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7390649 |
Sensor chips with multiple layers of polysiloxane
The invention relates to sensor chips with multiple layers of polysiloxane with improve homogeneity.
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7387836 |
Aziridine compounds and their use in medical devices
There are disclosed novel uses of aziridine compounds. The aziridine compounds can be formed into films by plasma deposition on a wide variety of substrates. The films prevent biofouling, impart...
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7384794 |
Micro-devices and analytical procedures for investigation of biological systems
Fibres with an extraction phase coated thereon in combination with a positioning device are described to perform adsorption of components of interest from an animal or animal tissue for the...
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7384659 |
Method of producing whole blood detecting electrode strip and reaction film formulation and the related products
The present invention relates to a method of producing a non-enzymatic whole blood uric acid detecting electrode strip for use on whole blood, characterized by comprising the step of
adding...
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7354733 |
Method for sorting and separating living cells
We disclose methods of sorting or separating mixtures of living cells (e.g., eukaryotic, prokaryotic, mammalian, pathogenic, bacterial, viral, etc.). We perform our methods by activating...
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7341756 |
Coated implants and methods of coating
A method including forming a first coating layer derived from an alkoxide on a substrate having a dimension suitable for an implant and forming a second coating layer on the first coating layer...
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7273896 |
Compositions and methods of using a transient colorant
This invention relates generally to compositions and systems for forming biomaterials containing a transient colorant for visualizing tissue or surgical materials coated with such biomaterials, to...
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7267837 |
Enzyme electrode and process for preparation thereof
The present invention relates to an enzyme electrode useful for estimation of cholesterol in aqueous medium, said electrode comprising:
i. an electrically conductive base plate, ii. a film...
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7256054 |
Core-shell metal particles coated with dextran or aminodextran carrying SH groups, and use thereof
Colloidal metal particles having a coating comprising non cross-linked, SH-activated dextran or aminodextran. Biomolecules may be linked directly or indirectly to the particles, which are useful as...
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7247337 |
Method and apparatus for microarray fabrication
The invention provides a method and apparatus for micro array fabrication exclusive from the impact of a gas. A housing with a gas free chamber provides for improved micro array fabrication with a...
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7232689 |
Calibration procedure for investigating biological systems
Use of calibrant in extraction phase is described for quantification of components of interest in samples in laboratory application as well as in on-site monitoring. This approach is particularly...
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7163712 |
Microstamping activated polymer surfaces
Methods of attaching a ligand to a surface are described that include contacting a surface with a substrate containing an amphiphilic comb polymer. The substrate is configured to provide a pattern...
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7153896 |
Element for protein microarrays
An element for the attachment of protein arrays, the element comprising a surface to which are attached a plurality of piperazine functional groups wherein the piperazine functional groups are...
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7132122 |
Direct micro-patterning of lipid bilayers using UV light and selected uses thereof
This invention provides novel methods for creation of patterned lipid bilayer membranes as well as methods for refunctionalization of such patterned membranes with selected components. Such...
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7125592 |
Detecting interactions at biomimetic interfaces with liquid crystals
A method of forming a liquid crystal device, includes: contacting an aqueous solution comprising a surfactant and a receptor molecule with a top surface of a liquid crystal. The liquid crystal is...
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7122110 |
Electrochemical test sensor
Disclosed is an improved electrochemical sensor for the detection of an analyte in a fluid test sample. The electrochemical sensor is of the type in which the fluid test sample is drawn into a...
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7118667 |
Biosensors having improved sample application and uses thereof
The present invention relates to biosensors having improved sample application and measuring properties and their uses for detection, preferably, quantitative measurement, of analyte in a liquid...
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7112453 |
Retentate chromatography and protein chip arrays with applications in biology and medicine
This invention provides methods of retentate chromatography for resolving analytes in a sample. The methods involve adsorbing the analytes to a substrate under a plurality of different selectivity...
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7108891 |
Random array of microspheres
A method of making a microarray comprising the steps of:
providing a support; coating on the support a receiving layer to receive microspheres, the receiving layer being capable of...
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7105289 |
Inverse emulsion methods of making polymeric imprint beads
The present invention provides imprint bead compositions useful for capturing, isolating, detecting, analyzing and/or quantifying molecules in a sample. The imprint bead compositions comprise a...
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7090974 |
Ultrasound-mediated high-speed biological reaction and tissue processing
Methods of fixing and processing tissue and samples on a membrane by using ultrasound radiation as a part of the method are presented. Ultrasound of a frequency in the range of 0.1–50 MHz is used...
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7083936 |
Aminodextran compositions and conjugates and method of making and using them
A composition containing polydisperse aminodextran polymer molecules is soluble in an aqueous solution at a concentration of 10 mg/ml. The molecules therein have a narrow size distribution...
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7056746 |
Array cytometry
A method and apparatus for the manipulation of colloidal particulates and biomolecules at the interface between an insulating electrode such as silicon oxide and an electrolyte solution....
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6992127 |
Polymeric coatings containing a pH buffer agent
A device containing a support member, a cross-linked polymer, and a pH buffer agent. A surface of the support member is coated with the cross-linked polymer in which the pH buffer agent is embedded.
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6989175 |
Acyl fluoride activation of carboxysilyl-coated glass substrates
A method for the acyl fluoride activation of a carboxysilyl-coated glass is described. The method includes providing a glass substrate having a surface with at least one pendant carboxysilyl linker...
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6951715 |
Optical detection of label-free biomolecular interactions using microreplicated plastic sensor elements
Methods and compositions are provided for detecting biomolecular interactions. The use of labels is not required and the methods can be performed in a high-throughput manner. The invention also...
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6943204 |
Process for the modification of elastomers with surface interpenetrating polymer networks and elastomers formed therefrom
A process for forming a surface modification on a polymer substrate and polymer substrates having such surface modifications. The process comprises the steps of absorbing a swelling monomer into...
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6921811 |
Bioactive coating composition and methods
The present invention provides a bioactive coating composition, method and devices for bodily fluid-contacting surfaces. The coating comprises a complex of Formula II: wherein R 1 is an C 1-18...
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6905724 |
Derivatization of support surfaces
The present invention relates to a process for derivatizing supports on a carriers, wherein a functional group is activated on a support surface by reaction with an activating reagent and then...
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6887427 |
Coated biosensor
The invention concerns a process for coating a metallic or semimetallic surface in which coating molecules containing reactive groups are bound covalently to the surface by irradiation with light...
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6884628 |
Multifunctional polymeric surface coatings in analytic and sensor devices
Multifunctional, polyionic copolymers with molecular architectures and properties optimized for specific applications are synthesized on/or applied to substrate surfaces for analytical and sensing...
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6869772 |
Method for labeling individual cells
A method is provided for the labeling of individual cells. Labeling is accomplished by coating a particle with at least one dye or nucleic acid sequence encoding a marker protein. The particle is...
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6815211 |
Oxygen monitoring methods and apparatus (I)
Apparatus or systems which employ luminescence quenching to produce an oxygen concentration indicative signal. Components of such systems include: (1) an airway adapter, sampling cell, or the like...
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6797393 |
Method for making biochip substrate
A gelatin-based substrate for fabricating protein arrays, the substrate containing: gelatin and a trifunctional compound A—L—B; wherein A is a functional group capable of interacting with the...
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6749887 |
Solution drying system
A system for drying chemical reagents on material, particularly for producing product used in making reagent test strips is described. By drying selected chemicals on substrate drawn past a radiant...
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6746708 |
Disposable plate electrode with biologicalactive film and manufacture method thereof
A manufacture method for forming a disposable plate electrode with biological active film is used to cooperate with a biological sensor for analyzing composition and measuring concentration of a...
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6746582 |
Electrodes with multilayer membranes and methods of making the electrodes
A sensor including a sensing layer is disposed over an electrode or an optode and a layer-by-layer assembled mass transport limiting membrane disposed over the sensing layer. The membrane includes...
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6740214 |
Microelectrode biosensor and method therefor
There is disclosed a biosensor comprising a conducting surface, a layer of dielectric material overlying the conducting surface, a plurality of micro electrodes constituted by a plurality of pores...
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6730201 |
Electronic tongue
An ion selective electrode (ISE) array is described, as well as methods for producing the same. The array can contain multiple ISE which are individually electronically addressed. The addressing...
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6730200 |
Electrochemical sensor for analysis of liquid samples
An electrochemical cell having an auxiliary area that contains a redox species on a working electrode. The auxiliary area provides a low resistance current path between the working electrode and a...
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6723371 |
Process for preparing an electrochemical test strip
As embodied and broadly described herein, the invention provides an electrode test strip. The electrochemical electrode test strip comprises an insulating base plate, a electrode system on the base...
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6709692 |
Surface absorbing polymers and the uses thereof to treat hydrophobic or hydrophilic surfaces
The invention provides methods for the treatment of surfaces using surface adsorbing polymers, methods for decreasing the adsorption of organic materials onto the surface of treated devices or...
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6699719 |
Biosensor arrays and methods
A surface detector array device suitable for use with a biosensor is disclosed. The device is formed of a substrate having a surface defining a plurality of distinct bilayer-compatible surface...
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6689478 |
Polyanion/polycation multilayer film for DNA immobilization
A substrate with a charged surface coated with one or more bilayers of oppositely charged polyelectrolytes. Subsequent optional bilayers of polyelectrolytes must bear alternating opposite charges....
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6689411 |
Solution striping system
A system for laying down stripes of solution on substrate is described. The substrate preferably comprises a web of material set on a backing roller passed by a specially configured die. The die...
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6589726 |
Method and apparatus for in situ synthesis on a solid support
The present invention relates to methods for fabricating solid supports. More specifically, the present invention features methods for fabricating solid supports for in situ synthesis and for...
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6558958 |
Optical fiber evanescent field excited fluorosensor and method of manufacture
An optical fiber is tapered, preferably adiabatically, and has a material coated on it for chemical bonding with fluorophores. When the fluorophores couple with the material, evanescent radiation...
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6534270 |
Biochip and method for fabricating the same
Disclosed are biochips having a high detecting sensitivity with readiness in fabrication of microarray, and a method for fabricating the same, in which a solid support wound with fibers is immersed...
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6521663 |
Aminoguanidinyl- and Alkoxyguanidinyl-substituted phenyl acetamides as protease inhibitors
Phenyl acetamide compounds are described, including compounds of Formula I: or a solvate, hydrate or pharmaceutically acceptable salt thereof; wherein R 3 -R 6 , R 11 , B, Y and W are set forth...
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6514772 |
Semiconductor nanoparticles for analysis of blood cell populations and methods of making same
A semiconductor nanoparticle for use in analysis of biological samples is described. This semiconductor nanoparticle is composed of an aminodextran which is bound to at least one nanoparticle of...
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