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6306176 |
Bonding layers for medical device surface coatings
The medical device is coated with a thin coherent bond coat of acrylics, epoxies, acetals, ethylene copolymers, vinyl polymers containing hydroxyl, amine, carboxyl, amide or other reactive groups,...
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6303179 |
Method for attachment of biomolecules to surfaces through amine-functional groups
A method of modifying the surface characteristics of a substrate having a surface with an amide-functional polymer thereon. The method involves contacting the amide-functional polymer with a source...
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6302909 |
Calcification-resistant biomaterials
The invention involves a bioprosthetic article including a biocompatible material having at least one bound exogenous storage structure, the storage structures having collectively greater than...
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6270831 |
Method and apparatus for providing a conductive, amorphous non-stick coating
A conductive, non-stick coating is provided using a ceramic material which is conductive, flexible and provides a surface which exhibits the property of lubricity. A room or near room temperature...
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6270902 |
Method of improving the adherence of certain crosslinked polymer coatings containing PEO or PVP to a substrate
A two step method or process for improving the adherence or bonding of a lubricious coating of a crosslinked polyurethane, polyurea or polyurethaneurea/PEO or PVP coating to a substrate surface,...
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6265016 |
Process for the preparation of slippery, tenaciously adhering, hydrophilic polyurethane hydrogel coatings, coated polymer and metal substrate materials, and coated medical devices
A process for the preparation of slippery, hydrophilic polyurethane hydrogel coating compositions, and materials composed of a polymeric plastic or rubber substrate or a metal substrate with a...
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6251142 |
Implantation device and a kit including the device
The apparatus comprises an implantation device having a body, the surface of which has at least a portion coated with a receptor, and a preparation containing a ligand formed from the combination...
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6245104 |
Method of fabricating a biocompatible stent
A method of forming an iridium oxide coating on a metal stent to achieve a firmattachment of a thin biocompatible coating of the iridium oxide such that the iridium oxide resists being dislodged...
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6242041 |
Method and composition for modifying the surface of an object
The present invention relates to several novel compositions and methods employing infrared radiation microwave radiation or high voltage polymerization for modifying the surfaces of materials to...
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6235340 |
Biopolymer-resistant coatings
The present invention relates to new biopolymer resistant coatings for materials that come in contact with such molecules in solution. Additionally, the present invention discloses a process for...
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6231600 |
Stents with hybrid coating for medical devices
A device such as a stent is provided with a hybrid coating including a time released, restenosis inhibiting coating and a non-thrombogenic coating to prevent clotting on the device. One first coat...
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6214926 |
Silicone membranes formed without the use of 1-1-1 trichloroethane
A solvent mixture to disperse or dissolve a copolymer of methyl-trifluoropropyl siloxane and dimethylsiloxane, the solvent mixture comprising perchlorethylene, a selected acid ester, and a selected...
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6214407 |
Method of surface coating medical implants
To coat a surface of a medical implant such as an organ part or a synthetic prosthesis with a coating of living cells, the implant is inserted and fixed into a receiving container which is at least...
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6210437 |
Chemical method to bond silicone to metal
Herein are disclosed devices, particularly medical devices, more particularly implantable medical devices, comprising a first layer of a metal and a short chain silicone terminating with silicon...
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6200588 |
Blood-compatible composition and medical device using same
The present invention provides a blood-compatible composition containing an ionic complex consisting of an organic cationic compound and heparin or a derivative thereof, wherein the organic...
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6200626 |
Surface-treatment of silicone medical devices comprising an intermediate carbon coating and graft polymerization
The present invention provides an optically clear, hydrophilic coating upon the surface of a silicone medical device by sequentially subjecting the surface of the lens to plasma polymerization...
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6187369 |
Hydrophilic substrates and method of making same
A substrate is rendered highly lubricious and wettable, by treating the substrate so that it becomes amine-functionalized, and chemically joining an aldonic acid to amine groups on the substrate....
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6184160 |
Method of making an hermetically sealed implantable medical device having a vacuum-treated liquid electrolyte-filled flat electrolytic capacitor
An implantable medical device such as a defibrillator is described. The device includes an hermetically sealed housing containing a flat electrolytic capacitor and an energy source such as a...
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6179817 |
Hybrid coating for medical devices
Disclosed are hybrid coatings for implantable medical devices. Such coatings include a first layer of an aqueous dispersion or emulsion of an organic acid functional group containing polymer, a...
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6180162 |
Method of producing antimicrobial metal articles and antimicrobial metal articles produced by the method
An excellent antibacterial property is afforded upon a metallic article by simple steps of coating a dispersion liquid or a solution of fine particles made of an antibacterial ingredient on the...
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6159531 |
Coating having biological activity and medical implant having surface carrying the same and method
A multi-step method for surface modification of a medical device having at least one surface exposed to tissue and/or blood. The steps comprise a low temperature plasma treatment of the said...
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6143354 |
One-step method for attachment of biomolecules to substrate surfaces
A method of modifying the surface characteristics of a substrate, particularly a polymeric material. The method involves grafting ethylenically unsaturated monomers and attaching biomolecules, such...
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6131580 |
Template imprinted materials by RFGD plasma deposition
Template-imprinted structures 10 are provided having at least one template-imprinted surface 12 defining indentations 14 that are capable of specifically binding cells and/or molecules, such as...
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6120536 |
Medical devices with long term non-thrombogenic coatings
A coating and method for implantable open lattice metallic stent prostheses are disclosed. The coating includes a relatively thin layer of biostable elastomeric material containing an amount of...
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6120847 |
Surface treatment method for stent coating
A method is provided for eliminating surface imperfections on a medical device having a drug release coating including a therapeutic substance in a polymeric carrier disposed on at least a portion...
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6110204 |
Implant
The present invention relates to an implant for use in the human body, an implant substrate being coated with a material which contains chemical compounds between one or more metals (M) of group IV...
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6099563 |
Substrates, particularly medical devices, provided with bio-active/biocompatible coatings
Disclosed is a method of enhancing the biocompatibility of a substrate by providing the substrate with a continuous bio-active surface coating. This method includes applying to the substrate a...
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6099852 |
Wettable silicone-based lenses
This invention provide silicone-based, biomedical devices that exhibit improved wettability as well as biocompatability through the use of functional silane agents. More specifically, the invention...
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6090995 |
Surface modifying composition and method
Synthetic surfaces such as surfaces of implantable prosthetic devices are modified to enhance their ability to support the growth, migration and attachment of epithelial cells. A surface modifier...
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6057031 |
Plastic substrate with thin metal-containing layer
The invention relates to a composite composed of a plastic substrate and a thin, continuous metal-containing layer, characterised in that the metal-containing layer is ductile, adheres firmly to...
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6033719 |
Method for covalent attachment of biomolecules to surfaces of medical devices
A method for making a medical device having at least one biomolecule immobilized on a substrate surface is provided. The method may include combining a biomolecule comprising a 1,2 dicarbonyl...
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6022553 |
Method of making a blood-compatible antimicrobial surface
A method for making antimicrobial, blood-compatible surfaces is provided, articles having surfaces made by this method, and the use of these articles in fields where controlling the spread of...
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6013855 |
Grafting of biocompatible hydrophilic polymers onto inorganic and metal surfaces
Methods for grafting unmodified PEO or any other water-soluble polymers to the surfaces of metals and glasses to form biocompatible surfaces having low protein affinity is provided. One technique...
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6011082 |
Process for the modification of elastomers with surface interpreting polymer networks and elastomers formed therefrom
A process for forming a surface modification on a polymer substrate and polymer substrates having such surface modifications. The process comprises the steps of absorbing a swelling monomer into...
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6005160 |
Heterobifunctional membrane in application of artificial cornea
This invention is a heterobifunctional artificial cornea or biomedical membrane and novel process for preparing the heterobifunctional artificial cornea. In this method, plasma induced graft...
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5980972 |
Method of applying drug-release coatings
The invention is directed to a method of applying drug-release coatings whereby a polymer can be dissolved in a first solvent (solvent A) to form a polymer system and a drug can be dissolved or...
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5980973 |
Implantable medical device with biocompatible surface and method for its manufacture
A method of providing biocompatible surface texturing on a metal component of an implantable device and the device so produced. The coating is provided by applying particles of metal falling...
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5976169 |
Stent with silver coating and method
A stent comprising a cylindrical member formed of metal and having a wall defining a bore extending therethrough along a longitudinal axis and having an inner surface and an outer surface. The wall...
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5976780 |
Encapsulated cell device
A macroencapsulation device for somatic cells using ultrapurified Na alginate and polysulfone hollow fibers of 30 kDa molecular weight cutoff. Ultrapurified Na alginate material is used which has a...
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5968824 |
Agents for inducing apoptosis and applications of said agents in therapy
Agents which modulate pathways of apoptotic induction or repression in which products of opioid peptide precursors genes participate, useful as inducers of apoptosis in cells and in tumor cells in...
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5968091 |
Stents and stent grafts having enhanced hoop strength and methods of making the same
Stents are coated with a polymer such that the polymeric coating binds the crossover points of the wires, or, in the case of a zig-zag stent, binds adjacent zig-zags of wires without occluding the...
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5968092 |
Method for making a biodegradable stent
A method for making a biodegradable stent for insertion into a lumen, the method involves the casting of a film including a matrix of collagen IV and laminin, drying the film, casting a film...
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5964807 |
Compositions and methods for intervertebral disc reformation
Methods of reforming degenerated intervertebral discs are provided in accordance with methods of the invention. Hybrid materials useful in methods of the present invention are also provided.
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5962136 |
Biomaterial and method for obtaining it
The present invention concerns a biomaterial for the selective adhesion of cell and/or tissue, which comprises a polymeric support having an heterogeneous surface conditioned with a surfactant and...
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5958504 |
Hydroxyapatite coatings and a method of their manufacture
A process for the production of a hydroxyapatite coated article includes contacting a coating comprising hydroxyapatite with a recrystallization medium, pressurizing the recrystallization medium,...
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5955588 |
Non-thrombogenic coating composition and methods for using same
The present invention provides an anti-thrombogenic coating composition for blood-contacting surfaces. The coating comprises a covalent complex of from 1 to 30 hydrophobic silyl moieties of Formula...
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5947893 |
Method of making a porous prothesis with biodegradable coatings
Medical devices, most particularly prosthesis, are defined having at least one porous tissue-mating surface. The tissue-mating surface of the device includes therein a pharmacologically active...
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5945457 |
Process for preparing biologically compatible polymers and their use in medical devices
A hemocompatible composition comprising a polymer containing at least one pharmacologic material chemically bonded to a polymer backbone. Such compositions may be obtained by reacting a...
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5942276 |
Method of manufacturing x-ray visible soluble covering
A method of fabricating a radiopaque dissolvable covering for a member on an implantable lead, including the steps of mixing a radiopaque material with a solvent to form a paste, applying the paste...
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5942558 |
Hydrogel lens pre-coated with lipid layer
A storage solution for a hydrogel contact lens comprising a material having polar groups at one end and non-polar groups at the other end. The storage solution desirably further contains an oil....
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