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7056499 |
Treating method for suppressing hair growth
The present invention relates to a treating method for hair growth inhibition, which comprises administering (A) the extract of a plant of the family Juniperus or a malt. In addition, the present...
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7041302 |
Therapeutic modulation of the tumor inflammatory response
The invention relates to compositions, kits, and methods for alleviating cancer (i.e., a tumor) in a human patient. The therapeutic modality effected by the invention involves inducing a type 1...
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6998122 |
Protein C derivatives
Novel protein C derivatives are described. These polypeptides retain the biological activity of the wild-type human protein C with substantially longer half-lives in human blood. These polypeptides...
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6989262 |
Plasmin variants and uses thereof
The invention concerns plasmin variants. Polynucleotides the disclosed plasmin variants are provided. Additionally, methods of using the plasmin polynucleotides and polynucleotides are provided...
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6969515 |
Method of thrombolysis by local delivery of reversibly inactivated acidified plasmin
Methods of thrombolysis that allow the use of a fibrinolytic composition comprising reversibly inactivated acidified plasmin and the localized delivery of the plasmin to a vascular thrombotic...
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6964764 |
Method of thrombolysis by local delivery of reversibly inactivated acidified plasmin
Methods of thrombolysis that allow the use of a fibrinolytic composition comprising reversibly inactivated acidified plasmin and the localized delivery of the plasmin to a vascular thrombotic...
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6958322 |
Factor X analog with an improved ability to be activated
This invention describes a factor Xa analog which has a substitution of a minimum of one of the amino acid between Glu226 and Arg234 and possibly Ile235, relative to the amino acid numbering...
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6958150 |
Reduction of adipose tissue
The amount of adipose tissue, including lipomas, at selected locations in the body is reduced by introducing collagenase or collagenase plus another proteinase into the tissue.
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6946128 |
Protease conjugates having sterically protected epitope regions
The present disclosure relates to subtilisin protease conjugate comprising a protease moiety and one or more addition moieties. Each addition moiety is covalently attached to an epitope protection...
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6923961 |
Chemically activated carboxypolysaccharides and methods for use to inhibit adhesion formation and promote hemostasis
Carboxypolysaccharides (CPS) including carboxymethyl cellulose and their derivatives are provided that can be made into sponges, gels, membranes, particulates and other forms, for a variety of...
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6921532 |
Biological Bioadhesive composition and methods of preparation and use
The present invention relates generally to the preparation and use of biological tissue adhesives which rely on combining fibrinogen and thrombin. More particularly, the present invention relates...
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6908757 |
Serine protease variants having amino acid deletions and substitutions
The present invention relates to variants of serine proteases having decreased immunogenicity relative to their corresponding wild-type proteases. More particularly, the present invention relates...
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6908628 |
Disinfectant and antiseptic composition
Wide spectrum disinfecting and antiseptic composition for use in the fields of human medicine, veterinary science and industry, characterized because it includes: Hydrogen peroxide, lactic acid...
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6902733 |
Staphylokinase derivatives with polyethyleneglycol
Methods for the identification, production and use of staphylokinase derivatives characterized by a reduced immunogenicity after administration in patients. The derivatives of the invention are...
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6899877 |
Process for generating plasmin in the vitreous of the eye and inducing separation of the posterior hyaloid from the retina
A process for inhibiting vascular proliferation separately introduces components into the eye to generate plasmin in the eye in amounts to induce complete posterior vitreous detachment where the...
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6881722 |
Saratin for inhibiting platelet adhesion to collagen
Use of the polypeptide Saratin for the manufacture of a medicament having the capability to significantly decrease platelet adhesion and platelet accumulation after vascular injuries or...
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6863886 |
Use of hyaluronidase in the manufacture of an ophthalmic preparation for liquefying vitreous humor in the treatment of eye disorders
An enzymatic method is provided for treating ophthalmic disorders of the mammalian eye. Prevention of neovascularization and the increased rate of clearance from the vitreous of materials toxic to...
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6861054 |
suPAR stimulating activity of tcuPA-mediated fibrinolysis and different uses thereof
The present invention relates to a complex (tcuPA/suPAR) of the two chain urokinase plasminogen activator (tcuPA) with the soluble urokinase plasminogen activator (suPAR), to pharmaceutical...
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6858587 |
Use of tissue factor agonist or tissue factor antagonist for treatment of conditions related to apoptosis
The present invention relates to use of FVII and/or FVIIa and/or another TF agonist and/or FVIIai and/or another TF antagonist in therapeutic treatment of pathological conditions increased or...
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6855687 |
Stimulation of cartilage growth with agonists of the non-proteolytically activated thrombin receptor
Disclosed is a method of stimulating cartilage growth, repair or regeneration at a site in a subject in need of such growth, repair or regeneration. The method comprises the step of administering a...
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6855734 |
Glycine betaine and its use
Pharmaceutical uses of glycine betaine, such as for the treatment of thromboses not induced by hyperhomocystenemia or homocystinuria, of blood disorders, such as blood coagulation, thrombi formation.
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6846485 |
Fish serine proteinase and their pharmaceutical and cosmetic use
Fish derived serine proteinases including trypsins and chymotrypsin derived from cod such as Atlantic cod is used for treating and/or preventing a variety of diseases and disorders such as...
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6830917 |
Method of isolation and purification of trypsin from pronase protease and use thereof
The present invention is directed to methods of isolation and purification of Streptomyces griseus trypsin (SGT) from PRONASE protease in a single affinity chromatography step and uses of the...
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6806070 |
Use of bacterial extracts of the pseudomonadaceae family as cosmetic agents
Use of an extract of bacterium from the family Pseudomonadaceae in the production of cosmetic compositions in particular for combating ageing of the skin.
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6794493 |
Antithrombin H-helix mutants
Mutant antithrombin modified to carry a more positive charge in the H-helix is provided. The modified antithrombin modulates the activities of thrombin, and extends the bioavailability of factor VIII.
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6787135 |
Modification of vitreal matrix metalloproteinase activity
Methods of modifying total MMP activity levels in the vitreous of an eye are provided. In a preferred embodiment, the method results in reduced MMP activity and comprises introducing plasmin into...
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6783757 |
Composition and method for increasing exorphin catabolism to treat autism
A composition for use in treating autism spectrum disorders. The composition preferably includes a genomeceutical type compound that increases the user's expression of DPPIV or like substances. The...
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6780411 |
Tissue sealant compositions
Tissue sealant compositions containing human recombinant fibrinogen, human recombinant factor XIII and human recombinant thrombin. Also disclosed are preferred formulations and uses therefore.
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6767539 |
Method of treating viral hemorrhagic fever
The present invention provides a method of treatment of viral hemorrhagic fever with protein C. The claimed invention provides a needed therapy for a serious and debilitating disorder while...
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6743426 |
Method of treating heparin-induced thrombocytopenia
The present invention provides a method of treatment of heparin-induced thrombocytopenia (HIT) with protein C. The claimed invention provides a needed therapy for a potentially serious and...
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6737055 |
Isolated cathepsin L type cysteine proteases and reducing intercorneocyte cohesion/promoting desquamation therewith
Isolated, substantially pure natural or synthetic polypeptides comprising cathepsin L type cysteine proteases, or polypeptide fragments or polypeptide admixtures obtained via proteolysis thereof,...
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6737075 |
Biochemical methods that eliminate corneal scars, opacification and haze
The invention disclosed herein relates to biochemical methods for the elimination of corneal collagen fiber disorganization to improve vision. Disorganization of corneal collagen fibers is seen in...
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6733750 |
Process and composition for inducing posterior vitreous detachment
A process for inducing posterior vitreous detachment and for dissolving blood clots in the vitreous introduces a composition into the ocular cavity of an eye of a subject. The composition includes...
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6709651 |
Treatment of substance P-related disorders
The present invention is directed to methods of treating a wide variety of diseases, disorders and conditions characterized by excessive activity of substance P. The treatment involves...
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6684405 |
Surgical and examination gloves
An examination or surgical glove having an inner coating of a compound which prevents the degranulation of mast cells which releases medicators of inflammation. The coating includes anti-mast cell...
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6682733 |
Fibrinolytic enzymes
A fibrinolytically active plasminogen activator of the tissue type, wherein the growth factor (G) domain has been deleted, and wherein also the K1 domain has been deleted and additionally has been...
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6649162 |
Hemostatic sponge based on collagen
The invention relates to a hemostatic sponge based on collagen and an activator or proactivator of blood coagulation homogeneously distributed therein, which is dried and contains a water content...
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6645509 |
Polypeptide expressed in the horny layer of epidermis and use thereof
The present invention relates to a cosmetic or pharmaceutical composition comprising, in a physiologically acceptable medium, a purified natural or synthetic epidermis-specific polypeptide which is...
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6638503 |
STREPTOMYCES MEGASPORUS SD5, PROCESS FOR THE ISOLATION THEREOF, NOVEL FIBRINOLYTIC ENZYME PREPARED THEREFROM, PROCESS FOR THE PRODUCTION OF SAID ENZYME AND METHOD OF TREATMENT OF THROMBOLYTIC DISORDERS USING SAID ENZYME
The present invention relates to a novel microorganism Streptomyces megasporus SD5. The present invention also relates to a process for the isolation of said Streptomyces megasporus SD5. The...
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6630139 |
Fibrinogenolytic proteases with thrombolytic and antihypertensive activities: medical application and novel process of expression and production
The present invention provides a process of producing highly purified proteases. The invention further provides the use of such purified proteases in treating cardiovascular disorders, including...
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6630137 |
Activated protein C formulations
The present invention relates to pharmaceutical formulations of activated protein C. The activated protein C formulations of the present invention are more stable than other formulations of...
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6613325 |
Prevention of post surgical adhesions using a fibrin monomer sealant
In accordance with the present invention it has been found that a fibrin polymer film formed by applying materials most closely resembling the natural clotting materials to a surgical adhesion...
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6613324 |
Adhesive for the gluing of biological tissues
Disclosed is an adhesive for gluing of biological tissue, in particular human body tissue. The adhesive contains fibrinogen, a substance capable of supplying calcium ions, blood-coagulating factor...
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6607897 |
Recombinant proCVF
Recombinant proCVF exhibits substantially the same activity as CVF and is useful for lowering complement activity.
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6596261 |
Method of administering a medicinal aerosol formulation
A method of treating in a human or animal a condition capable of treatment by oral or nasal inhalation has been found. The method comprises administering a medicinal aerosol formulation comprising...
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6592866 |
Non-selfdegrading endoprotease
The present invention relates to a novel endoproteolytic hatching enzyme called zonase. The new enzyme is a non-selfdegrading endoprotease. The inventors have purified the enzyme to sequence...
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6589770 |
Keratinocyte derived protease
Disclosed is an isolated polypeptide comprising an amino acid sequence substantially as shown in SEQ ID NO:2, or substantially similar to an amino acid sequence encoded by a nucleotide sequence in...
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6586390 |
Methods and materials relating to novel prothrombinase-like polypeptides and polynucleotides
The invention provides novel polynucleotides and polypeptides encoded by such polynucleotides and mutants or variants thereof that correspond to a novel human prothrombinase-like polypeptide. These...
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6585972 |
Process for crosslinking of collagen in the vitreous of the eye and inducing separation of the posterior hyaloid from the retina
A process for inhibiting vascular proliferation introduces a composition into the eye inducing posterior vitreous detachment. The composition includes a combination of plasminogen, a collagen...
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6579537 |
Method for producing fibronectin and fibrinogen compositions using a polyalkylene glycol and glycine or β-alanine
A method of producing a pharmaceutical preparation comprising fibronectin and fibrinogen is disclosed. The method involves admixing into a starting solution of fibrinogen and fibronectin, in a...
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