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7378078 |
Compositions and methods for detecting proteolytic activity
The invention provides compositions and methods for non-invasive imaging of enzyme (e.g., protease) activity in cells, tissues and organs and entire bodies in vitro, in vivo and in situ. The...
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7361344 |
Co-administration of a thrombolytic and an-anti-CD18 antibody in stroke
A method for improving clinical outcome in focal ischemic stroke in a mammal by increasing cerebral blood flow and/or reducing infarct size is described which involves administering an effective...
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7335645 |
Effectors of dipeptidyl peptidase IV for topical use
The invention relates to compounds for topically influencing the activity of dipeptidyl peptidase of the general formula
wherein
A is an amino acid having at least one functional...
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7332160 |
Medical device and method for tissue removal and repair
The present invention relates to medical devices that are to be implanted or inserted into the body of a patient for the purpose of removing undesired body tissues. In one embodiment of the...
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RE39941 |
Amelioration of Dupuytren's disease
The cords of Dupuytren's disease are injected with collagenase, the hand is immediately immobilized and maintained immobile for several hours. The cord becomes relaxed or ruptured, relieving the...
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7258856 |
Proteases from Carica having mitogenic activity and their methods of use
Proteases having mitogenic activity isolated from the genus Carica are provided. In particular the proteases are cysteine proteases isolated from Carica candamarcensis. In addition, the...
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7235638 |
Coagulation factor VII derivatives
The present invention relates to novel human coagulation Factor VII polypeptides, Factor VII derivatives as well as polynucleotide constructs encoding such polypeptides, vectors and host cells...
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7229959 |
Supplemented fibrin matrix delivery systems
This invention provides supplemented and unsupplemented tissue sealants as well as methods for their production and use thereof. Disclosed are tissue sealants supplemented with at least one...
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7196163 |
Assays using amyloid precursor proteins with modified β-secretase cleavage sites to monitor β-secretase activity
Provided are methods of identifying inhibitors of β-secretase that employ modified β-secretase substrates. The modified β-secretase substrates have β-secretase cleavage sites that are altered...
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7195903 |
Methods for the treatment of thrombosis
A fibrinolytically active metalloproteinase polypeptide (called “novel acting thrombolytic”) which is useful for blood clot lysis in vivo and methods and materials for its production by...
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7179461 |
Plasminogen activator to prevent corneal and subepithelial haze after laser vision correction surgery
The present invention is directed to a method to prevent or reduce postoperative corneal subepithelial haze after excimer laser photorefractive keratectomy (PRK), laser in situ keratomileusis...
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7141610 |
Compositions and methods for the induction of retinal detachments
A method comprising administering by ocular route a dose of a glycol ether effective to induce retinal detachment.
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7138150 |
Method of making an anti-infective composition for treating oral infections
This invention concerns a method of making an anti-infective composition for oral administration using an agent selected from the group consisting of lactoferrin protein and lysozyme protein. The...
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7138114 |
Pharmaceutical compositions of fibrinolytic agent
Frozen and lyophilized compositions for a metalloproteinase fibrinolytic agent (fibrolase or NAT), a method for preparing the lyophilized composition, and a kit and method for reconstituting the...
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7125683 |
Preparations for diagnosis extrapancreatic secretory function
A preparation for the diagnosis of pancreatic exocrine function by determining the amount in which a substance administered to a subject or a degradation product or metabolite thereof migrates into...
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7122514 |
Compositions and methods for treatment of staphylococcal infection while suppressing formation of antibiotic-resistant strains
Co-administration of a lysostaphin or other anti-staphylococcal agent which cleaves cross-links of peptidoglycans of staphylococci cell walls such as lysostaphin and an antibiotic effective...
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7118877 |
Caspase 9 activation and uses therefor
The present invention discloses methods for activating Caspase 9 in such a way that it can be used in assays to discover modulators of Caspase 9.
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7083964 |
Method for purifying enzymes from clostridium histolyticum using multi-stage chromatography
The invention relates to a method for purifying at least one enzyme obtained in an excess fermentation of Clostridium histolyticum. It is provided for that the enzymes of the excess...
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7078377 |
Compositions and methods for treatment of staphylococcal infection while suppressing formation of antibiotic-resistant strains
Co-administration of a lysostaphin or other anti-staphylococcal agent which cleaves cross-links of peptidoglycans of staphylococci cell walls such as lysostaphin and an antibiotic effective against...
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7074401 |
Methods, devices, and compositions for lysis of occlusive blood clots while sparing wound sealing clots
It has now been discovered that certain mutant forms of pro-urokinase (“pro-UK”), such as so-called pro-UK mutant “M5” (Lys 300 →His), perform in the manner of pro-UK in lysing “bad”...
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7070958 |
Methods of making pro-urokinase mutants
Methods are provided for producing non-glycosylated, single-chain and two-chain pro-urokinase (pro-UK) mutants. The methods include cultivating a specific E. coli type B strain that has been...
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7067124 |
Protease composition and method for treating a digestive disorder
There is provided methods, kits, combinations, and compositions comprising a Aspergillus oryzae protease enzyme, a Bacillus subtilis protease enzyme, and a Aspergillus niger lipase enzyme for...
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7060266 |
Human brain carboxypeptidase B
A novel carboxypeptidase and the encoding gene thereof were successfully identified by screening a human hippocampus extract using brain-APP-cleaving activity as an index. This protein and its gene...
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7041302 |
Therapeutic modulation of the tumor inflammatory response
The invention relates to compositions, kits, and methods for alleviating cancer (i.e., a tumor) in a human patient. The therapeutic modality effected by the invention involves inducing a type 1...
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7022521 |
Methods and compositions for treating platelet-related disorders using MPL pathway inhibitory agents
The invention relates to the treatment of subjects for the purpose inhibiting vaso-occlusive events, including thrombosis and embolism, by administering agents which reduce the number of...
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7014863 |
Additive for an animal feed
The present invention relates to the use of a combination of a protease and an inner salt of a quaternary amine carboxylic acid for the preparation of an agent for the treatment and/or prophylaxis...
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6991789 |
Methods of modulating intracellular degradation rates of toxins
The present invention provides for methods of modulating the degradation rate of a toxin in a cell, thereby modulating the half-life of the toxin. Particularly, the invention features methods of...
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6958150 |
Reduction of adipose tissue
The amount of adipose tissue, including lipomas, at selected locations in the body is reduced by introducing collagenase or collagenase plus another proteinase into the tissue.
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6958149 |
Repair of larynx, trachea, and other fibrocartilaginous tissues
Provided herein are methods and devices for inducing the formation of functional replacement nonarticular cartilage tissues and ligament tissues. These methods and devices involve the use of...
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6958148 |
Linkage of agents to body tissue using microparticles and transglutaminase
Methods, products and kits are provided for attaching agents to a body tissue surface via microparticles using endogenous or exogenous transglutaminase. The microparticles have surface available...
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6953577 |
Human methionine aminopeptidase type 3
Methionine aminopeptidases catalyse the co-translational removal of amino terminal methionine residues from nascent polypeptide chains. A newly-discovered enzyme, designated methionine...
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6919076 |
Conjugates of agents and transglutaminase substrate linking molecules
Methods, products, compositions and kits are provided for attaching agents to tissue with a linking molecule in the presence of transglutaminase. The linking molecule and/or agent is a substrate of...
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6908628 |
Disinfectant and antiseptic composition
Wide spectrum disinfecting and antiseptic composition for use in the fields of human medicine, veterinary science and industry, characterized because it includes: Hydrogen peroxide, lactic acid...
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6899877 |
Process for generating plasmin in the vitreous of the eye and inducing separation of the posterior hyaloid from the retina
A process for inhibiting vascular proliferation separately introduces components into the eye to generate plasmin in the eye in amounts to induce complete posterior vitreous detachment where the...
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6899876 |
Compositions and methods relating to reduction of symptoms of autism
Methods and compositions that can reduce the symptoms of autism in a human patient comprising administering a physiologically effective amount of one or both of a purified casomorphin inhibitor...
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6872551 |
Rapidly cleavable sumo fusion protein expression system for difficult to express proteins
A recombinant expression system for the expression of a poly amino acid, peptide or protein is provided. The poly amino acid of interest is expressed as a fusion protein that includes an amino acid...
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6863886 |
Use of hyaluronidase in the manufacture of an ophthalmic preparation for liquefying vitreous humor in the treatment of eye disorders
An enzymatic method is provided for treating ophthalmic disorders of the mammalian eye. Prevention of neovascularization and the increased rate of clearance from the vitreous of materials toxic to...
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6852316 |
Cancer treatment
The present invention relates to the use of angiotensin in a method for the treatment or prevention of cancer. The method comprises administering to a patient in need of treatment an effective...
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6846484 |
DTAT fusion toxin
The invention provides fusion toxins that contain one or more regions of diphtheria toxin and a portion of urokinase-type plasminogen activator, as well as the nucleic acids that encode the fusion...
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6835378 |
Method and compositions for inhibiting thrombin-induced coagulation
A method of achieving safe and effective treatment or prevention of potentially harmful blood clots, or in inhibiting the coagulation of blood when so desired such as during a wide array of disease...
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6827931 |
Method for treating endocrine disorders
Methods for treating endocrine disorders and for inhibiting gametogenesis by intracranial administration to a human patient of a therapeutically effective amount of a neurotoxin, such as a...
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6814964 |
Supramolecules containing binding and therapeutic molecules bound to hybridized nucleic acids
A supramolecule has a first supramolecular component including a first effector molecule covalently joined to a first nucleic acid, and a second supramolecular component including a second effector...
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6808927 |
Method of preparation of stabilized thrombin-activatable fibrinolysis inhibitor (TAFI) and methods of use thereof
The invention is directed in part to a purified form of stabilized activated thrombin-activatable fibrinolysis inhibitor (TAFIa). The invention is further directed to a method of producing...
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6783757 |
Composition and method for increasing exorphin catabolism to treat autism
A composition for use in treating autism spectrum disorders. The composition preferably includes a genomeceutical type compound that increases the user's expression of DPPIV or like substances. The...
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6759227 |
Caspase homologue
Caspases are cysteinyl aspartate-specific proteinases, many of which play a central role in apoptosis. This invention relates to the identification of a new murine caspase and its human homologue....
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6737075 |
Biochemical methods that eliminate corneal scars, opacification and haze
The invention disclosed herein relates to biochemical methods for the elimination of corneal collagen fiber disorganization to improve vision. Disorganization of corneal collagen fibers is seen in...
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6733750 |
Process and composition for inducing posterior vitreous detachment
A process for inducing posterior vitreous detachment and for dissolving blood clots in the vitreous introduces a composition into the ocular cavity of an eye of a subject. The composition includes...
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6709651 |
Treatment of substance P-related disorders
The present invention is directed to methods of treating a wide variety of diseases, disorders and conditions characterized by excessive activity of substance P. The treatment involves...
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6684405 |
Surgical and examination gloves
An examination or surgical glove having an inner coating of a compound which prevents the degranulation of mast cells which releases medicators of inflammation. The coating includes anti-mast cell...
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6645509 |
Polypeptide expressed in the horny layer of epidermis and use thereof
The present invention relates to a cosmetic or pharmaceutical composition comprising, in a physiologically acceptable medium, a purified natural or synthetic epidermis-specific polypeptide which is...
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