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8697118 Stabilizers for hemostatic products  
A hemostatic product that includes a dextran support, at least one hemostatic agent and at least one hemostatic agent stabilizer. The at least one hemostatic agent is selected from the group...
8679482 Method of promoting healing of a tympanic membrane perforation using plasminogen  
The present invention relates to the use of plasminogen and plasmin as agents for enhancing healing of tympanic membrane perforations or other wounds, and for reducing scars or necrotic tissue...
8673361 Cytokine modulating composition  
The invention relates to an agent having cytokine mediating activity. In particular the invention relates to a composition comprising a fraction of denatured plasma proteins and at least one metal,...
8663633 Protease screening methods and proteases identified thereby  
Methods for identifying modified proteases with modified substrate specificity or other properties are provided. The methods screen candidate and modified proteases by contacting them with a...
8652476 Pharmaceutical composition for treating ischemic events  
Methods and pharmaceutical compositions for treating severe ischemic events including cerebral infarction, cardiac infarction, or pulmonary embolism, comprising a thrombolytic intervention...
8647620 Chimeric factor VII molecules  
The present invention relates to chimeric Factor VII polypeptides and methods of using the same.
8642313 Methods and compositions for improving growth of pigs  
The present invention provides methods of improving growth performance, improving the efficiency of feed utilization, increasing feed digestibility, and decreasing mortality of immature and...
8637010 Method of accelerating wound healing by administration of plasminogen  
The present invention relates to the use of plasminogen and plasmin as agents for enhancing healing of tympanic membrane perforations or other wounds, and for reducing scars or necrotic tissue...
8628769 Modified vitamin K-dependent polypeptides  
The invention provides vitamin K-dependent polypeptides with enhanced membrane binding affinity. These polypeptides can be used to modulate clot formation in mammals. Methods of modulating clot...
8623810 Protease for wound conditioning and skin care  
We have identified by molecular cloning a protease which originates from the larvae of Lucilia sericata and which was termed debrilase due to its activities useful for debridement of wounds....
8568716 Kit comprising elastase  
The invention provides methods for treating an obstructed biological conduit that include administering to the conduit an agent that can degrade extracellular matrix of obstructing tissue....
8562983 System comprising elastase  
The invention provides systems for treating an obstructed biological conduit that include administering to the conduit an agent that can degrade extracellular matrix of obstructing tissue....
8551941 Process of making flowable hemostatic compositions and devices containing such compositions  
The present invention includes both sterilized and unsterilized hemostatic compositions that contain a continuous, biocompatible liquid phase having a solid phase of particles of a biocompatible...
8524226 Methods of prolonging patency of hemodialysis access  
The invention provides methods for treating an obstructed biological conduit that include administering to the conduit an agent that can degrade extracellular matrix of obstructing tissue....
8518400 Serine protease derivatives and uses in the prevention or the treatment of blood coagulation disorders  
The present invention relates to chimeric derivatives of serine protease zymogen containing the activation peptide of factor X or a fragment thereof for improving the half-life of said derivatives....
8501695 Tissue kallikrein for the treatment of diseases associated with amyloid protein  
This invention relates to methods of treating Alzheimer's disease or symptoms thereof, and amnesic mild cognitive impairment or symptoms thereof. Methods of the invention include administering a...
8476054 Thrombin-like enzyme of Agkistrodon acutus  
A thrombin-like enzyme isolated from Agkistrodon acutus venom, comprising an alpha subunit having the sequence of SEQ ID No. 1 and a beta subunit having the sequence of SEQ ID No. 2, which are...
8460655 Pharmacological vitreolysis  
A method of treating or preventing a disorder, or a complication of a disorder, of an eye of a subject comprising contacting a vitreous and/or aqueous humor with a composition comprising a...
8461115 Methods for local treatment with factor VII  
The present invention provides methods for the local treatment of bleeding in a subject and/or reducing unwanted effects associated with the systemic administration of thrombotic agents to a...
8455439 Antidotes for factor Xa inhibitors and methods of using the same in combination with blood coagulating agents  
The present invention relates to antidotes of anticoagulants targeting factor Xa which antidotes are used in combination with blood coagulating agents or other heparin antidotes to prevent or...
8455235 Protease variants for pharmaceutical use  
The invention relates to novel variants of a protease derived from Nocardiopsis sp. (SEQ ID NO: 1) and closely related proteases, as well as their pharmaceutical use. The variants show improved...
8455440 Combination anticoagulant therapy with a compound that acts as a factor Xa inhibitor  
The present invention is directed to methods of using combination therapies containing [2-({4-[(dimethylamino)iminomethyl]phenyl}carbonylamino)-5-m ethoxyphenyl]-N-(5-chloro(2-pyridyl))carboxamide...
8431535 Methods for treating local tracheal, bronchial or alveolar bleeding or hemoptysis  
The present invention provides methods for the local treatment of tracheal, bronchial or alveolar bleeding or hemoptysis and/or reducing unwanted effects associated with systemic administration of...
8420079 Recombinantly modified plasmin  
Polynucleotides and polypeptides relating to a recombinantly-modified plasmin(ogen) molecule are provided. The plasmin(ogen) molecule has a single kringle domain N-terminal to the activation site...
8415458 Modified vitamin K-dependent polypeptides  
The invention provides vitamin K-dependent polypeptides with enhanced membrane binding affinity. These polypeptides can be used to modulate clot formation in mammals. Methods of modulating clot...
8415457 Modified vitamin K-dependent polypeptides  
The invention provides vitamin K-dependent polypeptides with enhanced membrane binding affinity. These polypeptides can be used to modulate clot formation in mammals. Methods of modulating clot...
8410048 Method for producing insulin analogs having a dibasic B chain terminus  
The invention relates to a method for producing a type of insulin by genetically engineering a precursor thereof and converting said precursor to the respective insulin in an enzyme-catalyzed...
8389261 Method of isolation and purification of trypsin from pronase protease and use thereof  
The present invention provides methods of isolation and purification of Streptomyces griseus trypsin (SGT) from PRONASE protease mixture in a single affinity chromatography step and uses of the...
8383105 Pharmacological vitreolysis  
A method of treating or preventing a disorder, or a complication of a disorder, of an eye of a subject comprising contacting a vitreous and/or aqueous humor with a composition comprising a...
8383104 Thrombin-free biological adhesive and use thereof as a medicament  
The invention relates to a thrombin-free, fibrinogen-based biological adhesive for therapeutic use, which comprises factor VIIa and a source of calcium ions. The invention also relates to the use...
8383388 Modified coagulation factor IX polypeptides and use thereof for treatment  
Provided are modified factor IX (FIX) polypeptides and methods of generating modified FIX polypeptides. Also provided are pharmaceutical compositions, including compositions formulation for oral...
8377420 Injectable void filler for soft tissue augmentation  
The present invention teaches a micro-porous injectable, soft elastic, fully resorbable fibrin-based composition for use as a soft tissue lumen and void filler. The composition of the present...
8377864 Fibrin gel for controlled release of PDGF and uses thereof  
The present invention relates, in general, to fibrin sealants, which contain platelet derived growth factor (PDGF) for controlled release in situ for therapeutic applications, including...
8357365 Granulysin peptides and methods of use thereof  
Granulysin peptides are small antimicrobial agents with potent activity. A pharmaceutical composition comprising granulysin peptides as an active agent is administered therapeutically to a patient...
8337836 Methods for the treatment and prevention of diseases of biological conduits  
Methods are described for dilating biological conduits by removing elastin and remodeling collagens in the wall of the conduit. Methods include the use of agents that increase the release of...
8329168 Compositions and methods for modulating hemostasis  
Novel thrombin/prothrombin protease/zymogen variants which have anticoagulation activity and methods of use thereof are disclosed.
8318904 Liquid, aqueous pharmaceutical compositions of factor VII polypeptides  
The present invention is directed to liquid, aqueous pharmaceutical compositions stabilized against chemical and/or physical degradation containing Factor VII polypeptides, and methods for...
8313744 Composition for the prevention and treatment of absence seizures comprising PKC agonist as an effective ingredient  
The present invention relates to a composition comprising PKC agonist as an active ingredient. More precisely, the present inventors confirmed that absence seizure specific SWD was reduced by...
8293281 Analgesic and anti-inflammatory composition  
The present invention discloses a composition that contains (1) an effective amount of an analgesically and/or anti-inflammatory active fraction separated from a mixture of plasma and/or serum, and...
8293231 Methods and compositions for treating ischemia  
A method for treating ischemia that would benefit from angiogenesis is disclosed. The method comprises administering to a subject in need thereof a composition comprising: a) a fragment of human...
8293213 Method and apparatus for thrombus removal using magnetic particles  
A method and system for affecting a thrombus after ischemic stroke. The method may include injecting a plurality of magnetic particles into a bloodstream and moving or distorting a thrombus formed...
8268783 Antidotes for factor Xa inhibitors and methods of using the same  
The present invention relates antidotes to anticoagulants targeting factor Xa. The antidotes are factor X and factor Xa protein derivatives that bind to the factor Xa inhibitors thereby...
8257700 Proteomic analysis of active multiple sclerosis lesions  
The invention provides methods for treating demyelinating inflammatory diseases by administering to the subject an effective amount of an agent that provides activated protein C activity, where the...
8252340 Extract for treating thrombotic diseases  
An extract for preventing or treating thrombotic disease, particularly, an extract of leech and/or earthworm with molecular weight of not more than 5800 Dalton, and processes for preparation,...
8252302 Methods and compositions to treat hemorrhagic conditions of the brain  
The described invention provides a nonhuman animal model system for hemorrhagic brain conditions, methods for evaluating a substance for treating the hemorrhagic brain condition in a mammal,...
8236355 COX-2 inhibitor  
The present invention relates to an agent having COX-2 inhibition activity. In particular the present invention relates to a COX-2 inhibitor separated from a mixture of denatured plasma and at...
8231870 Pharmaceutical preparation for treating benign prostatic hyperplasia  
The present invention relates to the use of at least one protease for the manufacture of a medicament for the treatment and/or prevention of benign prostate hypertrophy/hyperplasia, wherein the...
8231869 Recombinant plasmin for opthalmic indications  
Methods of using polynucleotides and polypeptides relating to a recombinantly-modified plasmin(ogen) molecule are provided, including methods related to vitrectomy or vitreolysis. The plasmin(ogen)...
8226942 PDGF fusion proteins incorporated into fibrin foams  
Compositions for wound healing, use of the compositions, and kits and methods of using thereof are described herein. In a preferred aspect, the compositions are suitable for use in a method for...
8216568 Combination therapy with IgA1 proteases  
The present invention discloses the use of bacterial IgA1 proteases to treat IgA1 deposition in tissue and organs. Bacterial IgA1 proteases specifically cleave IgA1 molecules and thus provide a...