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7354576 |
Methods of treating diseases caused by deficiencies of recombinant α-L-iduronidase
The present invention provides a formulation comprising a pharmaceutical composition comprising a human recombinant α-L-iduronidase or biologically active or muteins thereof with a purity of...
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7351410 |
Treatment of Pompe's disease
The invention provides methods of treating Pompe's disease using human acid alpha glucosidase. A preferred treatment regime comprises administering greater than 10 mg/kg body weight per week to a...
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7348000 |
Therapeutic compositions and methods of treating glycolipid storage related disorders
A method for treating a glycolipid storage-related disorder, comprising administering a therapeutically effective amount of an inhibitor of glycolipid synthesis in combination with an agent capable...
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7335355 |
Antimicrobial agent
A method of identifying an agent that enhances the anti-microbial activity of cationic anti-microbial peptides by blocking the inhibitory effects of the proteinase/glycosaminoglycan pathway, which...
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7241442 |
Method for producing proteins suitable for treating lysosomal storage disorders
The present invention is based on the discovery that proteins produced in insect cell cultures are glycosylated in a unique manner that causes them to be selectively imported by cells that express...
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7232678 |
Identification of oligoadenylate synthetase-like genes
The present invention relates to compositions and methods for modulating conception in animals. More particularly, the composition modulates mRNA degradation during gametogenesis and early...
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7232576 |
Throat lozenge for the treatment of Streptococcus Group A
A lozenge for the treatment of Streptococcus Group A infections of the mouth, throat, and nasal passage is disclosed which comprises a lytic enzyme composition specific for Streptococcus Group...
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7189393 |
Recombinant anti-tumor RNAse
This invention provides for new recombinant ribonuclease proteins which are active when expressed by bacteria. This allows the recombinant ribonucleases of this invention to be fused in-frame with...
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7166278 |
Modified organs and cells for xenotransplantation
It has been discovered that there are at least two significant antigens present on the cells of animal species such as pigs that elicit an immune or inflammatory response immediately upon...
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7157083 |
Compositions and methods for treating retroviral infections
The present invention relates to hyaluronidase enzyme methods, vaccines and compositions for treating or preventing pathogenic infections, such as HIV, in a patient. The invention also relates to...
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7141582 |
Method for enhancing mutant enzyme activities in Gaucher disease
Method for enhancing in a mammalian cell the activity of an enzyme associated with Gaucher Disease by administering a competitive inhibitor of glucocerebrosidase in an amount effective to enhance...
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7132098 |
Method for the treatment of chemonucleolysis
The invention relates to a method of treatment for a mammal in need of chemonucleolysis. The method comprising the administration of an effective proteoglycan cleaving amount of a...
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7125683 |
Preparations for diagnosis extrapancreatic secretory function
A preparation for the diagnosis of pancreatic exocrine function by determining the amount in which a substance administered to a subject or a degradation product or metabolite thereof migrates into...
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7108851 |
Prevention and treatment of mycoplasma-associated diseases
The present invention relates to the prevention and treatment of diseases associated with undesirable cell proliferation, including atherosclerotic narrowing of blood vessels and malignancy,...
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7105330 |
Human plasma hyaluronidase
The invention is based on the discovery of methods for purification of an acid active hyaluronidase found in human plasma (hpHAse), including both biochemical and immunoaffinity purification...
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RE39238 |
Transgenic pathogen-resistant organism
Transgenic pathogen-resistant organism whose genome contains at least two different genes under the control of active promoters with pathogen-inhibiting action. This organism is distinguished by a...
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7067127 |
GIcNAc phosphotransferase of the lysosomal targeting pathway
The present invention provides nucleotide and amino sequences of the lysosomal targeting pathway enzyme GlcNAc-phosphotransferase, methods of producing and methods of purifying this enzyme.
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7060495 |
Fusion proteins for prodrug activation
The invention relates to compounds which contain an antigen binding region which is bound to at least one enzyme which is able to metabolize a compound (prodrug) which has little or no cytotoxicity...
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7033777 |
Method for detecting cockroach allergens and determining total allergen level
The present invention is directed to a method and a test kit for detecting cockroach allergens and/or determining the total allergen level. A sample from an environment in which cockroaches are...
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7029899 |
Selective toxicity of amino-terminal modified rnase a superfamily polypeptides
This invention provides RNase A superfamily polypeptides with modified amino terminal which can be used to selectively kill target Kaposi's sarcoma cells, neoplastic endothelial cells, and...
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7025960 |
Use of beta-glucuronidase not in combination with allergens for the preparation of medicaments for the treatment of immune or allergic diseases
The use of beta-glucuronidase not in combination with allergens for the preparation of medicaments for the treatment of immune or allergic diseases is disclosed.
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7014863 |
Additive for an animal feed
The present invention relates to the use of a combination of a protease and an inner salt of a quaternary amine carboxylic acid for the preparation of an agent for the treatment and/or prophylaxis...
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7011831 |
Recombinant α-galactosidase A therapy for Fabry disease
Fabry disease results from an X-linked deficiency in the enzyme α-galactosidase A. The present invention is directed to recombinant human α-galactosidase A and provides baculovirus expression...
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7005128 |
Enzyme feed additive and animal feed including it
The use is provided of a composition as a feed additive which comprises one or more endoglucanases, and 0–20% by weight, based upon the content of cellulase proteins in the composition, of a...
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7001994 |
Methods for introducing mannose 6-phosphate and other oligosaccharides onto glycoproteins
Methods to introduce highly phosphorylated mannopyranosyl oligosaccharide derivatives containing mannose 6-phosphate (M6P), or other oligosaccharides bearing other terminal hexoses, to carbonyl...
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6998121 |
Method of treatment of connective tissue disorders by administration of streptolysin O
Method for administering streptolysin O to treat various connective tissue disorders in humans and animals such as Dupuytren's contracture, scleroderma, Peyronie's disease, mastistis in animals,...
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6987009 |
αgalactosidases and methods of using them
A thermostable alpha-glycosidase derived from various Thermococcus, alcaliphilus AEDII12RA is disclosed. The enzymes are produced from native or recombinant host cells and can be utilized in the...
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6969514 |
Method for treating elevated intraocular pressure, including glaucoma
Hyaluronic acid, a polymer found in the trabecular meshwork of the eye, has a polymeric structure that is broken down by the enzyme hyaluronidase. A method is provided for reducing elevated...
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6949241 |
Use of lacrophyl preparation in eye drops containing therapeutically active compounds
The invention refers to the use of a lacrophyl preparation containing lysozyme, tris(hydroxymethyl)aminomethane, if desired other lacrophyl components, preferably ascorbic acid and/or citric acid...
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6939542 |
Hyaluronidase preparation for ophthalmic administration and enzymatic methods for accelerating clearance of hemorrhagic blood from the vitreous body of the eye
A thimerosal-free hyaluronidase preparation wherein the preferred hyaluronidase enzyme is devoid of molecular weight fractions below 40,000 MW, between 60-70,000 MW and above 100,000 MW. Also...
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6932966 |
Topically applied reconstituted ocean water mixture and method of producing and using the mixture
A skin treatment mixture for treating pierced skin such as that resulting from a body piercing procedure includes sea salt, lysozyme and reconstituted ocean water. The reconstituted ocean water...
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6932965 |
Purified forms of DNase
The present invention provides the identification and characterization of two components of a recombinant preparation of DNase. These components are the purified deamidated and non-deamidated human...
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6927053 |
Dual component dental composition containing enzyme
A two component desensitizing dentifrice composition is disclosed which comprises a first dentifrice component containing an enzyme such as papain and a second dentifrice component containing an...
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6916829 |
Method for enhancing mutant enzyme activity in gaucher disease
Method for enhancing in a mammalian cell the activity of an enzyme associated with Gaucher Disease by administering a competitive inhibitor of glucocerebrosidase in an amount effective to enhance...
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6908628 |
Disinfectant and antiseptic composition
Wide spectrum disinfecting and antiseptic composition for use in the fields of human medicine, veterinary science and industry, characterized because it includes: Hydrogen peroxide, lactic acid...
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6896884 |
Human chitinase, its recombinant production, its use for decomposing chitin, its use in therapy or prophylaxis against infection diseases
A new human chitinase having an amino acid sequence as shown in FIG. 1 or FIG. 2 . Modified forms of it having a similar chitin-hydrolyzing activity, and antigenic peptides representing one of...
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6863886 |
Use of hyaluronidase in the manufacture of an ophthalmic preparation for liquefying vitreous humor in the treatment of eye disorders
An enzymatic method is provided for treating ophthalmic disorders of the mammalian eye. Prevention of neovascularization and the increased rate of clearance from the vitreous of materials toxic to...
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6852841 |
Frozen food product
Anti-freeze protein comprising at least 40% of the amino acids serine, threonine and asparigine and having at least 80% of sequence identity with the amino acid sequence of SEQ ID NO:1 as well as...
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6814964 |
Supramolecules containing binding and therapeutic molecules bound to hybridized nucleic acids
A supramolecule has a first supramolecular component including a first effector molecule covalently joined to a first nucleic acid, and a second supramolecular component including a second effector...
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6787135 |
Modification of vitreal matrix metalloproteinase activity
Methods of modifying total MMP activity levels in the vitreous of an eye are provided. In a preferred embodiment, the method results in reduced MMP activity and comprises introducing plasmin into...
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6776989 |
Intratracheal administration of lysozyme
The subject invention is directed to the treatment of respiratory disorders by intratracheal administration of an effective amount of lysozyme. Respiratory disorders include emphysema, pneumonia,...
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6749865 |
Modification of biopolymers for improved drug delivery
A biologically active conjugate is disclosed comprising a biopolymer and a therapeutic agent joined by a disulfide bond. The conjugate, when formulated in a pharmaceutical composition with a...
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6743425 |
Therapeutic agents for achondroplasia
The present invention aims to provide novel therapeutic agents for achondroplasia caused by mutations in FGFR3. Therapeutic agents for achondroplasia caused by the cartilage growth inhibition...
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6723548 |
DNA repair polypeptides and methods of use
The present invention provides polypeptides having pyrimidine glycosylase activity, preferably, pyrimidine glycosylase/AP lyase activity. The polypeptides include a targeting sequence, preferably...
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6623750 |
Enzyme composition adapted for application to ruminant feed to increase protein digestability thereof and method of treating ruminant feeds relating thereto
Enzyme feed supplements containing fungal cellulase produced by Trichoderma viride are specially adapted for increasing protein digestability of dairy cow and cattle feed. Preferred embodiments...
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6599513 |
Products for topical applications comprising oil bodies
The present invention provides novel emulsion formulations which comprise oil bodies. The invention also provides a method for preparing the emulsions and the use of the emulsions in products for...
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6579850 |
Polypeptide, novel DNA and novel antibody
The present invention relates to a polypeptide having an activity of suppressing aging; DNA encoding the polypeptide; a method for improving livestock, using the DNA; a recombinant DNA prepared by...
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6562339 |
Composition and method for lactose hydrolysis
The present invention relates to a composition for the enzymatic hydrolysis of lactose containing two lactase enzymes having distinct pH optima. The composition is suitable for treating or...
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6558693 |
Animal feed additives
The present invention relates to animal feed additives comprising galactanase enzymes. More specifically the invention relates to animal feed additives comprising a arabinogalactan...
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6551590 |
Hyaluronidase preparation for ophthalmic administration and enzymatic methods for accelerating clearance of hemorrhagic blood from the vireous body of the eye
The invention provide a method for accelerating the clearance of hemorrhagic blood from the vitreous humor of a mammalian eye without producing toxicity to the eye, the method comprising contacting...
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