|
Match
|
Document |
Document Title |
|
|
8158132 |
Clostridial toxin derivatives able to modify peripheral sensory afferent functions
This invention describes a novel agent for the targeted control of a mammalian cell activity, in particular the agent is used to control the interaction of particular cell types with their external...
|
|
|
8142801 |
Pesticidal compositions and methods of use thereof
A pest-combating composition including sodium lauryl sulfate and one or more of C6-12 fatty acids, preferably lauric and/or capric and/or caprylic acid, soy methyl ester, and 2-undecanone, and...
|
|
|
8021660 |
Use of collagenase to facilitate guide wire crossing in total arterial occlusions
The use of a collagenase containing formulation for degrading collagen within an occlusive atherosclerotic plaque in a chronic fibrotic occlusion, chronically occluded animal tube or cavity. A...
|
|
|
8012471 |
Screening and treatment methods using IGS5 enzymes of the metalloprotease family
Polypeptides which are related to the neprilysin enzyme family and have zinc metalloprotease activities and are referred to as IGS5, polynucleotides encoding such polypeptides, vectors containing...
|
|
|
7943128 |
Anti-microbial compositions comprising a cationic peptide and a glycylglycine endopeptidase
There is provided an anti-microbial composition comprising a cationic peptide and a glycineglycine endopeptidase. The composition has been found to be synergistic against bacteria, especially Gram...
|
|
|
7935337 |
Method of therapy for degenerative intervertebral discs
To treat diseases accompanied by degenerative intervertebral discs, in particular, disk herniation, lumbar pain, discopathy and osteoarthritits of the spine, it is intended to provide a drug for...
|
|
|
7910094 |
Composition exhibiting a von willebrand factor (vWF) protease activity comprising a polypeptide chain with the amino acid sequence AAGGILHLELLV
The invention relates to vWF cleaving entities having a molecular weight of 180 kD, 170 kD, 160 kD, 120 kD or 110 kD and an N-terminal amino acid sequence of AAGGILHLELLV, vWF cleaving complexes...
|
|
|
7897147 |
Treatment of premenstrual disorders
Methods for preventing or treating a premenstrual disorder by peripheral administration of a botulinum toxin. The botulinum toxin can be administered to or to the vicinity of a trigeminal sensory...
|
|
|
7883699 |
Methods for enlarging the lumen of an obstructed biological conduit
The invention provides methods to for treating a an obstructed biological conduit that include administering to the conduit an agent that can degrade extracellular matrix of obstructing tissue....
|
|
|
7867747 |
Fibrinolytic metalloprotease and composition comprising the same
The present invention relates to a novel protease, a polynucleotide encoding the protease, and a fibrinolytic agent comprising the same. The protease is obtained from a new gene source by using...
|
|
|
7854929 |
Method for treating lateral epicondylitis using collagenase
Methods for treatment by collagenase injections are provided, which are effective in dissolving and lysing a collagenase septa network to treat carpal tunnel, plantar fasciitis and lateral...
|
|
|
7833524 |
Method of preparing botulinum neurotoxin type E light chain
The present invention provides a preparation of botulinum toxin light chain type A or E, wherein the preparation is both catalytically active and soluble. Preferably, the preparation consists...
|
|
|
7824673 |
Reduction of adipose tissue
A simple search was made on the Internet. There were at least a few hundred entries. The following seem to be the best of the few dozen examined. The first page of each is cited below for...
|
|
|
7811560 |
Compositions and methods for treating collagen-mediated diseases
A drug product comprising a combination of highly purified collagenase I and collagenase II from Colostridium histolyticum is disclosed. The drug product includes collagenase I and collagenase II...
|
|
|
7641900 |
Wound treatment utilizing collagenase and a phosphotidylcholine organogel
The effect of the action of collagenase in treating lesions containing collagen or mixed fibrin clots (e.g., burns or ulcers) is improved by applying collagenase to the wound in combination with an...
|
|
|
7550282 |
Biological glue based on thrombin-conjugated nanoparticles
Thrombin-conjugated nanoparticles, wherein said nanoparticles comprise one or more organic and/or inorganic compounds and process for preparing the same are provided. The thrombin-conjugated...
|
|
|
7517522 |
ADAMTS13 genes and proteins and variants and therapeutic compositions and methods utilizing the same
The present invention relates to a disintegrin and metalloproteinase containing thrombospondin 1-like domains (ADAMTS) and in particular to a novel ADAMTS13 protease and to nucleic acids encoding...
|
|
|
7501117 |
Composition exhibiting a von Willebrand factor (vWF) protease activity comprising a polypeptide chain with the amino acid sequence AAGGILHLELLV
The invention relates to vWF cleaving entities having a molecular weight of 180 kD, 170 kD, 160 kD, 120 kD or 110 kD and an N-terminal amino acid sequence of AAGGILHLELLV, vWF cleaving complexes...
|
|
|
7452543 |
Conjugates of galactose-binding lectins and clostridial neurotoxins as analgesics
A class of novel agents that are able to modify nociceptive afferent function is provided. The agents may inhibit the release of neurotransmitters from discrete populations of neurones and thereby...
|
|
|
7429377 |
Therapeutic composition containing a plurality of immobilized proteases
A pharmaceutical composition having thrombolytic, anti-inflammatory and cytoprotective properties is described. The composition contains active proteases attached to a gel or to a mixture of a gel...
|
|
|
7425326 |
Use of collagenase to facilitate guide wire crossing in total arterial occlusions
The use of a collagenase containing formulation for degrading collagen within an occlusive atherosclerotic plaque in a chronic fibrotic occlusion, chronically occluded animal tube or cavity. A...
|
|
|
7402309 |
Phage-associated lytic enzymes for treatment of Bacillus anthracis and related conditions
The present disclosure relates to methods, compositions and articles of manufacture useful for the treatment of Bacillus anthracis and B. cereus bacteria and spores, and related conditions. The...
|
|
|
7399466 |
Method and compositions for promoting osteogenesis
The object of the present invention is to increase PHEX activity to improve the osteogenic process in a mammal where this process has been diminished due to pathology or a condition that require...
|
|
|
7311908 |
Pharmaceutical compositions of fibrinolytic agent
Frozen and lyophilized compositions for a metalloproteinase fibrinolytic agent (fibrolase or NAT), a method for preparing the lyophilized composition, and a kit and method for reconstituting the...
|
|
|
RE39941 |
Amelioration of Dupuytren's disease
The cords of Dupuytren's disease are injected with collagenase, the hand is immediately immobilized and maintained immobile for several hours. The cord becomes relaxed or ruptured, relieving the...
|
|
|
7252820 |
Highly purified mocarhagin, a cobra venom protease, polynucleotides encoding same and related proteases, and therapeutic uses thereof
Methods and compositions for treating a wide range of inflammatory diseases and disorders, and for inhibiting selectin-mediated binding by administering a mocarhagin protein, or fragments thereof...
|
|
|
7208150 |
Analgesic from snake venom
A substantially non-toxic fraction isolated from snake venom is disclosed, which fraction has an analgesic effect. The fraction has the characteristics of a fraction from snake venom purified on a...
|
|
|
7141610 |
Compositions and methods for the induction of retinal detachments
A method comprising administering by ocular route a dose of a glycol ether effective to induce retinal detachment.
|
|
|
7083965 |
Human enzymes of the metalloprotease family
This invention relates to newly identified polypeptides which have zinc metalloprotease activities and are referred to as IGS5, and polynucleotides encoding such polypeptides, to their use in...
|
|
|
7083964 |
Method for purifying enzymes from clostridium histolyticum using multi-stage chromatography
The invention relates to a method for purifying at least one enzyme obtained in an excess fermentation of Clostridium histolyticum. It is provided for that the enzymes of the excess fermentation...
|
|
|
7052702 |
Conjugates of galactose-binding lectins and clostridial neurotoxins as analgesics
A class of novel agents that are able to modify nociceptive afferent function is provided. The agents may inhibit the release of neurotransmitters from discrete populations of neurones and thereby...
|
|
|
6962703 |
Clostridial toxin derivatives able to modify peripheral sensory afferent functions
The invention relates to an agent specific for peripheral sensory afferents. The agent may inhibit the transmission of signals between a primary sensory afferent and a projection neutron by...
|
|
|
6958150 |
Reduction of adipose tissue
The amount of adipose tissue, including lipomas, at selected locations in the body is reduced by introducing collagenase or collagenase plus another proteinase into the tissue.
|
|
|
6930084 |
Treating arthritis with TNF receptor releasing enzyme
The biological effects of the cytokine TNF are mediated by binding to receptors on the surface of cells. This disclosure describes new proteins and polynucleotides that promote enzymatic cleavage...
|
|
|
6913744 |
Method and composition for treating prostate cancer
A method of treating prostate cancer in a living mammal includes local administration of a composition that includes a therapeutically effective concentration of collagenase. In one embodiment, a...
|
|
|
6863886 |
Use of hyaluronidase in the manufacture of an ophthalmic preparation for liquefying vitreous humor in the treatment of eye disorders
An enzymatic method is provided for treating ophthalmic disorders of the mammalian eye. Prevention of neovascularization and the increased rate of clearance from the vitreous of materials toxic to...
|
|
|
6835378 |
Method and compositions for inhibiting thrombin-induced coagulation
A method of achieving safe and effective treatment or prevention of potentially harmful blood clots, or in inhibiting the coagulation of blood when so desired such as during a wide array of disease...
|
|
|
6821520 |
Clostridial toxin therapy for Hashimoto's thyroiditis
Methods for treating the hypothyroidism of Hashimoto's thyroiditis by local administration of a Clostridial toxin, such as a botulinum toxin, to the thyroid gland of a patient.
|
|
|
6783757 |
Composition and method for increasing exorphin catabolism to treat autism
A composition for use in treating autism spectrum disorders. The composition preferably includes a genomeceutical type compound that increases the user's expression of DPPIV or like substances. The...
|
|
|
6776992 |
Methods for treating tension headache
A method and composition for treating a patient suffering from a disease, disorder or condition and associated pain include the administration to the patient of a therapeutically effective amount...
|
|
|
6773711 |
Botulinum toxin therapy for Hashimoto's thyroiditis
Methods for treating the hypothyroidism of Hashimoto's thyroiditis by local administration of a neurotoxin, such as a botulinum toxin, to the thyroid gland of a patient.
|
|
|
6752989 |
Tooth surface treatment agent
The invention concerns surface treatment agents for hard tissue, including at least one enzyme and an agent inhibiting the enzyme activity, whereby the surface treatment agent remains on the hard...
|
|
|
6709651 |
Treatment of substance P-related disorders
The present invention is directed to methods of treating a wide variety of diseases, disorders and conditions characterized by excessive activity of substance P. The treatment involves...
|
|
|
6645509 |
Polypeptide expressed in the horny layer of epidermis and use thereof
The present invention relates to a cosmetic or pharmaceutical composition comprising, in a physiologically acceptable medium, a purified natural or synthetic epidermis-specific polypeptide which is...
|
|
|
6638751 |
Isolated human zinc protease proteins
The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the protease peptides of the present invention. The present invention specifically...
|
|
|
6599724 |
Stable factor VIII compositions
The present invention relates to a pharmaceutical composition comprising Factor VIII and the divalent metal ions Zn2+ and Cu2+, optionally in the presence of Ca2+ ions and/or Mn2+ ions, wherein...
|
|
|
6555109 |
Analgesic from snake venom
A substantially non-toxic fraction isolated from the venom of Vipera xanthina is disclosed which fraction has an analgesic effect. The fraction is preferably purified on an ion exchange column from...
|
|
|
6511662 |
Treatment of cytomegalovirus using aminopeptidase N
A method for the prevention or treatment of human cytomegalovirus is described. Aminopeptidases, preferably in soluble form is administered exogenously to the patient. The invention involves the...
|
|
|
6444791 |
Methods and compositions for the treatment of keratoconus using protease inhibitors
Compositions and methods for treating corneal diseases mediated by elevated protease activity include ocular administration of protease inhibitors. One or more protease inhibitors selected from an...
|
|
|
6416756 |
Modified protease having 5 to 13 covalently coupled polymeric molecules for skin care
Modified enzymes are prepared for use in skin care products by covalently coupling to the enzymes from 4 to 70 polymeric molecules with or without a linker such as a triazine ring. Molecular weight...
|