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8846063 Personal care composition containing a volatile and a terpene alcohol  
The present disclosure generally relates to a personal care composition containing a carrier, an oil phase having at least one terpene alcohol component, an at least partially fluorinated compound,...
8846044 Stabilizing alkylglycoside compositions and methods thereof  
The present invention relates to alkylglycoside-containing compositions and methods for increasing the stability, reducing the aggregation and immunogenicity, increasing the biological activity,...
8846874 IgG Fc fragment for a drug carrier and method for the preparation thereof  
Disclosed is an IgG Fc fragment useful as a drug carrier. Also, the present invention discloses a recombinant vector expressing the IgG Fc fragment, a transformant transformed with the recombinant...
8846054 Method of treating pregnant cows and/or heifers  
The present invention relates to combination vaccines for the prophylaxis and treatment of microbiological infections in cattle which comprise an attenuated bovine viral diarrhea virus (BVDV) for...
8846765 Pharmaceutical combination  
A pharmaceutical combination comprising as components (a) at least one 3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol compound, and (b) at least one NMDA-antagonist, a pharmaceutical...
8846609 Leukotoxin E/D as a new anti-inflammatory agent and microbicide  
The present invention relates to methods for preventing or treating Human Immunodeficiency Virus (HIV) infection, inflammatory conditions, and graft-versus-host-disease (GVHD) in a subject....
8846025 Crystal of recombinant interferon with altered spatial configuration, three-dimensional structure and uses thereof  
This invention provides crystalline recombinant interferon (rSIFN-co (SEQ ID NO: 1)) having (i) the same amino acid sequence as that of human consensus interferon, and (ii) altered...
8846078 Brucellosis DNA vaccine  
Brucellosis is a disease caused by facultative intracellular bacteria of the monospecific genus Brucella melitensis. The invention in one aspect is an immunogenic nucleic acid composition...
8846057 Recombinant live attenuated foot-and-mouth disease (FMD) vaccine containing mutations in the L protein coding region  
Previously we have identified a conserved domain (SAP, for SAF-A/B, Acinus, and PIAS) in the foot-and-mouth disease virus (FMDV) leader (L) protein coding region that is required for proper...
8846022 Crosslinked polyalkyleneimine hydrogels with tunable degradation rates  
One aspect of the present invention relates to methods of sealing a wound or tissue plane or filling a void space, or securing meshes, films or other devices within the body. In certain...
8846083 Method for the diffusion of molecules which are insoluble in an aqueous medium and composition using said method  
A process for local permucosal diffusion of amino acid salts of low dosage lipophlic non-steroidal anti-inflammatory or anti-mycotic molecules for an aqueous medicine for the treatment of...
8846071 Stent formed from crosslinked bioabsorbable polymer  
A stent having a stent body made from a crosslinked bioabsorbable polymer is disclosed. A method of making the stent including exposing a tube formed from a bioabsorbable polymer to radiation to...
8846084 Controlled release compositions containing zolpidem  
The present invention relates to controlled release compositions of Zolpidem or pharmaceutically acceptable salts thereof adapted to release Zolpidem over a predetermined time period, according to...
8846006 MRI markers, delivery and extraction systems, and methods of manufacture and use thereof  
Novel, non-toxic cobalt-based contrast and imaging agents for use in enhanced medical imaging modalities and processes are described, as well the manufacture of markers containing such contrast...
8846073 Low temperature processes for making cyclic lipid implants for intraocular use  
Biocompatible implants comprising a cyclic lipid therapeutic agent are made using a low temperature melt extrusion process. The implants are suitable for intraocular use to treat an ocular condition.
8846051 Modulation of replicative fitness by deoptimization of synonymous codons  
Methods of producing a pathogen with reduced replicative fitness are disclosed, as are attenuated pathogens produced using the methods. In particular examples, the method includes deoptimizing one...
8846859 Compositions and methods of use of targeting peptides against placenta and adipose tissues  
The present invention concerns compositions comprising and methods of identification and use of targeting peptides for placenta or adipose tissue. In certain embodiments, the targeting peptides...
8846089 Sugar-coated preparation and production method for the same  
A method is provided for producing a sugar-coated preparation including a solid composition containing a pharmacologically active ingredient and a sugar coating layer. The method comprises a step...
8846111 Compositions and methods for establishing and/or maintaining pregnancy  
Compositions comprising selenium (e.g., organic selenium (e.g., selenized yeast (e.g., SEL-PLEX))) and methods of using the same (e.g., as a therapeutic and/or prophylactic treatment) are provided....
8846000 Radiolabeled PDE10 inhibitors  
The present invention is directed to radiolabeled pyrimidinone compounds of general structural formula I which are useful as radiotracers for quantitative imaging of PDE10 in mammals.
8846030 Compounds and methods to enhance rAAV transduction  
Agents and methods to alter rAAV transduction are provided.
8846118 Use of anabolic agents, anti-catabolic agents, antioxidant agents and analgesics for protection, treatment and repair of connective tissues in humans and animals  
The present invention relates to compositions for the protection, treatment and repair of connective tissues in humans and animals comprising any or all of anabolic, anti-catabolic, anti-oxidant...
8846024 3′-[(2Z)-[1-(3,4-dimethylphenyl)-1,5-dihydro-3-methyl-5-oxo-4H-pyrazol-4-ylidene]hydrazino]-2′-hydroxy-[1,1′-biphenyl]-3-carboxylic acid bis-(monoethanolamine)  
An improved thrombopoietin mimetic, the bis-(monoethanolamine) salt of...
8846100 Controlled dose drug delivery system  
A multiple pulsed dose drug delivery system for pharmaceutically active amphetamine salts, comprising a pharmaceutically active amphetamine salt covered with an immediate-release coating and a...
8846115 Anti-inflammatory cyclooxygenase inhibitors  
Disclosed is a pharmaceutical composition including a therapeutic quantity of a COX-2 inhibitor having an IC50-WHMA COX-2/COX-1 ratio ranging from about 0.23 to about 3.33 with reduced...
8846039 Method for ameliorating pruritus  
A method for preventing, treating, or ameliorating pruritus caused by skin, mucosa, or systemic disorder. The method comprises administering to a subject with pruritus or topically applying to an...
8846034 Companion diagnostic for anti-hyaluronan agent therapy and methods of use thereof  
Methods and diagnostic agents for identification of subjects for cancer treatment with an anti-hyaluronan agent, such as a hyaluronan-degrading enzyme, are provided. Diagnostic agents for the...
8846049 Process for manufacturing vaccines  
The present application discloses an improved method for conducting saccharide—protein conjugation reactions using carbodiimide condensation chemistry. Depending on the nature of the saccharide o...
8846622 Targeted delivery of botulinum toxin to the sphenopalatine ganglion  
Botulinum toxin, among other presynaptic neurotoxins is used for the treatment and prevention of migraine and other headaches associated with vascular disorders. Presynaptic neurotoxins are...
8846085 Method for production of directly compressible ibuprofen formulations  
A directly tabletable ibuprofen formulation comprising a) 50-99% by weight of crystalline ibuprofen, b) 1-15% by weight of a finely divided excipient with a surface area of at least 100 m2/g, and...
8845999 Tracers for monitoring the activity of sodium/glucose cotransporters in health and disease  
Radiolabeled tracers for sodium/glucose cotransporters (SGLTs), their synthesis, and their use are provided. The tracers are methyl or ethyl pyranosides having an equatorial hydroxyl group at...
8846110 Polymeric systems for the delivery of anticancer drugs  
The present invention relates to compositions for the treatment of cancerous tissues in warm-blooded animals containing one or two anticancer agents attached to polymeric carriers having monomer...
8846007 Compositions providing a heating sensation for oral or dermal delivery  
The present invention relates to a heating or warming composition that may be delivered orally or to the skin or mucous membranes. The composition contains a warming agent in combination with a...
8846649 Natural combination hormone replacement formulations and therapies  
Estrogen and progesterone replacement therapies are provided herein. Among others, the following formulations are provided herein: solubilized estradiol without progesterone; micronized...
8846096 Nanoparticles and methods of use  
Provided herein are nanoparticles and methods for using nanoparticles. The nanoparticles include at least three antiretroviral agents. When introduced to cells the nanoparticles cause an increase...
8846308 Method for identifying immune response modulators  
Methods of identifying immune response modulators are disclosed. Some methods comprise identifying chemical candidates that modulate oligomerization of FOXP3 and/or fragments thereof comprising the...
8846107 In situ generation of peroxycarboxylic acids at alkaline pH, and methods of use thereof  
The present disclosure is related to percarboxylic acid compositions formed in situ in non-equilibrium reactions. The peroxycarboxylic acid compositions are formed using ester based starting...
8846867 Isolation of anti-desmoglein 1 antibodies by phage display of pemphigus foliaceus autoantibodies  
This invention relates to compositions and methods for the use of anti-autoimmune reagents that specifically bind to anti-desmoglein antibodies, which are responsible for pemphigus foliaceus. In...
8845961 Devices and articles comprising up-converting sterilizing compositions and methods for using the same  
There is disclosed various devices and articles comprising phosphors for converting electromagnetic energy to radiation having a shorter wavelength, the composition comprising at least one phosphor...
8846043 Nucleic acid and corresponding protein entitled 161P2F10B useful in treatment and detection of cancer  
A novel gene 0161P2F10B (also designated 161P2F10B) and its encoded protein, and variants thereof, are described wherein 161P2F10B exhibits tissue specific expression in normal adult tissue, and is...
8846028 Mitochondrial enhancement of cells  
Certain embodiments disclosed herein include, but are not limited to, at least one of compositions, methods, devices, systems, kits, or products regarding rejuvenation or preservation of stem...
8846050 N-domain of carcinoembryonic antigen and compositions, methods and uses thereof  
The present disclosure provides immunogenic compositions comprising the N-domain of carcinoembryonic antigen (CEA). These compositions are useful for inducing or enhancing an immune response, for...
8846625 Glucagon-like peptide-2 analogs  
Analogs of glucagon-like peptide 2, a product of glucagon gene expression, have been identified as intestinal tissue growth factors. Their formulation as pharmaceutical, and therapeutic use in...
RE45170 Streptococcus suis vaccines and diagnostic tests  
The invention relates to Streptococcus suis infection in pigs, vaccines directed against those infections and tests for diagnosing Streptococcus suis infections. The invention provides an isolated...
8846045 Anti-C5a receptor antibodies  
The present invention concerns human antibodies recognizing the human C5a receptor. By binding to C5aR the antibodies inhibit C5a signalling, whereby the pro-inflammatory signal is inhibited. Based...
8846069 Coatings for implantable devices comprising polymers of lactic acid and methods for fabricating the same  
Coatings for an implantable medical device and a method of fabricating thereof are disclosed, the coatings comprising polymers of lactic acid.
8846081 Liposome compositions and methods of use thereof  
The present application relates to compositions comprising and methods of using a liposome comprising a pHLIP polypeptide, wherein a lipid bilayer of the liposome is substantially free of the pHLIP...
8846104 Pharmaceutical compositions for the deterrence and/or prevention of abuse  
Provided herein is a pharmaceutical composition comprising an antagonist, an agonist, a seal coat, and a sequestering polymer, wherein the antagonist, agonist, seal coat and at least one...
8846091 Matrix for sustained, invariant and independent release of active compounds  
The invention concerns a storage stable pharmaceutical formulation comprising preferably two active compounds in a non-swellable diffusion matrix, whereby the compounds are released from the matrix...
8846035 Methods for preparing polymer microparticles  
The present invention describes methods and tools for preparing a population of monodisperse polymer microparticles, which are of particular interest in the field of drug delivery.