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7384630 |
Chimeric pancreas
Novel methods, tissues and compositions for increasing the pancreatic mass of a mammalian recipient including harvesting immature pancreatic tissue from a mammalian donor and transplanting said...
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7371513 |
Method of preserving corneal tissue using polyoxyethylene/polyoxypropylene copolymer
Tissue preservation media comprising a polyoxyethylene/polyoxypropylene copolymer are used to preserve tissues and organs for storage and transplantation. In particular embodiments, the...
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7361360 |
Method of treating cancer cells to create a modified cancer cell that provokes an immunogenic response
The present invention relates to a delipidation method employing a solvent system useful for extracting lipids from cancer cells, thereby creating a modified cancer cell particle. Upon delipidation...
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7338757 |
Process for decellularizing soft-tissue engineered medical implants, and decellularized soft-tissue medical implants produced
The invention provides methodologies and apparatus for producing acellular soft-tissue implants, both in small quantities and in commercializable quantities. Such soft-tissue implants include...
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7338461 |
Modified organ support devices
Methods and devices are provided that improve the function of organ support devices, and also provided are improved methods of treating conditions associated with hemodynamic instability.
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7311904 |
Tissue matrices comprising placental stem cells, and methods of making the same
A method of manufacturing a tissue matrix for implantation into a patient is disclosed. The method sets forth collecting embryonic stem cells from a placenta which has been treated to remove...
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7300748 |
Method for enhancing staining of microorganisms
The invention is directed to a method and composition of matter for enhancing the staining of tissue or features of interest therein by applying an effective amount of a bile salt in combination...
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7297540 |
Methods of generating tissue using devitalized, acellular scaffold matrices derived from micro-organs
Methods of generating, and isolating adult stem cells and utilizing such cells and/or embryonic stem cells in generating tissue of a specific function and micro-architecture are provided.
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7297500 |
Use of Troponin I as a species marker protein for meat speciation in both raw and heat-processed products
Monoclonal antibodies are provided which bind to heat-treated proteins of meats. The antibodies are useful in detecting the presence of an exogenous meat in a cooked or raw meat sample....
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7294508 |
Isolation of inner cell mass for the establishment of human embryonic stem cell (hESC) lines
A method for isolating an inner cell mass comprising the steps of immobilizing a blastocyst stage embryo having a zona pellucida, trophectoderm, and inner cell mass, creating an aperture in the...
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7276481 |
Method and composition for treatment of skeletal dysplasias
The present invention discloses pharmaceutical compositions for the treatment of skeletal dysplasias, comprising as an active ingredient at least one natriuretic peptide. Unexpectedly, it has been...
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7270946 |
Method for treatment of cellular materials with sugars prior to preservation
Living cellular material may be preserved by incubating the cellular material in a culture medium containing at least one sugar, particularly for at least three hours, and then subjecting the...
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7267980 |
Stabilizing solution for cells and tissues
Methods and compositions for stabilizing tissues, cells, and cell components such that desired antigenic sites, light scatter properties and cellular morphology are preserved for a useful period of...
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7255983 |
Evaluation and preservation solution
An evaluation and preservation solution for human and animal organs, tissues and parts thereof is described, wherein it comprises serum albumin at a concentration of 55-105 g/L, a scavenger and...
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7247423 |
Method to measure the effect of topically applied agents using skin maintained in organ culture
The method employs a piece of skin of area greater than 1 cm 2 cultured under conditions that maintain its viability and substantially normal structure for sufficient time for topically applied...
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7244552 |
Artificial dermis and production method therefor
Artificial dermis ( 1 ) obtained from plasma with platelets ( 2 ) and human fibroblasts. The plasma with platelets ( 2 ) is obtained from the fractionating of total blood ( 4 ) from the patient ( 8...
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7238469 |
Carbon monoxide improves outcomes in tissue and organ transplants and suppresses apoptosis
The present invention features methods for transplanting organs, tissues and individual cells. Also featured are methods for maintaining cells in vitro and for enhancing survival and/or function of...
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7220584 |
Method of making embryoid bodies from primate embryonic stem cells
Primate embryoid bodies are formed from primate ES cells. The ES cells form clumps. One then removes the clumps, as clumps, and permits incubation under non-adherent conditions. The development of...
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7220538 |
Composition for maintaining organ and cell viability
The present invention is directed to nanoparticle compositions for maintaining organ, tissue and cellular viability when such are separated from normal physiological supports. Compositions...
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7208265 |
Method of cryopreserving selected sperm cells
The present invention provides a method of cryopreserving sperm that have been selected for a specific characteristic. In a preferred embodiment, the method is employed to freeze sex-selected...
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7202212 |
Method for PR-39 peptide mediated selective inhibition of lκBα degradation
The present invention provides both a method and means for regulating IκBα degradation, NFκB activity, and NFκB-dependent gene expression within living cells, tissues, and organs in-situ. The...
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7186555 |
Prevention of brain damage in stroke
The present invention provides methods and pharmaceutical compositions of the human glycoprotein fetuin, or α2-HS glycoprotein, or fragments thereof to mitigate tissue damage associated with...
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7175979 |
Preserved tissue matrix of a hollow organ, particularly of a blood vessel, a method of producing same, and the use thereof
The invention relates to a preserved, deantigenated tissue matrix of an animal or human hollow organ, e.g. of a blood vessel, of the ureter or urinary bladder, which matrix is autologous, allogenic...
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7166576 |
Methods for preserving organs and tissues
The invention relates to a method for preserving an organ or tissue comprising contacting the organ or tissue with an effective amount of a kallikrein inhibitor and solutions useful for such a...
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7166477 |
Muscle sample prepared for prion assay
A method of preparing a sample of muscle tissue and of assaying the prepared sample to determine the presence of prions in the sample is disclosed. The muscle tissue is homogenized and mixed with a...
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7166464 |
Method of culturing cells to produce a tissue sheet
The disclosure provides methods and systems for tissue engineering including an apparatus and methods for the growth, maintenance, and use of robust tissue sheets using tissue manipulation devices....
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7157221 |
Processes for making protein hydrolysates from animal peptone and for preserving mucosa
A process for hydrolyzing products with enzymatic activity remaining in peptone solutions after mucosa hydrolysis is provided along with a process for preserving mucosa tissue. Broadly, the...
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7153684 |
Pluripotential embryonic stem cells and methods of making same
The present invention provides a non-mouse, including human, pluripotential embryonic stem cell which can:
(a) be maintained on feeder layers for at least 20 passages; and (b) give rise to...
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7147626 |
Cord blood and placenta collection kit
The present invention provides an improved kit for the collection of umbilical cord blood and placental blood, and collection of the placenta from which such blood is obtained. The kit improves...
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7138226 |
Preservation of RNA and morphology in cells and tissues
A solution for preservation and/or storage of a cell or tissue is described. This simple nonaqueous composition can have 10% polyethylene glycol and 90% methanol. It can be used at room...
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7129035 |
Method of preserving tissue
This invention relates to the sterilization and preservation of tissue for storage. More specifically, the invention relates to a method of using a solution to form a preserved tissue. The solution...
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7129034 |
Differentiation of whole bone marrow
A method is described for generating a clinically significant volume of neural progenitor cells from whole bone marrow. A mass of bone marrow cells may be grown in a culture supplemented with...
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7125713 |
Human mullerian duct-derived epithelial cells and methods of isolation and uses thereof
This invention discloses a substantially pure population of human Müllerian duct-derived epithelial cells and methods of isolating and culturing the Müllerian duct-derived epithelial cells. By...
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7112437 |
Methods of culturing embryonic stem cells and controlled differentiation
The present invention provides a preparation of undifferentiated embryonic stem (ES) cells sustainable for a prolonged period in an undifferentiated state which will undergo stem cell renewal or...
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7090974 |
Ultrasound-mediated high-speed biological reaction and tissue processing
Methods of fixing and processing tissue and samples on a membrane by using ultrasound radiation as a part of the method are presented. Ultrasound of a frequency in the range of 0.1–50 MHz is used...
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7087369 |
Cornea preservation medium
Steinhardt defined medium preserves cornea tissue during cold storage. Tissue preservation kits comprise a premeasured amount of Steinhardt's medium and copackaged instructions describing use of...
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7078163 |
Process for reducing mineralization of tissue used in transplantation
A method of making a tissue-derived implantable medical device that includes contacting the tissue with a composition comprising at least one oxidizing agent prior to implantation of the medical...
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7074552 |
Method of forming vascularized kidney tissue
A method for constructing a stable bioactive mammalian embryonic kidney is described herein. A kidney so constructed requires no artificial support, nor porous man made membranes or tubing to...
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7063942 |
System and method to simulate hemodynamics
A system for hemodynamic simulation comprises a vessel having properties of a blood vessel, a reservoir containing a quantity of fluid, tubing connecting the vessel and reservoir, and at least one...
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7060492 |
Isolation of spore-like cells from tissues exposed to extreme conditions
Highly undifferentiated spore-like cells can be isolated from many different tissues and bodily fluids after those tissues and fluids have been exposed to extreme conditions. The spore-like cells...
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7053264 |
Nuclear reprogramming using IWSI and related chromatin remodeling ATPases
Methods and compositions for dedifferentiating nuclei from somatic cells are provided. Such methods and compositions are useful for facilitating processes such as, for example, cloning and...
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7052829 |
Prevascularized constructs for implantation to provide blood perfusion
This application discloses methods and materials for preparing functional microvascular beds in the laboratory. These prevascularized constructs can be used to vascularize engineered tissue...
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7049118 |
Regulation of human serine-threonine protein kinase
Reagents that regulate human serine-threonine protein kinase and reagents which bind to human serine-threonine protein kinase gene products can play a role in preventing, ameliorating, or...
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7049057 |
Tissue engineered uterus
The invention is directed to compositions and methods for reconstructing artificial female reproductive organs. The constructs and methods of the invention can be used for ameliorating congenital...
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7045279 |
Isolated perfused heart preparation and method of use
An isolated heart preparation in which essentially normal pumping activity of all four chambers of the heart is preserved, allowing for the use of the preparation in conjunction with investigations...
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7033744 |
Method for proliferating a liver cell, a liver cell obtained thereby, and use thereof
The present invention provides a method comprising a step of transferring a cell proliferation factor gene into a mammalian liver cell to obtain an immortalized liver cell, a step of proliferating...
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7029839 |
Methods and solutions for storing donor organs
A method of preserving, storing and transplanting mammalian donor organs. The method includes the cooling of refrigeration preservation, loading pre-freezer preservation, cryopreservation and...
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7029838 |
Prevascularized contructs for implantation to provide blood perfusion
This application discloses methods and materials for preparing functional microvascular beds in the laboratory. These prevascularized constructs can be used to vascularize engineered tissue...
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7022097 |
Method for treating glandular diseases and malignancies
A method for the in situ treatment of diseases and malignancies in a living host body. The method includes exposing a diseased or malignant gland of a host body to an effective amount of a...
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7015039 |
Separating epithelium from stroma in LASEK surgery
A method of separating the epithelium and the stroma of a cornea includes providing a solution that includes a detaching agent diluted in a culture medium and applying the solution to the surface...
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