least one alginate, e.g., sodium alginate, wherein: the...
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6627393 |
Solutions for use as plasma expanders and substitutes
An artificial plasma-like substance having at least one water soluble polysaccharide oncotic agent selected from the group consisting of high molecular weight hydroxyethyl starch, low molecular...
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6613278 |
Tissue pooling process
This invention includes a novel method for safely, effectively and efficiently pooling of tissues for treatment prior to implantation into a recipient in need thereof. In one embodiment, the method...
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6589223 |
Method and compositions for use in perfusion applications
Methods and compositions for use in perfusion applications are provided. In the subject methods, a subject or derivative thereof, e.g. isolated organ or tissue, is infused, perfused and/or...
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6582953 |
Organ chamber for exsanguinous metabolic support system
An exsanguinous metabolic support system for maintaining an organ or tissue at a near normal metabolic rate is disclosed. The system employs an organ chamber comprising a container and a support...
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6555057 |
Intravascular methods and apparatus for isolation and selective cooling of the cerebral vasculature during surgical procedures
Patients having diminished circulation in the cerebral vasculature as a result of stroke or from other causes such as cardiac arrest, shock or head trauma, or aneurysm surgery or aortic surgery,...
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6544726 |
KVD solution for transplantable organs
The present invention is directed to a composition and method of preserving organs comprising exposing said organs to a preservation solution that includes at least an inhibitor or quencher of...
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6524785 |
Perfusion and/or preservation and/or re-perfusion solution during organ transplant
The invention concerns a perfusion and/or preservation and/or re-perfusion solution during organ transplant, in particular the cardiac organ, containing the following elements: K+ in the range of...
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6521402 |
Cryopreservation of tissues for use in nuclear transfer
This relates to methods to minimize the growth of cells until such time as cells are needed for the nuclear transfer. This method can be used for processes in which cells need to be preserved by...
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6506549 |
Plasma expanders and blood substitutes
Solutions are described which are useful as plasma expanders and blood substitutes in mammals, including primates, and methods for using the solutions.
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6482584 |
Cyclic implant perfusion cleaning and passivation process
This invention is a novel method for perfusion of a porous implant which achieves efficient interpenetration of desired factors into and removal of undesirable factors from the pores of the...
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6475716 |
Method for preserving mammalian organs
The method of the invention for preserving mammalian organs comprises two steps, one being the step of dehydration in which an organ having a physiologically normal water content is deprived of...
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